{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T13:35:36Z","timestamp":1784640936678,"version":"3.55.0"},"reference-count":31,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Ocular candidiasis is a critical and challenging complication of candidemia. The purpose of this study was to investigate the appropriate timing for ophthalmologic examinations, risk factors for complications of ocular lesions, and their association with mortality. This retrospective cohort study applied, using multiple logistic regression analysis and Cox regression models, to cases of candidemia (age \u2265 18 years) for patients who underwent ophthalmologic consultation. Of the 108 candidemia patients who underwent ophthalmologic examination, 27 (25%) contracted patients had ocular candidiasis, and 7 experienced the more severe condition of endophthalmitis, which included subjective ocular symptoms. In most cases, the initial ophthalmologic examination was performed within one week of the onset of candidiasis with a diagnosis of ocular candidiasis, but in three cases, the findings became apparent only after a second examination within 7\u201314 days after onset of candidiasis. The independent risk factor extracted for the development of ocular candidiasis was the isolation of C. albicans (OR, 4.85; 95% CI, 1.58\u201314.90), unremoved CVC (OR, 10.40; 95% CI, 1.74\u201362.16), and a high \u03b2DG value (&gt;108.2 pg\/mL) (HR, 2.83; 95% CI = 1.24\u20136.27). Continuous ophthalmologic examination is recommended in cases of candidemia with the above risk factors with an initial examination within 7 days of onset and a second examination 7\u201314 days after onset.<\/jats:p>","DOI":"10.3390\/jof8050497","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:19:46Z","timestamp":1652264386000},"page":"497","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Risk Factors and Clinical Characteristics of Patients with Ocular Candidiasis"],"prefix":"10.3390","volume":"8","author":[{"given":"Toru","family":"Sakamoto","sequence":"first","affiliation":[{"name":"Department of Infection Control and Prevention, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-5525","authenticated-orcid":false,"given":"Kenji","family":"Gotoh","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-8290","authenticated-orcid":false,"given":"Kenyu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Medicine, Shin Koga Hospital, Kurume 830-8577, Japan"},{"name":"Graduate School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiyoko","family":"Tanamachi","sequence":"additional","affiliation":[{"name":"School for Medical Technology, Kurume University, Kurume 830-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3715-2759","authenticated-orcid":false,"given":"Hiroshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Infection Control and Prevention, School of Medicine, Kurume University, Kurume 830-0011, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial Bloodstream Infections in US Hospitals: Analysis of 24,719 Cases from a Prospective Nationwide Surveillance Study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. 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