{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:42:40Z","timestamp":1785426160926,"version":"3.56.0"},"reference-count":146,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T00:00:00Z","timestamp":1785110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Major Science and Technology Special Project","award":["202602AE090078"],"award-info":[{"award-number":["202602AE090078"]}]},{"DOI":"10.13039\/501100008871","name":"College of Animal Science and Technology, Yunnan Agricultural University","doi-asserted-by":"publisher","award":["A3012025077"],"award-info":[{"award-number":["A3012025077"]}],"id":[{"id":"10.13039\/501100008871","id-type":"DOI","asserted-by":"publisher"}]},{"award":["A3012025077"],"award-info":[{"award-number":["A3012025077"]}],"id":[{"id":"https:\/\/ror.org\/04dpa3g90","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J. Xenobiot.","JoX"],"abstract":"<jats:p>Aquatic animals are increasingly exposed to complex mixtures of emerging environmental toxicants, including microplastics, nanoplastics, per- and polyfluoroalkyl substances (PFAS), and endocrine-disrupting chemicals (EDCs). This raises serious concerns for reproductive health, offspring survival rates, and long-term population stability. This narrative review synthesizes the available peer-reviewed evidence on the reproductive and developmental effects of these contaminant groups in aquatic animals. Growing evidence indicates that these contaminants adversely affect reproductive processes, impair offspring development, and reduce survival and fitness across a wide range of aquatic species. Their effects are mediated through interconnected pathways involving oxidative stress, endocrine disruption, inflammation, mitochondrial dysfunction, and epigenetic alterations, ultimately leading to reproductive and developmental abnormalities. These changes may weaken wild fish populations, reduce aquaculture productivity, and compromise aquatic biodiversity. However, interpretation of the available evidence is constrained by substantial heterogeneity in species, contaminant properties and concentrations, exposure durations, and reproductive endpoints, together with the predominance of laboratory-based single-contaminant studies. This review integrates current knowledge on the reproductive and developmental impacts of emerging contaminants by connecting mechanistic toxicity pathways with population-level and ecosystem consequences. Overall, this review emphasizes that protecting aquatic reproductive health requires an integrated framework linking contaminant monitoring, mechanistic biomarkers, reproductive performance, and ecosystem-level risk assessment.<\/jats:p>","DOI":"10.3390\/jox16040137","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:15:56Z","timestamp":1785140156000},"page":"137","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Emerging Environmental Toxicants Undermine Reproductive Success in Aquatic Animals: A Narrative Review"],"prefix":"10.3390","volume":"16","author":[{"given":"Yuchen","family":"Du","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuyue","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqin","family":"Liang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liqian","family":"Shang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4314-8000","authenticated-orcid":false,"given":"Xun","family":"Xiang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s44454-026-00032-6","article-title":"Impacts of environmental stressors on fertility and fecundity across taxa, with implications for planetary health","volume":"2","author":"Brander","year":"2026","journal-title":"npj Emerg. Contam."},{"key":"ref_2","first-page":"100755","article-title":"Understanding emerging contaminants in water and wastewater: A comprehensive review on detection, impacts, and solutions","volume":"18","author":"Nishmitha","year":"2025","journal-title":"J. Hazard. Mater. Adv."},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Peskova, N., and Blahova, J. (2025). Bisphenols: Endocrine Disruptors and Their Impact on Fish: A Review. Fishes, 10.","DOI":"10.3390\/fishes10080365"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr. Environ. Assess. Manag."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1039\/D5EM00145E","article-title":"Advancing the understanding of PFAS-induced reproductive toxicity in key model species","volume":"27","author":"Tao","year":"2025","journal-title":"Environ. Sci. Processes Impacts"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"114362","DOI":"10.1016\/j.envpol.2020.114362","article-title":"Reproductive dysfunction linked to alteration of endocrine activities in zebrafish exposed to mono-(2-ethylhexyl) phthalate (MEHP)","volume":"265","author":"Park","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"10752","DOI":"10.1038\/s41598-025-94902-5","article-title":"Synergistic endocrine disruption and cellular toxicity of polyethylene microplastics and bisphenol A in MLTC-1 cells and zebrafish","volume":"15","author":"Ye","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"108432","DOI":"10.1016\/j.envint.2024.108432","article-title":"The invisible Threat: Assessing the reproductive and transgenerational impacts of micro-and nanoplastics on fish","volume":"183","author":"Yi","year":"2024","journal-title":"Environ. Int."},{"key":"ref_9","unstructured":"Organisation for Economic Co-operation and Development (2024). Policy Scenarios for Eliminating Plastic Pollution by 2040: A Global Plastic Outlook Model-Based Analysis, Organisation for Economic Co-operation and Development."