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One mechanism by which the host immune system attempts to control and eliminate Coccidioides is through granuloma formation. However, very little is known about granulomas during Coccidioides infection. Granulomas were first identified in tuberculosis (TB) lungs as early as 1679, and yet many gaps in our understanding of granuloma formation, maintenance, and regulation remain. Granulomas are best defined in TB, providing clues that may be leveraged to understand Coccidioides infections. Granulomas also form during several other infectious and spontaneous diseases including sarcoidosis, chronic granulomatous disease (CGD), and others. This review explores our current understanding of granulomas, as well as potential mechanisms, and applies this knowledge to unraveling coccidioidomycosis granulomas.<\/jats:p>","DOI":"10.3390\/jof9060650","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T02:03:18Z","timestamp":1686276198000},"page":"650","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Coccidioidomycosis Granulomas Informed by Other Diseases: Advancements, Gaps, and Challenges"],"prefix":"10.3390","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7003-8368","authenticated-orcid":false,"given":"Nadia","family":"Miranda","sequence":"first","affiliation":[{"name":"Quantitative Systems Biology Graduate Program, University of California Merced, Merced, CA 95343, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5443-0733","authenticated-orcid":false,"given":"Katrina K.","family":"Hoyer","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, CA 95343, USA"},{"name":"Health Sciences Research Institute, University of California Merced, Merced, CA 95343, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"ref_1","unstructured":"California Department of Health (2023, May 20). Infectious Diseases by Disease, County, Year, and Sex\u2014California Health and Human Services Open Data Portal, Available online: https:\/\/data.chhs.ca.gov\/dataset\/infectious-disease."},{"key":"ref_2","unstructured":"(2023, May 20). Arizona Department of Health Services, AZDHS|Epidemiology & Disease Control\u2014Valley Fever, Available online: http:\/\/www.azdhs.gov\/preparedness\/epidemiology-disease-control\/valley-fever\/index.php."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1029\/2019GH000209","article-title":"Expansion of Coccidioidomycosis Endemic Regions in the United States in Response to Climate Change","volume":"3","author":"Gorris","year":"2019","journal-title":"Geohealth"},{"key":"ref_4","unstructured":"CDC (2023, May 20). Information for Healthcare Professionals|Coccidioidomycosis|Types of Fungal Diseases|Fungal|CDC, Available online: https:\/\/www.cdc.gov\/fungal\/diseases\/coccidioidomycosis\/health-professionals.html."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/myc.12150","article-title":"Fungal diseases mimicking primary lung cancer: Radiologic-pathologic correlation","volume":"57","author":"Gazzoni","year":"2014","journal-title":"Mycoses"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Williams, S.L., and Chiller, T. (2022). Update on the Epidemiology, Diagnosis, and Treatment of Coccidioidomycosis. J. Fungi, 8.","DOI":"10.3390\/jof8070666"},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Whiston, E., Zhang Wise, H., Sharpton, T.J., Jui, G., Cole, G.T., and Taylor, J.W. (2012). Comparative transcriptomics of the saprobic and parasitic growth phases in Coccidioides spp.. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0041034"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz-Hern\u00e1ndez, B., Palma-Cort\u00e9s, G., Cabello-Guti\u00e9rrez, C., and Mart\u00ednez-Rivera, M.A. (2014). Parasitic polymorphism of Coccidioides spp.. BMC Infect. Dis., 14.","DOI":"10.1186\/1471-2334-14-213"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1146\/annurev-immunol-032712-100022","article-title":"The Formation and Function of Granulomas","volume":"36","author":"Ramakrishnan","year":"2018","journal-title":"Annu. Rev. Immunol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/nri1412","article-title":"Fibrotic disease and the T(H)1\/T(H)2 paradigm","volume":"4","author":"Wynn","year":"2004","journal-title":"Nat. Rev. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: Therapeutic translation for fibrotic disease","volume":"18","author":"Wynn","year":"2012","journal-title":"Nat. