{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:22:59Z","timestamp":1790745779245,"version":"4.1.0"},"reference-count":96,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds d\u2019aide \u00e0 l\u2019\u00e9mergence et \u00e0 l\u2019excellence du CHRU de Lille-Bonus H 2022"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>The landscape of invasive candidiasis and invasive aspergillosis has changed dramatically in intensive care units over the past two decades. Today, we are faced with new risk factors such as the emergence of resistance, but are also equipped with new therapeutic strategies and diagnostic tools which are changing epidemiological data and diagnostic algorithms. Some common points need to be addressed: (i) the best way to use microbiological tools and to integrate their results in decisional algorithms; (ii) the need to find the optimum balance between under-diagnosis and overtreatment; (iii) and the need to decipher pathophysiology. In this short review, we will try to illustrate these points.<\/jats:p>","DOI":"10.3390\/jof8090946","type":"journal-article","created":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T04:54:41Z","timestamp":1662699281000},"page":"946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Changing Landscape of Invasive Fungal Infections in ICUs: A Need for Risk Stratification to Better Target Antifungal Drugs and the Threat of Resistance"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6017-5353","authenticated-orcid":false,"given":"Julien","family":"Poissy","sequence":"first","affiliation":[{"name":"UMR 8576\u2013UGSF\u2013Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS, P\u00f4le de M\u00e9decine Intensive-R\u00e9animation, Inserm U1285, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anahita","family":"Rouz\u00e9","sequence":"additional","affiliation":[{"name":"UMR 8576\u2013UGSF\u2013Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS, P\u00f4le de M\u00e9decine Intensive-R\u00e9animation, Inserm U1285, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjorie","family":"Cornu","sequence":"additional","affiliation":[{"name":"UMR 8576\u2013UGSF\u2013Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS, Institut de Microbiologie-Centre de Biologie Pathologie G\u00e9n\u00e9tique, Service de Mycologie M\u00e9dicale, Inserm U1285, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saad","family":"Nseir","sequence":"additional","affiliation":[{"name":"UMR 8576\u2013UGSF\u2013Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS, P\u00f4le de M\u00e9decine Intensive-R\u00e9animation, Inserm U1285, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-7325","authenticated-orcid":false,"given":"Boualem","family":"Sendid","sequence":"additional","affiliation":[{"name":"UMR 8576\u2013UGSF\u2013Unit\u00e9 de Glycobiologie Structurale et Fonctionnelle, CNRS, Institut de Microbiologie-Centre de Biologie Pathologie G\u00e9n\u00e9tique, Service de Mycologie M\u00e9dicale, Inserm U1285, Universit\u00e9 de Lille, CHU Lille, F-59000 Lille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1086\/421946","article-title":"Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study","volume":"39","author":"Wisplinghoff","year":"2004","journal-title":"Clin. 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