{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:51:34Z","timestamp":1788940294735,"version":"build-2803163510"},"reference-count":77,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH NIAID","award":["1R01AI141202"],"award-info":[{"award-number":["1R01AI141202"]}]},{"name":"NIH NIAID","award":["938451"],"award-info":[{"award-number":["938451"]}]},{"name":"NIH NIAID","award":["KL2TR001882"],"award-info":[{"award-number":["KL2TR001882"]}]},{"name":"American Heart Association","award":["1R01AI141202"],"award-info":[{"award-number":["1R01AI141202"]}]},{"name":"American Heart Association","award":["938451"],"award-info":[{"award-number":["938451"]}]},{"name":"American Heart Association","award":["KL2TR001882"],"award-info":[{"award-number":["KL2TR001882"]}]},{"name":"NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI","award":["1R01AI141202"],"award-info":[{"award-number":["1R01AI141202"]}]},{"name":"NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI","award":["938451"],"award-info":[{"award-number":["938451"]}]},{"name":"NIH National Center for Advancing Translational Science (NCATS) UCLA CTSI","award":["KL2TR001882"],"award-info":[{"award-number":["KL2TR001882"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Candida auris is a multi-drug-resistant fungal pathogen that can survive outside the host and can easily spread and colonize the healthcare environment, medical devices, and human skin. C. auris causes serious life-threatening infections (up to 60% mortality) in immunosuppressed patients staying in such contaminated healthcare facilities. Some isolates of C. auris are resistant to virtually all clinically available antifungal drugs. Therefore, alternative therapeutic approaches are urgently needed. Using in silico protein modeling and analysis, we identified a highly immunogenic and surface-exposed epitope that is conserved between C. albicans hyphal-regulated protein (Cal-Hyr1p) and Hyr1p\/Iff-like proteins in C. auris (Cau-HILp). We generated monoclonal antibodies (MAb) against this Cal-Hyr1p epitope, which recognized several clinical isolates of C. auris representing all four clades. An anti-Hyr1p MAb prevented biofilm formation and enhanced opsonophagocytic killing of C. auris by macrophages. When tested for in vivo efficacy, anti-Hyr1p MAb protected 55% of mice against lethal systemic C. auris infection and showed significantly less fungal burden. Our study is highly clinically relevant and provides an effective alternative therapeutic option to treat infections due to MDR C. auris.<\/jats:p>","DOI":"10.3390\/jof9010103","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T03:11:02Z","timestamp":1673493062000},"page":"103","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Protective Efficacy of Anti-Hyr1p Monoclonal Antibody against Systemic Candidiasis Due to Multi-Drug-Resistant Candida auris"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6521-0998","authenticated-orcid":false,"given":"Shakti","family":"Singh","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"},{"name":"David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Barbarino","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman G.","family":"Youssef","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Declan","family":"Coleman","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"},{"name":"Biology Department, Pomona College, Pomona, CA 91711, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teclegiorgis","family":"Gebremariam","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3787-8530","authenticated-orcid":false,"given":"Ashraf S.","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, The Lundquist Institute for Biomedical Innovation at Harbor-University of California at Los Angeles (UCLA) Medical Center, Torrance, CA 90502, USA"},{"name":"David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1093\/cid\/ciw691","article-title":"Simultaneous Emergence of Multidrug-Resistant Candida auris on 3 Continents Confirmed by Whole-Genome Sequencing and Epidemiological Analyses","volume":"64","author":"Lockhart","year":"2017","journal-title":"Clin. Infect. Dis."