{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T01:42:26Z","timestamp":1792201346846,"version":"4.4.0"},"reference-count":147,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Dyes, such as indigo carmine, have become indispensable to modern life, being widely used in the food, textile, pharmaceutical, medicine, and cosmetic industry. Although indigo carmine is considered toxic and has many adverse effects, it is found in many foods, and the maximum permitted level is 500 mg\/kg. Indigo carmine is one of the most used dyes in the textile industry, especially for dyeing denim, and it is also used in medicine due to its impressive applicability in diagnostic methods and surgical procedures, such as in gynecological and urological surgeries and microsurgery. It is reported that indigo carmine is toxic for humans and can cause various pathologies, such as hypertension, hypotension, skin irritations, or gastrointestinal disorders. In this review, we discuss the structure and properties of indigo carmine; its use in various industries and medicine; the adverse effects of its ingestion, injection, or skin contact; the effects on environmental pollution; and its toxicity testing. For this review, 147 studies were considered relevant. Most of the cited articles were those about environmental pollution with indigo carmine (51), uses of indigo carmine in medicine (45), and indigo carmine as a food additive (17).<\/jats:p>","DOI":"10.3390\/jox13030033","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T22:38:45Z","timestamp":1695249525000},"page":"509-528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Indigo Carmine: Between Necessity and Concern"],"prefix":"10.3390","volume":"13","author":[{"given":"Madalina-Elena","family":"Ristea","sequence":"first","affiliation":[{"name":"Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, R-050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6894-3281","authenticated-orcid":false,"given":"Otilia","family":"Zarnescu","sequence":"additional","affiliation":[{"name":"Faculty of Biology, University of Bucharest, Splaiul Independentei 91-95, R-050095 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Ngaha, M.C.D., Njanja, E., Doungmo, G., Kamdem, A.T., and Tonle, I.L. (2019). Indigo carmine and 2,6 dichlorophenolindophenol removal using cetyltrimethylammonium bromide-modified palm oil fiber: Adsorption isotherms and mass transfer kinetics. Int. J. Biomater., 2019.","DOI":"10.1155\/2019\/6862825"},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Khan, I., Saeed, K., Zekker, I., Zhang, B., Hendi, A.A., Ahmad, A., Ahmad, S., Zada, N., Ahmad, H., and Shah, L.A. (2022). Review on methylene blue: Its properties, uses, toxicity and photodegradation. Water, 14.","DOI":"10.3390\/w14020242"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"107891","DOI":"10.1016\/j.inoche.2020.107891","article-title":"A review on classifications, recent synthesis and applications of textile dyes","volume":"115","author":"Benkhaya","year":"2020","journal-title":"Inorg. Chem. Commun."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"137222","DOI":"10.1016\/j.scitotenv.2020.137222","article-title":"Synthetic organic dyes as contaminants of the aquatic environment and their implications for ecosystems: A review","volume":"717","author":"Tkaczyk","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"30801","DOI":"10.1039\/C4RA16959J","article-title":"Recent advances in new generation dye removal technologies: Novel search for approaches to reprocess wastewater","volume":"5","author":"Ahmad","year":"2015","journal-title":"RSC Adv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"9940","DOI":"10.1007\/s11356-016-7201-4","article-title":"Influence of alternating current on the adsorption of indigo carmine","volume":"24","author":"Kesraoui","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_7","first-page":"13","article-title":"Efficiency method for methylene blue recovery using aqueous two-phase systems based on cholinium-ionic liquids","volume":"6","author":"Alencar","year":"2020","journal-title":"J. Fashion Technol. Text."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.ijbiomac.2019.12.002","article-title":"Fast and highly efficient removal of dye from aqueous solution using natural locust bean gum based hydrogels as adsorbent","volume":"143","author":"Pandey","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"104725","DOI":"10.1016\/j.jece.2020.104725","article-title":"Phytogenic fabrication of ZnO and gold decorated ZnO nanoparticles for photocatalytic degradation of Rhodamine B","volume":"9","author":"Ahmad","year":"2020","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"112609","DOI":"10.1016\/j.envres.2021.112609","article-title":"Emerging contaminants of high concern for the environment: Current trends and future","volume":"207","author":"Khan","year":"2022","journal-title":"Environ. Res."},{"key":"ref_11","first-page":"85","article-title":"Azo dyes: Characterization and toxicity\u2014A review","volume":"2","year":"2013","journal-title":"Text. Light Ind. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"110372","DOI":"10.1016\/j.jenvman.2020.110372","article-title":"Adsorption of indigo carmine on functional chitosan and \u03b2-cyclodextrin\/chitosan beads: Equilibrium, kinetics and mechanism studies","volume":"262","author":"Kekes","year":"2020","journal-title":"J. Environ. Manag."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1080\/00207233.2020.1745573","article-title":"Biosorption characteristics of methylene blue by two fungal biomasses","volume":"78","author":"Bouras","year":"2020","journal-title":"Int. J. Environ. Stud."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"10553","DOI":"10.1007\/s13762-023-04810-2","article-title":"A critical review of textile industry wastewater: Green technologies for the removal of indigo dyes","volume":"20","year":"2023","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1007\/s13762-020-02720-1","article-title":"Synthesis of Ag\/Fe\/CAC for colour and COD removal from methylene blue dye wastewater","volume":"17","author":"Fong","year":"2020","journal-title":"Int. J. Environ. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Pagnacco, M., Maksimovi\u0107, J.P., Nikoli\u0107, N.T., Bogdanovi\u0107, D.V.B., Kragovi\u0107, M.M., Stojmenovi\u0107, M.D., Blagojevi\u0107, S.N., and Sen\u0107anski, J.V. (2022). Indigo carmine in a food dye: Spectroscopic characterization and determining its micro-concentration through the clock reaction. Molecules, 27.","DOI":"10.3390\/molecules27154853"},{"key":"ref_17","first-page":"204","article-title":"Dyes for the medical industry","volume":"Volume 2","author":"Clark","year":"2011","journal-title":"Handbook of Textile and Industrial Dyeing: Applications of Dyes"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1016\/j.jenvman.2008.01.002","article-title":"Rice husk ash as an effective adsorbent: Evaluation of adsorptive characteristics for indigo carmine dye","volume":"90","author":"Lakshmi","year":"2009","journal-title":"J. Environ. Manag."},{"key":"ref_19","first-page":"87","article-title":"Electrochemical analysis of indigo carmine using polyarginine modified carbon paste electrode","volume":"11","author":"Edwin","year":"2021","journal-title":"J. Electrochem. Sci. Eng."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"100753","DOI":"10.1016\/j.scp.2022.100753","article-title":"Enhanced removal of indigo carmine dye from textile effluent using green cost-efficient nanomaterial: Adsorption, kinetics, thermodynamics and mechanisms","volume":"29","author":"Elkhatib","year":"2022","journal-title":"Sustain. Chem. Pharm."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1111\/jocd.14695","article-title":"Effects of some cosmetic dyes and pigments on the proliferation of human foreskin fibroblasts and cellular oxidative stress; potential cytotoxicity of chlorophyllin and indigo carmine on fibroblasts","volume":"21","author":"Pasdaran","year":"2022","journal-title":"J. Cosmet. Dermatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1007\/s10800-022-01709-7","article-title":"Electrodeposition of lead dioxide on Fe electrode application to the degradation of indigo carmine dye","volume":"52","author":"Tabti","year":"2022","journal-title":"J. Appl. Electrochem."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3346\/jkms.2005.20.4.702","article-title":"Indigo carmine for the selective endoscopic intervertebral nuclectomy","volume":"20","author":"Kim","year":"2005","journal-title":"J. Korean Med. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.spinee.2013.01.019","article-title":"Time and dose dependent cytotoxicities of ioxitalamate and indigocarmine in human nucleus pulposus cells","volume":"13","author":"Kim","year":"2013","journal-title":"Spine J."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"EFSA ANS Panel (European Food Safety Authority Panel on Food Additives and Nutrient Sources Added to Food) (2014). Scientific opinion on the re-evaluation of indigo carmine (E 132) as a food additive. EFSA J., 12, 3768.","DOI":"10.2903\/j.efsa.2014.3768"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.2166\/wst.2016.388","article-title":"Efficient removal of indigo carmine dye by a separation process","volume":"74","author":"Caprarescu","year":"2016","journal-title":"Water Sci. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ecoenv.2017.05.043","article-title":"Lethal and sub-lethal evaluation if indigo carmine dye and byproducts after TiO2 photocatalysis in the immune system of Eisenia andrei earthworms","volume":"143","author":"Pereira","year":"2017","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_28","first-page":"36","article-title":"Indigo carmine related tooth discoloration. Excipients: A pending subject","volume":"43","year":"2019","journal-title":"Farm. Hosp."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.desal.2011.04.031","article-title":"An experimental study of indigo carmine removal from aqueous solution by electrocoagulation","volume":"277","author":"Secula","year":"2011","journal-title":"Desalination"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/jcat.2001.3232","article-title":"Photocatalytic degradation of dyes in water: Case study of indigo and of indigo carmine","volume":"201","author":"Vautier","year":"2001","journal-title":"J. Catal."