{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T05:33:39Z","timestamp":1787981619431,"version":"build-2784847793"},"reference-count":75,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005026","name":"Stichting tegen kanker","doi-asserted-by":"publisher","award":["031\/2021"],"award-info":[{"award-number":["031\/2021"]}],"id":[{"id":"10.13039\/501100005026","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Chemotherapy-induced cardiotoxicity is a critical issue in cardio-oncology, as cancer treatments often lead to severe cardiovascular complications. Approximately 10% of cancer patients succumb to cardiovascular problems, with lung cancer patients frequently experiencing arrhythmias, cardiac failure, tamponade, and cardiac metastasis. The cardiotoxic effects of anti-cancer treatments manifest at both cellular and tissue levels, causing deformation of cardiomyocytes, leading to contractility issues and fibrosis. Repeated irradiation and chemotherapy increase the risk of valvular, pericardial, or myocardial diseases. Multi-OMICs analyses reveal that targeting specific pathways as well as specific protein modifications, such as ubiquitination and phosphorylation, could offer potential therapeutic alternatives to current treatments, including Angiotensin converting enzymes (ACE) inhibitors and beta-blockers that mitigate symptoms but do not prevent cardiomyocyte death, highlighting the need for more effective therapies to manage cardiovascular defects in cancer survivors. This review explores the xenobiotic nature of chemotherapy agents and their impact on cardiovascular health, aiming to identify novel biomarkers and therapeutic targets to mitigate cardiotoxicity.<\/jats:p>","DOI":"10.3390\/jox15010009","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T09:30:45Z","timestamp":1736328645000},"page":"9","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cardiotoxicity of Chemotherapy: A Multi-OMIC Perspective"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-7779-0773","authenticated-orcid":false,"given":"Yan","family":"Ma","sequence":"first","affiliation":[{"name":"VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1163-7499","authenticated-orcid":false,"given":"Mandy O. J.","family":"Grootaert","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Dentistry, UC Louvain, Avenue Hippocrate 55, 1200 Woluwe-Saint-Lambert, Belgium"},{"name":"Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, Herestraat 49, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9238-3242","authenticated-orcid":false,"given":"Raj N.","family":"Sewduth","sequence":"additional","affiliation":[{"name":"VIB-KU Leuven Center for Cancer Biology, VIB, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Zaborowska-Szmit, M., Krzakowski, M., Kowalski, D.M., and Szmit, S. (2020). Cardiovascular Complications of Systemic Therapy in Non-Small-Cell Lung Cancer. J. Clin. Med., 9.","DOI":"10.3390\/jcm9051268"},{"key":"ref_2","first-page":"82","article-title":"Cardiac and lymphatic metastases from lung cancer","volume":"21","year":"2018","journal-title":"Arch. Iran. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1200\/JCO.2007.14.9328","article-title":"Cardiac involvement at presentation of non-small-cell lung cancer","volume":"26","author":"Jassem","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"994","DOI":"10.5603\/KP.2013.0245","article-title":"Cardiac involvement of lung cancer mimicking myocardial infarction","volume":"71","author":"Ciurus","year":"2013","journal-title":"Kardiol. Pol."},{"key":"ref_5","first-page":"489","article-title":"Primary lung cancer (adenocarcinoma) associated with cardiac sarcoidosis","volume":"37","author":"Mizutani","year":"1999","journal-title":"Nihon Kokyuki Gakkai Zasshi = J. Jpn. Respir. Soc."},{"key":"ref_6","first-page":"691","article-title":"Cardiac tamponade and superior vena cava syndrome in lung cancer\u2014A case report","volume":"55","author":"Gowda","year":"2004","journal-title":"Angiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1159\/000218368","article-title":"Pro-brain natriuretic peptide is a sensitive marker for detecting cardiac metastases in patients with non-small cell lung cancer","volume":"32","author":"Lafaras","year":"2009","journal-title":"Onkologie"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1378\/chest.71.5.607","article-title":"Cardiac metastases in lung cancer","volume":"71","author":"Strauss","year":"1977","journal-title":"Chest"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Paul, S., Bodner, W.R., Garg, M., Tang, J., and Ohri, N. (2020). Cardiac Irradiation Predicts