{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:42:54Z","timestamp":1791582174193,"version":"4.3.4"},"reference-count":22,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T00:00:00Z","timestamp":1677456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"Coccidioidomycosis","doi-asserted-by":"publisher","award":["NIH 5U19AI166798"],"award-info":[{"award-number":["NIH 5U19AI166798"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Liver disease causes relative compromise of the host immune system through multiple overlapping mechanisms and is an established risk factor for invasive fungal diseases including candidiasis and cryptococcosis. This immunologic derangement also leads to rapid progression of disease with resultant increases in morbidity and mortality. We describe severe coccidioidomycosis cases in the setting of liver dysfunction. Collaborative multi-center epidemiologic studies should be performed to determine the incidence of severe coccidioidomycosis in patients with concurrent liver disease.<\/jats:p>","DOI":"10.3390\/jof9030305","type":"journal-article","created":{"date-parts":[[2023,2,27]],"date-time":"2023-02-27T05:20:50Z","timestamp":1677475250000},"page":"305","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Case Series of End-Stage Liver Disease Patients with Severe Coccidioidomycosis"],"prefix":"10.3390","volume":"9","author":[{"given":"Daniel","family":"Ho","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen D.","family":"Kelley","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of California Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satya","family":"Dandekar","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA 95616, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart H.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"George R.","family":"Thompson","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology and Immunology, University of California Davis, Davis, CA 95616, USA"},{"name":"Department of Internal Medicine, Division of Infectious Diseases, University of California Davis, Sacramento, CA 95817, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,2,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e112","DOI":"10.1093\/cid\/ciw360","article-title":"2016 Infectious Diseases Society of America (IDSA) Clinical Practice Guideline for the Treatment of Coccidioidomycosis","volume":"63","author":"Galgiani","year":"2016","journal-title":"Clin. 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Dis."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"958","DOI":"10.3201\/eid1206.060028","article-title":"Coccidioidomycosis as a Common Cause of Community-acquired Pneumonia","volume":"12","author":"Valdivia","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.idc.2021.03.010","article-title":"Coccidioidomycosis","volume":"35","author":"Bays","year":"2021","journal-title":"Infect. Dis. Clin. North Am."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"e3814","DOI":"10.1093\/cid\/ciaa1154","article-title":"Natural History of Disseminated Coccidioidomycosis: Examination of the Veterans Af-fairs-Armed Forces Database","volume":"73","author":"Bays","year":"2021","journal-title":"Clin. Infect. Dis."},{"key":"ref_8","first-page":"e159491","article-title":"Immunogenetics associated with severe coccidioidomycosis","volume":"7","author":"Hsu","year":"2022","journal-title":"J. Clin. Investig."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"ofab543","DOI":"10.1093\/ofid\/ofab543","article-title":"Sex Differences in Susceptibility to Coccidioidomycosis","volume":"9","author":"McHardy","year":"2022","journal-title":"Open Forum Infect. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/CLEP.S34434","article-title":"Coccidioidomycosis: Epidemiology","volume":"5","author":"Thompson","year":"2013","journal-title":"Clin. Epidemiology"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"ofv197","DOI":"10.1093\/ofid\/ofv197","article-title":"End-Stage Liver Disease Is a Strong Predictor of Early Mortality in Cryptococcosis","volume":"3","author":"Spec","year":"2015","journal-title":"Open Forum Infect. Dis."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0168-8278(91)90900-V","article-title":"Fungal infection: A common, unrecognised complication of acute liver failure","volume":"12","author":"Rolando","year":"1991","journal-title":"J. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/myc.13387","article-title":"Global epidemiological burden of fungal infections in cirrhosis patients: A systematic review with meta-analysis","volume":"65","author":"Verma","year":"2021","journal-title":"Mycoses"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.jhep.2014.08.010","article-title":"Cirrhosis-associated immune dysfunction: Distinctive features and clinical relevance","volume":"61","author":"Albillos","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bpg.2006.07.004","article-title":"Prevention and treatment of infections in patients with cirrhosis","volume":"21","author":"Ghassemi","year":"2007","journal-title":"Best Pr. Res. Clin. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-019-12381-5","article-title":"Fungal dissemination is limited by liver macrophage filtration of the blood","volume":"10","author":"Sun","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/hep.1840170206","article-title":"Prospective controlled trial of selective parenteral and enteral antimicrobial regimen in fulminant liver failure","volume":"17","author":"Rolando","year":"1993","journal-title":"Hepatology"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Lee, C.Y., Thompson, G.R., Hastey, C.J., Hodge, G.C., Lunetta, J.M., Pappagianis, D., and Heinrich, V. (2015). Coccidioides Endospores and Spherules Draw Strong Chemotactic, Adhesive, and Phagocytic Responses by Individual Human Neutrophils. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129522"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1086\/509580","article-title":"The Impact of Cirrhosis on CD4+ T Cell Counts in HIV-Seronegative Patients","volume":"44","author":"McGovern","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.aidm.2013.09.005","article-title":"Liver cirrhosis as a predisposing factor for esophageal candidiasis","volume":"1","author":"Ou","year":"2014","journal-title":"Adv. Dig. Med."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"myab069","DOI":"10.1093\/mmy\/myab069","article-title":"Factors determining the mortality in cirrhosis patients with invasive candidiasis: A systematic review and meta-analysis","volume":"60","author":"Verma","year":"2021","journal-title":"Med. Mycol."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Spernovasilis, N., and Kofteridis, D.P. (2018). Pre-Existing Liver Disease and Toxicity of Antifungals. J. 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