{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:24:12Z","timestamp":1792697052509,"version":"4.5.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,12,9]],"date-time":"2022-12-09T00:00:00Z","timestamp":1670544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Background: An increase in the number of recurrent and recalcitrant dermatophytoses calls for a tool to guide the clinician to correlate in vitro minimum inhibitory concentration (MIC) data, antifungal treatment with clinical outcomes. This systematic review aims to explore a possible correlation between one aspect of this, previous antifungal exposure, and clinical outcomes. Methods: A systematic literature search for articles on previous antifungal treatment, treatment outcome, susceptibility methods used, organism (genus\/species), and MIC values was conducted. Results: A total of 720 records were identified of which 19 articles met the inclusion criteria. Forty percent of the cases had contact with or travel to India, 28% originated from or had traveled to other countries where treatment unresponsive tinea infections had been reported. Tinea corporis was the most common clinical presentation and the species involved were Trichophyton (T.) indotineae and T. rubrum, followed by T. mentagrophyte\/interdigitale complex and T. tonsurans. Nearly all patients had previously been exposed to one or more antifungals. The studies were too heterogeneous to perform a statistical analysis to test if previous antifungal exposure was related to resistance. Conclusions: Only a few studies were identified, which had both sufficient and robust data on in vitro susceptibility testing and clinical treatment failure. Further research on the value of susceptibility testing to improve clinical practice in the management of dermatophyte infections is needed.<\/jats:p>","DOI":"10.3390\/jof8121290","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T01:42:27Z","timestamp":1670809347000},"page":"1290","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["A Review of Antifungal Susceptibility Testing for Dermatophyte Fungi and It\u2019s Correlation with Previous Exposure and Clinical Responses"],"prefix":"10.3390","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4996-9106","authenticated-orcid":false,"given":"Sidra Saleem","family":"Khan","sequence":"first","affiliation":[{"name":"The Dermatology Centre, Salford Royal NHS Foundation Trust, Manchester M6 8HD, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick James","family":"Hay","sequence":"additional","affiliation":[{"name":"St. John\u2019s Institute of Dermatology, King\u2019s College London, London SE1 9RT, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7953-1047","authenticated-orcid":false,"given":"Ditte Marie Lindhardt","family":"Saunte","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Zealand University Hospital, DK-4000 Roskilde, Denmark"},{"name":"Institute of Clinical Medicine, Faculty of Health Science, University of Copenhagen, DK-1350 Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jdin.2020.10.003","article-title":"The global, regional, and national burden of fungal skin diseases in 195 countries and territories: A cross-sectional analysis from the Global Burden of Disease Study 2017","volume":"2","author":"Urban","year":"2020","journal-title":"JAAD Int."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/ijd.12122","article-title":"Psychosocial impact of onychomycosis: A review","volume":"52","author":"Chacon","year":"2013","journal-title":"Int. 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