{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T04:46:11Z","timestamp":1771649171300,"version":"3.50.1"},"reference-count":38,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2020,4,21]],"date-time":"2020-04-21T00:00:00Z","timestamp":1587427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: Very little is known regarding the prevalence of opioid induced hyperalgesia (OIH) in day to day medical practice. The aim of this study was to evaluate the physician\u2019s perception of the prevalence of OIH within their practice, and to assess the level of physician\u2019s knowledge with respect to the identification and treatment of this problem. Methods: An electronic questionnaire was distributed to physicians who work in anesthesiology, chronic pain, and\/or palliative care in Canada. Results: Of the 462 responses received, most were from male (69%) anesthesiologists (89.6%), in the age range of 36 to 64 years old (79.8%). In this study, the suspected prevalence of OIH using the average number of patients treated per year with opioids was 0.002% per patient per physician practice year for acute pain, and 0.01% per patient per physician practice year for chronic pain. Most physicians (70.2%) did not use clinical tests to help make a diagnosis of OIH. The treatment modalities most frequently used were the addition of an NMDA antagonist, combined with lowering the opioid doses and using opioid rotation. Conclusions: The perceived prevalence of OIH in clinical practice is a relatively rare phenomenon. Furthermore, more than half of physicians did not use a clinical test to confirm the diagnosis of OIH. The two main treatment modalities used were NMDA antagonists and opioid rotation. The criteria for the diagnosis of OIH still need to be accurately defined.<\/jats:p>","DOI":"10.3390\/jpm10020027","type":"journal-article","created":{"date-parts":[[2020,4,22]],"date-time":"2020-04-22T04:15:13Z","timestamp":1587528913000},"page":"27","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Opioid Induced Hyperalgesia, a Research Phenomenon or a Clinical Reality? Results of a Canadian Survey"],"prefix":"10.3390","volume":"10","author":[{"given":"Grisell","family":"Vargas-Schaffer","sequence":"first","affiliation":[{"name":"Pain Center. Centre Universitaire de l\u2019Universit\u00e9 de Montr\u00e9al, CHUM, Montreal, QC H2X 3E4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzie","family":"Paquet","sequence":"additional","affiliation":[{"name":"Pain Center. Centre Universitaire de l\u2019Universit\u00e9 de Montr\u00e9al, CHUM, Montreal, QC H2X 3E4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9e","family":"Neron","sequence":"additional","affiliation":[{"name":"Pain Center. Centre Universitaire de l\u2019Universit\u00e9 de Montr\u00e9al, CHUM, Montreal, QC H2X 3E4, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Cogan","sequence":"additional","affiliation":[{"name":"Montreal Hearth Institute, Montreal, QC H1T 1C8, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,4,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.36076\/ppj.2011\/14\/145","article-title":"A comprehensive review of opioid-induced hyperalgesia","volume":"14","author":"Lee","year":"2011","journal-title":"Pain Physician"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1097\/AJP.0b013e31816b2f43","article-title":"Opioid-induced Hyperalgesia in Humans","volume":"24","author":"Chu","year":"2008","journal-title":"Clin. J. Pain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11916-010-0171-1","article-title":"Opioid-Induced hyperalgesia: Clinically relevant or extraneous research phenomenon?","volume":"15","author":"Tompkins","year":"2011","journal-title":"Curr. Pain Headache Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1503\/cmaj.080372","article-title":"A guide for the design and conduct of self-administered surveys of clinicians","volume":"179","author":"Burns","year":"2008","journal-title":"Can. Med Assoc. J."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000542-200008000-00019","article-title":"Acute opioid tolerance: Intraoperative remifentanil increases postoperative pain and morphine requirement","volume":"93","author":"Guignard","year":"2000","journal-title":"Anesthesiology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1097\/j.pain.0000000000000160","article-title":"A classification of chronic pain for ICD-11","volume":"156","author":"Treede","year":"2015","journal-title":"Pain"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1213\/ANE.0b013e31821d72bc","article-title":"Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy","volume":"113","author":"Song","year":"2011","journal-title":"Anesthesia Analg."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/00000542-200507000-00022","article-title":"Remifentanil-induced postoperative hyperalgesia and its prevention with small-dose ketamine","volume":"103","author":"Joly","year":"2005","journal-title":"Anesthesiology"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/j.jvca.2011.03.185","article-title":"Target-controlled dosing of remifentanil during cardiac surgery reduces postoperative hyperalgesia","volume":"25","author":"Pouquet","year":"2011","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.EJA.0000434967.03790.0e","article-title":"Influence of high-dose intraoperative remifentanil with or without amantadine on postoperative pain intensity and morphine consumption in major abdominal surgery patients","volume":"31","author":"Treskatsch","year":"2014","journal-title":"Eur. J. Anaesthesiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0304-3959(03)00276-8","article-title":"Short-term infusion of the mu-opioid agonist remifentanil in humans causes hyperalgesia during withdrawal","volume":"106","author":"Angst","year":"2003","journal-title":"Pain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0304-3959(03)00294-X","article-title":"Naloxone provokes similar pain facilitation as observed after short-term infusion of remifentanil in humans","volume":"106","author":"Koppert","year":"2003","journal-title":"Pain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1213\/00000539-200102000-00017","article-title":"The effect of remifentanil on the heat pain threshold in volunteers","volume":"92","author":"Gustorff","year":"2001","journal-title":"Anesth. Analg."