Activity Decline in Patients Receiving Concurrent Chemoradiation for Locally Advanced Lung Cancer. Int. J. Radiat. Oncol. Biol. Phys.","DOI":"10.1016\/j.ijrobp.2020.05.042"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Bertolini, D., Pizzi, C., Donal, E., and Galli, E. (2024). Cancer and Heart Failure: Dangerous Liaisons. J. Cardiovasc. Dev. Dis., 11.","DOI":"10.3390\/jcdd11090263"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1002\/cam4.2922","article-title":"Left ventricular ejection fraction decrease related to BRAF and\/or MEK inhibitors in metastatic melanoma patients: A retrospective analysis","volume":"9","author":"Berger","year":"2020","journal-title":"Cancer Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1097\/CORR.0000000000002628","article-title":"What is the Effect of Bevacizumab on Cartilage and Synovium in a Rabbit Model of Hemophilic Arthropathy?","volume":"481","author":"Mert","year":"2023","journal-title":"Clin. Orthop. Relat. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s44313-024-00004-y","article-title":"Real-world incidence and risk factors of bortezomib-related cardiovascular adverse events in patients with multiple myeloma","volume":"59","author":"Jang","year":"2024","journal-title":"Blood Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"101830","DOI":"10.1016\/j.esmoop.2023.101830","article-title":"Risk profiles and incidence of cardiovascular events across different cancer types","volume":"8","author":"Mitchell","year":"2023","journal-title":"ESMO Open"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.jaccao.2024.07.016","article-title":"Anthracycline Cardiotoxicity in Adult Cancer Patients","volume":"6","author":"Camilli","year":"2024","journal-title":"JACC CardioOncol"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Liu, L., Wang, Y., Dong, Y., Lin, S., Guan, W., and Song, J. (2024). Resveratrol as a cardioprotective adjuvant for 5-fluorouracil in the treatment of gastric cancer cells. Braz. J. Med. Biol. Res., 57.","DOI":"10.1590\/1414-431x2024e13537"},{"key":"ref_17","first-page":"190","article-title":"The prevention of cardiovascular disease in cancer survivors","volume":"39","author":"Daher","year":"2012","journal-title":"Tex. Heart Inst. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1080\/02841860903229124","article-title":"(2009). Cardiotoxicity induced by tyrosine kinase inhibitors","volume":"48","author":"Orphanos","year":"2009","journal-title":"Acta Oncol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2459\/JCM.0000000000000232","article-title":"Chemotherapy cardiotoxicity: Cardioprotective drugs and early identification of cardiac dysfunction","volume":"17","author":"Leggio","year":"2016","journal-title":"J. Cardiovasc. Med."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"10732748241285755","DOI":"10.1177\/10732748241285755","article-title":"Unveiling the Cardiotoxicity Conundrum: Navigating the Seas of Tyrosine Kinase Inhibitor Therapies","volume":"31","author":"Ekram","year":"2024","journal-title":"Cancer Control"},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Paterek, A., Okni\u0144ska, M., Pilch, Z., Sosnowska, A., Ramji, K., Mackiewicz, U., Golab, J., Nowis, D., and M\u0105czewski, M. (2023). Arginase Inhibition Mitigates Bortezomib-Exacerbated Cardiotoxicity in Multiple Myeloma. Cancers, 15.","DOI":"10.3390\/cancers15072191"},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Ramji, K., Grzywa, T.M., Sosnowska, A., Paterek, A., Okninska, M., Pilch, Z., Barankiewicz, J., Garbicz, F., Borg, K., and Bany-Laszewicz, U. (2022). Targeting arginase-1 exerts antitumor effects in multiple myeloma and mitigates bortezomib-induced cardiotoxicity. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-24137-1"},{"key":"ref_23","first-page":"65","article-title":"Dexrazoxane prevents vascular toxicity in doxorubicin-treated mice","volume":"10","author":"Bosman","year":"2024","journal-title":"Cardiooncology"},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Ivanisevic, T., and Sewduth, R.N. (2023). Multi-Omics Integration for the Design of Novel Therapies and the Identification of Novel Biomarkers. Proteomes, 11.","DOI":"10.3390\/proteomes11040034"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: A comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1161\/CIRCULATIONAHA.120.046471","article-title":"Early Cardiac Remodeling Promotes Tumor Growth and Metastasis","volume":"142","author":"Avraham","year":"2020","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.advenzreg.2007.11.016","article-title":"Nuclear organization and chromatin dynamics\u2014Sp1, Sp3 and histone deacetylases","volume":"48","author":"Davie","year":"2008","journal-title":"Adv. Enzym. Regul."