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jctube.2017.02.001","article-title":"Histopathologic review of granulomatous inflammation","volume":"7","author":"Shah","year":"2017","journal-title":"J. Clin. Tuberc. Other Mycobact. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.immuni.2008.06.011","article-title":"Tumor necrosis factor signaling mediates resistance to mycobacteria by inhibiting bacterial growth and macrophage death","volume":"29","author":"Clay","year":"2008","journal-title":"Immunity"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"170012","DOI":"10.1183\/16000617.0012-2017","article-title":"Differential diagnosis of granulomatous lung disease: Clues and pitfalls: Number 4 in the Series \u201cPathology for the clinician\u201d Edited by Peter Dorfm\u00fcller and Alberto Cavazza","volume":"26","author":"Ohshimo","year":"2017","journal-title":"Eur. Respir. Rev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.micinf.2014.06.011","article-title":"Valley fever: Danger lurking in a dust cloud","volume":"16","author":"Johnson","year":"2014","journal-title":"Microbes Infect."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Shubitz, L.F., Powell, D.A., Dial, S.M., Butkiewicz, C.D., Trinh, H.T., Hsu, A.P., Buntzman, A., Frelinger, J.A., and Galgiani, J.N. (2022). Reactivation of Coccidioidomycosis in a Mouse Model of Asymptomatic Controlled Disease. J. Fungi, 8.","DOI":"10.3390\/jof8100991"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"775326","DOI":"10.3389\/fimmu.2021.775326","article-title":"Foam Cell Macrophages in Tuberculosis","volume":"12","author":"Agarwal","year":"2021","journal-title":"Front. Immunol."},{"key":"ref_18","first-page":"91","article-title":"The Formation of Macrophages, Epithelioid Cells and Giant Cells from Leucocytes in Incubated Blood","volume":"1","author":"Lewis","year":"1925","journal-title":"Am. J. Pathol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.cell.2016.09.054","article-title":"DNA Damage Signaling Instructs Polyploid Macrophage Fate in Granulomas","volume":"167","author":"Herrtwich","year":"2016","journal-title":"Cell"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2144","DOI":"10.15252\/embr.201744121","article-title":"Mycobacteria exploit nitric oxide-induced transformation of macrophages into permissive giant cells","volume":"18","author":"Gharun","year":"2017","journal-title":"EMBO Rep."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1016\/j.immuni.2022.04.004","article-title":"Multimodal profiling of lung granulomas in macaques reveals cellular correlates of tuberculosis control","volume":"55","author":"Gideon","year":"2022","journal-title":"Immunity"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.molmed.2021.11.004","article-title":"Understanding the tuberculosis granuloma: The matrix revolutions","volume":"28","author":"Elkington","year":"2022","journal-title":"Trends Mol. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"804838","DOI":"10.3389\/fneur.2022.804838","article-title":"Tuberculous Granuloma: Emerging Insights from Proteomics and Metabolomics","volume":"13","author":"Sholeye","year":"2022","journal-title":"Front. Neurol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"e14127","DOI":"10.7717\/peerj.14127","article-title":"Radiomics combined with clinical features in distinguishing non-calcifying tuberculosis granuloma and lung adenocarcinoma in small pulmonary nodules","volume":"10","author":"Dong","year":"2022","journal-title":"PeerJ"},{"key":"ref_25","first-page":"139127","article-title":"The tuberculous granuloma: An unsuccessful host defence mechanism providing a safety shelter for the bacteria?","volume":"2012","author":"Breiman","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"434","DOI":"10.3389\/fimmu.2016.00434","article-title":"Granulomas and Inflammation: Host-Directed Therapies for Tuberculosis","volume":"7","author":"Ndlovu","year":"2016","journal-title":"Front. Immunol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/s41590-021-01121-x","article-title":"The immunoregulatory landscape of human tuberculosis granulomas","volume":"23","author":"McCaffrey","year":"2022","journal-title":"Nat. Immunol."