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Quantitative trait loci mapping analysis was performed to assess genetic variants associated with mononuclear-cells-derived cytokines induced by P. brasiliensis on 158 individuals. We identified the rs11053595 SNP, which is present in the CLEC7A gene (encodes the Dectin-1 receptor) and the rs62290169 SNP located in the PROM1 gene (encodes CD133) associated with the production of IL-1\u03b2 and IL-22, respectively. Functionally, the blockade of the dectin-1 receptor abolished the IL-1\u03b2 production in P. brasiliensis-stimulated PBMCs. Moreover, the rs62290169-GG genotype was associated with higher frequency of CD38+ Th1 cells in PBMCs cultured with P. brasiliensis yeasts. Therefore, our research indicates that the CLEC7A and PROM1 genes are important for the cytokine response induced by P. brasiliensis and may influence the Paracoccidioidomycosis disease outcome.<\/jats:p>","DOI":"10.3390\/jof9040428","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T01:31:30Z","timestamp":1680139890000},"page":"428","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genome-Wide Association Study Reveals CLEC7A and PROM1 as Potential Regulators of Paracoccidioides brasiliensis-Induction of Cytokine Production in Peripheral Blood Mononuclear Cells"],"prefix":"10.3390","volume":"9","author":[{"given":"Ana Marina B.","family":"de Figueiredo","sequence":"first","affiliation":[{"name":"Laborat\u00f3rio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74605-050, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9191-7356","authenticated-orcid":false,"given":"J\u00e9ssica Cristina","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6963-1001","authenticated-orcid":false,"given":"Brenda","family":"Kischkel","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"},{"name":"Departamento de Microbiologia, Instituto de Ci\u00eancia Biom\u00e9dicas, Universidade de S\u00e3o Paulo, S\u00e3o Paulo 05508-000, S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Ardiansyah","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marije","family":"Oosting","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grazzielle","family":"Guimar\u00e3es Matos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74605-050, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iara","family":"Barreto Neves Oliveira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74605-050, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"van de Veerdonk","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai G.","family":"Netea","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Radboud Institute for Molecular Sciences (RILMS) and Radboud Center of Infectious Diseases (RCI), Radboud University Medical Center, 6524 Nijmegen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-9840","authenticated-orcid":false,"given":"C\u00e9lia Maria de Almeida","family":"Soares","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Biologia Molecular, Instituto de Ci\u00eancias Biol\u00f3gicas, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74690-900, Goi\u00e1s, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7950-3414","authenticated-orcid":false,"given":"F\u00e1tima","family":"Ribeiro-Dias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Imunidade Natural (LIN), Instituto de Patologia Tropical e Sa\u00fade P\u00fablica, Universidade Federal de Goi\u00e1s, Goi\u00e2nia 74605-050, Goi\u00e1s, 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