{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T06:45:24Z","timestamp":1783406724346,"version":"3.54.6"},"reference-count":34,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T00:00:00Z","timestamp":1697068800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoF"],"abstract":"<jats:p>Background: Lobomycosis is a rare cutaneous tropical neglected disease caused by the fungal agent Lacazia loboi, recently renamed Paracoccidioides lobogeorgii. Our objectives were to present all cases of lobomycosis diagnosed in French Guiana, to offer a precise description of their histopathological features and to propose a new clinico-histological prognostic classification. Methods: All cases of lobomycosis diagnosed in French Guiana between 1959 and 2022 were included. We looked for associations between the occurrence of relapses and the clinic-histological form. Results: 31 patients diagnosed with lobomycosis were included. An epidemiological shift was observed in the 2000s as Brazilian patients became the most important ethnic group. Gold mining, forestry and fishing\/sailing were reported as professional exposures. New histological features, such as inflammatory \u201crosettes\u201d formations were described. We describe two clinic-histological patterns: a major form (high fungal density and\/or multifocal lesions) and a minor form (low fungal density, unifocal lesions, association with fewer relapses). Conclusions: The changing epidemiology of lobomycosis in French Guiana is characterized by a shift towards Brazilian patients, mostly gold miners. Minor forms should be treated with surgery, major forms with a combination of surgery followed by nultiple drug therapy (MDT) or posaconazole.<\/jats:p>","DOI":"10.3390\/jof9101005","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T03:07:47Z","timestamp":1697080067000},"page":"1005","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Fungal Density in Lobomycosis in French Guiana: A Proposal for a New Clinico-Histological and Therapeutic Classification"],"prefix":"10.3390","volume":"9","author":[{"given":"Geoffrey","family":"Grotta","sequence":"first","affiliation":[{"name":"Dermatology Department, Cayenne Hospital, Cayenne 97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Couppie","sequence":"additional","affiliation":[{"name":"Dermatology Department, Cayenne Hospital, Cayenne 97306, French Guiana"},{"name":"UMR TBIP Tropical Biomes and Immunophysiopathology, University of French Guiana, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3414-0821","authenticated-orcid":false,"given":"Magalie","family":"Demar","sequence":"additional","affiliation":[{"name":"UMR TBIP Tropical Biomes and Immunophysiopathology, University of French Guiana, Cayenne 97300, French Guiana"},{"name":"Parasitology Department, Cayenne Hospital, Cayenne 97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5975-2627","authenticated-orcid":false,"given":"Kinan","family":"Drak Alsibai","sequence":"additional","affiliation":[{"name":"Histopathology Department, Centre Hospitalier de Cayenne, Cayenne 97306, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3695-6824","authenticated-orcid":false,"given":"Romain","family":"Blaizot","sequence":"additional","affiliation":[{"name":"Dermatology Department, Cayenne Hospital, Cayenne 97306, French Guiana"},{"name":"UMR TBIP Tropical Biomes and Immunophysiopathology, University of French Guiana, Cayenne 97300, French Guiana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,10,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Vilela, R., De Hoog, S., Bensch, K., Bagagli, E., and Mendoza, L. 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