},{"key":"ref_28","first-page":"727","article-title":"PD-1\/PD-L1 pathway: Current researches in cancer","volume":"10","author":"Han","year":"2020","journal-title":"Am. J. Cancer Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e52668","DOI":"10.7554\/eLife.52668","article-title":"Anti-PD-1 immunotherapy leads to tuberculosis reactivation via dysregulation of TNF-\u03b1","volume":"9","author":"Tezera","year":"2020","journal-title":"eLife"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"eaat2702","DOI":"10.1126\/scitranslmed.aat2702","article-title":"Tuberculosis following PD-1 blockade for cancer immunotherapy","volume":"11","author":"Barber","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41577-020-00490-y","article-title":"Myeloid-derived suppressor cells in the era of increasing myeloid cell diversity","volume":"21","author":"Veglia","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"773","DOI":"10.4049\/jimmunol.1300113","article-title":"Microenvironments in tuberculous granulomas are delineated by distinct populations of macrophage subsets and expression of nitric oxide synthase and arginase isoforms","volume":"191","author":"Mattila","year":"2013","journal-title":"J. Immunol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s11046-018-0264-7","article-title":"Inflammatory and Anti-inflammatory Responses Co-exist Inside Lung Granuloma of Fatal Cases of Coccidioidomycosis: A Pilot Report","volume":"183","year":"2018","journal-title":"Mycopathologia"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1128\/IAI.01985-05","article-title":"High levels of interleukin-10 impair resistance to pulmonary coccidioidomycosis in mice in part through control of nitric oxide synthase 2 expression","volume":"74","author":"Jimenez","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cellimm.2005.01.004","article-title":"L-Arginine modulates CD3zeta expression and T cell function in activated human T lymphocytes","volume":"232","author":"Zea","year":"2004","journal-title":"Cell. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"545413","DOI":"10.3389\/fimmu.2020.545413","article-title":"Treatment of Sarcoidosis: A Multidisciplinary Approach","volume":"11","author":"Gerke","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2147\/TCRM.S192922","article-title":"Refractory Sarcoidosis: A Review","volume":"16","author":"Jamilloux","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.3389\/fimmu.2020.01719","article-title":"Current Sarcoidosis Models and the Importance of Focusing on the Granuloma","volume":"11","author":"Locke","year":"2020","journal-title":"Front. Immunol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1165\/rcmb.2010-0401OC","article-title":"Novel murine model of chronic granulomatous lung inflammation elicited by carbon nanotubes","volume":"45","author":"Huizar","year":"2011","journal-title":"Am. J. Respir. Cell. Mol. Biol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000477736","article-title":"Increased Risk of Atherosclerosis in Patients with Sarcoidosis","volume":"84","author":"Bargagli","year":"2017","journal-title":"Pathobiology"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"27","DOI":"10.24294\/ti.v4.i1.721","article-title":"Serological Biomarkers of Granuloma Progression in Sarcoidosis","volume":"4","author":"Nguyen","year":"2018","journal-title":"Trends Immunother."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1002\/eji.201243185","article-title":"Invariant natural killer T (iNKT) cell exhaustion in sarcoidosis","volume":"43","author":"Nixon","year":"2013","journal-title":"Eur. J. Immunol."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2353\/ajpath.2009.080580","article-title":"FoxP3+ regulatory T cells suppress early stages of granuloma formation but have little impact on sarcoidosis lesions","volume":"174","author":"Taflin","year":"2009","journal-title":"Am. J. Pathol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1164\/rccm.201401-0188OC","article-title":"Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity","volume":"190","author":"Braun","year":"2014","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Garay, J.A., Silva, J.E., Di Genaro, M.S., and Davicino, R.C. (2022). The Multiple Faces of Nitric Oxide in Chronic Granulomatous Disease: A Comprehensive Update. Biomedicines, 10.","DOI":"10.3390\/biomedicines10102570"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1182\/blood.2021011798","article-title":"Heightened