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"132359","DOI":"10.1016\/j.jhazmat.2023.132359","article-title":"Polystyrene microplastics disrupt female reproductive health and fertility via sirt1 modulation in zebrafish (Danio rerio)","volume":"460","author":"Gupta","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"162664","DOI":"10.1016\/j.scitotenv.2023.162664","article-title":"Polystyrene microplastics enhance the microcystin-LR-induced gonadal damage and reproductive endocrine disruption in zebrafish","volume":"876","author":"Lin","year":"2023","journal-title":"Sci. Total Environ."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12302-018-0134-4","article-title":"Short-chain perfluoroalkyl acids: Environmental concerns and a regulatory strategy under REACH","volume":"30","author":"Brendel","year":"2018","journal-title":"Environ. Sci. Eur."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s12302-025-01281-9","article-title":"Developmental exposure to environmentally relevant PFOS and PFBS disrupts adult behaviour, reproductive fitness, and lipid metabolism in Zebrafish","volume":"37","author":"Fallet","year":"2025","journal-title":"Environ. Sci. Eur."},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Okuthe, G.E., Dube, E., and Mafunda, P.S. (2025). Effects of pharmaceuticals and endocrine-disrupting chemicals on reproductive biology of aquatic fauna: Penguins as sentinel species. J. Xenobiotics, 15.","DOI":"10.3390\/jox15040110"},{"key":"ref_15","first-page":"100215","article-title":"Microplastics pollution: A brief review of its source and abundance in different aquatic ecosystems","volume":"9","author":"Ashrafy","year":"2023","journal-title":"J. Hazard. Mater. Adv."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Boucher, J., and Friot, D. (2017). Primary Microplastics in the Oceans: A Global Evaluation of Sources, IUCN.","DOI":"10.2305\/IUCN.CH.2017.01.en"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"6633","DOI":"10.1038\/s41598-019-43023-x","article-title":"The contribution of washing processes of synthetic clothes to microplastic pollution","volume":"9","author":"Cocca","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"143806","DOI":"10.1016\/j.chemosphere.2024.143806","article-title":"Pollutants in urban runoff: Scientific evidence on toxicity and impacts on freshwater ecosystems","volume":"369","author":"Cojoc","year":"2024","journal-title":"Chemosphere"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"118095","DOI":"10.1016\/j.trac.2024.118095","article-title":"Tire wear particles in aquatic ecosystems: Current knowledge and future perspectives","volume":"183","author":"Wang","year":"2025","journal-title":"TrAC Trends Anal. Chem."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"109720","DOI":"10.1016\/j.envint.2025.109720","article-title":"Quantification and mapping of tyre wear emissions: From EU regional analysis to global projections","volume":"203","author":"Sun","year":"2025","journal-title":"Environ. Int."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.chemosphere.2019.06.197","article-title":"Microplastics in the wastewater treatment plants (WWTPs): Occurrence and removal","volume":"235","author":"Xu","year":"2019","journal-title":"Chemosphere"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"146267","DOI":"10.1016\/j.jclepro.2025.146267","article-title":"Microplastic removal and environmental emissions from municipal wastewater treatment plants","volume":"521","author":"Cavazzoli","year":"2025","journal-title":"J. Clean. Prod."},{"key":"ref_23","first-page":"10","article-title":"Road dust-associated microplastics as a carrier of plastic additives in urban small-scale river sediment","volume":"5","author":"Yamahara","year":"2025","journal-title":"Environ. Monit. Contam. Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s43591-024-00097-3","article-title":"Microplastics in an advanced wastewater treatment plant: Sustained and robust removal rates unfazed by seasonal variations","volume":"4","author":"Iordachescu","year":"2024","journal-title":"Microplastics Nanoplastics"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"172675","DOI":"10.1016\/j.scitotenv.2024.172675","article-title":"Microplastics removal in wastewater treatment plants: A review of the different approaches to limit their release in the environment","volume":"930","author":"Miino","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"119952","DOI":"10.1016\/j.jece.2025.119952","article-title":"The nexuses of micro (nano) plastics at environmental interfaces: Challenges in wastewater treatment and sustainable water management","volume":"13","author":"Nyoni","year":"2025","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"100590","DOI":"10.1016\/j.ese.2025.100590","article-title":"How soon will landfilled plastics integrate into the geological carbon cycle?","volume":"26","author":"Yang","year":"2025","journal-title":"Environ. Sci. Ecotechnol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"140195","DOI":"10.1016\/j.jhazmat.2025.140195","article-title":"Sources and occurrence of per-and polyfluoroalkyl substances in industrial wastewater and assessment of current treatment approaches: A review","volume":"499","author":"Jia","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s11270-025-08225-2","article-title":"A Systematic Review and Meta Analysis on the Occurrence of Per-and Polyfluoroalkyl Substances (PFAS) in Wastewater Treatment Plants","volume":"236","author":"Duru","year":"2025","journal-title":"Water Air Soil Pollut."