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"153977","DOI":"10.1016\/j.tox.2024.153977","article-title":"Knock-down of FOXO3, GATA2, NFE2L2 and AHR promotes doxorubicin-induced cardiotoxicity in human cardiomyocytes","volume":"509","author":"Faber","year":"2024","journal-title":"Toxicology"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1631\/jzus.B2300691","article-title":"Cynaroside regulates the AMPK\/SIRT3\/Nrf2 pathway to inhibit doxorubicin-induced cardiomyocyte pyroptosis","volume":"25","author":"Zou","year":"2024","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"459","DOI":"10.2459\/JCM.0000000000001115","article-title":"Preventing cancer therapy-related heart failure: The need for novel studies","volume":"22","author":"Fogarassy","year":"2021","journal-title":"J. Cardiovasc. Med."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1042\/CS20241084","article-title":"Endothelial cell-cardiomyocyte cross-talk: Understanding bidirectional paracrine signaling in cardiovascular homeostasis and disease","volume":"138","author":"Adao","year":"2024","journal-title":"Clin. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Antoniak, S., Phungphong, S., Cheng, Z., and Jensen, B.C. (2021). Novel Mechanisms of Anthracycline-Induced Cardiovascular Toxicity: A Focus on Thrombosis, Cardiac Atrophy, and Programmed Cell Death. Front. Cardiovasc. Med., 8.","DOI":"10.3389\/fcvm.2021.817977"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4089","DOI":"10.2147\/DDDT.S469331","article-title":"Cardiotoxicity of Anticancer Drugs: Molecular Mechanisms, Clinical Management and Innovative Treatment","volume":"18","author":"Gao","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"829","DOI":"10.2147\/DDDT.S443107","article-title":"Understanding Sorafenib-Induced Cardiovascular Toxicity: Mechanisms and Treatment Implications","volume":"18","author":"Li","year":"2024","journal-title":"Drug Des. Devel Ther."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.cels.2019.03.009","article-title":"Adaptation of Human iPSC-Derived Cardiomyocytes to Tyrosine Kinase Inhibitors Reduces Acute Cardiotoxicity via Metabolic Reprogramming","volume":"8","author":"Wang","year":"2019","journal-title":"Cell Syst."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"152281","DOI":"10.1016\/j.tox.2019.152281","article-title":"Mitochondrial oxidative stress plays a critical role in the cardiotoxicity of sunitinib: Running title: Sunitinib and oxidative stress in hearts","volume":"426","author":"Bouitbir","year":"2019","journal-title":"Toxicology"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1016\/j.stem.2024.10.007","article-title":"CRISPRi\/a screens in human iPSC-cardiomyocytes identify glycolytic activation as a druggable target for doxorubicin-induced cardiotoxicity","volume":"31","author":"Liu","year":"2024","journal-title":"Cell Stem Cell"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.jaccao.2024.07.010","article-title":"Preventing Cardiac Damage in Patients Treated for Breast Cancer and Lymphoma: The PROACT Clinical Trial","volume":"6","author":"Austin","year":"2024","journal-title":"JACC CardioOncol"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Li, D., Song, C., Zhang, J., and Zhao, X. (2023). Resveratrol alleviated 5-FU-induced cardiotoxicity by attenuating GPX4 dependent ferroptosis. J. Nutr. Biochem., 112.","DOI":"10.1016\/j.jnutbio.2022.109241"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1159\/000471759","article-title":"A Prospective Study to Evaluate the Effect of Paclitaxel on Cardiac Ejection Fraction","volume":"12","author":"Osman","year":"2017","journal-title":"Breast Care"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/echo.12621","article-title":"Effects of Paclitaxel and Carboplatin combination on mechanical myocardial and microvascular functions: A transthoracic Doppler echocardiography and two-dimensional strain imaging study","volume":"32","author":"Altin","year":"2015","journal-title":"Echocardiography"},{"key":"ref_42","first-page":"1105","article-title":"Liposomal paclitaxel induces fewer hematopoietic and cardiovascular complications than bioequivalent doses of Taxol","volume":"53","author":"Huang","year":"2018","journal-title":"Int. J. Oncol."