turnover and failed maturation of monocyte-derived macrophages in murine chronic granulomatous disease","volume":"139","author":"Gibbings","year":"2022","journal-title":"Blood"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2855","DOI":"10.1182\/blood.2021015365","article-title":"Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice","volume":"139","author":"Bhattacharya","year":"2022","journal-title":"Blood"},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Herb, M., and Schramm, M. (2021). Functions of ROS in Macrophages and Antimicrobial Immunity. Antioxidants, 10.","DOI":"10.3390\/antiox10020313"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Hsu, A.P., Korzeniowska, A., Aguilar, C.C., Gu, J., Karlins, E., Oler, A.J., Chen, G., Reynoso, G.V., Davis, J., and Chaput, A. (2022). Immunogenetics associated with severe coccidioidomycosis. JCI Insight, 7.","DOI":"10.1172\/jci.insight.159491"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/j.jaci.2015.07.003","article-title":"Endemic mycoses in patients with STAT3-mutated hyper-IgE (Job) syndrome","volume":"136","author":"Odio","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"581101","DOI":"10.3389\/fcimb.2020.581101","article-title":"Host Response to Coccidioides Infection: Fungal Immunity","volume":"10","author":"Diep","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nri1785","article-title":"Neutrophils and immunity: Challenges and opportunities","volume":"6","author":"Nathan","year":"2006","journal-title":"Nat. Rev. Immunol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-immunol-093019-112809","article-title":"Tissue-Resident Immune Cells in Humans","volume":"40","author":"Gray","year":"2022","journal-title":"Annu. Rev. Immunol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41423-018-0192-y","article-title":"Tissue-resident lymphocytes: From adaptive to innate immunity","volume":"16","author":"Sun","year":"2019","journal-title":"Cell. Mol. Immunol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1111\/imm.13143","article-title":"Tissue-resident innate immunity in the lung","volume":"159","author":"Ardain","year":"2020","journal-title":"Immunology"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1093\/infdis\/153.5.933","article-title":"Influence of fungal surface components on the interaction of Coccidioides immitis with polymorphonuclear neutrophils","volume":"153","author":"Frey","year":"1986","journal-title":"J. Infect. Dis."},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Lee, C.Y., Thompson, G.R., Hastey, C.J., Hodge, G.C., Lunetta, J.M., Pappagianis, D., and Heinrich, V. (2015). Coccidioides Endospores and Spherules Draw Strong Chemotactic, Adhesive, and Phagocytic Responses by Individual Human Neutrophils. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0129522"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Diep, A.L., Tejeda-Garibay, S., Miranda, N., and Hoyer, K.K. (2021). Macrophage and Dendritic Cell Activation and Polarization in Response to Coccidioidesposadasii Infection. J. Fungi, 7.","DOI":"10.3390\/jof7080630"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"891878","DOI":"10.3389\/fcimb.2022.891878","article-title":"Pathological and protective roles of dendritic cells in Mycobacterium tuberculosis infection: Interaction between host immune responses and pathogen evasion","volume":"12","author":"Kim","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1128\/IAI.01066-15","article-title":"Card9- and MyD88-Mediated Gamma Interferon and Nitric Oxide Production Is Essential for Resistance to Subcutaneous Coccidioides posadasii Infection","volume":"84","author":"Hung","year":"2016","journal-title":"Infect. Immun."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"4511","DOI":"10.1128\/IAI.05726-11","article-title":"Vaccine immunity to coccidioidomycosis occurs by early activation of three signal pathways of T helper cell response (Th1, Th2, and Th17)","volume":"79","author":"Hung","year":"2011","journal-title":"Infect. Immun."