{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:53:28Z","timestamp":1768442008153,"version":"3.49.0"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Cryptococcosis is a severe life-threatening disease and a major cause of mortality in people with advanced AIDS and CD4 \u2264 100 cells\/\u00b5L. Considering the knowledge gap regarding the benefits of routine application of antigenemia tests in HIV-infected patients with 100\u2013200 CD4 cells\/\u00b5L for the prevention of cryptococcal meningitis (CM), we aimed to evaluate the prevalence of positive antigenemia through lateral flow assay (LFA) and associated factors in HIV-infected patients with CD4 &lt; 200 cells\/\u00b5L. Our findings of 3.49% of positive LFA (LFA+) patients with CD4 &lt; 100 cells\/\u00b5L and 2.24% with CD4 between 100\u2013200 cells\/\u00b5L have been included in a Bayesian analysis with 12 other studies containing similar samples worldwide. This analysis showed a proportion of 3.6% LFA+ patients (95% credible interval-Ci [2.5\u20135.7%]) with CD4 &lt; 100 cells\/\u00b5L and 1.1% (95%Ci [0.5\u20134.3%]) with CD4 between 100\u2013200 cells\/\u00b5L, without statistical difference between these groups. The difference between mortality rates in LFA+ and negative LFA groups was e = 0.05013. Cryptococcoma and CM were observed in the LFA+ group with 100\u2013200 and &lt;100 CD4 cells\/\u00b5L, respectively. Considering the benefits of antifungal therapy for LFA+ patients, our data reinforced the recommendation to apply LFA as a routine test in patients with 100\u2013200 CD4 cells\/\u00b5L aiming to expand cost-effectiveness studies in this group.<\/jats:p>","DOI":"10.3390\/jof8121284","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T04:05:29Z","timestamp":1670472329000},"page":"1284","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence and Associated Factors of Cryptococcal Antigenemia in HIV-Infected Patients with CD4 &lt; 200 Cells\/\u00b5L in S\u00e3o Paulo, Brazil: A Bayesian Analysis"],"prefix":"10.3390","volume":"8","author":[{"given":"Evanthia Vetos","family":"Mimicos","sequence":"first","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas, Faculdade de Medicina, University of S\u00e3o Paulo, Av. En\u00e9ias C. Aguiar, 255, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Fossaluza","sequence":"additional","affiliation":[{"name":"Instituto de Matem\u00e1tica e Estat\u00edstica, University of S\u00e3o Paulo, S\u00e3o Paulo 05508-090, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2455-5831","authenticated-orcid":false,"given":"Camila de Melo","family":"Picone","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas, Faculdade de Medicina, University of S\u00e3o Paulo, Av. En\u00e9ias C. Aguiar, 255, S\u00e3o Paulo 05403-000, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Caroline","family":"de Sena","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation in Neurology (LIM 15), Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lio Rodrigues","family":"Gomes","sequence":"additional","affiliation":[{"name":"Laboratory of Investigation in Neurology (LIM 15), Hospital das Cl\u00ednicas, Faculdade de Medicina, Universidade de Sao Paulo, S\u00e3o Paulo 01246-903, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina dos Santos","family":"L\u00e1zari","sequence":"additional","affiliation":[{"name":"Division of Infectious and Parasitic Diseases, Hospital das Cl\u00ednicas, Faculdade de Medicina, University of S\u00e3o Paulo, Av. En\u00e9ias C. 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