},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Poels, K., Vos, W.G., Lutgens, E., and Seijkens, T.T.P. (2020). E3 Ubiquitin Ligases as Immunotherapeutic Target in Atherosclerotic Cardiovascular Disease. Front. Cardiovasc. Med., 7.","DOI":"10.3389\/fcvm.2020.00106"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"3616","DOI":"10.1038\/s41467-019-11551-9","article-title":"WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling","volume":"10","author":"Chen","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e002485","DOI":"10.1161\/JAHA.115.002485","article-title":"HECT-Type Ubiquitin E3 Ligase ITCH Interacts With Thioredoxin-Interacting Protein and Ameliorates Reactive Oxygen Species-Induced Cardiotoxicity","volume":"5","author":"Otaki","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1111\/jcmm.15538","article-title":"WWP2 regulates SIRT1-STAT3 acetylation and phosphorylation involved in hypertensive angiopathy","volume":"24","author":"Zhang","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2426","DOI":"10.2174\/1381612828666220729103430","article-title":"Fasudil Protects Against Adriamycin-induced Acute Heart Injury by Inhibiting Oxidative Stress, Apoptosis, and Cellular Senescence","volume":"28","author":"Yan","year":"2022","journal-title":"Curr. Pharm. Des."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1161\/CIRCULATIONAHA.117.030352","article-title":"Phosphoinositide 3-Kinase Gamma Inhibition Protects From Anthracycline Cardiotoxicity and Reduces Tumor Growth","volume":"138","author":"Li","year":"2018","journal-title":"Circulation"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"3275","DOI":"10.1016\/S0735-1097(21)04629-5","article-title":"PCSK9 Inhibitor Evolocumab Reduced Cardiotoxicity of Doxorubicin and Trastuzumab Sequential Treatmential Treatmrnt Through Myd88\/NFKB\/Mtorc1 Pathways","volume":"77","author":"Maurea","year":"2024","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"e2303367","DOI":"10.1002\/advs.202303367","article-title":"Spatial Mechano-Signaling Regulation of GTPases through Non-Degradative Ubiquitination","volume":"10","author":"Sewduth","year":"2023","journal-title":"Adv. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Yong, D., Green, S.R., Ghiabi, P., Santhakumar, V., and Vedadi, M. (2023). Discovery of Nedd4 auto-ubiquitination inhibitors. Sci. Rep., 13.","DOI":"10.1038\/s41598-023-42997-z"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"3162","DOI":"10.1038\/s41467-019-11224-7","article-title":"A multi-lock inhibitory mechanism for fine-tuning enzyme activities of the HECT family E3 ligases","volume":"10","author":"Wang","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"13191","DOI":"10.1074\/jbc.RA118.002649","article-title":"Targeting TRAF6 E3 ligase activity with a small-molecule inhibitor combats autoimmunity","volume":"293","author":"Brenke","year":"2018","journal-title":"J. Biol. Chem."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1161\/CIRCRESAHA.119.315730","article-title":"The Noonan Syndrome Gene","volume":"126","author":"Sewduth","year":"2020","journal-title":"Circ. Res."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"4832","DOI":"10.1038\/ncomms5832","article-title":"The ubiquitin ligase PDZRN3 is required for vascular morphogenesis through Wnt\/planar cell polarity signalling","volume":"5","author":"Sewduth","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"eaag3209","DOI":"10.1126\/scisignal.aag3209","article-title":"PDZRN3 destabilizes endothelial cell-cell junctions through a PKC\u03b6-containing polarity complex to increase vascular permeability","volume":"10","author":"Sewduth","year":"2017","journal-title":"Sci. Signal"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/s41419-022-05100-4","article-title":"Tripartite motif 25 ameliorates doxorubicin-induced cardiotoxicity by degrading p85\u03b1","volume":"13","author":"Shen","year":"2022","journal-title":"Cell Death Dis."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"684","DOI":"10.52547\/rbmb.11.4.684","article-title":"Potential Inhibitors of The OTUB1 Catalytic Site to Develop an Anti-Cancer Drug Using","volume":"11","year":"2023","journal-title":"Rep. Biochem. Mol. Biol."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1007\/s11684-024-1056-8","article-title":"Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFR\u03b2","volume":"18","author":"Xu","year":"2024","journal-title":"Front. Med."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"110937","DOI":"10.1016\/j.cellsig.2023.110937","article-title":"Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC","volume":"113","author":"Xu","year":"2024","journal-title":"Cell Signal"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"8425","DOI":"10.1038\/s41467-024-52739-y","article-title":"Deletion of ASPP1 in myofibroblasts alleviates myocardial fibrosis by reducing p53 degradation","volume":"15","author":"Li","year":"2024","journal-title":"Nat. Commun."