},{"key":"ref_31","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives) (2018). Compendium of Food Additive Specifications\u201486th Meeting, Joint FAO\/WHO Expert Committee on Food Additives."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"202000901","DOI":"10.1590\/s0102-865020200090000001","article-title":"Evaluation of indigo carmine on hepatic ischemia and reperfusion injury","volume":"35","author":"Rancan","year":"2020","journal-title":"Acta Cir. Bras."},{"key":"ref_33","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives) (2010). Combined Compendium of Food Additive Specifications\u2014All Specifications Monographs from the 1st to the 73rd Meeting (1956\u20132010), Joint FAO\/WHO Expert Committee on Food Additives."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1093\/advances\/nmab081","article-title":"The effects of natural and synthetic blue dyes on human health: A review of current knowledge and therapeutic perspectives","volume":"12","author":"Olas","year":"2021","journal-title":"Adv. Nutr."},{"key":"ref_35","unstructured":"Scotter, M.J. (2015). Colour Additives for Foods and Beverages, Woodhead Publishing."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.talanta.2017.05.062","article-title":"Mediated electrochemical method for the determination of indigo carmine levels in food products","volume":"173","author":"Arvand","year":"2017","journal-title":"Talanta"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.gie.2020.06.047","article-title":"Highly accurate artificial intelligence systems to predict the invasion depth of gastric cancer: Efficacy of conventional white-light imaging, nonmagnifying narrow-band imaging, and indigo carmine dye contrast imaging","volume":"92","author":"Nagao","year":"2020","journal-title":"Gastrointest. Endosc."},{"key":"ref_38","unstructured":"European Commission (2023, August 11). Commission regulation (EU) No 231\/2012 of 9 March 2012 Laying Down Specifications for Food Additives Listed in Annexes II and III to Regulation (EC), No 1333\/2008 of the European Parliament and of the Council. Available online: https:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?uri=celex%3A32012R0231."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jcat.2014.04.012","article-title":"Indigo dye production by enzymatic mimicking based on an iron (III) porphyrin","volume":"315","author":"Rebelo","year":"2014","journal-title":"J. Catal."},{"key":"ref_40","unstructured":"Elvers, B. (2004). Ullmann\u2019s Encyclopedia of Industrial Chemistry, Wiley-VCH."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.20510\/ukjpb\/4\/i4\/110639","article-title":"Assessment of the health implications of synthetic and natural food colourants\u2014A critical review","volume":"4","author":"Okafor","year":"2016","journal-title":"J. Pharm. Biosci."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"479","DOI":"10.15421\/021871","article-title":"The influence of the synthetic food colourings tartrazine, allura red and indigo carmine on the body weight of Tenebrio molitor (Coleoptera, Tenebrionidae) larvae","volume":"9","author":"Martynov","year":"2018","journal-title":"Regul. Mech."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.yrtph.2015.09.026","article-title":"Health safety issues of synthetic food colorants","volume":"73","author":"Amchova","year":"2015","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.tifs.2021.03.023","article-title":"Natural blue food colorants: Consumer acceptance, current alternatives, trends, challenges, and future strategies","volume":"112","author":"Neves","year":"2021","journal-title":"Trends Food Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","unstructured":"Merinas-Amo, R., Mart\u00ednez-Jurado, M., Jurado-G\u00fceto, S., Alonso-Moraga, A., and Merinas-Amo, T. (2019). Biological effects of food coloring in in vivo and in vitro model systems. Foods, 8.","DOI":"10.3390\/foods8050176"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.sjbs.2020.08.025","article-title":"Dietary intake of artificial food color additives containing food products by school-going children","volume":"28","author":"Ahmed","year":"2021","journal-title":"Saudi J. Biol. Sci."},{"key":"ref_47","unstructured":"GSFA (General Standard Food Additives) (2023, August 11). Food Additive Details: GSFA Provisions for Indigotine (Indigo Carmine). Available online: https:\/\/www.fao.org\/gsfaonline\/additives\/details.html?id=96&d-3586470-s=2&d-3586470-o=2&print=true."},{"key":"ref_48","unstructured":"JECFA (Joint FAO\/WHO Expert Committee on Food Additives) (2020). Safety Evaluation of Certain Food Additives: Prepared by the Eighty-Sixth Meeting of the JECFA, Joint FAO\/WHO Expert Committee on Food Additives."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1023\/A:1024716322120","article-title":"Optimization of conditions for the HPLC determination of synthetic dyes in food","volume":"58","author":"Kiseleva","year":"2003","journal-title":"J. Anal. Chem."