{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T21:17:41Z","timestamp":1793999861693,"version":"4.8.0"},"reference-count":126,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JoX"],"abstract":"<jats:p>Pesticides play an essential role in modern agriculture, yet increasing evidence links their widespread use to neurotoxic effects that contribute to both neurodegenerative and neurodevelopmental disorders. In recent years, new classes of pesticides such as neonicotinoids and pyrethroids have garnered attention due to their potential to disrupt neurodevelopment, even at low exposure levels. Furthermore, emerging evidence underscores the involvement of the gut\u2013brain axis, neuroinflammation, and epigenetic modulation in pesticide-induced neuropathology. This review aims to synthesize these latest advancements while highlighting underexplored mechanisms, thereby offering a comprehensive and current perspective on pesticide-related neurotoxicity. Data from the Rapid Alert System for Food and Feed (RASFF) indicate that several food products include residues of pesticides recognized for their neurotoxic properties. Although environmental exposure levels are lower than those in occupational contexts, the magnitude and persistence of food-based exposure demand thorough evaluation. This review integrates evidence coming from epidemiological, in vivo and in vitro investigations, emphasizing the correlations between pesticide exposure and conditions such as Alzheimer\u2019s disease, Parkinson\u2019s disease, and cognitive deficits in children. Neurodevelopmental toxicity is especially alarming since symptoms may manifest subtly and with a delayed onset after early-life exposure, indicating the significant neurotoxic potential of pesticide residues and emphasizing the need for their careful evaluation in food safety assessments. Improved regulatory procedures and public health efforts are essential to reducing long-term brain damage.<\/jats:p>","DOI":"10.3390\/jox15030083","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T12:27:09Z","timestamp":1748867229000},"page":"83","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Neurotoxic Effects of Pesticides: Implications for Neurodegenerative and Neurobehavioral Disorders"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9647-9724","authenticated-orcid":false,"given":"Alexandra Andreea","family":"Botnaru","sequence":"first","affiliation":[{"name":"Faculty of Pharmacy, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Iasi, Romania"},{"name":"Department of Environmental and Food Chemistry, \u201cGrigore T. 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Balancing Health and Sustainability: Assessing the Benefits of Plant-Based Diets and the Risk of Pesticide Residues. Nutrients, 17.","DOI":"10.3390\/nu17040727"},{"key":"ref_2","first-page":"9983201","article-title":"Clothianidin and Thiacloprid Mixture Administration Induces Degenerative Damage in the Dentate Gyrus and Alteration in Short-Term Memory in Rats","volume":"2021","author":"Guevara","year":"2021","journal-title":"J. Toxicol."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Rohlman, D.S., Olson, J.R., Ismail, A.A., Bonner, M.R., Abdel Rasoul, G., and Hendy, O. (2022). Identifying and Preventing the Neurotoxic Effects of Pesticides. Advances in Neurotoxicology, Elsevier Inc.","DOI":"10.1016\/bs.ant.2022.05.001"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108926","DOI":"10.1016\/j.envres.2019.108926","article-title":"Systematic Review of Comparative Studies Assessing the Toxicity of Pesticide Active Ingredients and Their Product Formulations","volume":"181","author":"Nagy","year":"2020","journal-title":"Environ. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"574","DOI":"10.25259\/JNRP_58_2023","article-title":"Influence of Pesticide Exposure on Farmers\u2019 Cognition: A Systematic Review","volume":"14","author":"Finhler","year":"2023","journal-title":"J. Neurosci. Rural Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.envint.2018.07.037","article-title":"Current EU Research Activities on Combined Exposure to Multiple Chemicals","volume":"120","author":"Bopp","year":"2018","journal-title":"Environ. Int."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Hsieh, N.H., and Kwok, E.S.C. (2025). Biomonitoring-Based Risk Assessment of Pyrethroid Exposure in the U.S. Population: Application of High-Throughput and Physiologically Based Kinetic Models. Toxics, 13.","DOI":"10.3390\/toxics13030216"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.fct.2018.12.043","article-title":"Hormetic Neurobehavioral Effects of Low Dose Toxic Chemical Mixtures in Real-Life Risk Simulation (RLRS) in Rats","volume":"125","author":"Tsatsakis","year":"2019","journal-title":"Food Chem. Toxicol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.envint.2017.07.001","article-title":"Environmental Exposure to Pesticides and the Risk of Parkinson\u2019s Disease in the Netherlands","volume":"107","author":"Brouwer","year":"2017","journal-title":"Environ. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"101966","DOI":"10.1016\/j.jchemneu.2021.101966","article-title":"Pesticides and Parkinson\u2019s Disease: Current and Future Perspective","volume":"115","author":"Islam","year":"2021","journal-title":"J. Chem. Neuroanat."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S1474-4422(13)70278-3","article-title":"Neurobehavioural Effects of Developmental Toxicity","volume":"13","author":"Grandjean","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4103\/2152-7806.153876","article-title":"Glyphosate, Pathways to Modern Diseases III: Manganese, Neurological Diseases, and Associated Pathologies","volume":"6","author":"Samsel","year":"2015","journal-title":"Surg. Neurol. Int."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"A1","DOI":"10.1016\/j.matpr.2022.12.153","article-title":"Risk of Parkinson Disease Associated with Pesticide Exposure and Protection by Probiotics","volume":"69","author":"Bhardwaj","year":"2022","journal-title":"Mater. Today Proc."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41390-018-0200-z","article-title":"Children\u2019s Low-Level Pesticide Exposure and Associations with Autism and ADHD: A Review","volume":"85","author":"Roberts","year":"2019","journal-title":"Pediatr. Res."},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"S\u00e1nchez, R.M., Bermeo Losada, J.F., and Mar\u00edn Mart\u00ednez, J.A. (2024). The Research Landscape Concerning Environmental Factors in Neurodevelopmental Disorders: Endocrine Disrupters and Pesticides\u2014A Review. Front. Neuroendocrinol., 73.","DOI":"10.1016\/j.yfrne.2024.101132"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.toxlet.2020.03.005","article-title":"Pesticides, Cognitive Functions and Dementia: A Review","volume":"326","author":"Aloizou","year":"2020","journal-title":"Toxicol. Lett."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1476-069X-7-50","article-title":"Potential Developmental Neurotoxicity of Pesticides Used in Europe","volume":"7","author":"Andersen","year":"2008","journal-title":"Environ. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1007\/s12291-018-0791-5","article-title":"Neurochemical and Behavioral Dysfunctions in Pesticide Exposed Farm Workers: A Clinical Outcome","volume":"33","author":"Kori","year":"2018","journal-title":"Indian J. Clin. Biochem."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Kapeleka, J.A., Ngowi, A.V., Mng\u2019anya, S., Willis, S.E., Salmon, J.P., Tyrell, K.F., Williamson, S., Eddleston, M., and Stuart, A.M. (2025). Assessment of Unintentional Acute Pesticide Poisoning (UAPP) Amongst Cotton Farmers in Tanzania. Toxics, 13.","DOI":"10.3390\/toxics13040300"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1111\/1541-4337.13109","article-title":"Nondestructive Testing Methods for Pesticide Residue in Food Commodities: A Review","volume":"22","author":"Sindhu","year":"2023","journal-title":"Compr. Rev. Food Sci Food Saf."},{"key":"ref_21","first-page":"e06479","article-title":"Statement on the Derivation of Health-Based Guidance Values (HBGVs) for Regulated Products That Are Also Nutrients","volume":"19","author":"More","year":"2021","journal-title":"EFSA J."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1002\/jsfa.8821","article-title":"How Effective Are Common Household Preparations on Removing Pesticide Residues from Fruit and Vegetables? A Review","volume":"98","author":"Chung","year":"2018","journal-title":"J. Sci. Food Agric."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1007\/s12161-020-01809-0","article-title":"Development of a Multiresidue QuEChERS\u2013DLLME\u2014Fast GC\u2013MS Method for Determination of Selected Pesticides in Yogurt Samples","volume":"13","author":"Szarka","year":"2020","journal-title":"Food Anal. Methods"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.foodcont.2018.09.033","article-title":"Analysis of RASFF Notifications on Food Products Contaminated with Listeria Monocytogenes Reveals Options for Improvement in the Rapid Alert System for Food and Feed","volume":"96","author":"Boone","year":"2019","journal-title":"Food Control."},{"key":"ref_25","first-page":"e8753","article-title":"The 2022 European Union Report on Pesticide Residues in Food","volume":"22","author":"Dujardin","year":"2024","journal-title":"EFSA J."