{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T01:22:17Z","timestamp":1768353737467,"version":"3.49.0"},"reference-count":19,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T00:00:00Z","timestamp":1694563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIEHS visiting fellowship","award":["ES103379-01"],"award-info":[{"award-number":["ES103379-01"]}]},{"DOI":"10.13039\/100000066","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES103379-01"],"award-info":[{"award-number":["ES103379-01"]}],"id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>A sharp rise in autism spectrum disorder (ASD) prevalence estimates, beginning in the 1990s, suggested factors additional to genetics were at play. This stimulated increased research investment in nongenetic factors, including the study of environmental chemical exposures, diet, nutrition, lifestyle, social factors, and maternal medical conditions. Consequently, both peer- and non-peer-reviewed bodies of evidence investigating environmental contributors to ASD etiology have grown significantly. The heterogeneity in the design and conduct of this research results in an inconclusive and unwieldy \u2018virtual stack\u2019 of publications. We propose to develop a Web-based tool for Autism Research and the Environment (aWARE) to comprehensively aggregate and assess these highly variable and often conflicting data. The interactive aWARE tool will use an approach for the development of systematic evidence maps (SEMs) to identify and display all available relevant published evidence, enabling users to explore multiple research questions within the scope of the SEM. Throughout tool development, listening sessions and workshops will be used to seek perspectives from the broader autism community. New evidence will be indexed in the tool annually, which will serve as a living resource to investigate the association between environmental factors and ASD.<\/jats:p>","DOI":"10.3390\/jox13030031","type":"journal-article","created":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T05:31:28Z","timestamp":1694583088000},"page":"492-499","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Becoming aWARE: The Development of a Web-Based Tool for Autism Research and the Environment"],"prefix":"10.3390","volume":"13","author":[{"given":"Anisha","family":"Singh","sequence":"first","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy P.","family":"Lawler","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vickie R.","family":"Walker","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4821-5153","authenticated-orcid":false,"given":"Katherine E.","family":"Pelch","sequence":"additional","affiliation":[{"name":"Natural Resources Defense Council, San Francisco, CA 94104, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda E.","family":"Garton","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew A.","family":"Rooney","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid C.","family":"Haugen","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences, Durham, NC 27709, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1542\/peds.108.5.1155","article-title":"Prevalence of Autism in a United States Population: The Brick Township, New Jersey, Investigation","volume":"108","author":"Bertrand","year":"2001","journal-title":"Pediatrics"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/mrdd.20043","article-title":"Identifying environmental contributions to autism: Provocative clues and false leads","volume":"10","author":"Lawler","year":"2004","journal-title":"Ment. 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