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.aca.2006.10.002","article-title":"Determination of 13 synthetic food colorants in water-soluble foods by reversed-phase high-performance liquid chromatography coupled with diode-array detector","volume":"583","author":"Minioti","year":"2007","journal-title":"Anal. Chim. Acta"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1080\/10826076.2010.526876","article-title":"Highly sensitive determination of 10 dyes in food with complex matrices using SPE followed by UPLC-DAD-tandem mass spectrometry","volume":"34","author":"Chao","year":"2011","journal-title":"J. Liq. Chromatogr. Relat."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1016\/j.jchromb.2011.04.014","article-title":"Highly sensitive and accurate screening of 40 dyes in soft drinks by liquid chromatography-electrospray tandem mass spectrometry","volume":"879","author":"Feng","year":"2011","journal-title":"J. Chromatogr. B Analyt. Technol. Biomed. Life Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/S0021-9673(02)00441-7","article-title":"Determining eight colorants in milk beverages by capillary electrophoresis","volume":"959","author":"Huang","year":"2002","journal-title":"J. Chromatogr. A."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.chroma.2006.09.071","article-title":"Validation of methodology for simultaneous determination of synthetic dyes in alcoholic beverages by capillary electrophoresis","volume":"1136","author":"Prado","year":"2006","journal-title":"J. Chromatogr. A"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"European Commission (2013). Analysis of needs in post-market monitoring of food additives and preparatory work for future projects in this field. EFSA Support. Publ., 10, 419E.","DOI":"10.2903\/sp.efsa.2013.EN-419"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3726","DOI":"10.1021\/jf400029y","article-title":"Determination of seven certified color additives in food products using liquid chromatography","volume":"61","author":"Harp","year":"2013","journal-title":"J. Agric. Food Chem."},{"key":"ref_57","unstructured":"EFSA ANS Panel (European Food Safety Authority Panel on Food Additives and Nutrient Sources Added to Food) (2023). Follow-up of the re-evaluation of indigo carmine (E 132) as a food additive. EFSA J., 21, 8108."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1590\/S1984-82502010000400014","article-title":"Exploratory study on sequestration of some essential metals by indigo carmine food dye","volume":"46","author":"Zanoni","year":"2010","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"114061","DOI":"10.1016\/j.molliq.2020.114061","article-title":"Current treatment technologies and mechanisms for removal of indigo carmine dyes from wastewater: A review","volume":"318","author":"Chowdhury","year":"2020","journal-title":"J. Mol. Liq."},{"key":"ref_60","first-page":"87","article-title":"Indigo carmine: Understanding a problematic blue dye","volume":"57","author":"Knaller","year":"2013","journal-title":"Stud. Conserv."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.2166\/wst.2010.158","article-title":"Removal of acidic indigo carmine textile dye from aqueous solutions using radiation induced cationic hydrogels","volume":"61","author":"Sari","year":"2010","journal-title":"Water Sci. Technol."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"109692","DOI":"10.1016\/j.enzmictec.2020.109692","article-title":"Production of indigo through the use of a dual-function substrate and a bifunctional fusion enzyme","volume":"142","author":"Fabara","year":"2020","journal-title":"Enzyme Microb. Technol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.apcata.2005.10.016","article-title":"Synthesis and modification of ZSM-5 with manganese and lanthanum and their effects on decolorization of indigo carmine dye","volume":"299","author":"Othman","year":"2006","journal-title":"Appl. Catal."},{"key":"ref_64","doi-asserted-by":"crossref","unstructured":"Pattanaik, L., Duraivadivel, P., Hariprasad, P., and Naik, S.N. (2020). Utilization and re-use of solid and liquid waste generated from the natural indigo dye production process-a zero waste approach. Bioresour. Technol., 301.","DOI":"10.1016\/j.biortech.2019.122721"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/jcis.2002.8537","article-title":"Interaction of indigo carmine dye with chitosan evaluated by adsorption and thermochemical data","volume":"253","author":"Vieira","year":"2002","journal-title":"J. Colloid Interface Sci."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.matpr.2019.06.419","article-title":"Removal of hazardous indigo carmine dye from wastet water using treated red mud","volume":"17","author":"Babu","year":"2019","journal-title":"Mater. Today Proc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"54876","DOI":"10.1007\/s11356-021-14432-1","article-title":"Synthesis and characterization of FSB@Fe3O4 composites and application in removal of indigo carmine dye from industrial wastewaters","volume":"28","author":"Achieng","year":"2021","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"55315","DOI":"10.1007\/s11356-021-14819-0","article-title":"Electrocoagulation induced treatment of indigo carmine textile dye in an aqueous medium: The effect of process variables on efficiency evaluated using biochemical response of Gammarus pulex","volume":"28","author":"Tanyol","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jenvman.2006.02.012","article-title":"Guidelines and legislation for dye house effluents","volume":"83","author":"Hessel","year":"2007","journal-title":"J. Environ. Manag."