},{"key":"ref_26","unstructured":"European Commission (2024, December 30). Rapid Alert System for Food and Feed (RASFF). Available online: https:\/\/food.ec.europa.eu\/food-safety\/rasff_en."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1007\/s11356-020-07864-8","article-title":"Single or Combined Exposure to Chlorpyrifos and Cypermethrin Provoke Oxidative Stress and Downregulation in Monoamine Oxidase and Acetylcholinesterase Gene Expression of the Rat\u2019s Brain","volume":"27","author":"Elhakim","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"61","DOI":"10.17533\/udea.rccp.v35n2a7","article-title":"Chlorpyrifos Should Be Banned in Agriculture and Livestock Production in Colombia","volume":"35","author":"Villar","year":"2022","journal-title":"Rev. Colomb. de Cienc. Pecu."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"113972","DOI":"10.1016\/j.ecoenv.2022.113972","article-title":"Neurotoxicity of Pesticides\u2014A Link to Neurodegeneration","volume":"243","author":"Vellingiri","year":"2022","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_30","first-page":"206","article-title":"Early Brain Magnetic Resonance Imaging Can Predict Short and Long-Term Outcomes after Organophosphate Poisoning in a Rat Model","volume":"48","author":"Shrot","year":"2015","journal-title":"Neuro Toxicology"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s00401-019-02033-9","article-title":"Neurotoxicity of Pesticides","volume":"138","author":"Richardson","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"37","DOI":"10.2165\/00139709-200524010-00003","article-title":"Organophosphate-Induced Delayed Polyneuropathy","volume":"24","author":"Lotti","year":"2005","journal-title":"Toxicol. Rev."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134236","DOI":"10.1016\/j.jhazmat.2024.134236","article-title":"Organophosphate Toxicity Patterns: A New Approach for Assessing Organophosphate Neurotoxicity","volume":"470","author":"Karaboga","year":"2024","journal-title":"J. Hazard. Mater."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Lorke, D.E., and Oz, M. (2025). A Review on Oxidative Stress in Organophosphate-Induced Neurotoxicity. Int. J. Biochem. Cell Biol., 180.","DOI":"10.1016\/j.biocel.2025.106735"},{"key":"ref_35","first-page":"308","article-title":"Neurological Syndromes Following Organophosphate Poisoning","volume":"48","author":"Singh","year":"2000","journal-title":"Neurol. India."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/celldisc.2017.24","article-title":"TRPA1 Channel Mediates Organophosphate-Induced Delayed Neuropathy","volume":"3","author":"Ding","year":"2017","journal-title":"Cell Discov."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"4844","DOI":"10.1038\/s41598-018-22977-4","article-title":"Analysis of the Neurotoxic Effects of Neuropathic Organophosphorus Compounds in Adult Zebrafish","volume":"8","author":"Faria","year":"2018","journal-title":"Sci Rep."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.4239\/wjd.v12.i11.1818","article-title":"Organophosphate Pesticides and New-Onset Diabetes Mellitus: From Molecular Mechanisms to a Possible Therapeutic Perspective","volume":"12","author":"Chung","year":"2021","journal-title":"World J. Diabetes"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"117337","DOI":"10.1016\/j.envres.2023.117337","article-title":"Accumulation of Organophosphorus Pollutants in Adipose Tissue of Obese Women\u2014Metabolic Alterations","volume":"239","author":"Sousa","year":"2023","journal-title":"Environ. Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"24799","DOI":"10.1007\/s11356-020-09045-z","article-title":"Oxidative Stress and Mitochondrial Dysfunction in Organophosphate Pesticide-Induced Neurotoxicity and Its Amelioration: A Review","volume":"27","author":"Farkhondeh","year":"2020","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"120903","DOI":"10.1016\/j.envpol.2022.120903","article-title":"Postnatal Exposure to Organic Pollutants in Maternal Milk in North-Western Spain","volume":"318","author":"Sanguos","year":"2023","journal-title":"Environ. Pollut."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s40201-019-00398-3","article-title":"Evaluation of Chlorpyrifos Residue in Breast Milk and Its Metabolite in Urine of Mothers and Their Infants Feeding Exclusively by Breast Milk in North of Iran","volume":"17","author":"Brahmand","year":"2019","journal-title":"J. Environ. Health Sci Eng."