{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T02:37:54Z","timestamp":1781577474110,"version":"3.54.5"},"reference-count":31,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003069","name":"Instituto Polit\u00e9cnico Nacional","doi-asserted-by":"publisher","award":["SIP20220742"],"award-info":[{"award-number":["SIP20220742"]}],"id":[{"id":"10.13039\/501100003069","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Magnusiomyces capitatus (also denominated \u201cGeotrichum capitatum\u201d and \u201cthe teleomorph stage of Saprochaete capitata\u201d) mainly affects immunocompromised patients with hematological malignancies in rare cases of invasive fungal infections (IFIs). Few cases have been reported for pediatric patients with acute lymphoblastic leukemia (ALL), in part because conventional diagnostic methods do not consistently detect M. capitatus in infections. The current contribution describes a systemic infection in a 15-year-old female diagnosed with ALL. She arrived at the Children\u2019s Hospital of Mexico City with a fever and neutropenia and developed symptoms of septic shock 4 days later. M. capitatus ENCB-HI-834, the causal agent, was isolated from the patient\u2019s blood, urine, bile, and peritoneal fluid samples. It was identified with matrix-assisted laser desorption\/ionization time-of-flight mass spectrometry (MALDI-TOF MS) and a phylogenetic reconstruction using internal transcribed spacer (ITS) and 28S ribosomal sequences. The phylogenetic sequence of M. capitatus ENCB-HI-834 clustered with other M. capitatus-type strains with a 100% identity. In vitro antifungal testing, conducted with the Sensititre YeastOne susceptibility system, found the following minimum inhibitory concentration (MIC) values (\u03bcg\/mL): posaconazole 0.25, amphotericin B 1.0, fluconazole &gt; 8.0, itraconazole 0.25, ketoconazole 0.5, 5-flucytosine \u2264 0.06, voriconazole 0.25, and caspofungin &gt; 16.0. No clinical breakpoints have been defined for M. capitatus. This is the first clinical case reported in Mexico of an IFI caused by M. capitatus in a pediatric patient with ALL. It emphasizes the importance of close monitoring for a timely and accurate diagnosis of neutropenia-related IFIs to determine the proper treatment with antibiotics, antifungals, and chemotherapy for instance including children with ALL.<\/jats:p>","DOI":"10.3390\/jof8080851","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T01:47:21Z","timestamp":1660528041000},"page":"851","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Invasive Fungal Infection Caused by Magnusiomyces capitatus in an Immunocompromised Pediatric Patient with Acute Lymphoblastic Leukemia in Mexico City: A Case Report"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5359-6280","authenticated-orcid":false,"given":"Jossue","family":"Ortiz-\u00c1lvarez","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular de Bacterias y Levaduras, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Res\u00e9ndiz-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Hospital Infantil de M\u00e9xico, Federico G\u00f3mez (HIMFG), Doctor M\u00e1rquez 162, Doctores, Mexico City 06720, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Ju\u00e1rez-Montiel","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular de Bacterias y Levaduras, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Alfredo","family":"Hern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular de Bacterias y Levaduras, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4092-5158","authenticated-orcid":false,"given":"Edwin","family":"V\u00e1zquez-Guerrero","sequence":"additional","affiliation":[{"name":"Laboratorio de Gen\u00e9tica Microbiana, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9sar","family":"Hern\u00e1ndez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular de Bacterias y Levaduras, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0055-2991","authenticated-orcid":false,"given":"Lourdes","family":"Villa-Tanaca","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular de Bacterias y Levaduras, Departamento de Microbiolog\u00eda, Escuela Nacional de Ciencias Biol\u00f3gicas Instituto Polit\u00e9cnico Nacional, Plan de Ayala y Prolongaci\u00f3n Carpio, Santo Tomas, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1470-9465.2004.00842.x","article-title":"Invasive infections caused by Blastoschizomyces capitatus and Scedosporium spp","volume":"10","author":"Bouza","year":"2004","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1128\/JCM.42.4.1832-1836.2004","article-title":"Genotyping and antifungal susceptibility profile of Dipodascus capitatus isolates causing disseminated infection in seven hematological patients of a tertiary hospital","volume":"42","author":"Gadea","year":"2004","journal-title":"J. Clin. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S1473-3099(10)70218-8","article-title":"Emerging opportunistic yeast infections","volume":"11","author":"Miceli","year":"2011","journal-title":"Lancet Infect. Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.3389\/fmicb.2019.02196","article-title":"Saprochaete clavata Invasive Infections\u2014A New Threat to Hematological-Oncological Patients","volume":"10","author":"Buchta","year":"2019","journal-title":"Front. Microbiol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.riam.2013.02.004","article-title":"Invasive infections caused by Saprochaete capitata in patients with haematological malignancies: Report of five cases and review of the antifungal therapy","volume":"30","author":"Amutio","year":"2013","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1080\/13693780500474327","article-title":"Differences in beta-glucan levels in culture supernatants of a variety of fungi","volume":"44","author":"Odabasi","year":"2006","journal-title":"Med. Mycol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/1469-0691.12360","article-title":"ESCMID and ECMM joint clinical guidelines for the diagnosis and management of rare invasive yeast infections","volume":"20","author":"Arendrup","year":"2014","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1128\/JCM.00039-14","article-title":"Misidentification of Saprochaete clavata as