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1016\/j.heliyon.2019.e02711","article-title":"Textile finishing dyes and their impact on aquatic environs","volume":"5","author":"Berradi","year":"2019","journal-title":"Heliyon"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.4236\/jep.2016.712137","article-title":"Degradation of indigo carmine using advanced oxidation processes: Synergy effects and toxicological study","volume":"7","author":"Ortiz","year":"2016","journal-title":"J. Environ. Prot. Sci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"15522","DOI":"10.1038\/s41598-022-19595-6","article-title":"Adsorption of indigo carmine dye by Acacia nilotica sawdust activated carbon in fixed bed column","volume":"12","author":"Gupta","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"5337","DOI":"10.1039\/D2RA07883J","article-title":"Synthesis, characterization and application of chitosan\/grapheme oxide\/copper ferrite nanocomposite for the adsorptive removal of anionic and cationic dyes from wastewater","volume":"13","author":"Ahmed","year":"2023","journal-title":"RSC Adv."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.envint.2004.02.001","article-title":"Removal of synthetic dyes from wastewaters: A review","volume":"30","author":"Forgacs","year":"2004","journal-title":"Environ. Int."},{"key":"ref_75","first-page":"301","article-title":"An overview of treatments for the removal of textile dyes","volume":"7","author":"Karthik","year":"2014","journal-title":"J. Chem. Pharm. Sci."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1735-2746-9-17","article-title":"Experimental study of dye removal from industrial wastewater by membrane technologies of reverse osmosis and nanofiltration","volume":"9","author":"Abid","year":"2012","journal-title":"Iran J. Environ. Health Sci. Eng."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.memsci.2014.06.057","article-title":"Treatment of highly concentrated wastewater containing multiple synthetic dyes by a combined process of coagulation\/flocculation and nanofiltration","volume":"469","author":"Liang","year":"2014","journal-title":"J. Membr. Sci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1016\/j.seppur.2018.08.052","article-title":"Fast decolourization of indigo carmine and crystal violet in aqueous environments through micellar catalysis","volume":"210","author":"Puiu","year":"2019","journal-title":"Sep. Purif. Technol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3790","DOI":"10.1016\/j.arabjc.2019.01.003","article-title":"ZnO-Bi2O3\/graphitic carbon nitride photocatalytic system with H2O2-assisted enhanced degradation of indigo carmine under visible light","volume":"13","author":"Huy","year":"2020","journal-title":"Arab. J. Chem."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.chemosphere.2018.09.102","article-title":"Photolysis of indigo carmine solution by planar vacuum-ultraviolet (147 nm) light source","volume":"214","author":"Zukawa","year":"2019","journal-title":"Chemosphere"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ibiod.2015.04.007","article-title":"Reductive decolorization of indigo carmine dye with Bacillus sp. MZS10","volume":"103","author":"Li","year":"2015","journal-title":"Int. Biodeterior. Biodegrad."},{"key":"ref_82","unstructured":"Galanakis, C.M. (2021). Innovative Food Analysis, Acadamic Press."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.jhazmat.2009.05.102","article-title":"Sorption of indigo carmine by a Fe-zeolitic tuff and carbonaceous material from pyrolyzed sewage sludge","volume":"170","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1080\/01496395.2013.863340","article-title":"Comparative study on the adsorption of tartrazine and indigo carmine onto maize cob carbon","volume":"49","author":"Zhang","year":"2014","journal-title":"Sep. Sci. Technol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.envpol.2019.05.072","article-title":"Recent advances for dyes removal using novel adsorbents: A review","volume":"252","author":"Zhou","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.jenvman.2018.07.046","article-title":"A review on geopolymers as emerging materials for the adsorption of heavy metals and dyes","volume":"224","author":"Siyal","year":"2018","journal-title":"J. Environ. Manag."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jhazmat.2007.08.092","article-title":"The removal of the indigo carmine dye from aqueous solutions using cross-linked chitosan\u2014Evaluation of adsorption thermodynamics using a full factorial design","volume":"153","author":"Cestari","year":"2007","journal-title":"J. Hazard. Mater."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"126300","DOI":"10.1016\/j.jhazmat.2021.126300","article-title":"Mechanistically understanding adsorption of methyl orange, indigo carmine, and methylene blue onto ionic\/nonionic polystyrene adsorbents","volume":"418","author":"Pan","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_89","first-page":"1","article-title":"Removal of indigo carmine dye from aqueous solution using magnesium hydroxide as an adsorbent","volume":"2015","author":"Ramesh","year":"2015","journal-title":"J. Mater."