{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T02:13:57Z","timestamp":1775614437390,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,8,30]],"date-time":"2022-08-30T00:00:00Z","timestamp":1661817600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Recurrent vulvovaginal candidiasis (RVVC) is a debilitating, chronic condition that affects over 138 million (6%) women of reproductive age annually. We performed a retrospective audit of RVVC referrals to our tertiary care Candida clinic to evaluate the impact of the significantly updated British Association of Sexual Health and HIV (BASHH) 2019 vulvovaginal candidiasis guidelines on patient outcomes, the principles of which were implemented at our centre at the onset of the guideline revision process in 2017. A total of 78 women referred with suspected RVVC in 2017\u20132020 were included. Their mean symptom duration prior to referral was 6.7 years. RVVC was the definitive diagnosis in 73% of cases. In the 27% of patients without RVVC, the most common diagnoses were acute VVC (29%), vulval eczema (14%), dry skin (14%) and vulvodynia (10%). Of those with RVVC, 60% were diagnosed with an additional diagnosis, most commonly vulval eczema or vulvodynia. Only 12% of women had been counselled on appropriate vulval skin care, the mainstay of RVVC management. Long-term antifungal suppression was initiated in 68% of women. Azole-resistant Candida, for which there is no licensed treatment available in the UK, was identified in 23% of women with RVVC. In the follow-up, 82% of patients reported good control of symptoms using antifungal suppression therapy and recommended skin care, 16% had partial symptom control with some \u201cflare-ups\u201d responding to treatment, none reported poor control and for 2% this information was not available. RVVC-related morbidity can be reduced by following the principles outlined in the BASHH guidelines.<\/jats:p>","DOI":"10.3390\/jof8090924","type":"journal-article","created":{"date-parts":[[2022,8,31]],"date-time":"2022-08-31T00:13:56Z","timestamp":1661904836000},"page":"924","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Compliance with the Updated BASHH Recurrent Vulvovaginal Candidiasis Guidelines Improves Patient Outcomes"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9896-8682","authenticated-orcid":false,"given":"Lottie","family":"Brown","sequence":"first","affiliation":[{"name":"Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M23 9LT, UK"},{"name":"Guys and St Thomas\u2019 NHS Foundation Trust, London SE1 7EH, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathilde","family":"Chamula","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Mycology Reference Centre Manchester, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Weinberg","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"The Mid Yorkshire Hospitals NHS Trust, Wakefield WF1 4DG, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frakinda","family":"Jbueen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1071-6040","authenticated-orcid":false,"given":"Riina","family":"Rautemaa-Richardson","sequence":"additional","affiliation":[{"name":"Division of Evolution, Infection and Genomics, Faculty of Biology, Medicine and Health, University of Manchester, Manchester M23 9LT, UK"},{"name":"Department of Infectious Diseases, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"},{"name":"Mycology Reference Centre Manchester, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester M23 9LT, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e339","DOI":"10.1016\/S1473-3099(18)30103-8","article-title":"Global burden of recurrent vulvovaginal candidiasis: A systematic review","volume":"18","author":"Denning","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1177\/0956462419825948","article-title":"British Association for Sexual Health and HIV national guideline for the management of infection with Mycoplasma genitalium (2018)","volume":"30","author":"Soni","year":"2019","journal-title":"Int. J. STD AIDS"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Willems, H., Ahmed, S., Liu, J., Xu, Z., and Peters, B.M. (2020). Vulvovaginal Candidiasis: A Current Understanding and Burning Questions. J. Fungi, 6.","DOI":"10.3390\/jof6010027"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1439-0507.2009.01754.x","article-title":"Self-elimination of risk factors for recurrent vaginal candidosis","volume":"54","author":"Donders","year":"2011","journal-title":"Mycoses"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1097\/QAD.0b013e32836290b6","article-title":"Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: Implications for HIV transmission","volume":"27","author":"Verwijs","year":"2013","journal-title":"AIDS"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S1081-1206(10)62804-9","article-title":"Recurrent vaginal candidiasis and allergic rhinitis: A common association","volume":"81","author":"Moraes","year":"1998","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/j.1439-0507.2005.01164.x","article-title":"The serum levels of calcium, magnesium, iron and zinc in patients with recurrent vulvovaginal candidosis during attack, remission and in healthy controls","volume":"48","author":"Spacek","year":"2005","journal-title":"Mycoses"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11908-010-0137-9","article-title":"Vulvovaginal Candidiasis Caused by Non-albicans Candida Species: New Insights","volume":"12","author":"Kennedy","year":"2010","journal-title":"Curr. Infect. Dis. Rep."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/sti.79.3.249","article-title":"Vulvovaginal carriage of yeasts other than Candida albicans","volume":"79","author":"Holland","year":"2003","journal-title":"Sex. Transm. Infect."