{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:18:13Z","timestamp":1788905893852,"version":"build-2803163510"},"reference-count":31,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T00:00:00Z","timestamp":1688515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Vulvovaginitis with Candida spp. is the most common infection in women and the rate is increased during pregnancy. Antifungal prescription in pregnant women continues to present challenges and the decision must balance the risk of fetal toxicity with the benefits to the fetus and mother. Starting from the idea that clotrimazole is the most recommended antifungal in candidal vaginitis in pregnancy, we tested the sensitivity of different species of Candida spp. to other azoles, polyenes, and antimetabolites. This retrospective study (January to June 2019) assessed 663 pregnant women hospitalized for various pregnancy-related symptoms in which samples of phage secretion were taken. The laboratory results confirmed 21% of cases, indicating 140 positive mycologic samples. In this study, vaginal candidiasis was mostly related to the first trimester of pregnancy (53.57%,) and less related in the last trimester (17.14%). Candida albicans was the most frequent isolated strain in this study, accounting for 118 cases, followed by 16 strains of Candida glabrata and 6 cases of Candida krusei. The highest sensitivity for C. albicans was found in azoles, mostly in miconazole (93.2%), while C. krusei was completely resistant to polyene with low sensitivity in antimetabolites and even in some azoles, such as fluconazole. In our study, higher resistance rates to flucytosine were found, with C. glabrata and C. krusei exhibiting greater resistance than C. albicans.<\/jats:p>","DOI":"10.3390\/jox13030023","type":"journal-article","created":{"date-parts":[[2023,7,6]],"date-time":"2023-07-06T00:54:41Z","timestamp":1688604881000},"page":"312-322","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Vulvovaginal Candidiasis in Pregnancy\u2014Between Sensitivity and Resistance to Antimycotics"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0918-5534","authenticated-orcid":false,"given":"Nicoleta-Maricica","family":"Maftei","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"},{"name":"Medical Laboratory Department, \u201cSf\u00e2ntul Ioan\u201d Children\u2019s Emergency Hospital, 800487 Gala\u021bi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Arbune","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"},{"name":"Infectious Diseases Department, Clinical Hospital of Infectious Diseases \u201cSf. Cuvioasa Parascheva\u201d, 800179 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costinela Valerica","family":"Georgescu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"},{"name":"Department of Public Health, Clinical Hospital of Obstetrics and Gynecology \u201cBuna Vestire\u201c, 800151 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Mihaela","family":"Elisei","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, Research Centre in the Medical-Pharmaceutical Field, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-0818","authenticated-orcid":false,"given":"Alina Viorica","family":"Iancu","sequence":"additional","affiliation":[{"name":"Medical Laboratory Department, Clinical Hospital of Infectious Diseases \u201cSf. Cuvioasa Parascheva\u201d, 800179 Galati, Romania"},{"name":"Department of Morphological and Functional Sciences, Faculty of Medicine and Pharmacy, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4290-7068","authenticated-orcid":false,"given":"Alin Laurentiu","family":"Tatu","sequence":"additional","affiliation":[{"name":"Clinical Medical Department, Faculty of Medicine and Pharmacy, University \u201cDun\u0103rea de Jos\u201d, 800010 Galati, Romania"},{"name":"Research Center in the Field of Medical and Pharmaceutical Sciences, ReFORM-UDJ, 800010 Galati, Romania"},{"name":"Dermatology Department, Clinical Hospital of Infectious Diseases \u201cSf. Cuvioasa Parascheva\u201d, 800179 Galati, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1111\/myc.12141","article-title":"Prevalence, and epidemiological characteristics of vaginal candidiasis in the UAE","volume":"57","author":"Hamad","year":"2014","journal-title":"Mycoses"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"5016810","DOI":"10.1155\/2019\/5016810","article-title":"Emergence of Vulvovaginal Candidiasis among Lebanese Pregnant Women: Prevalence, Risk Factors, and Species Distribution","volume":"2019","author":"Ghaddar","year":"2019","journal-title":"Infect. Dis. Obstet. 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