{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T23:52:08Z","timestamp":1775087528985,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T00:00:00Z","timestamp":1657324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Highly variable estimates of COVID-19-associated fungal diseases (IFDs) have been reported. We aimed to determine the incidence of clinically important fungal diseases in hospitalized COVID-19 patients during the first year of the pandemic. We performed a multicenter survey of IFDs among patients hospitalized with COVID-19 in 13 hospitals in Israel between February 2020 and May 2021. COVID-19-associated pulmonary mold disease (PMD) and invasive candidiasis (IC) were defined using ECMM\/ISHAM and EORTC\/MSG criteria, respectively. Overall rates of IC and PMD among patients with critical COVID-19 were 10.86 and 10.20 per 1000 admissions, respectively, with significant variability among medical centers. PMD rates were significantly lower in centers where galactomannan was a send-out test versus centers with on-site testing (p = 0.035). The 30-day mortality rate was 67.5% for IC and 57.5% for PMD. Treatment with an echinocandin for IC or an extended-spectrum azole for PMD was associated with significantly lower mortality rates (adjusted hazard ratio [95% confidence interval], 0.26 [0.07\u20130.91] and 0.23 [0.093\u20130.57], respectively). In this multicenter national survey, variable rates of PMD were associated with on-site galactomannan testing, suggesting under-detection in sites lacking this capacity. COVID-19-related IFDs were associated with high mortality rates, which were reduced with appropriate antifungal therapy.<\/jats:p>","DOI":"10.3390\/jof8070721","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T22:48:00Z","timestamp":1657493280000},"page":"721","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Invasive Fungal Diseases in Hospitalized Patients with COVID-19 in Israel: A Multicenter Cohort Study"],"prefix":"10.3390","volume":"8","author":[{"given":"Meital","family":"Elbaz","sequence":"first","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maya","family":"Korem","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center, Jerusalem 9101002, Israel"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-2340","authenticated-orcid":false,"given":"Oshrat","family":"Ayalon","sequence":"additional","affiliation":[{"name":"Hadassah Medical Center, Jerusalem 9101002, Israel"},{"name":"Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yonit","family":"Wiener-Well","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel"},{"name":"Shaare Zedek Medical Center, Jerusalem 9101002, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8353-0108","authenticated-orcid":false,"given":"Yael","family":"Shachor-Meyouhas","sequence":"additional","affiliation":[{"name":"Rambam Medical Center, Haifa 3109601, Israel"},{"name":"Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regev","family":"Cohen","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel"},{"name":"Laniado Medical Center, Netanya 4290200, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jihad","family":"Bishara","sequence":"additional","affiliation":[{"name":"Rabin Medical Medical Center, Petah-Tiqva 4910002, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Atamna","sequence":"additional","affiliation":[{"name":"Rabin Medical Medical Center, Petah-Tiqva 4910002, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7154-2032","authenticated-orcid":false,"given":"Tal","family":"Brosh-Nissimov","sequence":"additional","affiliation":[{"name":"Samson Assuta Ashdod University Hospital, Ashdod 7747629, Israel"},{"name":"Faculty of Health Sciences, Ben Gurion University in the Negev, Beer Sheba 8443944, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Maaravi","sequence":"additional","affiliation":[{"name":"Samson Assuta Ashdod University Hospital, Ashdod 7747629, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1230-0428","authenticated-orcid":false,"given":"Lior","family":"Nesher","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Ben Gurion University in the Negev, Beer Sheba 8443944, Israel"},{"name":"Soroka Medical Center, Beer Sheba 8443944, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bibiana","family":"Chazan","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel"},{"name":"Ha\u2019Emek Medical Center, Afula 1834111, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Reisfeld","sequence":"additional","affiliation":[{"name":"Rappaport Faculty of Medicine, Technion, Haifa 3109601, Israel"},{"name":"Hillel Yaffe Medical Center, Hadera 3810101, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oren","family":"Zimhony","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Hebrew University, Jerusalem 9101002, Israel"},{"name":"Kaplan Medical Center, Rehovot 7610001, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"Chowers","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Meir Medical Center, Kfar Saba 4428164, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7258-3434","authenticated-orcid":false,"given":"Yasmin","family":"Maor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"},{"name":"Wolfson Medical Center, Holon 5822012, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugene","family":"Katchman","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0628-0798","authenticated-orcid":false,"given":"Ronen","family":"Ben-Ami","sequence":"additional","affiliation":[{"name":"Tel Aviv Sourasky Medical Center, Tel Aviv 6997801, Israel"},{"name":"Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e0009421","DOI":"10.1128\/CMR.00094-21","article-title":"Pathogenesis of Respiratory Viral and Fungal Coinfections","volume":"35","author":"Salazar","year":"2021","journal-title":"Clin. 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