{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:54:01Z","timestamp":1790099641889,"version":"4.0.1"},"reference-count":34,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>(1) Background: Aspergillus produces high morbidity and mortality, especially in at-risk populations. In Spain, the evolution of mortality in recent years due to this fungus is not well established. The aim of this study was to estimate the case fatality rate of aspergillosis in inpatients from 1997 to 2017 in Spain. (2) Methodology: A retrospective descriptive study was conducted with records of inpatients admitted to the National Health System with a diagnosis of aspergillosis. (3) Principal findings: Of 32,960 aspergillosis inpatients, 24.5% of deaths were registered, and 71% of the patients who died were men. The percentage of deaths increased progressively with age. The case fatality rate progressively decreased over the period, from 25.4 and 27.8% in 1997\u20131998 to values of 20.6 and 20.8% in 2016 and 2017. Influenza and pneumonia occurrence\/association significantly increased case fatality rates in all cases. (4) Conclusions: Our study shows that lethality significantly decreased in the last two decades despite the increase in cases. This highlights the fact that patients with solid and\/or hematological cancer do not have a much higher mortality rate than the group of patients with pneumonia or influenza alone, these two factors being the ones that cause the highest CFRs. We also need studies that analyze the causes of mortality to decrease it and studies that evaluate the impact of COVID-19.<\/jats:p>","DOI":"10.3390\/jof8060576","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:40:45Z","timestamp":1653702045000},"page":"576","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["How Has the Aspergillosis Case Fatality Rate Changed over the Last Two Decades in Spain?"],"prefix":"10.3390","volume":"8","author":[{"given":"Pablo","family":"Gonz\u00e1lez-Garc\u00eda","sequence":"first","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Marqu\u00e9s de Valdecilla, IDIVAL, Universidad de Cantabria, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alonso-Sard\u00f3n","sequence":"additional","affiliation":[{"name":"\u00c1rea de Medicina Preventiva, Epidemiolog\u00eda y Salud P\u00fablica, IBSAL, CIETUS, Universidad de Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Rodr\u00edguez-Alonso","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Almeida","sequence":"additional","affiliation":[{"name":"Servi\u00e7io de Medicina Interna, Unidade Local de Sa\u00fade de Guarda, 6300 Guarda, Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngela","family":"Romero-Alegr\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9294-564X","authenticated-orcid":false,"given":"V\u00edctor-Jos\u00e9","family":"Vega-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, CAUSA, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amparo","family":"L\u00f3pez-Bern\u00fas","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-8785","authenticated-orcid":false,"given":"Juan Luis","family":"Mu\u00f1oz-Bellido","sequence":"additional","affiliation":[{"name":"Servicio de Microbiolog\u00eda y Parasitolog\u00eda, CAUSA, CIETUS, IBSAL, Departamento de Ciencias Biom\u00e9dicas y del Diagn\u00f3stico, Universidad de Salamanca, CSIC, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-4740","authenticated-orcid":false,"given":"Antonio","family":"Muro","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Group (e-INTRO), IBSAL-CIETUS, Faculty of Pharmacy, University of Salamanca, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Pardo-Lled\u00edas","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Hospital Marqu\u00e9s de Valdecilla, IDIVAL, Universidad de Cantabria, 39008 Santander, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2230-1256","authenticated-orcid":false,"given":"Moncef","family":"Belhassen-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Servicio de Medicina Interna, Unidad de Enfermedades Infecciosas CAUSA, IBSAL, CIETUS, 37007 Salamanca, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/513943","article-title":"Invasive aspergillosis","volume":"26","author":"Denning","year":"1998","journal-title":"Clin. 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