{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:08:53Z","timestamp":1780474133041,"version":"3.54.1"},"reference-count":59,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T00:00:00Z","timestamp":1722211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Bilharziasis is a widespread trematode parasite that poses a severe public health burden. Dandelion (Taraxacum officinale) has several pharmacological and traditional properties critical for treating several hepatic disorders. The present study was designed to assess the potential efficacy of T. officinale root (TOR) dietary supplementation with or without praziquantel (PZQ) against liver and intestinal disorders in mice infected with Schistosoma mansoni. This study was conducted on five groups; G1: uninfected control, G2: untreated S. mansoni-infected mice, G3: infected animals treated with 250 mg\/kg PZQ for three alternative days, G4: infected animals were orally administered 600 mg\/kg bw TOR daily for 10 days, and G5: infected animals that received both PZQ and TOR as previously described. The current findings after different treatments indicated topographical scanning electron microscopy alterations of male adult worms and a critical reduction in worm burden, ova count, granuloma diameter, hepatic and intestinal histological abnormalities, fibrosis, immunohistochemical expression of CD3+ and CD20+ cells, oxidative stress, and interleukin-10, also upregulation of interferon-gamma, and antioxidant enzymes, when compared to the infected untreated mice. The best results were obtained in mice administered PZQ+TOR together because of their antioxidant properties and ability to promote the host immune response to parasitic infection.<\/jats:p>","DOI":"10.3390\/jox14030056","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T18:04:59Z","timestamp":1722535499000},"page":"1003-1022","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["In Vivo Antischistosomicidal and Immunomodulatory Effects of Dietary Supplementation with Taraxacum officinale"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3641-258X","authenticated-orcid":false,"given":"Amany","family":"Nofal","sequence":"first","affiliation":[{"name":"Histology and Histochemistry Unit, Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1301-2900","authenticated-orcid":false,"given":"Amal","family":"Shaaban","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5137-0058","authenticated-orcid":false,"given":"Hany","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Immunology Unit, Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7658-2444","authenticated-orcid":false,"given":"Faten","family":"Abouelmagd","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, Faculty of Medicine, Sohag University, Sohag 82524, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0770-7194","authenticated-orcid":false,"given":"Azza","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science, Menoufia University, Shebin El-Kom 32511, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1021\/acsinfecdis.3c00081","article-title":"Perspective on schistosomiasis drug discovery: Highlights from a schistosomiasis drug discovery Workshop at Wellcome Collection, London, September 2022","volume":"9","author":"Caldwell","year":"2023","journal-title":"ACS Infect Dis."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"52","DOI":"10.3390\/zoonoticdis3010006","article-title":"Livestock Reservoir Hosts: An Obscured Threat to Control of Human Schistosomiasis in Nigeria","volume":"3","author":"Mogaji","year":"2023","journal-title":"Zoonotic Dis."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"e14754","DOI":"10.1016\/j.heliyon.2023.e14754","article-title":"The epidemiology of Schistosoma mansoni in the Lake Tana Basin (Ethiopia): Review with retrospective data analyses","volume":"9","author":"Abera","year":"2023","journal-title":"Heliyon"},{"key":"ref_4","unstructured":"WHO (2023, February 01). 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