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"111070","DOI":"10.1016\/j.cellsig.2024.111070","article-title":"USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy","volume":"117","author":"Wang","year":"2024","journal-title":"Cell Signal"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jacc.2013.02.092","article-title":"A novel paradigm for heart failure with preserved ejection fraction: Comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation","volume":"62","author":"Paulus","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"7060","DOI":"10.1007\/s12010-023-04434-9","article-title":"The Interaction of OTUB1 and TRAF3 Mediates NLRP3 Inflammasome Activity to Regulate TGF-\u03b21-induced BEAS-2B Cell Injury","volume":"195","author":"Shang","year":"2023","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1161\/CIRCRESAHA.110.226928","article-title":"Multiple facets of NF-\u03baB in the heart: To be or not to NF-\u03baB","volume":"108","author":"Gordon","year":"2011","journal-title":"Circ. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/10985549.2024.2338727","article-title":"Selective Hypoxia-Sensitive Oxomer Formation by FIH Prevents Binding of the NF-\u03baB Inhibitor I\u03baB\u03b2 to NF-\u03baB Subunits","volume":"44","author":"Volkova","year":"2024","journal-title":"Mol. Cell Biol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/s41392-024-01977-z","article-title":"Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNF\u03b1-TRAF3-TAK1-MAPK axis","volume":"9","author":"Xie","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Xie, L., Zang, D., Yang, J., Xue, F., Sui, W., and Zhang, Y. (2024). Combination of ADAM17 knockdown with eplerenone is more effective than single therapy in ameliorating diabetic cardiomyopathy. Front. Pharmacol., 15.","DOI":"10.3389\/fphar.2024.1364827"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1093\/cvr\/cvz188","article-title":"Epac1 inhibition as a novel cardioprotective strategy: Lights and shadows on GRK5 canonical and non-canonical functions","volume":"115","author":"Boccella","year":"2019","journal-title":"Cardiovasc. Res."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"e83831","DOI":"10.7554\/eLife.83831","article-title":"EPAC1 inhibition protects the heart from doxorubicin-induced toxicity","volume":"12","author":"Mazevet","year":"2023","journal-title":"eLife"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41420-023-01565-0","article-title":"Nrf2: A dark horse in doxorubicin-induced cardiotoxicity","volume":"9","author":"Zhao","year":"2023","journal-title":"Cell Death Discov."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sun, M.L., Dong, J.M., Liu, C., Li, P., Zhang, C., Zhen, J., and Chen, W. (2024). Metformin-mediated protection against doxorubicin-induced cardiotoxicity. Biomed. Pharmacother., 180.","DOI":"10.1016\/j.biopha.2024.117535"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"177027","DOI":"10.1016\/j.ejphar.2024.177027","article-title":"Small-molecule mediated MuRF1 inhibition protects from doxorubicin-induced cardiac atrophy and contractile dysfunction","volume":"984","author":"Alves","year":"2024","journal-title":"Eur. J. Pharmacol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Chen, J.K., Ramesh, S., Islam, M.N., Shibu, M.A., Kuo, C.H., Hsieh, D.J., Lin, S.Z., Kuo, W.W., Huang, C.Y., and Ho, T.J. (2024). Artemisia argyi mitigates doxorubicin-induced cardiotoxicity by inhibiting mitochondrial dysfunction through the IGF-IIR\/Drp1\/GATA4 signaling pathway. Biotechnol. Appl. Biochem.","DOI":"10.1002\/bab.2671"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1093\/cvr\/cvae208","article-title":"Interleukin-12p40 deficiency attenuates myocardial ferroptosis in doxorubicin-induced chronic cardiomyopathy by inhibiting Th17 differentiation and interleukin-17A production","volume":"120","author":"Zhang","year":"2024","journal-title":"Cardiovasc. Res."}],"container-title":["Journal of Xenobiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4713\/15\/1\/9\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T10:24:53Z","timestamp":1759919093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4713\/15\/1\/9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":75,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,2]]}},"alternative-id":["jox15010009"],"URL":"https:\/\/doi.org\/10.3390\/jox15010009","relation":{},"ISSN":["2039-4713"],"issn-type":[{"value":"2039-4713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]}}}