},{"key":"ref_2","unstructured":"(2022, December 10). Centers for Disease Control and Prevention Screening for Candida auris Colonization|Candida auris|Fungal Diseases|CDC, Available online: https:\/\/www.cdc.gov\/fungal\/candida-auris\/c-auris-screening.html."},{"key":"ref_3","unstructured":"(2022, December 10). CDC Tracking Candida auris, Available online: https:\/\/www.cdc.gov\/fungal\/candida-auris\/tracking-c-auris.html."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00134-014-3603-2","article-title":"Incidence, Characteristics and Outcome of ICU-Acquired Candidemia in India","volume":"41","author":"Chakrabarti","year":"2015","journal-title":"Intensive Care Med."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1128\/JCM.00319-11","article-title":"First Three Reported Cases of Nosocomial Fungemia Caused by Candida auris","volume":"49","author":"Lee","year":"2011","journal-title":"J. Clin. Microbiol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2147\/IDR.S116229","article-title":"Current Perspective on Emergence, Diagnosis and Drug Resistance in Candida auris","volume":"10","author":"Sarma","year":"2017","journal-title":"Infect. Drug Resist."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.3201\/eid2410.180649","article-title":"Candida auris in Healthcare Facilities, New York, USA, 2013\u20132017","volume":"24","author":"Adams","year":"2018","journal-title":"Emerg. Infect. Dis."},{"key":"ref_8","unstructured":"National Center for Emerging and Zoonotic Infectious Diseases (NCEZID), and Center for Disease Control and Prevention (CDC) (2022, December 10). Candida auris: A Drug-Resistant Germ That Spreads in Healthcare Facilities, Available online: https:\/\/www.cdc.gov\/fungal\/diseases\/candidiasis\/pdf\/Candida_auris_508.pdf."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1017\/ice.2017.127","article-title":"Environmental Surfaces in Healthcare Facilities Are a Potential Source for Transmission of Candida auris and Other Candida Species","volume":"38","author":"Piedrahita","year":"2017","journal-title":"Infect. Control Hosp. Epidemiol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1111\/ajt.14121","article-title":"Investigation of the First Seven Reported Cases of Candida auris, a Globally Emerging Invasive, Multidrug-Resistant Fungus\u2014United States, May 2013\u2013August 2016","volume":"17","author":"Vallabhaneni","year":"2017","journal-title":"Am. J. Transplant."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1111\/myc.12790","article-title":"Five-Year Profile of Candidaemia at an Indian Trauma Centre: High Rates of Candida auris Blood Stream Infections","volume":"61","author":"Mathur","year":"2018","journal-title":"Mycoses"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"e00029-17","DOI":"10.1128\/CMR.00029-17","article-title":"Candida auris: A Review of the Literature","volume":"31","author":"Taori","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.jhin.2016.08.004","article-title":"Multidrug-Resistant Candida auris: \u2018New Kid on the Block\u2019 in Hospital-Associated Infections?","volume":"94","author":"Chowdhary","year":"2016","journal-title":"J. Hosp. Infect."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s40588-020-00143-7","article-title":"Candida auris infection and biofilm formation: Going beyond the surface","volume":"7","author":"Horton","year":"2020","journal-title":"Curr. Clin. Microbiol. Rep."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3201\/eid2302.161320","article-title":"Biofilm-Forming Capability of Highly Virulent, Multidrug-Resistant Candida auris","volume":"23","author":"Sherry","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3201\/eid2301.161497","article-title":"Invasive Infections with Multidrug-Resistant Yeast Candida auris, Colombia","volume":"23","year":"2017","journal-title":"Emerg. Infect. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s10238-021-00751-7","article-title":"COVID-19-Associated Opportunistic Infections: A Snapshot on the Current Reports","volume":"22","author":"Abdoli","year":"2022","journal-title":"Clin. Exp. Med."