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"104928","DOI":"10.1016\/j.eti.2026.104928","article-title":"Emerging contaminant pollution and source contributions in a mixed-land-use lake in Lam Dong, Vietnam: An integrated multivariate, receptor modeling, and ecological risk assessment","volume":"42","author":"Kang","year":"2026","journal-title":"Environ. Technol. Innov."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s44274-026-00557-y","article-title":"Toxicological implications of emerging pollutants on aquatic organisms","volume":"4","author":"Sefali","year":"2026","journal-title":"Discov. Environ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"134","DOI":"10.26650\/experimed.1192592","article-title":"Determination of bisphenol a and phthalate levels in wastewater samples","volume":"12","author":"Akcay","year":"2022","journal-title":"Experimed"},{"key":"ref_33","first-page":"811","article-title":"Effects of diffused pollution on surface waters due to agricultural runoff","volume":"44","author":"Pericherla","year":"2023","journal-title":"J. Adv. Zool."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"41796","DOI":"10.1038\/s41598-025-25697-8","article-title":"Occurrence, fate and ecological risks of phthalate esters and bisphenol A in coastal wastewater discharges","volume":"15","author":"Soleimani","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s44475-026-00042-3","article-title":"Environmental and health implications of emerging pollutants in landfill leachate: A review","volume":"2","author":"Macaulay","year":"2026","journal-title":"Discov. Hazards"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Campanale, C., Massarelli, C., Savino, I., Locaputo, V., and Uricchio, V.F. (2020). A detailed review study on potential effects of microplastics and additives of concern on human health. Int. J. Environ. Res. Public Health, 17.","DOI":"10.3390\/ijerph17041212"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s12302-025-01234-2","article-title":"Comprehensive review of the co-transport of microplastics and suspended sediments in aquatic environments: Macroscopic transport and microscopic mechanisms","volume":"37","author":"Jiang","year":"2025","journal-title":"Environ. Sci. Eur."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"100188","DOI":"10.1016\/j.eehl.2025.100188","article-title":"From water to sediment: A meta-analysis of microplastic distribution and the impact of dams in reservoir ecosystems","volume":"4","author":"Gao","year":"2025","journal-title":"Eco-Environ. Health"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Wang, M.-M., Xia, Z., Jiang, J., Wu, H., Huang, H., Zhang, X., Hong, W.-J., Li, M., and Guo, L.-H. (2025). Per-and polyfluoroalkyl substances in coastal plain water network areas: Shifting management focus to sediments. Front. Mar. Sci., 12.","DOI":"10.3389\/fmars.2025.1586800"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.enceco.2025.08.011","article-title":"Occurrence and ecological risks of endocrine-disrupting chemicals in three National Aquatic Germplasm Resources Reserves in the South China Sea","volume":"7","author":"Chen","year":"2025","journal-title":"Environ. Chem. Ecotoxicol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"140270","DOI":"10.1016\/j.jhazmat.2025.140270","article-title":"Exposure pathway derived accumulation of microplastics in freshwater fish: A critical review","volume":"500","author":"Gao","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_42","doi-asserted-by":"crossref","unstructured":"Ullah, I., Chen, H., Wang, J., Kaiser, H., Basher, A.A., Li, J., and Zhu, X. (2025). Impacts of Microplastics on the Early Life Stages of Fish: Sources, Mechanisms, Ecological Consequences, and Mitigation Strategies. Toxics, 14.","DOI":"10.3390\/toxics14010027"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Shurson, G.C. (2025). The alarming effects of per-and polyfluoroalkyl substances (PFAS) on one health and interconnections with food-producing animals in circular and sustainable agri-food systems. Sustainability, 17.","DOI":"10.3390\/su17156957"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1017\/plc.2023.9","article-title":"Environmental toxicology of marine microplastic pollution","volume":"1","author":"Wang","year":"2023","journal-title":"Camb. Prism. Plast."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e009","DOI":"10.48130\/newcontam-0026-0004","article-title":"Trophic transfer of per-and polyfluoroalkyl substances in aquatic ecosystems","volume":"2","author":"Yang","year":"2026","journal-title":"New Contam."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1007\/s11356-026-37412-9","article-title":"An overview of the impact of PFAS on animals, humans, and the environment using a One Health approach","volume":"33","author":"Ferretti","year":"2026","journal-title":"Environ. Sci. Pollut. Res."},{"key":"ref_47","first-page":"400","article-title":"Evaluation of Possible Ameliorative Role of Robinetin to Counteract Polystyrene Microplastics Instigated Renal Toxicity in Rats","volume":"44","author":"Ijaz","year":"2024","journal-title":"Pak. Vet. J."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"130274","DOI":"10.1016\/j.jhazmat.2022.130274","article-title":"Transgenerational impacts of micro (nano) plastics in the aquatic and terrestrial environment","volume":"443","author":"Junaid","year":"2023","journal-title":"J. Hazard. Mater."