},{"key":"ref_62","first-page":"100319","article-title":"Polarization and Repolarization of Macrophages","volume":"6","author":"Fraternale","year":"2015","journal-title":"J. Clin. Cell. Immunol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.4049\/jimmunol.1900235","article-title":"Intracellular Neutrophil Oxidants: From Laboratory Curiosity to Clinical Reality","volume":"202","author":"Dahlgren","year":"2019","journal-title":"J. Immunol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1128\/IAI.73.3.1553-1560.2005","article-title":"Innate immunity to the pathogenic fungus Coccidioides posadasii is dependent on Toll-like receptor 2 and Dectin-1","volume":"73","author":"Viriyakosol","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_65","doi-asserted-by":"crossref","unstructured":"Castro-Lopez, N., and Hung, C.-Y. (2017). Immune Response to Coccidioidomycosis and the Development of a Vaccine. Microorganisms, 5.","DOI":"10.3390\/microorganisms5010013"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nri2939","article-title":"Immunity to fungal infections","volume":"11","author":"Romani","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.4049\/jimmunol.1400650","article-title":"Early or late IL-10 blockade enhances Th1 and Th17 effector responses and promotes fungal clearance in mice with cryptococcal lung infection","volume":"193","author":"Murdock","year":"2014","journal-title":"J. Immunol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1080\/mmy.39.1.31.40","article-title":"The parasitic cell wall of Coccidioides immitis","volume":"39","author":"Cole","year":"2001","journal-title":"Med. Mycol."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.micpath.2010.11.006","article-title":"Coccidioides releases a soluble factor that suppresses nitric oxide production by murine primary macrophages","volume":"50","author":"Gonzalez","year":"2011","journal-title":"Microb. Pathog."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.micpath.2011.03.013","article-title":"Nitric oxide synthase activity has limited influence on the control of Coccidioides infection in mice","volume":"51","author":"Gonzalez","year":"2011","journal-title":"Microb. Pathog."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1196\/annals.1406.020","article-title":"Virulence mechanisms of coccidioides","volume":"1111","author":"Hung","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1146\/annurev.micro.59.030804.121055","article-title":"Defining virulence genes in the dimorphic fungi","volume":"60","author":"Rappleye","year":"2006","journal-title":"Annu. Rev. Microbiol."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1128\/IAI.73.10.6689-6703.2005","article-title":"A metalloproteinase of Coccidioides posadasii contributes to evasion of host detection","volume":"73","author":"Hung","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.imbio.2018.11.010","article-title":"Reactive oxygen species (ROS) in macrophage activation and function in diabetes","volume":"224","author":"Rendra","year":"2019","journal-title":"Immunobiology"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/EC.4.1.111-120.2005","article-title":"Coccidioides posadasii contains a single 1,3-beta-glucan synthase gene that appears to be essential for growth","volume":"4","author":"Kellner","year":"2005","journal-title":"Eukaryot. Cell"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"e00597-12","DOI":"10.1128\/mBio.00597-12","article-title":"Dectin-1 Is Required for Resistance to Coccidioidomycosis in Mice","volume":"4","author":"Viriyakosol","year":"2013","journal-title":"mBio"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1615\/CritRevEukarGeneExpr.v20.i2.10","article-title":"Tumor Necrosis Factor-\u03b1 Signaling in Macrophages","volume":"20","author":"Parameswaran","year":"2010","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1128\/iai.34.2.347-353.1981","article-title":"Role of lymphocytes in macrophage-induced killing of Coccidioides immitis in vitro","volume":"34","author":"Beaman","year":"1981","journal-title":"Infect. Immun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1128\/iai.28.2.594-600.1980","article-title":"In vitro response of alveolar macrophages to infection with Coccidioides immitis","volume":"28","author":"Beaman","year":"1980","journal-title":"Infect. Immun."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.imbio.2017.11.001","article-title":"Macrophages: Their role, activation and polarization in pulmonary diseases","volume":"223","author":"Arora","year":"2018","journal-title":"Immunobiology"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-gamma: An overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1128\/IAI.74.1.504-515.2006","article-title":"Urease produced by Coccidioides posadasii contributes to the virulence of this respiratory pathogen","volume":"74","author":"Schaller","year":"2006","journal-title":"Infect. Immun."