},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Arastehfar, A., Carvalho, A., Nguyen, M.H., Hedayati, M.T., Netea, M.G., Perlin, D.S., and Hoenigl, M. (2020). COVID-19-Associated Candidiasis (Cac): An Underestimated Complication in the Absence of Immunological Predispositions?. J. Fungi, 6.","DOI":"10.3390\/jof6040211"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jgar.2020.06.003","article-title":"The Lurking Scourge of Multidrug Resistant Candida auris in Times of COVID-19 Pandemic","volume":"22","author":"Chowdhary","year":"2020","journal-title":"J. Glob. Antimicrob. Resist."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.riam.2020.07.001","article-title":"Fungal Co-Infection in COVID-19 Patients: Should We Be Concerned?","volume":"37","author":"Salavert","year":"2020","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_21","unstructured":"(2022, November 09). CDC 2019 Antibiotic Resistance Threats Report|CDC, Available online: https:\/\/www.cdc.gov\/drugresistance\/Biggest-Threats.html%0Ahttps:\/\/www.cdc.gov\/drugresistance\/\/biggest-threats.html."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e00458-19","DOI":"10.1128\/mSphere.00458-19","article-title":"Combined Antifungal Resistance and Biofilm Tolerance: The Global Threat of Candida auris","volume":"4","author":"Kean","year":"2019","journal-title":"mSphere"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/S1473-3099(18)30609-1","article-title":"Candida auris: A Global Fungal Public Health Threat","volume":"18","author":"Meis","year":"2018","journal-title":"Lancet Infect. Dis."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e01427-18","DOI":"10.1128\/AAC.01427-18","article-title":"Limited ERG11 Mutations Identified in Isolates of Candida auris Directly Contribute to Reduced Azole Susceptibility","volume":"62","author":"Healey","year":"2018","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Chatterjee, S., Alampalli, S.V., Nageshan, R.K., Chettiar, S.T., Joshi, S., and Tatu, U.S. (2015). Draft Genome of a Commonly Misdiagnosed Multidrug Resistant Pathogen Candida auris. BMC Genom., 16.","DOI":"10.1186\/s12864-015-1863-z"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1567-1364.2009.00541.x","article-title":"Covalently Linked Cell Wall Proteins of Candida albicans and Their Role in Fitness and Virulence","volume":"9","author":"Klis","year":"2009","journal-title":"FEMS Yeast Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1128\/EC.3.4.955-965.2004","article-title":"Proteomic Analysis of Candida albicans Cell Walls Reveals Covalently Bound Carbohydrate-Active Enzymes and Adhesins","volume":"3","author":"Cunningham","year":"2004","journal-title":"Eukaryot. Cell"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"5353","DOI":"10.1128\/jb.178.18.5353-5360.1996","article-title":"The Candida albicans HYR1 Gene, Which Is Activated in Response to Hyphal Development, Belongs to a Gene Family Encoding Yeast Cell Wall Proteins","volume":"178","author":"Bailey","year":"1996","journal-title":"J. Bacteriol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S0966-842X(01)01984-9","article-title":"The ALS Gene Family of Candida albicans","volume":"9","author":"Hoyer","year":"2001","journal-title":"Trends Microbiol."},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Lipke, P.N. (2018). What We Do Not Know about Fungal Cell Adhesion Molecules. J. Fungi, 4.","DOI":"10.3390\/jof4020059"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1086\/652407","article-title":"Candida albicans Hyr1p Confers Resistance to Neutrophil Killing and Is a Potential Vaccine Target","volume":"201","author":"Luo","year":"2010","journal-title":"J. Infect. Dis."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"476","DOI":"10.2174\/1570162X19666210812113137","article-title":"New Insights into Ocular Complications of Human Immunodeficiency Virus Infection","volume":"19","author":"Wang","year":"2021","journal-title":"Curr. HIV Res."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Reithofer, V., Fern\u00e1ndez-Pereira, J., Alvarado, M., de Groot, P., and Essen, L.O. (2021). A Novel Class of Candida glabrata Cell Wall Proteins with \u03b2-Helix Fold Mediates Adhesion in Clinical Isolates. PLoS Pathog., 17.","DOI":"10.1371\/journal.ppat.1009980"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1006\/jmbi.1999.3242","article-title":"Folding Pattern of the \u03b1-Crystallin Domain in AA-Crystallin Determined by Site-Directed Spin Labeling","volume":"294","author":"Koteiche","year":"1999","journal-title":"J. Mol. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1128\/EC.00279-10","article-title":"Candida albicans Als3, a Multifunctional Adhesin and Invasin","volume":"10","author":"Liu","year":"2011","journal-title":"Eukaryot. Cell"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1128\/IAI.00013-13","article-title":"Investigation of the Function of Candida albicans Als3 by Heterologous Expression in Candida glabrata","volume":"81","author":"Fu","year":"2013","journal-title":"Infect. Immun."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1128\/IAI.74.5.3039-3041.2006","article-title":"The Anti-Candida Vaccine Based on the Recombinant N-Terminal Domain of Als1p Is Broadly Active against Disseminated Candidiasis","volume":"74","author":"Ibrahim","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"6191","DOI":"10.1128\/IAI.73.9.6191-6193.2005","article-title":"The Anti-Candida albicans Vaccine Composed of the Recombinant N Terminus of Als1p Reduces Fungal Burden and Improves Survival in Both Immunocompetent and Immunocompromised Mice","volume":"73","author":"Spellberg","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"7594","DOI":"10.1016\/j.vaccine.2012.10.038","article-title":"NDV-3, a Recombinant Alum-Adjuvanted Vaccine for Candida and Staphylococcus aureus, Is Safe and Immunogenic in Healthy Adults","volume":"30","author":"Schmidt","year":"2012","journal-title":"Vaccine"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1086\/504691","article-title":"Efficacy of the Anti-Candida RAls3p-N or RAls1p-N Vaccines against Disseminated and Mucosal Candidiasis","volume":"194","author":"Spellberg","year":"2006","journal-title":"J. Infect. Dis."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/cid\/ciy185","article-title":"A Fungal Immunotherapeutic Vaccine (NDV-3A) for Treatment of Recurrent Vulvovaginal Candidiasis-A Phase 2 Randomized, Double-Blind, Placebo-Controlled Trial","volume":"66","author":"Edwards","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Singh, S., Uppuluri, P., Mamouei, Z., Alqarihi, A., Elhassan, H., French, S., Lockhart, S.R., Chiller, T., Edwards, J.E., and Ibrahim, A.S. (2019). The NDV-3A Vaccine Protects Mice from Multidrug Resistant Candida auris Infection. PLoS Pathog., 15.","DOI":"10.1371\/journal.ppat.1007460"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.1128\/IAI.00700-08","article-title":"The Antifungal Vaccine Derived from the Recombinant N Terminus of Als3p Protects Mice against the Bacterium Staphylococcus aureus","volume":"76","author":"Spellberg","year":"2008","journal-title":"Infect. Immun."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"76","DOI":"10.3389\/fimmu.2020.00076","article-title":"Monoclonal IgM Antibodies Targeting Candida albicans Hyr1 Provide Cross-Kingdom Protection Against Gram-Negative Bacteria","volume":"11","author":"Youssef","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Uppuluri, P., Lin, L., Alqarihi, A., Luo, G., Youssef, E.G., Alkhazraji, S., Yount, N.Y., Ibrahim, B.A., Bolaris, M.A., and Edwards, J.E. (2018). The Hyr1 Protein from the Fungus Candida albicans Is a Cross Kingdom Immunotherapeutic Target for Acinetobacter Bacterial Infection. PLoS Pathog., 14.","DOI":"10.1371\/journal.ppat.1007056"},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Smoak, R.A., Snyder, L.F., Fassler, J.S., and He, B.Z. (2022). Parallel Expansion and Divergence of the Hyr\/Iff-like (Hil) Adhesin Family in Pathogenic Yeasts Including Candida auris. bioRxiv.","DOI":"10.1101\/2022.02.09.479577"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/nprot.2015.053","article-title":"The Phyre2 Web Portal for Protein Modeling, Prediction and Analysis","volume":"10","author":"Kelley","year":"2015","journal-title":"Nat. Protoc."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nmeth.3213","article-title":"The I-TASSER Suite: Protein Structure and Function Prediction","volume":"12","author":"Yang","year":"2014","journal-title":"Nat. Methods"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1002\/prot.24065","article-title":"Ab Initio Protein Structure Assembly Using Continuous Structure Fragments and Optimized Knowledge-Based Force Field","volume":"80","author":"Xu","year":"2012","journal-title":"Proteins Struct. Funct. Bioinform."