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"110042","DOI":"10.1016\/j.cbpc.2024.110042","article-title":"Environmental toxicology of microplastic particles on fish: A review","volume":"287","author":"Banaee","year":"2025","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_50","first-page":"62","article-title":"Chromium and Nickel Toxicity in Sheep: Pathophysiology and Management Approaches","volume":"45","author":"Aljohani","year":"2025","journal-title":"Pak. Vet. J."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41545-026-00568-5","article-title":"Perfluoroalkyl chain-length-dependent environmental fate and treatment outcomes of PFAS in water","volume":"9","author":"Lee","year":"2026","journal-title":"npj Clean Water"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/etc.2043","article-title":"Interactions between chemical and climate stressors: A role for mechanistic toxicology in assessing climate change risks","volume":"32","author":"Hooper","year":"2013","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"15956","DOI":"10.1021\/acs.est.5c02872","article-title":"Accelerated weathering of microplastics: A systematic approach to model microplastic production","volume":"59","author":"Hong","year":"2025","journal-title":"Environ. Sci. Technol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"119470","DOI":"10.1016\/j.ecoenv.2025.119470","article-title":"Environmental pollutant-induced cholinergic disruption: Advances and perspectives in mechanistic insights, target heterogeneity, and neurotoxic synergy","volume":"308","author":"Li","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"12820","DOI":"10.1021\/acs.est.0c03244","article-title":"Are fluoropolymers really of low concern for human and environmental health and separate from other PFAS?","volume":"54","author":"Lohmann","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_56","first-page":"63","article-title":"Protective Effects of Naringenin on 5-Fluorouracil Induced Pulmonary Toxicity Via Modulation of NF-? B and Nrf2 Pathway","volume":"44","author":"Vemula","year":"2024","journal-title":"Pak. Vet. J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"116712","DOI":"10.1016\/j.ecoenv.2024.116712","article-title":"A review of the neurobehavioural, physiological, and reproductive toxicity of microplastics in fishes","volume":"282","author":"Hasan","year":"2024","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_58","first-page":"703","article-title":"Modulation of energy drink-induced hepato-renal and testicular toxicity by pomegranate peel extract: Insights from histopathological and immunohistochemical analyses","volume":"45","author":"Gaballa","year":"2024","journal-title":"Pak. Vet. J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"107538","DOI":"10.1016\/j.aquatox.2025.107538","article-title":"BPA disrupts crustacean reproduction: Tissue-specific accumulation, oxidative stress, and gene dysregulation in Macrobrachium nipponense","volume":"287","author":"Liu","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1126\/science.281.5381.1309","article-title":"Mitochondria and apoptosis","volume":"281","author":"Green","year":"1998","journal-title":"Science"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Cedergreen, N. (2014). Quantifying synergy: A systematic review of mixture toxicity studies within environmental toxicology. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0096580"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1007\/s00204-023-03562-9","article-title":"Reactive oxygen species, toxicity, oxidative stress, and antioxidants: Chronic diseases and aging","volume":"97","author":"Jomova","year":"2023","journal-title":"Arch. Toxicol."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Wang, Y., Su, M., Chen, Y., Huang, X., Ruan, L., Lv, Q., and Li, L. (2023). Research progress on the role and mechanism of DNA damage repair in germ cell development. Front. Endocrinol., 14.","DOI":"10.3389\/fendo.2023.1234280"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mrgentox.2013.08.008","article-title":"Epigenetics in an ecotoxicological context","volume":"764","author":"Vandegehuchte","year":"2014","journal-title":"Mutat. Res.\/Genet. Toxicol. Environ. Mutagen."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.aquatox.2015.10.020","article-title":"Reproductive toxicity of low level bisphenol A exposures in a two-generation zebrafish assay: Evidence of male-specific effects","volume":"169","author":"Chen","year":"2015","journal-title":"Aquat. Toxicol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"113024","DOI":"10.1016\/j.envpol.2019.113024","article-title":"Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)","volume":"254","author":"Wang","year":"2019","journal-title":"Environ. Pollut."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/raq.12041","article-title":"The zebrafish (Danio rerio) as a model organism, with emphasis on applications for finfish aquaculture research","volume":"6","author":"Ribas","year":"2014","journal-title":"Rev. Aquac."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"113418","DOI":"10.1016\/j.marpolbul.2022.113418","article-title":"Elasmobranchs as bioindicators of pollution in the marine environment","volume":"176","author":"Alves","year":"2022","journal-title":"Mar. Pollut. Bull."