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"9","DOI":"10.17098\/amj.304660","article-title":"Determination of the Residue Levels of Some Commonly Used Organophosphorus Pesticides in Breast Milk Baz\u0131 S\u0131k Kullan\u0131lan Organofosfatl\u0131 Pestisitlerin Anne S\u00fct\u00fcnde Kal\u0131nt\u0131lar\u0131n\u0131n Belirlenmesi","volume":"17","author":"Uskun","year":"2017","journal-title":"Ankara Med. J."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.ajem.2014.04.030","article-title":"Body Mass Index as a Prognostic Factor in Organophosphate-Poisoned Patients","volume":"32","author":"Lee","year":"2014","journal-title":"Am. J. Emerg. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pharmthera.2019.01.001","article-title":"Environmental Neurotoxicant-Induced Dopaminergic Neurodegeneration: A Potential Link to Impaired Neuroinflammatory Mechanisms","volume":"197","author":"Kanthasamy","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Mirarchi, A., Albi, E., and Arcuri, C. (2024). Microglia Signatures: A Cause or Consequence of Microglia-Related Brain Disorders?. Int. J. Mol. Sci., 25.","DOI":"10.3390\/ijms252010951"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"144204","DOI":"10.1016\/j.chemosphere.2025.144204","article-title":"Changes in Molecular Biomarkers of Neurotoxicity in Newborns Following Prenatal Exposure to Organophosphate Compounds","volume":"374","year":"2025","journal-title":"Chemosphere"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s10565-022-09697-2","article-title":"Perinatal Exposure to Pesticides Alters Synaptic Plasticity Signaling and Induces Behavioral Deficits Associated with Neurodevelopmental Disorders","volume":"39","author":"Cuartero","year":"2023","journal-title":"Cell Biol. Toxicol."},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Dhaini, H.R. (2009). Neuroinflammation: Modulating Pesticide-Induced Neurodegeneration. Encyclopedia of Neuroscience, Springer.","DOI":"10.1007\/978-3-540-29678-2_3870"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.2741\/2758","article-title":"Neurotoxicity of Pesticides: A Brief Review","volume":"13","author":"Costa","year":"2008","journal-title":"Front. Biosci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.ajem.2009.01.035","article-title":"Carbamate Poisoning: Treatment Recommendations in the Setting of a Mass Casualties Event","volume":"27","author":"Rosman","year":"2009","journal-title":"Am J. Emerg. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1191\/096032700672133218","article-title":"Aldicarb Poisoning","volume":"19","author":"Tracqui","year":"2000","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s12088-023-01153-x","article-title":"Cypermethrin: An Emerging Pollutant and Its Adverse Effect on Fish Health and Some Preventive Approach\u2014A Review","volume":"64","author":"Sinha","year":"2024","journal-title":"Indian J. Microbiol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Tarazona, J.V., Cattaneo, I., Niemann, L., Pedraza-Diaz, S., Gonz\u00e1lez-Caballero, M.C., de Alba-Gonzalez, M., Ca\u00f1as, A., Dominguez-Morueco, N., Esteban-L\u00f3pez, M., and Casta\u00f1o, A. (2022). A Tiered Approach for Assessing Individual and Combined Risk of Pyrethroids Using Human Biomonitoring Data. 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Pharmacol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"138251","DOI":"10.1016\/j.chemosphere.2023.138251","article-title":"Pesticides at Brain Borders: Impact on the Blood-Brain Barrier, Neuroinflammation, and Neurological Risk Trajectories","volume":"324","author":"Cresto","year":"2023","journal-title":"Chemosphere"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.2147\/TCRM.S269161","article-title":"Acute Imidacloprid Poisoning in Thailand","volume":"16","author":"Sriapha","year":"2020","journal-title":"Ther. Clin. Risk Manag."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"140591","DOI":"10.1016\/j.scitotenv.2020.140591","article-title":"Parkinson\u2019s Disease and Pesticides: Are MicroRNAs the Missing Link?","volume":"744","author":"Aloizou","year":"2020","journal-title":"Sci. Total Environ."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s Disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.tox.2017.02.009","article-title":"Paraquat and Maneb Co-Exposure Induces Noradrenergic Locus Coeruleus Neurodegeneration through NADPH Oxidase-Mediated Microglial Activation","volume":"380","author":"Hou","year":"2017","journal-title":"Toxicology"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41531-023-00568-z","article-title":"Linking Environmental Risk Factors with Epigenetic Mechanisms in Parkinson\u2019s Disease","volume":"9","author":"Tsalenchuk","year":"2023","journal-title":"NPJ Park. Dis."