{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:08:26Z","timestamp":1790816906242,"version":"4.1.0"},"reference-count":105,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T00:00:00Z","timestamp":1682035200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Fomitiporia mediterranea (Fmed) is the primary Basidiomycota species causing white rot in European vineyards affected by the Esca complex of diseases (ECD). In the last few years, an increasing number of studies have highlighted the importance of reconsidering the role of Fmed in ECD etiology, justifying an increase in research interest related to Fmed\u2019s biomolecular pathogenetic mechanisms. In the context of the current re-evaluation of the binary distinction (brown vs. white rot) between biomolecular decay pathways induced by Basidiomycota species, our research aims to investigate the potential for non-enzymatic mechanisms adopted by Fmed, which is typically described as a white rot fungus. Our results demonstrate how, in liquid culture reproducing nutrient restriction conditions often found in wood, Fmed can produce low molecular weight compounds, the hallmark of the non-enzymatic \u201cchelator-mediated Fenton\u201d (CMF) reaction, originally described for brown rot fungi. CMF reactions can redox cycle with ferric iron, generating hydrogen peroxide and ferrous iron, necessary reactants leading to hydroxyl radical (\u2022OH) production. These observations led to the conclusion that a non-enzymatic radical-generating CMF-like mechanism may be utilized by Fmed, potentially together with an enzymatic pool, to contribute to degrading wood constituents; moreover, indicating significant variability between strains.<\/jats:p>","DOI":"10.3390\/jof9040498","type":"journal-article","created":{"date-parts":[[2023,4,21]],"date-time":"2023-04-21T04:48:11Z","timestamp":1682052491000},"page":"498","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["First Description of Non-Enzymatic Radical-Generating Mechanisms Adopted by Fomitiporia mediterranea: An Unexplored Pathway of the White Rot Agent of the Esca Complex of Diseases"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0731-5836","authenticated-orcid":false,"given":"Samuele","family":"Moretti","sequence":"first","affiliation":[{"name":"Laboratoire Vigne, Biotechnologies et Environnement UPR-3991, Universit\u00e9 de Haute-Alsace, 33 rue de Herrlisheim, 68000 Colmar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8462-5582","authenticated-orcid":false,"given":"Mary-Lor\u00e8ne","family":"Goddard","sequence":"additional","affiliation":[{"name":"Laboratoire Vigne, Biotechnologies et Environnement UPR-3991, Universit\u00e9 de Haute-Alsace, 33 rue de Herrlisheim, 68000 Colmar, France"},{"name":"Laboratoire d\u2019Innovation Mol\u00e9culaire et Applications, Universit\u00e9 de Haute-Alsace, Universit\u00e9 de Strasbourg, CNRS, LIMA, UMR 7042, CEDEX, 68093 Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Puca","sequence":"additional","affiliation":[{"name":"Laboratoire Vigne, Biotechnologies et Environnement UPR-3991, Universit\u00e9 de Haute-Alsace, 33 rue de Herrlisheim, 68000 Colmar, France"},{"name":"Department of Agricultural, Food, Environmental and Forestry Science and Technology (DAGRI), Plant Pathology and Entomology Section, University of Florence, P.le delle Cascine, 28, 50144 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-0335","authenticated-orcid":false,"given":"Jacques","family":"Lalev\u00e9e","sequence":"additional","affiliation":[{"name":"Institut de Science des Materiaux IS2M, Universit\u00e9 de Haute-Alsace, CNRS, IS2M UMR 7361, F-68100 Mulhouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2786-4277","authenticated-orcid":false,"given":"Stefano","family":"Di Marco","sequence":"additional","affiliation":[{"name":"Institute of Bioeconomy, CNR, Via Gobetti, 101, 40129 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-9764","authenticated-orcid":false,"given":"Laura","family":"Mugnai","sequence":"additional","affiliation":[{"name":"Department of Agricultural, Food, Environmental and Forestry Science and Technology (DAGRI), Plant Pathology and Entomology Section, University of Florence, P.le delle Cascine, 28, 50144 Firenze, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Gelhaye","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Lorraine, INRAE, IAM, F-54000 Nancy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7798-7419","authenticated-orcid":false,"given":"Barry","family":"Goodell","sequence":"additional","affiliation":[{"name":"Department of Microbiology, University of Massachusetts, Amherst, MA 01003, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Bertsch","sequence":"additional","affiliation":[{"name":"Laboratoire Vigne, Biotechnologies et Environnement UPR-3991, Universit\u00e9 de Haute-Alsace, 33 rue de Herrlisheim, 68000 Colmar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8974-4644","authenticated-orcid":false,"given":"Sibylle","family":"Farine","sequence":"additional","affiliation":[{"name":"Laboratoire Vigne, Biotechnologies et Environnement UPR-3991, Universit\u00e9 de Haute-Alsace, 33 rue de Herrlisheim, 68000 Colmar, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1094\/PDIS-08-17-1181-FE","article-title":"Grapevine Trunk Diseases: A Review of Fifteen Years of Trials for Their Control with Chemicals and 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