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"112189","DOI":"10.1016\/j.mce.2024.112189","article-title":"Endocrine disruption in crustaceans: New findings and perspectives","volume":"585","year":"2024","journal-title":"Mol. Cell. Endocrinol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"14625","DOI":"10.1021\/acs.est.5b04099","article-title":"Ingestion of nanoplastics and microplastics by Pacific oyster larvae","volume":"49","author":"Cole","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.scitotenv.2004.12.070","article-title":"Review of evidence: Are endocrine-disrupting chemicals in the aquatic environment impacting fish populations?","volume":"343","author":"Mills","year":"2005","journal-title":"Sci. Total Environ."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Sunny, A.R., Sazzad, S.A., Islam, M.A., Mithun, M.H., Hussain, M., Raposo, A., and Bhuiyan, M.K.A. (2025). Microplastics in aquatic ecosystems: A global review of distribution, ecotoxicological impacts, and human health risks. Water, 17.","DOI":"10.3390\/w17121741"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"107478","DOI":"10.1016\/j.aquatox.2025.107478","article-title":"Mechanistic insights into microplastic-induced reproductive toxicity in aquatic organisms: A comprehensive review","volume":"286","author":"Hasan","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Kundu, S., Kumar, N., Kumar, P., PS, B., Singh, A.K., Godse, D., and Reddy, K.S. (2026). Micro\/nanoplastics pollution: Emerging challenges for aquatic animals and food crops. Front. Toxicol., 8.","DOI":"10.3389\/ftox.2026.1768236"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"121995","DOI":"10.1016\/j.jenvman.2024.121995","article-title":"Aged polystyrene microplastics exposure affects apoptosis via inducing mitochondrial dysfunction and oxidative stress in early life of zebrafish","volume":"367","author":"Ding","year":"2024","journal-title":"J. Environ. Manag."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110122","DOI":"10.1016\/j.cbpc.2025.110122","article-title":"Reproductive toxicity of perfluorobutane sulfonate in zebrafish (Danio rerio): Impacts on oxidative stress, hormone disruption and HPGL axis dysregulation","volume":"289","author":"Santhi","year":"2025","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1080\/15592294.2016.1182272","article-title":"Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio)","volume":"11","author":"Laing","year":"2016","journal-title":"Epigenetics"},{"key":"ref_78","doi-asserted-by":"crossref","unstructured":"Dasmahapatra, A.K., Chatterjee, J., and Tchounwou, P.B. (2025). A systematic review of the effects of nanoplastics on fish. Front. Toxicol., 7.","DOI":"10.3389\/ftox.2025.1530209"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.aquatox.2016.04.005","article-title":"Zebrafish reproductive toxicity induced by chronic perfluorononanoate exposure","volume":"175","author":"Zhang","year":"2016","journal-title":"Aquat. Toxicol."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Tang, K.H.D. (2025). Genotoxicity of microplastics on living organisms: Effects on chromosomes, DNA and gene expression. Environments, 12.","DOI":"10.3390\/environments12010010"},{"key":"ref_81","doi-asserted-by":"crossref","unstructured":"Wu, B., Yu, H., Yi, J., Lei, P., He, J., Ruan, J., Xu, P., Tao, R., Jin, L., and Wu, W. (2024). Behavioral studies of zebrafish reveal a new perspective on the reproductive toxicity of micro-and nanoplastics. Toxics, 12.","DOI":"10.3390\/toxics12030178"},{"key":"ref_82","doi-asserted-by":"crossref","unstructured":"Dubey, I., Khan, S., and Kushwaha, S. (2022). Developmental and reproductive toxic effects of exposure to microplastics: A review of associated signaling pathways. Front. Toxicol., 4.","DOI":"10.3389\/ftox.2022.901798"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"107331","DOI":"10.1016\/j.aquatox.2025.107331","article-title":"Polyethylene microplastics perforate the chorion defense, triggering developmental cardiotoxicity at zebrafish","volume":"282","author":"Kim","year":"2025","journal-title":"Aquat. Toxicol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1073\/pnas.1519019113","article-title":"Oyster reproduction is affected by exposure to polystyrene microplastics","volume":"113","author":"Sussarellu","year":"2016","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/j.envpol.2018.08.020","article-title":"Nanoplastics impaired oyster free living stages, gametes and embryos","volume":"242","author":"Tallec","year":"2018","journal-title":"Environ. Pollut."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"113978","DOI":"10.1016\/j.envpol.2020.113978","article-title":"High density polyethylene (HDPE) microplastics impair development and swimming activity of Pacific oyster D-larvae, Crassostrea gigas, depending on particle size","volume":"260","author":"Bringer","year":"2020","journal-title":"Environ. Pollut."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"14480","DOI":"10.1021\/acs.est.8b05266","article-title":"Uptake, whole-body distribution, and depuration of nanoplastics by the scallop Pecten maximus at environmentally realistic concentrations","volume":"52","author":"Rowland","year":"2018","journal-title":"Environ. Sci. Technol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"12336","DOI":"10.1021\/es503001d","article-title":"Nanoplastic affects growth of S. obliquus and reproduction of D. magna","volume":"48","author":"Besseling","year":"2014","journal-title":"Environ. Sci. Technol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1021\/es401932b","article-title":"Size-dependent effects of micro polystyrene particles in the marine copepod Tigriopus japonicus","volume":"47","author":"Lee","year":"2013","journal-title":"Environ. Sci. Technol."