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In addition, there are accumulations of comorbidities and immune senescence in some cases. This cohort study evaluated the clinical and epidemiological characteristics of older adults (\u226560 years old) with sporotrichosis. The cohort consisted of 911 patients with a median age of 67 years, most of whom were female (72.6%), white (62.1%), and afflicted with comorbidities (64.5%). The lymphocutaneous form occurred in 62% of the patients, followed by the fixed form (25.7%), cutaneous disseminated form (8.9%), and extracutaneous\/disseminated forms (3.3%). In this study, we draw attention to the frequency of osteoarticular involvement (2.1%) secondary to skin lesions such as osteomyelitis and\/or tenosynovitis. A clinical cure was achieved in 87.3% of cases. Itraconazole was used in 81.1% of cases, while terbinafine was used in 22.7% of cases, usually in low doses. Survival analysis showed that the median treatment time was 119 days, and the multiple Cox model demonstrated that the presentation of a black coloration and diabetes was associated with a longer treatment time required to establish a cure. Therefore, these subgroups should be monitored more closely to reduce possible difficulties during treatment. It would be interesting to conduct more studies analyzing older adults with sporotrichosis from different geographic areas to better comprehend the disease in this group.<\/jats:p>","DOI":"10.3390\/jof9080804","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T03:30:02Z","timestamp":1690774202000},"page":"804","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sporotrichosis in Older Adults: A Cohort Study of 911 Patients from a Hyperendemic Area of Zoonotic Transmission in Rio de Janeiro, Brazil"],"prefix":"10.3390","volume":"9","author":[{"given":"Rachel da Silva Ribeiro","family":"Gomes","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio Carlos Francesconi","family":"do Valle","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. Brasil, 4365, Manguinhos, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-2438","authenticated-orcid":false,"given":"Dayvison Francis Saraiva","family":"Freitas","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. 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Brasil, 4365, Manguinhos, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel de Vasconcellos Carvalhaes","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Epidemiology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-6058","authenticated-orcid":false,"given":"Rodrigo","family":"Almeida-Paes","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosely Maria","family":"Zancop\u00e9-Oliveira","sequence":"additional","affiliation":[{"name":"Laboratory of Mycology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Rio de Janeiro 21040-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7906-8275","authenticated-orcid":false,"given":"Maria Clara","family":"Gutierrez-Galhardo","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical Research in Infectious Dermatology, Evandro Chagas National Institute of Infectious Diseases, Oswaldo Cruz Foundation, Av. 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Dis."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1590\/S0102-311X2012001000006","article-title":"Esporotricose urbana: Epidemia negligenciada no Rio de Janeiro. Brasil","volume":"28","author":"Silva","year":"2012","journal-title":"Cad. Saude Publica"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Rossow, J.A., Queiroz-Telles, F., Caceres, D.H., Beer, K.D., Jackson, B.R., Pereira, J.G., Gremi\u00e3o, I.D.F., and Pereira, S.A. (2020). A One Health Approach to Combatting Sporothrix brasiliensis: Narrative Review of an Emerging Zoonotic Fungal Pathogen in South America. J. Fungi, 6.","DOI":"10.3390\/jof6040247"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Thomson, P., Gonz\u00e1lez, C., Blank, O., Ram\u00edrez, V., R\u00edo, C.D., Santib\u00e1\u00f1ez, S., and Pena, P. (2023). Sporotrichosis Outbreak Due to Sporothrix brasiliensis in Domestic Cats in Magallanes, Chile: A One-Health-Approach Study. J. Fungi, 9.","DOI":"10.3390\/jof9020226"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mmcr.2022.12.004","article-title":"The first three reported cases of Sporothrix brasiliensis cat-transmitted sporotrichosis outside South America","volume":"39","author":"Barnacle","year":"2022","journal-title":"Med. Mycol. Case Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1469-0691.2009.02824.x","article-title":"Different virulence levels of the species of Sporothrix in a murine model","volume":"15","author":"Capilla","year":"2009","journal-title":"Clin. Microbiol. Infect."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Freitas, D.F.S., do Valle, A.C.F., da Silva, M.B.T., Campos, D.P., Lyra, M.R., de Souza, R.V., Veloso, V.G., Zancop\u00e9-Oliveira, R.M., Bastos, F.I., and Galhardo, M.C.G. (2014). Sporotrichosis: An emerging neglected opportunistic infection in HIV-infected patients in Rio de Janeiro. Brazil. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003110"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/mmy\/myz024","article-title":"Zoonotic sporotrichosis with greater severity in Rio de Janeiro. Brazil: 118 hospitalizations and 11 deaths in the last 2 decades in a reference institution","volume":"58","author":"Pires","year":"2020","journal-title":"Med. Mycol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fichman, V., Freitas, D.F.S., do Valle, A.C.F., de Souza, R.V., Curi, A.L.L., Valete-Rosalino, C.M., de Macedo, P.M., Varon, A.G., Figueiredo-Carvalho, M.H.G., and Almeida-Silva, F. (2022). Severe Sporotrichosis Treated with Amphotericin B: A 20-Year Cohort Study in an Endemic Area of Zoonotic Transmission. J. Fungi, 8.","DOI":"10.3390\/jof8050469"},{"key":"ref_12","unstructured":"Bennett, J.E., Dolin, R., and Blaser, M.J. (2019). Mandell, Douglas and Bennett\u2019s Principles and Practice of Infectious Diseases, Elsevier Health Sciences. [9th ed.]."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00281-020-00806-z","article-title":"The interplay between immunosenescence and age-related diseases","volume":"42","author":"Funchal","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.mad.2006.11.016","article-title":"Inflammaging and anti-inflammaging: A systemic perspective on aging and longevity emerged from studies in humans","volume":"128","author":"Franceschi","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1038\/nri3547","article-title":"Age-dependent dysregulation of innate immunity","volume":"13","author":"Shaw","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1532-5415.2006.00745.x","article-title":"Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society\/National Institute on Aging Research Conference on Frailty in Older Adults","volume":"54","author":"Walston","year":"2006","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1128\/CVI.00430-06","article-title":"Use of mycelial-phase Sporothrix schenckii exoantigens in an enzyme-linked immunosorbent assay for diagnosis of sporotrichosis by antibody detection","volume":"14","author":"Pimenta","year":"2007","journal-title":"Clin. Vaccine Immunol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1086\/522765","article-title":"Clinical Practice Guidelines for the Management of Sporotrichosis: 2007 Update by the Infectious Diseases Society of America","volume":"45","author":"Kauffman","year":"2007","journal-title":"Clin. Infect. Dis."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1111\/j.1468-3083.2009.03306.x","article-title":"Terbinafine (250 mg\/day): An effective and safe treatment of cutaneous sporotrichosis","volume":"23","author":"Francesconi","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1111\/bjd.17532","article-title":"Cryosurgery for the treatment of cutaneous sporotrichosis: Experience with 199 cases","volume":"180","author":"Fichman","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1086\/322685","article-title":"Fungal infections in older adults","volume":"33","author":"Kauffman","year":"2001","journal-title":"Clin. Infect. Dis."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/S0140-6736(14)61597-X","article-title":"Health in an ageing world\u2014What do we know?","volume":"385","author":"Suzman","year":"2015","journal-title":"Lancet"},{"key":"ref_23","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (2023, June 02). Ag\u00eancia de Not\u00edcias, Available online: https:\/\/agenciadenoticias.ibge.gov.br\/agencia-noticias\/2012-agencia-de-noticias\/noticias\/20980-numero-de-idosos-cresce-18-em-5-anos-e-ultrapassa-30-milhoes-em-2017."},{"key":"ref_24","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (2023, June 02). Ag\u00eancia de Not\u00edcias. Available online: https:\/\/agenciabrasil.ebc.com.br\/geral\/noticia\/2016-10\/brasil-tera-19-milhoes-de-idosos-com-mais-de-80-anos-em-2060-estima-ibge."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Lloyd-Sherlock, P. (2004). Living Longer: Ageing, Development and Social Protection, United Nations Research Institute for Social Development. Zed Books: Nova York, NY, USA.","DOI":"10.5040\/9781350221154.ch-001"},{"key":"ref_26","unstructured":"Bennett, J.E., Dolin, R., and Blaser, M.J. (2019). Mandell, Douglas, and Bennett\u2019s Principles and Practice of Infectious Diseases, Elsevier Health Sciences. [9th ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.arr.2003.08.003","article-title":"Skin infections and ageing","volume":"3","author":"Laube","year":"2004","journal-title":"Ageing Res. Rev."},{"key":"ref_28","unstructured":"Sociedade Brasileira de Dermatologia (2023, May 31). Envelhecimento: O Processo. Available online: https:\/\/www.sbd.org.br\/doencas\/envelhecimento\/."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Almeida-Paes, R., Marques, M.E.d.O., Freitas, D.F.S., do Valle, A.C.F., Zancop\u00e9-Oliveira, M.R., and Gutierrez-Galhardo, M.C. (2014). Sporotrichosis in Rio de Janeiro. Brazil: Sporothrix brasiliensis is associated with atypical clinical presentations. PLoS Negl. Trop. Dis., 8.","DOI":"10.1371\/journal.pntd.0003094"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.pmr.2017.06.004","article-title":"Physiologic Changes of the Musculoskeletal System with Aging: A Brief Review","volume":"28","author":"Frontera","year":"2017","journal-title":"Phys. Med. Rehabil. Clin. N. Am."