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0022-2836(81)90087-5","article-title":"Identification of Common Molecular Subsequences","volume":"147","author":"Smith","year":"1981","journal-title":"J. Mol. Biol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1002\/jcc.20084","article-title":"UCSF Chimera\u2014A Visualization System for Exploratory Research and Analysis","volume":"25","author":"Pettersen","year":"2004","journal-title":"J. Comput. Chem."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1093\/nar\/gki524","article-title":"TM-Align: A Protein Structure Alignment Algorithm Based on the TM-Score","volume":"33","author":"Zhang","year":"2005","journal-title":"Nucleic Acids Res."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3389\/fimmu.2018.01349","article-title":"Human Anti-Als3p Antibodies Are Surrogate Markers of NDV-3A Vaccine Efficacy Against Recurrent Vulvovaginal Candidiasis","volume":"9","author":"Uppuluri","year":"2018","journal-title":"Front. Immunol."},{"key":"ref_54","first-page":"1","article-title":"Metabolism of Immunoglobulins","volume":"13","author":"Waldmann","year":"1969","journal-title":"Prog. Allergy"},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"5141","DOI":"10.1038\/s41598-018-23481-5","article-title":"In Vivo Depletion of Serum IgG by an Affibody Molecule Binding the Neonatal Fc Receptor","volume":"8","author":"Seijsing","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Luo, G., Ibrahim, A.S., French, S.W., Edwards, J.E., and Fu, Y. (2011). Active and Passive Immunization with RHyr1p-N Protects Mice against Hematogenously Disseminated Candidiasis. PLoS ONE, 6.","DOI":"10.1371\/journal.pone.0025909"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"925821","DOI":"10.3389\/fimmu.2022.925821","article-title":"Antibodies Targeting Candida albicans Als3 and Hyr1 Antigens Protect Neonatal Mice from Candidiasis","volume":"13","author":"Singh","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ebiom.2016.09.015","article-title":"Bacterial Abscess Formation Is Controlled by the Stringent Stress Response and Can Be Targeted Therapeutically","volume":"12","author":"Mansour","year":"2016","journal-title":"EBioMedicine"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2297","DOI":"10.1099\/mic.0.049395-0","article-title":"Hyphal Induction in the Human Fungal Pathogen Candida albicans Reveals a Characteristic Wall Protein Profile","volume":"157","author":"Heilmann","year":"2011","journal-title":"Microbiology"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"5346","DOI":"10.1038\/s41467-018-07779-6","article-title":"Genomic Insights into Multidrug-Resistance, Mating and Virulence in Candida auris and Related Emerging Species","volume":"9","author":"Gade","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2012.12.001","article-title":"Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis","volume":"38","author":"Yona","year":"2013","journal-title":"Immunity"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"5288","DOI":"10.1038\/s41467-018-07738-1","article-title":"Single Human B Cell-Derived Monoclonal Anti-Candida Antibodies Enhance Phagocytosis and Protect against Disseminated Candidiasis","volume":"9","author":"Rudkin","year":"2018","journal-title":"Nat. Commun."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"19500","DOI":"10.1038\/s41598-021-98659-5","article-title":"A New Humanized Antibody Is Effective against Pathogenic Fungi In Vitro","volume":"11","author":"Vanzolini","year":"2021","journal-title":"Sci. Rep."