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"110134","DOI":"10.1016\/j.cbpc.2025.110134","article-title":"Reproductive toxicity and transgenerational effects of co-exposure to polystyrene microplastics and arsenic in zebrafish","volume":"290","author":"Luo","year":"2025","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"128","DOI":"10.2478\/aopf-2024-0012","article-title":"How endocrine disruptors affect fish reproduction on multiple levels: A review","volume":"32","author":"Socha","year":"2024","journal-title":"Fish. Aquat. Life"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"135198","DOI":"10.1016\/j.chemosphere.2022.135198","article-title":"Effects of pristine or contaminated polyethylene microplastics on zebrafish development","volume":"303","author":"Tarasco","year":"2022","journal-title":"Chemosphere"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"172876","DOI":"10.1016\/j.scitotenv.2024.172876","article-title":"Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio)","volume":"932","author":"Li","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"125537","DOI":"10.1016\/j.jhazmat.2021.125537","article-title":"Adaptation of life-history traits and trade-offs in marine medaka (Oryzias melastigma) after whole life-cycle exposure to polystyrene microplastics","volume":"414","author":"Wang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"107023","DOI":"10.1016\/j.aquatox.2024.107023","article-title":"Female zebrafish (Danio rerio) exposure to polystyrene nanoplastics induces reproductive toxicity in mother and their offspring","volume":"273","author":"Zhang","year":"2024","journal-title":"Aquat. Toxicol."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1021\/acsestwater.2c00348","article-title":"Zebrafish (Danio rerio) reproduction is affected by life-cycle exposure to differently charged polystyrene nanoplastics with sex-specific responses","volume":"2","author":"Teng","year":"2022","journal-title":"ACS ES T Water"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"e00170","DOI":"10.1016\/j.teac.2022.e00170","article-title":"Microplastics and associated emerging contaminants in the environment: Analysis, sorption mechanisms and effects of co-exposure","volume":"35","author":"Santos","year":"2022","journal-title":"Trends Environ. Anal. Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"103000","DOI":"10.1016\/j.rechem.2025.103000","article-title":"Short-chain PFAS: A global challenge-Environmental fate, health risks, and promising removal technologies","volume":"20","author":"Kannan","year":"2025","journal-title":"Results Chem."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"107169","DOI":"10.1016\/j.rineng.2025.107169","article-title":"Comprehensive review of per-and polyfluoroalkyl substances in drinking water: Physiochemical properties, sources, health impacts, regulatory limits, and future perspectives","volume":"28","author":"Mahdi","year":"2025","journal-title":"Results Eng."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"24503","DOI":"10.1038\/s41598-024-73538-x","article-title":"Long-term exposure to environmentally relevant Bisphenol-A levels affects growth, swimming, condition factor, sex ratio and histology of juvenile zebrafish","volume":"14","author":"Rajapaksa","year":"2024","journal-title":"Sci. Rep."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"119029","DOI":"10.1016\/j.ecoenv.2025.119029","article-title":"Environmental reproductive toxicity of common pesticides: Mechanisms and implications throughout the zebrafish life cycle","volume":"304","author":"Yang","year":"2025","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_102","doi-asserted-by":"crossref","unstructured":"Burch, E., Hussein, M.A., Zaki, M., Kamal, L.T., Zaki, G., Shoeib, T., Dawood, M., Sewilam, H., and Abdelnaser, A. (2025). Assessing the effects of pesticides on aquacultured fish and ecosystems: A comprehensive environmental health review. Fishes, 10.","DOI":"10.3390\/fishes10050223"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"125133","DOI":"10.1016\/j.envpol.2024.125133","article-title":"Combined toxicity of perfluoroalkyl substances and microplastics on the sentinel species Daphnia magna: Implications for freshwater ecosystems","volume":"363","author":"Soltanighias","year":"2024","journal-title":"Environ. Pollut."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"176897","DOI":"10.1016\/j.scitotenv.2024.176897","article-title":"Toxicity of parental co-exposure of microplastic and bisphenol compounds on adult zebrafish: Multi-omics investigations on offspring","volume":"955","author":"Xue","year":"2024","journal-title":"Sci. Total Environ."},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Wang, P., Shi, Y.-Z., and Guan, Q. (2025). The microplastic\u2013PFAS nexus: From co-occurrence to combined toxicity in aquatic environments. Toxics, 13.","DOI":"10.3390\/toxics13121041"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Knigge, T., LeBlanc, G.A., and Ford, A.T. (2021). A crab is not a fish: Unique aspects of the crustacean endocrine system and considerations for endocrine toxicology. Front. Endocrinol., 12.","DOI":"10.3389\/fendo.2021.587608"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"112040","DOI":"10.1016\/j.envres.2021.112040","article-title":"Effects of endocrine disrupting chemicals on gonad development: Mechanistic insights from fish and mammals","volume":"204","author":"Delbes","year":"2022","journal-title":"Environ. Res."