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"e00264-13","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 Polarization Dynamically Adapts to Changes in Cytokine Microenvironments in Cryptococcus neoformans Infection","volume":"4","author":"Davis","year":"2013","journal-title":"mBio"},{"key":"ref_84","first-page":"188","article-title":"The endemic mimic: Blastomycosis an illness often misdiagnosed","volume":"125","author":"Bradsher","year":"2014","journal-title":"Trans. Am. Clin. Clim. Assoc."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1093\/mmy\/myy039","article-title":"The endozoan, small-mammal reservoir hypothesis and the life cycle of Coccidioides species","volume":"57","author":"Taylor","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1086\/502972","article-title":"Both CD4+ and CD8+ T Cells Can Mediate Vaccine-Induced Protection against Coc-cidioides immitis Infection in Mice","volume":"193","author":"Fierer","year":"2021","journal-title":"J. Infect. Dis."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3389\/fimmu.2014.00506","article-title":"Antifungal Th Immunity: Growing up in Family","volume":"5","author":"Borghi","year":"2014","journal-title":"Front. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"S85","DOI":"10.1093\/mmy\/myy146","article-title":"A review of innate and adaptive immunity to coccidioidomycosis","volume":"57","author":"Hung","year":"2019","journal-title":"Med. Mycol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"3923","DOI":"10.1128\/IAI.73.7.3923-3928.2005","article-title":"Cellular immune suppressor activity resides in lymphocyte cell clusters adjacent to granulomata in human coccidioidomycosis","volume":"73","author":"Li","year":"2005","journal-title":"Infect. Immun."},{"key":"ref_90","first-page":"733","article-title":"Coccidioides immitis. A rare cause of pulmonary mycetoma","volume":"112","author":"Putnam","year":"1975","journal-title":"Am. Rev. Respir. Dis."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"3196","DOI":"10.1128\/IAI.00459-09","article-title":"A genetically engineered live attenuated vaccine of Coccidioides posadasii protects BALB\/c mice against coccidioidomycosis","volume":"77","author":"Xue","year":"2009","journal-title":"Infect. Immun."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1093\/infdis\/151.2.314","article-title":"In situ localization of T lymphocytes in disseminated coccidioidomycosis","volume":"151","author":"Modlin","year":"1985","journal-title":"J. Infect. Dis."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1259\/bjr\/12054884","article-title":"Acute pulmonary coccidioidomycosis: CT findings from 15 patients","volume":"81","author":"Capone","year":"2008","journal-title":"Br. J. Radiol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.immuni.2023.01.014","article-title":"Single-cell and spatial transcriptomics reveal aberrant lymphoid developmental programs driving granuloma formation","volume":"56","author":"Krausgruber","year":"2023","journal-title":"Immunity"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"226","DOI":"10.3389\/fcimb.2020.00226","article-title":"3D Imaging of the Transparent Mycobacterium tuberculosis-Infected Lung Verifies the Localization of Innate Immune Cells With Granuloma","volume":"10","author":"Kang","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Galgiani, J.N., Shubitz, L.F., Orbach, M.J., Mandel, M.A., Powell, D.A., Klein, B.S., Robb, E.J., Ohkura, M., Seka, D.J., and Tomasiak, T.M. (2022). Vaccines to Prevent Coccidioidomycosis: A Gene-Deletion Mutant of Coccidioides Posadasii as a Viable Candidate for Human Trials. J. Fungi, 8.","DOI":"10.3390\/jof8080838"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/6\/650\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T19:51:18Z","timestamp":1760125878000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/6\/650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":96,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2023,6]]}},"alternative-id":["jof9060650"],"URL":"https:\/\/doi.org\/10.3390\/jof9060650","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]}}}