{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T01:21:13Z","timestamp":1760232073410,"version":"build-2065373602"},"reference-count":28,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>This case highlights the use of (1,3)-beta-d glucan to direct treatment of a cervical spinal cord Aspergillus fumigatus infection in a 22-year-old woman immunocompromised due to steroid and anti-TNF therapy in the context of ulcerative colitis and interferon gamma deficiency. A 4-year treatment course requiring neurosurgical intervention on four occasions and prolonged antifungal therapy, including isavuconazole, resulted in clinical cure with a corresponding decrease in CSF beta-d-glucan to &lt;30 pg\/mL. Serum and CSF galactomannan levels were not elevated at any point during the clinical course.<\/jats:p>","DOI":"10.3390\/jof8060557","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T05:12:27Z","timestamp":1653455547000},"page":"557","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isavuconazole Treatment of Spinal Cord Invasive Aspergillosis Guided by Cerebrospinal Fluid (1,3)-\u03b2-d-Glucan Levels in a Patient with Low Interferon-Gamma and Ulcerative Colitis"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4071-9517","authenticated-orcid":false,"given":"Siobhan","family":"O\u2019Regan","sequence":"first","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"},{"name":"International Health and Tropical Medicine Department, Royal College of Surgeons Ireland University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9367-6576","authenticated-orcid":false,"given":"Brendan","family":"O\u2019Kelly","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Reidy","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aoibhlinn","family":"O\u2019Toole","sequence":"additional","affiliation":[{"name":"Gastroenterology Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Caird","sequence":"additional","affiliation":[{"name":"Neurosurgery Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cora","family":"McNally","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"McConkey","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"},{"name":"International Health and Tropical Medicine Department, Royal College of Surgeons Ireland University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eoghan","family":"De Barra","sequence":"additional","affiliation":[{"name":"Infectious Diseases Service, Beaumont Hospital, D09 V2N0 Dublin, Ireland"},{"name":"International Health and Tropical Medicine Department, Royal College of Surgeons Ireland University of Medicine and Health Sciences, D02 YN77 Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.idnow.2021.04.002","article-title":"Clinical manifestations, diagnosis, and treatment outcome of CNS aspergillosis: A systematic review of 235 cases","volume":"51","author":"Meena","year":"2021","journal-title":"Infect. 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