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1289\/ehp.8062","article-title":"Screening and testing for endocrine disruption in fish\u2014Biomarkers as \u201csignposts,\u201d not \u201ctraffic lights,\u201d in risk assessment","volume":"114","author":"Hutchinson","year":"2005","journal-title":"Environ. Health Perspect."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.envint.2007.09.008","article-title":"Vitellogenin as a biomarker of exposure to estrogenic compounds in aquatic invertebrates: A review","volume":"34","author":"Matozzo","year":"2008","journal-title":"Environ. Int."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/jat.4104","article-title":"Summary of reference chemicals evaluated by the fish short-term reproduction assay, OECD TG229, using Japanese Medaka, Oryzias latipes","volume":"41","author":"Onishi","year":"2021","journal-title":"J. Appl. Toxicol."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Gr\u0103dinariu, L., Cre\u021bu, M., Vizireanu, C., and Dediu, L. (2025). Oxidative stress biomarkers in fish exposed to environmental concentrations of pharmaceutical pollutants: A review. Biology, 14.","DOI":"10.3390\/biology14050472"},{"key":"ref_112","unstructured":"U.S. Environmental Protection Agency (2007). Validation of the Fish Short-Term Reproduction Assay: Integrated Summary Report."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.aquatox.2009.10.016","article-title":"Impaired reproductive health of killifish (Fundulus heteroclitus) inhabiting Newark Bay, NJ, a chronically contaminated estuary","volume":"96","author":"Bugel","year":"2010","journal-title":"Aquat. Toxicol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"110453","DOI":"10.1016\/j.cbpc.2026.110453","article-title":"Multigenerational effects of selected environmental contaminants in fishes: A comprehensive review","volume":"302","author":"Uddin","year":"2026","journal-title":"Comp. Biochem. Physiol. Part C Toxicol. Pharmacol."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.marpolbul.2005.06.046","article-title":"Baseline study of perfluorooctane sulfonate occurrence in mussels, Mytilus galloprovincialis, from north-central Portuguese estuaries","volume":"50","author":"Cunha","year":"2005","journal-title":"Mar. Pollut. Bull."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"140306","DOI":"10.1016\/j.jhazmat.2025.140306","article-title":"Exposure to environmentally relevant levels of perfluorotetradecanoic acid (PFTeDA) affects respiratory and reproductive functions of Mytilus trossulus: An experimental study","volume":"500","author":"Smolarz","year":"2025","journal-title":"J. Hazard. Mater."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"116058","DOI":"10.1016\/j.fct.2026.116058","article-title":"Per-and polyfluoroalkyl substances (PFAS) in aquaculture feeds and potential dietary exposure to and from aquaculture fish","volume":"212","author":"Blevins","year":"2026","journal-title":"Food Chem. Toxicol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"10720","DOI":"10.1038\/s41467-025-65746-4","article-title":"Unravelling the magnitude and drivers of PFAS trophic magnification: A meta-analysis","volume":"16","author":"Ricolfi","year":"2025","journal-title":"Nat. Commun."},{"key":"ref_119","doi-asserted-by":"crossref","unstructured":"Das, B.K., Das, S., Kumar, V., Roy, S., Mitra, A., and Mandal, B. (2025). Microplastics in ecosystems: Ecotoxicological threats and strategies for mitigation and governance. Front. Mar. Sci., 12.","DOI":"10.3389\/fmars.2025.1672484"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"101516","DOI":"10.1016\/j.envc.2026.101516","article-title":"Per-and polyfluoroalkyl substances in fish: A review of bioaccumulation, trophic transfer, and environmental health risks","volume":"23","author":"Khoshmanesh","year":"2026","journal-title":"Environ. Chall."},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Subaramaniyam, U., Allimuthu, R.S., Vappu, S., Ramalingam, D., Balan, R., Paital, B., Panda, N., Rath, P.K., Ramalingam, N., and Sahoo, D.K. (2023). Effects of microplastics, pesticides and nano-materials on fish health, oxidative stress and antioxidant defense mechanism. Front. Physiol., 14.","DOI":"10.3389\/fphys.2023.1217666"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Ma, T., Wu, P., Wang, L., Li, Q., Li, X., and Luo, Y. (2023). Toxicity of per-and polyfluoroalkyl substances to aquatic vertebrates. Front. Environ. Sci., 11.","DOI":"10.3389\/fenvs.2023.1101100"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: An Endocrine Society scientific statement","volume":"30","author":"Bourguignon","year":"2009","journal-title":"Endocr. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"112136","DOI":"10.1016\/j.ecoenv.2021.112136","article-title":"Combined toxicity of endocrine-disrupting chemicals: A review","volume":"215","author":"Hamid","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1002\/etc.4268","article-title":"Microplastics in the aquatic environment: Evidence for or against adverse impacts and major knowledge gaps","volume":"37","author":"Burns","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/etc.4323","article-title":"Toward an ecotoxicological risk assessment of microplastics: Comparison of available hazard and exposure data in freshwaters","volume":"38","author":"Adam","year":"2019","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1002\/etc.2663","article-title":"Fate and effects of poly-and perfluoroalkyl substances in the aquatic environment: A review","volume":"33","author":"Ahrens","year":"2014","journal-title":"Environ. Toxicol. Chem."