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"2824","DOI":"10.1016\/S0043-1354(01)00521-8","article-title":"Removal of dyes from a synthetic textile dye effluent by biosorption on apple pomace and wheat straw","volume":"36","author":"Robinson","year":"2002","journal-title":"Water Res."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1080\/01496395.2012.658485","article-title":"Application of nano surfactant modified biosorbent as an efficient adsorbent for dye removal","volume":"47","author":"Ansari","year":"2012","journal-title":"Sep. Sci. Technol."},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Wani, K.A., and Jangid, N.K. (2019). Impact of Textile Dyes on Public Health and the Environment, IGI Global Publishers.","DOI":"10.4018\/978-1-7998-0311-9"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"124433","DOI":"10.1016\/j.jhazmat.2020.124433","article-title":"Adsorption of indigo carmine dye onto the surface-modified adsorbent prepared from municipal waste and simulation using deep neural network","volume":"408","author":"Ahmad","year":"2020","journal-title":"J. Hazard. Mater."},{"key":"ref_94","first-page":"897","article-title":"MnO2 efficiently removes indigo carmine dyes from polluted water","volume":"4","author":"Lekshmi","year":"2018","journal-title":"Heliyon"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Pavel, O.D., Stamate, A.E., Zavoianu, R., Cruceanu, A., Tirsoaga, A., Birjega, R., Brezestean, I.A., Ciorita, A., Culita, D.A., and Dias, A.P.S. (2023). Mo-LDH-GO hybrid catalysts for indigo carmine advanced oxidation. Materials, 16.","DOI":"10.3390\/ma16083025"},{"key":"ref_96","first-page":"39","article-title":"Flow injection analysis of indigo carmine using green coconut (Cocos Nucifera L.) fiber as a bioadsorbent","volume":"1","author":"Zaidan","year":"2015","journal-title":"Int. J. Eng. Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1097\/00000542-196801000-00078","article-title":"The vasopressor effect of indigo carmine","volume":"29","author":"Erickson","year":"1968","journal-title":"Anesthesiology"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0090-4295(94)80149-5","article-title":"Severe hypotension, bronchospasm, and urticaria from intravenous indigo carmine","volume":"44","author":"Naitoh","year":"1994","journal-title":"Urology"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/jcu.20682","article-title":"Preoperative localization of cystic lesions in the knee using ultrasound-guided injection of indigo carmine","volume":"38","author":"Park","year":"2010","journal-title":"J. Clin. Ultrasound"},{"key":"ref_100","first-page":"57","article-title":"Indigo carmine-induced hypotension in patients undergoing general anaesthesia","volume":"53","author":"Jeon","year":"2012","journal-title":"Singap. Med. J."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0022-5347(17)62624-7","article-title":"Cardiovascular and respiratory effects of indigo carmine","volume":"100","author":"Kennedy","year":"1968","journal-title":"J. Urol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/0090-4295(77)90192-3","article-title":"Severe hypertensive reaction to indigo carmine","volume":"9","author":"Jeffords","year":"1977","journal-title":"Urology"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1111\/ijd.12871","article-title":"A postoperative blue rash: Indigo carmine dye extravasation","volume":"54","author":"Chu","year":"2015","journal-title":"Int. J. Dermatol."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10877-015-9719-2","article-title":"Effects of indigo carmine intravenous injection on noninvasive and continuous total hemoglobin measurement","volume":"30","author":"Isosu","year":"2016","journal-title":"J. Clin. Monit. Comput."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.2174\/1874325001307010008","article-title":"Effect of indigo carmine on human chondrocytes in vitro","volume":"7","author":"Zippelius","year":"2013","journal-title":"Open Orthop. J."},{"key":"ref_106","unstructured":"Ray, S.D. (2014). Side Effects of Drugs Annual, Elsevier."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1048-6666(03)00021-1","article-title":"Posterolateral percutane endoscopic lumbar discectomy","volume":"13","author":"Tsou","year":"2003","journal-title":"Oper. Technol. Orthop."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.arthro.2010.10.017","article-title":"Color-aided visualization of dorsal wrist ganglion stalks aids in complete arthroscopic excision","volume":"27","author":"Yao","year":"2011","journal-title":"Arthroscopy"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0090-4295(98)00414-2","article-title":"Effect of methylene blue, indigo carmine, and Renografin on human sperm motility","volume":"53","author":"Sheynkin","year":"1999","journal-title":"Urology"},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/0952-8180(91)90229-G","article-title":"Acute hemodynamic effects of indigo carmine in the presence of compromised cardiac function","volume":"3","author":"Yang","year":"1991","journal-title":"J. Clin. Anesth."