Magnusiomyces capitatus in clinical isolates: Utility of internal transcribed spacer sequencing and matrix-assisted laser desorption ionization-time of flight mass spectrometry and importance of reliable databas","volume":"52","author":"Blanc","year":"2014","journal-title":"J. Clin. Microbiol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.mmcr.2019.07.009","article-title":"Magnusiomyces capitatus fungemia: The value of direct microscopy in early diagnosis","volume":"25","author":"Alobaid","year":"2019","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"El Zein, S., Hindy, J.R., and Kanj, S.S. (2020). Invasive Saprochaete Infections: An Emerging Threat to Immunocompromised Patients. Pathogens, 9.","DOI":"10.3390\/pathogens9110922"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0378-1119(87)90131-4","article-title":"A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli","volume":"57","author":"Hoffman","year":"1987","journal-title":"Gene"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"4238","DOI":"10.1128\/jb.172.8.4238-4246.1990","article-title":"Rapid genetic identification and mapping of enzymatically amplified ribosomal DNA from several Cryptococcus species","volume":"172","author":"Vilgalys","year":"1990","journal-title":"J. Bacteriol."},{"key":"ref_13","unstructured":"Innis, M.A., Gelfand, D.H., Sninsky, J.J., and White, T.J. (1990). Amplification and direct sequencing of fungal ribosomal RNA genes form phylogenetics. PCR Protocols: A Guide to Methods and Applications, Academic Press Inc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J. Mol. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1093\/nar\/gkh340","article-title":"MUSCLE: Multiple sequence alignment with high accuracy and high throughput","volume":"32","author":"Edgar","year":"2004","journal-title":"Nucleic Acids Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1093\/molbev\/msn083","article-title":"jModelTest: Phylogenetic model averaging","volume":"25","author":"Posada","year":"2008","journal-title":"Mol. Biol. Evol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/molbev\/msy096","article-title":"MEGA X: Molecular Evolutionary Genetics Analysis across Computing Platforms","volume":"35","author":"Kumar","year":"2018","journal-title":"Mol. Biol. Evol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1093\/annonc\/mdw557","article-title":"Infection-related complications during treatment for childhood acute lymphoblastic leukemia","volume":"28","author":"Inaba","year":"2017","journal-title":"Ann. Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1086\/380643","article-title":"Blastoschizomyces capitatus infection in patients with leukemia: Report of 26 cases","volume":"38","author":"Martino","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1128\/JCM.43.4.1818-1828.2005","article-title":"Invasive infections caused by Trichosporon species and Geotrichum capitatum in patients with hematological malignancies: A retrospective multicenter study from Italy and review of the literature","volume":"43","author":"Girmenia","year":"2005","journal-title":"J. Clin. Microbiol."},{"key":"ref_21","first-page":"14228","article-title":"Invasive fungal infection caused by Geotrichum capitatum in patients with acute lymphoblastic leukemia: A case study and literature review","volume":"8","author":"Gao","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"98","DOI":"10.3201\/eid1801.111192","article-title":"Emergence of Blastoschizomyces capitatus yeast infections, Central Europe","volume":"18","author":"Birrenbach","year":"2012","journal-title":"Emerg. Infect. Dis."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1093\/mmy\/myv075","article-title":"Emergence of Magnusiomyces capitatus infections in Western Nepal","volume":"54","author":"Gokhale","year":"2016","journal-title":"Med. Mycol."},{"key":"ref_24","first-page":"2324709618795268","article-title":"A Case of Magnusiomyces capitatus Peritonitis Without Underlying Malignancies","volume":"6","author":"Lee","year":"2018","journal-title":"J. Investig. Med. High Impact Case Rep."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e01427-17","DOI":"10.1128\/JCM.01427-17","article-title":"Molecular Diagnostics of Arthroconidial Yeasts, Frequent Pulmonary Opportunists","volume":"56","author":"Kaplan","year":"2017","journal-title":"J. Clin. Microbiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mmcr.2017.03.004","article-title":"First case of invasive Magnusiomyces capitatus infection in Slovakia","volume":"16","author":"Tanuskova","year":"2017","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.3201\/eid2609.200341","article-title":"Saprochaete clavata Outbreak Infecting Cancer Center through Dishwasher","volume":"26","author":"Menu","year":"2020","journal-title":"Emerg. Infect. Dis."},{"key":"ref_28","first-page":"65","article-title":"Magnusiomyces clavatus infection in a child after allogeneic hematotopoietic stem cell transplantation: Diagnostic and therapeutic implications","volume":"21","author":"Leoni","year":"2018","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1182\/blood-2014-03-560847","article-title":"Infection-related mortality in children with acute lymphoblastic leukemia: An analysis of infectious deaths on UKALL2003","volume":"124","author":"Bate","year":"2014","journal-title":"Blood"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/s41579-022-00720-1","article-title":"Tackling the emerging threat of antifungal resistance to human health","volume":"29","author":"Fisher","year":"2022","journal-title":"Nat. Rev. Microbiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/clinchem\/hvab217","article-title":"Emerging Fungal Infections: New Species, New Names, and Antifungal Resistance","volume":"68","author":"Wiederhold","year":"2021","journal-title":"Clin. Chem."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/8\/851\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T00:08:42Z","timestamp":1760141322000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/8\/8\/851"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2022,8]]}},"alternative-id":["jof8080851"],"URL":"https:\/\/doi.org\/10.3390\/jof8080851","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]}}}