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Rosario-colon, J., Eberle, K., Adams, A., Courville, E., and Xin, H. (2021). Candida Cell-Surface-Specific Monoclonal Antibodies Protect Mice against Candida auris Invasive Infection. Int. J. Mol. Sci., 22.","DOI":"10.3390\/ijms22116162"},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Lin, L., Ibrahim, A.S., Xu, X., Farber, J.M., Avanesian, V., Baquir, B., Fu, Y., French, S.W., Edwards, J.E., and Spellberg, B. (2009). Th1-Th17 Cells Mediate Protective Adaptive Immunity against Staphylococcus aureus and Candida albicans Infection in Mice. PLoS Pathog., 5.","DOI":"10.1371\/journal.ppat.1000703"},{"key":"ref_66","doi-asserted-by":"crossref","unstructured":"Torosantucci, A., Chiani, P., Bromuro, C., De Bernardis, F., Palma, A.S., Liu, Y., Mignogna, G., Maras, B., Colone, M., and Stringaro, A. (2009). Protection by Anti-b-Glucan Antibodies Is Associated with Restricted b-1,3 Glucan Binding Specificity and Inhibition of Fungal Growth and Adherence. PLoS ONE, 4.","DOI":"10.1371\/journal.pone.0005392"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/j.intimp.2010.08.027","article-title":"Efficacy of Combination Immunotherapy of IgM MAb B6.1 and Amphotericin B against Disseminated Candidiasis","volume":"10","author":"Han","year":"2010","journal-title":"Int. Immunopharmacol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/j.1365-2567.2004.01819.x","article-title":"Protection against systemic candidiasis in mice immunized with secreted aspartic proteinase 2","volume":"111","author":"Vilanova","year":"2004","journal-title":"Immunology"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1093\/jac\/dkn075","article-title":"Efungumab and Caspofungin: Pre-Clinical Data Supporting Synergy","volume":"61","author":"Hodgetts","year":"2008","journal-title":"J. Antimicrob. Chemother."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1128\/iai.55.3.749-752.1987","article-title":"Protection of Mice against Experimental Cryptococcosis by Anti-Cryptococcus neoformans Monoclonal Antibody","volume":"55","author":"Dromer","year":"1987","journal-title":"Infect. Immun."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1128\/AAC.49.3.952-958.2005","article-title":"Phase I Evaluation of the Safety and Pharmacokinetics of Murine-Derived Anticryptococcal Antibody 18B7 in Subjects with Treated Cryptococcal Meningitis","volume":"49","author":"Larsen","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1002\/eji.200838513","article-title":"Passive Immunization with Monoclonal Antibody against a 70-KDa Putative Adhesin of Sporothrix schenckii Induces Protection in Murine Sporotrichosis","volume":"38","author":"Nascimento","year":"2008","journal-title":"Eur. J. Immunol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6534","DOI":"10.1128\/IAI.71.11.6534-6542.2003","article-title":"Characterization of Gp70 and Anti-Gp70 Monoclonal Antibodies in Paracoccidioides brasiliensis Pathogenesis","volume":"71","author":"Mariano","year":"2003","journal-title":"Infect. Immun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1172\/JCI19361","article-title":"Antibodies to a Cell Surface Histone-like Protein Protect against Histoplasma capsulatum","volume":"112","author":"Nosanchuk","year":"2003","journal-title":"J. Clin. Investig."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"fnz015","DOI":"10.1093\/femsle\/fnz015","article-title":"A Novel Monoclonal Antibody against Enolase Antigen of Aspergillus fumigatus Protects Experimental Aspergillosis in Mice","volume":"366","author":"Yadav","year":"2019","journal-title":"FEMS Microbiol. Lett."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"eaaw1327","DOI":"10.1126\/sciadv.aaw1327","article-title":"Anti-CotH3 antibodies protect mice from mucormycosis by prevention of invasion and augmenting opsonophagocytosis","volume":"5","author":"Gebremariam","year":"2019","journal-title":"Sci. Adv."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2165\/11531280-000000000-00000","article-title":"Clinical Pharmacokinetics of Therapeutic Monoclonal Antibodies","volume":"49","author":"Keizer","year":"2010","journal-title":"Clin. Pharmacokinet."}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/1\/103\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:03:56Z","timestamp":1760119436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/1\/103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":77,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,1]]}},"alternative-id":["jof9010103"],"URL":"https:\/\/doi.org\/10.3390\/jof9010103","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]}}}