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Fichman, V., Mota-Damasceno, C.G., Proc\u00f3pio-Azevedo, A.C., Almeida-Silva, F., de Macedo, P.M., Medeiros, D.M., Astacio, G.S., Zancop\u00e9-Oliveira, R.M., Almeida-Paes, R., and Freitas, D.F.S. (2022). Pulmonary Sporotrichosis Caused by Sporothrix brasiliensis: A 22-Year, Single-Center, Retrospective Cohort Study. J. Fungi, 8.","DOI":"10.3390\/jof8050536"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1055\/s-0035-1562901","article-title":"Pulmonary Sporotrichosis: An Evolving Clinical Paradigm","volume":"36","author":"Aung","year":"2015","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Queiroz-Telles, F., Buccheri, R., and Benard, G. (2019). Sporotrichosis In Immunocompromised Hosts. J. Fungi, 5.","DOI":"10.3390\/jof5010008"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"ofy081","DOI":"10.1093\/ofid\/ofy081","article-title":"Chronic Meningitis and Hydrocephalus due to Sporothrix brasiliensis in Immunocompetent Adults: A Challenging Entity","volume":"5","author":"Mialski","year":"2018","journal-title":"Open Forum Infect. Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Lima, M.A., Freitas, D.F.S., Oliveira, R.V.C., Fichman, V., Varon, A.G., Freitas, A.D., Lamas, C.C., Andrade, H.B., Veloso, V.G., and Almeida-Paes, R. (2022). Meningeal Sporotrichosis Due to Sporothrix brasiliensis: A 21-Year Cohort Study from a Brazilian Reference Center. J. Fungi, 9.","DOI":"10.3390\/jof9010017"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"e13485","DOI":"10.1111\/tid.13485","article-title":"Zoonotic sporotrichosis in renal transplant recipients from Rio de Janeiro, Brazil","volume":"23","author":"Fichman","year":"2021","journal-title":"Transpl. Infect. Dis."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1111\/bjd.20646","article-title":"Hypersensitivity reactions in sporotrichosis: A retrospective cohort of 325 patients from a reference hospital in Rio de Janeiro. Brazil (2005\u20132018)","volume":"185","author":"Rabello","year":"2021","journal-title":"Br. J. Dermatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.riam.2018.09.002","article-title":"Diagnostic performance of mycologic and serologic methods in a cohort of patients with suspected sporotrichosis","volume":"36","author":"Oliveira","year":"2019","journal-title":"Rev. Iberoam. Micol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/1809-9823.2008.110311","article-title":"Implica\u00e7\u00f5es da imunossenesc\u00eancia na vacina\u00e7\u00e3o de idosos","volume":"11","author":"Malafaia","year":"2008","journal-title":"Rev Bras. Geriatr. Gerontol."},{"key":"ref_40","unstructured":"Freitas, E.V., and Py, L. (2022). Tratado de Geriatria e Gerontologia, Guanabara Koogan. 5th E-Book."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1080\/14740338.2018.1546841","article-title":"An update on the clinical consequences of polypharmacy in older adults: A narrative review","volume":"17","author":"Wastesson","year":"2018","journal-title":"Expert Opin. Drug Saf."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"e200","DOI":"10.1093\/cid\/cir245","article-title":"Treatment of cutaneous sporotrichosis with itraconazole\u2014Study of 645 patients","volume":"52","author":"Schubach","year":"2011","journal-title":"Clin. Infect. Dis."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s11046-010-9380-8","article-title":"Comparative Study of 250 mg\/day Terbinafine and 100 mg\/day Itraconazole for the Treatment of Cutaneous Sporotrichosis","volume":"171","author":"Francesconi","year":"2011","journal-title":"Mycopathologia"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"601","DOI":"10.2174\/138920011796504527","article-title":"Age-related changes in pharmacokinetics","volume":"12","author":"Shi","year":"2011","journal-title":"Curr. Drug Metab."},{"key":"ref_45","unstructured":"Instituto Brasileiro de Geografia e Estat\u00edstica (2023, June 02). Desigualdades Sociais por Cor ou Ra\u00e7a no Brasil. 2\u00aa Edi\u00e7\u00e3o. Estudos e Pesquisas. In: Informa\u00e7\u00e3o Demogr\u00e1fica e Socioecon\u00f4mica no 48, Available online: https:\/\/biblioteca.ibge.gov.br\/visualizacao\/livros\/liv101972_informativo.pdf."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Instituto de Pesquisa Econ\u00f4mica Aplicada, Tomasiello, D.B., Bazzo, J., Parga, J., Servo, L.M., and Pereira, R.H.M. (2023, June 03). Desigualdades raciais e de Renda no Acesso \u00e0 Sa\u00fade nas Cidades Brasileiras, Available online: https:\/\/repositorio.ipea.gov.br\/bitstream\/11058\/11454\/1\/td_desigualdades_raciais_renda_publicacao_preliminar.pdf.","DOI":"10.38116\/td2832"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1161\/CIRCULATIONAHA.116.022194","article-title":"Clinical Update: Cardiovascular Disease in Diabetes Mellitus: Atherosclerotic Cardiovascular Disease and Heart Failure in Type 2 Diabetes Mellitus\u2014Mechanisms, Management, and Clinical Considerations","volume":"133","author":"Hess","year":"2016","journal-title":"Circulation"}],"container-title":["Journal of Fungi"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/8\/804\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:22:25Z","timestamp":1760127745000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2309-608X\/9\/8\/804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,30]]},"references-count":47,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2023,8]]}},"alternative-id":["jof9080804"],"URL":"https:\/\/doi.org\/10.3390\/jof9080804","relation":{},"ISSN":["2309-608X"],"issn-type":[{"value":"2309-608X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7,30]]}}}