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Gunnarsson, L.-G., and Bodin, L. (2019). Occupational Exposures and Neurodegenerative Diseases\u2014A Systematic Literature Review and Meta-Analyses. Int. J. Environ. Res. Public Health, 16.","DOI":"10.3390\/ijerph16030337"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.biopha.2017.03.100","article-title":"Parkinson\u2019s Disease and Pesticides: A Meta-Analysis of Disease Connection and Genetic Alterations","volume":"90","author":"Ahmed","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.toxrep.2021.03.009","article-title":"Metal Elements and Pesticides as Risk Factors for Parkinson\u2019s Disease\u2014A Review","volume":"8","author":"Ullah","year":"2021","journal-title":"Toxicol. Rep."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.fct.2017.05.067","article-title":"The Toxic Influence of Paraquat on Hippocampal Neurogenesis in Adult Mice","volume":"106","author":"Li","year":"2017","journal-title":"Food Chem. Toxicol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.toxlet.2014.01.039","article-title":"Pesticides Exposure as Etiological Factors of Parkinson\u2019s Disease and Other Neurodegenerative Diseases\u2014A Mechanistic Approach","volume":"230","author":"Baltazar","year":"2014","journal-title":"Toxicol. Lett."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/s41531-024-00703-4","article-title":"Lysosomal Genes Contribute to Parkinson\u2019s Disease near Agriculture with High Intensity Pesticide Use","volume":"10","author":"Ngo","year":"2024","journal-title":"NPJ Park. Dis."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1016\/j.scitotenv.2018.07.143","article-title":"Organophosphate Pesticide Exposure and Differential Genome-Wide DNA Methylation","volume":"645","author":"Paul","year":"2018","journal-title":"Sci. Total Environ."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/s41531-024-00704-3","article-title":"Genetic Variation and Pesticide Exposure Influence Blood DNA Methylation Signatures in Females with Early-Stage Parkinson\u2019s Disease","volume":"10","author":"Schaffner","year":"2024","journal-title":"NPJ Park. Dis."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-020-00582-4","article-title":"Genome-Wide Epigenetic Analyses in Japanese Immigrant Plantation Workers with Parkinson\u2019s Disease and Exposure to Organochlorines Reveal Possible Involvement of Glial Genes and Pathways Involved in Neurotoxicity","volume":"21","author":"Go","year":"2020","journal-title":"BMC Neurosci."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/2047-9158-1-9","article-title":"The Changing Phenotype of Microglia from Homeostasis to Disease","volume":"1","author":"Luo","year":"2012","journal-title":"Transl. Neurodegener."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1021\/tx5002223","article-title":"Benomyl, Aldehyde Dehydrogenase, DOPAL, and the Catecholaldehyde Hypothesis for the Pathogenesis of Parkinsons Disease","volume":"27","author":"Casida","year":"2014","journal-title":"Chem. Res. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/0960327118758152","article-title":"Paraquat-Induced Inflammatory Response of Microglia through HSP60\/TLR4 Signaling","volume":"37","author":"Sun","year":"2018","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.celrep.2017.12.092","article-title":"Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson\u2019s Disease","volume":"22","author":"Chinta","year":"2018","journal-title":"Cell Rep."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.tiv.2018.08.009","article-title":"Involvement of PINK1\/Parkin-Mediated Mitophagy in Paraquat- Induced Apoptosis in Human Lung Epithelial-like A549 Cells","volume":"53","author":"Sun","year":"2018","journal-title":"Toxicol. Vitr."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.chemosphere.2017.10.032","article-title":"Paraquat Affects Mitochondrial Bioenergetics, Dopamine System Expression, and Locomotor Activity in Zebrafish (Danio Rerio)","volume":"191","author":"Wang","year":"2018","journal-title":"Chemosphere"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.taap.2017.03.027","article-title":"Developmental Neurotoxicity of Different Pesticides in PC-12 Cells in Vitro","volume":"325","author":"Christen","year":"2017","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1007\/s11064-018-2638-0","article-title":"Signature of Aberrantly Expressed MicroRNAs in the Striatum of Rotenone-Induced Parkinsonian Rats","volume":"43","author":"Horst","year":"2018","journal-title":"Neurochem. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"106225","DOI":"10.1016\/j.biocel.2022.106225","article-title":"Environmental Neurotoxic Pesticide Exposure Induces Gut Inflammation and Enteric Neuronal Degeneration by Impairing Enteric Glial Mitochondrial Function in Pesticide Models of Parkinson\u2019s Disease: Potential Relevance to Gut-Brain Axis Inflammation in Parkinson\u2019s Disease Pathogenesis","volume":"147","author":"Palanisamy","year":"2022","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"136344","DOI":"10.1016\/j.chemosphere.2022.136344","article-title":"Exposure to the Environmentally Toxic Pesticide Maneb Induces Parkinson\u2019s Disease-like Neurotoxicity in Mice: A Combined Proteomic and Metabolomic Analysis","volume":"308","author":"Liu","year":"2022","journal-title":"Chemosphere"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"16440","DOI":"10.1007\/s11356-017-9218-8","article-title":"Effects of Deltamethrin on Striatum and Hippocampus Mitochondrial Integrity and the Protective Role of Quercetin in Rats","volume":"24","author":"Gasmi","year":"2017","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"112562","DOI":"10.1016\/j.bbr.2020.112562","article-title":"The Pesticide Fipronil Injected into the Substantia Nigra of Male Rats Decreases Striatal Dopamine Content: A Neurochemical, Immunohistochemical and Behavioral Study","volume":"384","author":"Bharatiya","year":"2020","journal-title":"Behav. Brain Res."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jneuroim.2019.01.004","article-title":"Gut Microbiota in Neurodegenerative Disorders","volume":"328","author":"Banerjee","year":"2019","journal-title":"J. Neuroimmunol."},{"key":"ref_85","first-page":"1079","article-title":"Pesticides and the Microbiome-Gut-Brain Axis: Convergent Pathways in the Pathogenesis of Parkinson\u2019s Disease","volume":"13","author":"Kulcsarova","year":"2023","journal-title":"J. Park. Dis."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40168-021-01107-9","article-title":"Fecal Microbiota Transplantation Protects Rotenone-Induced Parkinson\u2019s Disease Mice via Suppressing Inflammation Mediated by the Lipopolysaccharide-TLR4 Signaling Pathway through the Microbiota-Gut-Brain Axis","volume":"9","author":"Zhao","year":"2021","journal-title":"Microbiome"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"937555","DOI":"10.3389\/fimmu.2022.937555","article-title":"Gut Microbiota: A Novel Therapeutic Target for Parkinson\u2019s Disease","volume":"13","author":"Zhu","year":"2022","journal-title":"Front. Immunol."},{"key":"ref_88","doi-asserted-by":"crossref","unstructured":"Abou Diwan, M., Lahimer, M., Bach, V., Gosselet, F., Khorsi-Cauet, H., and Candela, P. (2023). Impact of Pesticide Residues on the Gut-Microbiota\u2013Blood\u2013Brain Barrier Axis: A Narrative Review. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms24076147"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.toxrep.2020.03.011","article-title":"Organochlorine Pesticide Levels in Greek Patients with Parkinson\u2019s Disease","volume":"7","author":"Dardiotis","year":"2020","journal-title":"Toxicol. Rep."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.puhe.2024.10.035","article-title":"Environmental and Occupational Exposure to Organochlorine Pesticides Associated with Parkinson\u2019s Disease Risk: A Systematic Review and Meta-Analysis Based on Epidemiological Evidence","volume":"237","author":"Xu","year":"2024","journal-title":"Public Health"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Yadav, B., Kaur, S., Yadav, A., Verma, H., Kar, S., Sahu, B.K., Pati, K.R., Sarkar, B., Dhiman, M., and Mantha, A.K. (2024). Implications of Organophosphate Pesticides on Brain Cells and Their Contribution toward Progression of Alzheimer\u2019s Disease. J. Biochem. Mol. Toxicol., 38.","DOI":"10.1002\/jbt.23660"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"102091","DOI":"10.1016\/j.arr.2023.102091","article-title":"Role of Diet and Exercise in Aging, Alzheimer\u2019s Disease, and Other Chronic Diseases","volume":"91","author":"Khemka","year":"2023","journal-title":"Ageing Res. Rev."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00204-016-1849-x","article-title":"Pesticides: An Update of Human Exposure and Toxicity","volume":"91","author":"Mostafalou","year":"2017","journal-title":"Arch. Toxicol."