{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:00:34Z","timestamp":1788314434654,"version":"build-2803163510"},"reference-count":23,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T00:00:00Z","timestamp":1637020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Malaria and Leishmaniasis are two major parasitic diseases, endemic in large areas of tropical countries with high morbidity and mortality across the world. Nanoparticles in small sizes are specifically considered in medicine due to their ability to enter the cells, control the distribution of the administered drug and carry the drug specifically to the place of action. The present study aims to introduce the application of silica nanoparticles as new promising nanotools in malaria and leishmaniasis treatment. Ion doped silica nanomaterials revealed antileishmanial activities indicating the positive role of calcium, magnesium and copper to the surface of the particles against Leishmania parasites. Artemisinin-loaded nanoparticles presented the most promising antiparasitic properties with a sustained release able to overcome the parasite invasion. The sustainable release of artemisinin guarantee both the maintenance of its potential efficacy and also introduce an administration of drug to avoid subsequent drug resistance.<\/jats:p>","DOI":"10.3390\/jox11040011","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T21:32:07Z","timestamp":1637184727000},"page":"155-162","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Silica Based Nanoparticles against Plasmodium\u00a0falciparum and Leishmania infantum parasites"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-3920","authenticated-orcid":false,"given":"Ioannis","family":"Tsamesidis","sequence":"first","affiliation":[{"name":"Pharmadev, UMR 152, Universit\u00e9 de Toulouse, IRD, UPS, 31000 Toulouse, France"},{"name":"Department of Biomedical Sciences, International Hellenic University, 57022 Sindos, Greece"},{"name":"School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Lymperaki","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, International Hellenic University, 57022 Sindos, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3408-5471","authenticated-orcid":false,"given":"Chinedu O.","family":"Egwu","sequence":"additional","affiliation":[{"name":"Pharmadev, UMR 152, Universit\u00e9 de Toulouse, IRD, UPS, 31000 Toulouse, France"},{"name":"Department of Biochemistry, College of Medicine, Alex-Ekwueme Federal University Ndufu-Alike Ikwo, Abakaliki PMB 1010, Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4503-0038","authenticated-orcid":false,"given":"Georgia K.","family":"Pouroutzidou","sequence":"additional","affiliation":[{"name":"School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"},{"name":"School of Physics, Faculty of Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantina","family":"Kazeli","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, International Hellenic University, 57022 Sindos, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Reybier","sequence":"additional","affiliation":[{"name":"Pharmadev, UMR 152, Universit\u00e9 de Toulouse, IRD, UPS, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Bourgeade-Delmas","sequence":"additional","affiliation":[{"name":"Pharmadev, UMR 152, Universit\u00e9 de Toulouse, IRD, UPS, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis","family":"Valentin","sequence":"additional","affiliation":[{"name":"Pharmadev, UMR 152, Universit\u00e9 de Toulouse, IRD, UPS, 31000 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-4828","authenticated-orcid":false,"given":"Eleana","family":"Kontonasaki","sequence":"additional","affiliation":[{"name":"School of Dentistry, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,16]]},"reference":[{"key":"ref_1","unstructured":"(2021, November 04). 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