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1213\/00000539-200102000-00053","article-title":"Vaginal indigo carmine-induced severe hypotension","volume":"92","author":"Yanagidate","year":"2001","journal-title":"Anesth. Analg."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jmig.2016.06.009","article-title":"Options to evaluate ureter patency at cystoscopy in a world without indigo carmine","volume":"23","author":"Luketic","year":"2016","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/0890-6238(93)90041-5","article-title":"Methylene blue but not indigo carmine is toxic to human luteal cells in vitro","volume":"7","author":"Mahadevan","year":"1993","journal-title":"Reprod. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ejogrb.2022.09.020","article-title":"Visualizing the dissectable layer for vaginal hysterectomy with indigo carmine","volume":"278","author":"Imai","year":"2022","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ccd.27813","article-title":"Utility of indigo carmine angiography in patients with critical limb ischemia: Prospective multi-center intervention study (DIESEL-study)","volume":"93","author":"Higashimori","year":"2019","journal-title":"Catheter. Cardiovasc. Interv."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0022-5347(17)38474-4","article-title":"Indigo carmine as a quantitative indicator of urothelial integrity","volume":"145","author":"Monson","year":"1991","journal-title":"J. Urol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/IOP.0000000000001457","article-title":"Endoscopic evaluation of lacrimal mucosa with indigo carmine stain","volume":"36","author":"Mimura","year":"2020","journal-title":"Ophthalm. Plast. Reconstr. Surg."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.cgh.2022.03.003","article-title":"Texture and color enhancement imaging with indigo carmine dye accentuates slightly depressed early gastric cancer lesions","volume":"20","author":"Kubo","year":"2022","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1007\/s00464-020-07706-1","article-title":"Benefits of linked color imaging for recognition of early differentiated-type gastric cancer: In comparison with indigo carmine contrast method and blue laser imaging","volume":"35","author":"Yasuda","year":"2021","journal-title":"Surg. Endosc."},{"key":"ref_120","first-page":"3900","article-title":"3D reconstruction of whole stomach from endoscope video using structure-from-motion","volume":"2019","author":"Resindra","year":"2019","journal-title":"Annu. Int. Conf. IEEE Eng. Med. Biol. Soc."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1093\/ibd\/izaa291","article-title":"Chromoendoscopy with indigo carmine vs virtual chromoendoscopy (iSCAN1) for neoplasia screening in patients with inflammatory bowel disease: A prospective randomized study","volume":"27","author":"Riestra","year":"2021","journal-title":"Inflamm. Bowel Dis."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.3748\/wjg.v24.i10.1167","article-title":"Colonic lesion characterization in inflammatory bowel disease: A systematic review and meta-analysis","volume":"24","author":"Lord","year":"2018","journal-title":"World J. Gastroenterol."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1055\/s-2004-826039","article-title":"Chromoendoscopy using indigo carmine dye spraying with magnifying observation is the most reliable method for differential diagnosis between non-neoplastic and neoplastic colorectal lesions: A prospective study","volume":"36","author":"Fu","year":"2004","journal-title":"Endoscopy"},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1067\/mge.2002.123620","article-title":"Pressure dye-spray: A simple and reliable method for differentiating adenomas from hyperplastic polyps in the colon","volume":"55","author":"Kanamori","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2559.2003.01736.x","article-title":"The role of flat and depressed colorectal lesions in colorectal carcinogenesis: New insights from clinicopathological findings in high-magnification chromoscopic colonoscopy","volume":"43","author":"Hurlstone","year":"2003","journal-title":"Histopathology"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/00004836-200401000-00004","article-title":"Perspectives of chromo and magnifying endoscopy: How, how much, when, and whom should we stain?","volume":"38","author":"Kiesslich","year":"2004","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0016-5107(96)70222-5","article-title":"Diagnosis of colorectal timorous lesions by magnifying endoscopy","volume":"44","author":"Kudo","year":"1996","journal-title":"Gastrointest. Endosc."},{"key":"ref_128","first-page":"336","article-title":"The role of chromoendoscopy in evaluating colorectal dysplasia","volume":"13","author":"Buchner","year":"2017","journal-title":"Gastroenterol. Hepatol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"6402904","DOI":"10.1155\/2022\/6402904","article-title":"Magnifying chromoendoscopy with flexible spectral imaging color enhancement, indigo carmine, and crystal violet in predicting the histopathology of colorectal polyps: Diagnostic value in a scare-setting resource","volume":"2022","author":"Pham","year":"2022","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0022-5347(17)58715-7","article-title":"Reaction to indigo carmine","volume":"116","author":"Ng","year":"1976","journal-title":"J. Urol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1111\/j.1399-6576.2007.01320.x","article-title":"Intravenous indigo carmine might cause cerebral ischemia","volume":"51","author":"Kawaguchi","year":"2007","journal-title":"Acta Anaesthesiol. Scand."