},{"key":"ref_10","unstructured":"Lazaro, N. (2022, July 17). Royal College of General Practitioners Sexually Transmitted Infections in Primary Care. Available online: www.bashh.org\/guidelines."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1097\/LGT.0000000000000413","article-title":"Long-term outcomes of women with recurrent vulvovaginal candidiasis after a course of maintenance antifungal therapy","volume":"22","author":"Crouss","year":"2018","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1001\/archinte.1990.00390200111021","article-title":"The limited value of symptoms and signs in the diagnosis of vaginal infections","volume":"150","author":"Schaaf","year":"1990","journal-title":"Arch. Intern. Med."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Whaley, S.G., Berkow, E.L., Rybak, J.M., Nishimoto, A.T., Barker, K.S., and Rogers, P.D. (2017). Azole antifungal resistance in Candida albicans and emerging non-albicans Candida Species. Front. Microbiol.","DOI":"10.3389\/fmicb.2016.02173"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.ejogrb.2006.03.009","article-title":"Clinical aspects and luteal phase assessment in patients with recurrent vulvovaginal candidiasis","volume":"131","author":"Buchta","year":"2007","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1001\/archderm.141.10.1328","article-title":"Genital Dermatology Atlas","volume":"141","author":"Laumann","year":"2005","journal-title":"Arch. Dermatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.ijgo.2011.04.016","article-title":"The effect of \u201cbreathable\u201d panty liners on the female lower genital tract","volume":"115","author":"Giraldo","year":"2011","journal-title":"Int. J. Gynecol. Obstet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1016\/j.ajog.2003.11.027","article-title":"Risk factors for recurrent vulvovaginal candidiasis in women receiving maintenance antifungal therapy: Results of a prospective cohort study","volume":"190","author":"Patel","year":"2004","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"70","DOI":"10.2188\/jea.JE20081046","article-title":"Vaginal douching in cambodian women: Its prevalence and association with vaginal candidiasis","volume":"20","author":"Heng","year":"2010","journal-title":"J. Epidemiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.ejogrb.2012.12.001","article-title":"Weekly fluconazole therapy for recurrent vulvovaginal candidiasis: A systematic review and meta-analysis","volume":"167","author":"Rosa","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_20","first-page":"117","article-title":"Fluconazole and boric acid for treatment of vaginal candidiasis- new words about old issue","volume":"90","author":"Khameneie","year":"2013","journal-title":"East Afr. Med. J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"613.e1","DOI":"10.1016\/j.ajog.2008.06.029","article-title":"Individualized decreasing-dose maintenance fluconazole regimen for recurrent vulvovaginal candidiasis (ReCiDiF trial)","volume":"199","author":"Donders","year":"2008","journal-title":"Am. J. Obstet. Gynecol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/01.LGT.0000171664.63976.FB","article-title":"Successful treatment of refractory recurrent vaginal candidiasis with cetirizine plus fluconazole","volume":"9","author":"Neves","year":"2005","journal-title":"J. Low. Genit. Tract Dis."},{"key":"ref_23","unstructured":"(2021, July 17). Medical Research Council and NHS Health Research Authority Decision Tools: Is My Study Research and Do I Need NHS Research Ethics Committee Review?. Available online: http:\/\/www.hra-decisiontools.org.uk\/research\/ and http:\/\/www.hra-decisiontools.org.uk\/ethics\/."},{"key":"ref_24","first-page":"595","article-title":"Women\u2019s use of over-the-counter antifimgal medications for gynecologic symptoms","volume":"42","author":"Ferris","year":"1996","journal-title":"J. Fam. Pract."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1136\/jcp.41.11.1247-c","article-title":"Candida and Candidosis","volume":"41","author":"Mackenzie","year":"1988","journal-title":"J. Clin. Pathol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1099\/00222615-11-3-233","article-title":"Quantitative studies of the vaginal flora of healthy women and of obstetric and gynaecological patients","volume":"11","author":"Lindner","year":"1978","journal-title":"J. Med. Microbiol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Drell, T., Lillsaar, T., Tummeleht, L., Simm, J., Aasp\u00f5llu, A., Vain, E., Saarma, I., Salumets, A., Donders, G.G.G., and Metsis, M. (2013). Characterization of the Vaginal Micro- and Mycobiome in Asymptomatic Reproductive-Age Estonian Women. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0054379"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1093\/cid\/ciab750","article-title":"Ibrexafungerp Versus Placebo for Vulvovaginal Candidiasis Treatment: A Phase 3, Randomized, Controlled Superiority Trial (VANISH 303)","volume":"74","author":"Schwebke","year":"2022","journal-title":"Clin. Infect. Dis."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Lawton, S., and Littlewood, S. (2006). Vulval skin disease: Clinical features, assessment and management. Nurs. Stand.","DOI":"10.7748\/ns2006.06.20.42.57.c6555"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/jdv.14096","article-title":"2016 European guideline for the management of vulval conditions","volume":"31","author":"Boffa","year":"2017","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7648152","DOI":"10.1155\/2018\/7648152","article-title":"Mannose-binding lectin gene polymorphism and its association with susceptibility to recurrent vulvovaginal candidiasis","volume":"2018","author":"Hammad","year":"2018","journal-title":"Biomed Res. 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