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.scitotenv.2015.04.023","article-title":"Review on the occurrence, fate and removal of perfluorinated compounds during wastewater treatment","volume":"524","author":"Arvaniti","year":"2015","journal-title":"Sci. Total Environ."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of poly-and perfluoroalkyl substances (PFASs) in US drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants","volume":"3","author":"Hu","year":"2016","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1559325815598308","DOI":"10.1177\/1559325815598308","article-title":"Global assessment of bisphenol A in the environment: Review and analysis of its occurrence and bioaccumulation","volume":"13","author":"Corrales","year":"2015","journal-title":"Dose-Response"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"4019","DOI":"10.1021\/es505233b","article-title":"Occurrence, fate, behavior and ecotoxicological state of phthalates in different environmental matrices","volume":"49","author":"Net","year":"2015","journal-title":"Environ. Sci. Technol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"5750","DOI":"10.1073\/pnas.1500232112","article-title":"Agricultural insecticides threaten surface waters at the global scale","volume":"112","author":"Stehle","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1210\/er.2011-1050","article-title":"Hormones and endocrine-disrupting chemicals: Low-dose effects and nonmonotonic dose responses","volume":"33","author":"Vandenberg","year":"2012","journal-title":"Endocr. Rev."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"103497","DOI":"10.1016\/j.etap.2020.103497","article-title":"Detrimental effects of bisphenol compounds on physiology and reproduction in fish: A literature review","volume":"81","author":"Faheem","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1039\/D5EN01084E","article-title":"Waterborne nanoplastics and microplastics: Analytical advances, modelling, and future directions","volume":"13","author":"Wang","year":"2026","journal-title":"Environ. Sci. Nano"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"13851","DOI":"10.1039\/D5RA09062H","article-title":"A review on microplastics: Sources, environmental fate, degradation pathways, and analytical identification methods","volume":"16","author":"Kamalasekaran","year":"2026","journal-title":"RSC Adv."},{"key":"ref_137","unstructured":"EPA (2024). PFAS Analytical Methods Development and Sampling Research."},{"key":"ref_138","unstructured":"EPA (2024). EPA\u2019s PFAS Strategic Roadmap: Three Years of Progress."},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1039\/D5VA00092K","article-title":"A review on technologies for the removal of per-and polyfluoroalkyl substances (PFASs) in aquatic environments","volume":"4","author":"Zang","year":"2025","journal-title":"Environ. Sci. Adv."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"25256","DOI":"10.1039\/D5RA04074D","article-title":"Sustainable coagulative removal of microplastic from aquatic systems: Recent progress and outlook","volume":"15","author":"Badawi","year":"2025","journal-title":"RSC Adv."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"100042","DOI":"10.1016\/j.envc.2021.100042","article-title":"Microplastics with adsorbed contaminants: Mechanisms and Treatment","volume":"3","author":"Joo","year":"2021","journal-title":"Environ. Chall."},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1021\/acs.est.5c17011","article-title":"Combining nanofiltration and adsorbents to achieve effective PFAS removal in wastewater effluent","volume":"60","author":"Griffin","year":"2026","journal-title":"Environ. Sci. Technol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"277","DOI":"10.12911\/22998993\/211594","article-title":"Microplastic removal in coagulation-flocculation: Optimization through chemometric and morphological insights","volume":"27","author":"Yimrattanabovorn","year":"2026","journal-title":"J. Ecol. Eng."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1021\/acs.estlett.9b00397","article-title":"Energy-efficient electrochemical oxidation of perfluoroalkyl substances using a Ti4O7 reactive electrochemical membrane anode","volume":"6","author":"Le","year":"2019","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"142364","DOI":"10.1016\/j.chemosphere.2024.142364","article-title":"Constructed wetlands for the removal of organic micropollutants from wastewater: Current status, progress, and challenges","volume":"360","author":"Kushwaha","year":"2024","journal-title":"Chemosphere"},{"key":"ref_146","doi-asserted-by":"crossref","unstructured":"Li, B., Zhang, Y., Du, J., Liu, C., Zhou, G., Li, M., and Yan, Z. (2025). Application of multi-omics techniques in aquatic ecotoxicology: A review. Toxics, 13.","DOI":"10.3390\/toxics13080653"}],"container-title":["Journal of Xenobiotics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2039-4713\/16\/4\/137\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T08:44:30Z","timestamp":1785141870000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2039-4713\/16\/4\/137"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":146,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,8]]}},"alternative-id":["jox16040137"],"URL":"https:\/\/doi.org\/10.3390\/jox16040137","relation":{},"ISSN":["2039-4713"],"issn-type":[{"value":"2039-4713","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,27]]}}}