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1097\/SPV.0b013e3181986ace","article-title":"The safety of intravenous indigo carmine to assess ureteric patency during transvaginal uterosacral suspension of the vaginal vault","volume":"15","author":"Craik","year":"2009","journal-title":"J. Pelvic Med. Surg."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1053\/j.jvca.2015.02.013","article-title":"Indigo carmine-induced hypotension in a parturient with idiopathic pulmonary artery hypertension, hypertrophic cardiomyopathy, and LAD myocardial bridging","volume":"30","author":"Sutton","year":"2016","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1213\/00000539-199611000-00043","article-title":"Upper extremity discoloration caused by subcutaneous indigo carmine injection","volume":"83","author":"Connors","year":"1996","journal-title":"Anesth. Analg."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"499","DOI":"10.4097\/kjae.2012.62.5.499","article-title":"Extensive skin color change caused by extravasation of indigo carmine","volume":"62","author":"Choi","year":"2012","journal-title":"Korean J. Anesthesiol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"5863","DOI":"10.1016\/S0009-2509(99)00178-5","article-title":"The prediction of sorption from a binary mixture of acidic dyes using single and mixed isotherm variants of the ideal adsorbed solute theory","volume":"54","author":"Porter","year":"1999","journal-title":"Chem. Eng. Sci."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"18521","DOI":"10.1074\/jbc.M400334200","article-title":"Superoxide converts indigo carmine to isatin sulfonic acid: Implications for the hypothesis that neutrophils produce ozone","volume":"279","author":"Kettle","year":"2004","journal-title":"J. Biol. Chem."},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1002\/jib.261","article-title":"Indigo carmine degradation in the presence of maltose and ethanol","volume":"121","author":"Savel","year":"2015","journal-title":"J. Inst. Brew."},{"key":"ref_139","unstructured":"Bamforth, C.W. (2016). Brewing Materials and Processes. A Practical Approach to Beer Excellence, Academic Press."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0015-6264(69)80261-0","article-title":"Short-term toxicity study on indigo carmine in the pig","volume":"7","author":"Gaunt","year":"1969","journal-title":"Food Cosmet. Toxicol."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0015-6264(75)80001-0","article-title":"Long-term in toxicity carmine in mice","volume":"13","author":"Hooson","year":"1975","journal-title":"Food Cosmet. Toxicol."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/0041-008X(66)90097-4","article-title":"Chronic toxicity of two food colors, Brilliant Blue FCF and Indigotine","volume":"8","author":"Hansen","year":"1966","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1006\/bbrc.1993.2070","article-title":"Bio-metabolism of green S and Indigo Carmine through caecal microflora of rats","volume":"195","author":"Singh","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/S0278-6915(98)00039-8","article-title":"Mutagenicity and DNA-damaging activity of decomposed products of food colours under UV radiation","volume":"36","author":"Ozaki","year":"1998","journal-title":"Food Chem. Toxicol."},{"key":"ref_145","first-page":"218","article-title":"Evaluation of reproductive toxicity caused by indigo carmine on male swiss albino mice","volume":"1","author":"Dixit","year":"2013","journal-title":"Pharmacologyonline"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.spinee.2023.02.008","article-title":"Patent blue versus methylene blue and indigo carmine as a better dye for chromodiscography: In vitro staining efficacy and cytotoxicity study using bovine coccygeal intervertebral discs","volume":"23","author":"Peng","year":"2023","journal-title":"Spine J."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1111\/1759-7714.14814","article-title":"Stability and safety of transbronchial dye mixture for preoperative localization in a porcine model","volume":"14","author":"Yoo","year":"2023","journal-title":"Thorac. Cancer"}],"container-title":["Journal of Xenobiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4713\/13\/3\/33\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:53:44Z","timestamp":1760129624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4713\/13\/3\/33"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,20]]},"references-count":147,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["jox13030033"],"URL":"https:\/\/doi.org\/10.3390\/jox13030033","relation":{},"ISSN":["2039-4713"],"issn-type":[{"value":"2039-4713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,20]]}}}