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"128238","DOI":"10.1016\/j.chemosphere.2020.128238","article-title":"The Association between Toxic Pesticide Environmental Exposure and Alzheimer\u2019s Disease: A Scientometric and Visualization Analysis","volume":"263","author":"Li","year":"2021","journal-title":"Chemosphere"},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Rawat, P., Sehar, U., Bisht, J., Selman, A., Culberson, J., and Reddy, P.H. (2022). Phosphorylated Tau in Alzheimer\u2019s Disease and Other Tauopathies. Int. J. Mol. Sci., 23.","DOI":"10.3390\/ijms232112841"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Tang, B.L. (2020). Neuropathological Mechanisms Associated with Pesticides in Alzheimer\u2019s Disease. Toxics, 8.","DOI":"10.3390\/toxics8020021"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Alzheimer\u2019s Association (2018). 2018 Alzheimer\u2019s Disease Facts and Figures. Alzheimer\u2019s Dement., 14, 367\u2013429.","DOI":"10.1016\/j.jalz.2018.02.001"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"115932","DOI":"10.1016\/j.psychres.2024.115932","article-title":"Environmental Pesticide Exposure and Alzheimer\u2019s Disease in Southern Spain: A Cross-Sectional Study","volume":"337","author":"Cardona","year":"2024","journal-title":"Psychiatry Res."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"892","DOI":"10.2174\/1567205020666230206142738","article-title":"Pesticide Exposure and Alzheimer\u2019s Disease: A Case-Control Study","volume":"19","author":"Kiani","year":"2023","journal-title":"Curr. Alzheimer Res."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/1028415X.2018.1492772","article-title":"Crocin-Protected Malathion-Induced Spatial Memory Deficits by Inhibiting TAU Protein Hyperphosphorylation and Antiapoptotic Effects","volume":"23","author":"Mohammadzadeh","year":"2020","journal-title":"Nutr. Neurosci."},{"key":"ref_101","doi-asserted-by":"crossref","unstructured":"Farag, M.R., Alagawany, M., Moselhy, A.A.A., Said, E.N., Ismail, T.A., Di Cerbo, A., Pugliese, N., and Ahmed, M.M. (2022). The Neonicotinoid Thiacloprid Interferes with the Development, Brain Antioxidants, and Neurochemistry of Chicken Embryos and Alters the Hatchling Behavior: Modulatory Potential of Phytochemicals. Biology, 11.","DOI":"10.3390\/biology11010073"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"09603271241235408","DOI":"10.1177\/09603271241235408","article-title":"Persistent Diazinon Induced Neurotoxicity: The Effect on Inhibitory Avoidance Memory Performance, Amyloid Precursor Proteins, and TNF-\u03b1 Levels in the Prefrontal Cortex of Rats","volume":"43","author":"Afshari","year":"2024","journal-title":"Hum. Exp. Toxicol."},{"key":"ref_103","doi-asserted-by":"crossref","unstructured":"Jim\u00e9nez, J.A., Simon, J.M., Hu, W., Moy, S.S., Harper, K.M., Liu, C.-W., Lu, K., and Zylka, M.J. (2022). Developmental Pyrethroid Exposure and Age Influence Phenotypes in a Chd8 Haploinsufficient Autism Mouse Model. Sci. Rep., 12.","DOI":"10.1038\/s41598-022-09533-x"},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Gama, J., Neves, B., and Pereira, A. (2022). Chronic Effects of Dietary Pesticides on the Gut Microbiome and Neurodevelopment. Front. Microbiol., 13.","DOI":"10.3389\/fmicb.2022.931440"},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000448912","article-title":"Intellectual Disability in a Birth Cohort: Prevalence, Etiology, and Determinants at the Age of 4 Years","volume":"19","author":"Karam","year":"2016","journal-title":"Public Health Genom."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s40291-022-00600-7","article-title":"Modern Biomarkers for Autism Spectrum Disorder: Future Directions","volume":"26","author":"Jensen","year":"2022","journal-title":"Mol. Diagn. Ther."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"pgad085","DOI":"10.1093\/pnasnexus\/pgad085","article-title":"Developmental Pyrethroid Exposure Causes a Neurodevelopmental Disorder Phenotype in Mice","volume":"2","author":"Curtis","year":"2023","journal-title":"PNAS Nexus"},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1176\/appi.ajp.2018.17101129","article-title":"Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort","volume":"175","author":"Brown","year":"2018","journal-title":"Am. J. Psychiatry"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.envres.2016.05.048","article-title":"Residential Proximity to Organophosphate and Carbamate Pesticide Use during Pregnancy, Poverty during Childhood, and Cognitive Functioning in 10-Year-Old Children","volume":"150","author":"Rowe","year":"2016","journal-title":"Environ. Res."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.envint.2015.09.019","article-title":"Pre- and Postnatal Exposures to Pesticides and Neurodevelopmental Effects in Children Living in Agricultural Communities from South-Eastern Spain","volume":"85","year":"2015","journal-title":"Environ. Int."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"7871","DOI":"10.1073\/pnas.1203396109","article-title":"Brain Anomalies in Children Exposed Prenatally to a Common Organophosphate Pesticide","volume":"109","author":"Rauh","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA."},{"key":"ref_112","first-page":"80","article-title":"Prenatal Exposure to the Organophosphate Pesticide Chlorpyrifos and Childhood Tremor","volume":"51","author":"Rauh","year":"2015","journal-title":"Neuro Toxicol."},{"key":"ref_113","doi-asserted-by":"crossref","unstructured":"Hertz-Picciotto, I., Sass, J.B., Engel, S., Bennett, D.H., Bradman, A., Eskenazi, B., Lanphear, B., and Whyatt, R. (2018). Organophosphate Exposures during Pregnancy and Child Neurodevelopment: Recommendations for Essential Policy Reforms. PLoS Med, 15.","DOI":"10.1371\/journal.pmed.1002671"},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1002\/jat.4746","article-title":"6-Chloronicotinic Acid Induces Toxicity in Mouse Neural Stem Cells via the C3ar1 Signaling","volume":"45","author":"He","year":"2025","journal-title":"J. Appl. Toxicol."},{"key":"ref_115","doi-asserted-by":"crossref","unstructured":"Sevim, \u00c7., Akp\u0131nar, E., Aksu, E.H., \u00d6m\u00fcr, A.D., Y\u0131ld\u0131r\u0131m, S., Kara, M., Bolat, \u0130., Tsatsakis, A., Mesnage, R., and Golokhvast, K.S. (2023). Reproductive Effects of S. Boulardii on Sub-Chronic Acetamiprid and Imidacloprid Toxicity in Male Rats. Toxics, 11.","DOI":"10.3390\/toxics11020170"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"e15840","DOI":"10.1016\/j.heliyon.2023.e15840","article-title":"Neurocytotoxicity of Imidacloprid- and Acetamiprid-Based Comercial Insecticides over the Differentiation of SH-SY5Y Neuroblastoma Cells","volume":"9","author":"Aguayo","year":"2023","journal-title":"Heliyon"},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"111632","DOI":"10.1016\/j.fct.2020.111632","article-title":"Assessing the Combined Toxicity Effects of Three Neonicotinoid Pesticide Mixtures on Human Neuroblastoma SK-N-SH and Lepidopteran Sf-9 Cells","volume":"145","author":"Cheng","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.toxrep.2017.05.002","article-title":"Oxidative Injury Caused by Individual and Combined Exposure of Neonicotinoid, Organophosphate and Herbicide in Zebrafish","volume":"4","author":"Shukla","year":"2017","journal-title":"Toxicol. Rep."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Mariani, A., Comolli, D., Fanelli, R., Forloni, G., and De Paola, M. (2024). Neonicotinoid Pesticides Affect Developing Neurons in Experimental Mouse Models and in Human Induced Pluripotent Stem Cell (IPSC)-Derived Neural Cultures and Organoids. Cells, 13.","DOI":"10.3390\/cells13151295"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"117215","DOI":"10.1016\/j.taap.2024.117215","article-title":"Embryonic Exposure to Acetamiprid Insecticide Induces CD68-Positive Microglia and Purkinje Cell Arrangement Abnormalities in the Cerebellum of Neonatal Rats","volume":"495","author":"Lee","year":"2025","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.neurobiolaging.2010.02.018","article-title":"Long Term Exposure to Cypermethrin Induces Nigrostriatal Dopaminergic Neurodegeneration in Adult Rats: Postnatal Exposure Enhances the Susceptibility during Adulthood","volume":"33","author":"Singh","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1096\/fj.14-260901","article-title":"Developmental Pesticide Exposure Reproduces Features of Attention Deficit Hyperactivity Disorder","volume":"29","author":"Richardson","year":"2015","journal-title":"FASEB J."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.brainresbull.2018.08.007","article-title":"Deltamethrin Intranasal Administration Induces Memory, Emotional and Tyrosine Hydroxylase Immunoreactivity Alterations in Rats","volume":"142","author":"Souza","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"153189","DOI":"10.1016\/j.tox.2022.153189","article-title":"Persistent Neurobehavioral and Neurochemical Anomalies in Middle-Aged Rats after Maternal Diazinon Exposure","volume":"472","author":"Hawkey","year":"2022","journal-title":"Toxicology"},{"key":"ref_125","first-page":"11","article-title":"Fenobucarb-Induced Developmental Neurotoxicity and Mechanisms in Zebrafish","volume":"79","author":"Zhu","year":"2020","journal-title":"Neuro Toxicol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1080\/03601234.2016.1239973","article-title":"Mother Gestational Exposure to Organophosphorus Pesticide Induces Neuron and Glia Loss in Daughter Adult Brain","volume":"52","author":"Chen","year":"2017","journal-title":"J. Environ. Sci. 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