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1002\/j.1532-2149.2012.00211.x","article-title":"The impact of intra-operative sufentanil dosing on post-operative pain, hyperalgesia and morphine consumption after cardiac surgery","volume":"17","author":"Fechner","year":"2012","journal-title":"Eur. J. Pain"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/bja\/aeu137","article-title":"Opioid-induced hyperalgesia in patients after surgery: A systematic review and a meta-analysis","volume":"112","author":"Fletcher","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"ref_16","first-page":"6","article-title":"Opioid-induced hyperalgesia: What to do when it occurs?","volume":"1","author":"Schug","year":"2012","journal-title":"Ann. Palliat. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/SPC.0b013e328335ddfe","article-title":"Opioid hyperalgesia","volume":"4","author":"Bannister","year":"2010","journal-title":"Curr. Opin. Support Palliat. Care"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2125.2005.02418.x","article-title":"Oral opioid administration and hyperalgesia in patients with cancer or chronic nonmalignant pain","volume":"60","author":"Reznikov","year":"2005","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_19","first-page":"10","article-title":"Opioid-induced hyperalgesia after rapid titration with intravenous morphine: Switching and re-titration to intravenous methadone","volume":"1","author":"Mercadante","year":"2012","journal-title":"Ann. Palliat. Med."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Kim, S.H., Stoicea, N., Soghomonyan, S., and Bergese, S. (2014). Intraoperative use of remifentanil and opioid induced hyperalgesia\/acute opioid tolerance: Systematic review. Front. Pharmacol., 5.","DOI":"10.3389\/fphar.2014.00108"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jpain.2008.10.003","article-title":"Hyperalgesia in opioid-managed chronic pain and opioid-dependent patients","volume":"10","author":"Hay","year":"2009","journal-title":"J. Pain"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/bja\/aep363","article-title":"Opioid-induced hyperalgesia in a mice model of orthopaedic pain: Preventive effect of ketamine","volume":"104","author":"Minville","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.2119\/molmed.2012.00244","article-title":"Morphine induces hyperalgesia without involvement of \u03bc-opioid receptor or morphine-3-glucuronide","volume":"18","author":"Swartjes","year":"2012","journal-title":"Mol. Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jpain.2008.07.004","article-title":"TRPV1 receptor in expression of opioid-induced hyperalgesia","volume":"10","author":"Vardanyan","year":"2008","journal-title":"J. Pain"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1523\/JNEUROSCI.4054-04.2005","article-title":"Cholecystokinin in the rostral ventromedial medulla mediates opioid-induced hyperalgesia and antinociceptive tolerance","volume":"25","author":"Xie","year":"2005","journal-title":"J. Neurosci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1097\/j.pain.0000000000000164","article-title":"Activation of JNK pathway in spinal astrocytes contributes to acute ultra\u2013low-dose morphine thermal hyperalgesia","volume":"156","author":"Sanna","year":"2015","journal-title":"Pain"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00000542-200603000-00023","article-title":"Opioid-induced Hyperalgesia in a Murine Model of Postoperative Pain: Role of Nitric Oxide Generated from the Inducible Nitric Oxide Synthase","volume":"104","author":"Maldonado","year":"2006","journal-title":"Anesthesiology"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Leal, P.D.C., and Sakata, R.K. (2014). Methods for the assessment of opioid-induced hyperalgesia in the perioperative period. Rev. Dor, 15.","DOI":"10.5935\/1806-0013.20140064"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00000542-200603000-00028","article-title":"Postoperative hyperalgesia: Its clinical importance and relevance","volume":"104","year":"2006","journal-title":"Anesthesiology"},{"key":"ref_30","first-page":"11","article-title":"Hyperalg\u00e9sie postop\u00e9ratoire. Description clinique, m\u00e9canismes et pr\u00e9vention","volume":"7","author":"Leal","year":"2006","journal-title":"Douleurs"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/bja\/aeq257","article-title":"Maintenance anaesthetics during remifentanil-based anaesthesia might affect postoperative pain control after breast cancer surgery","volume":"105","author":"Shin","year":"2010","journal-title":"Br. J. Anaesth."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/00000542-200307000-00025","article-title":"Differential Modulation of Remifentanil-Induced Analgesia and Postinfusion Hyperalgesia by S-ketamine and Clonidine in Humans","volume":"99","author":"Koppert","year":"2003","journal-title":"Anesthesiology"},{"key":"ref_33","first-page":"1533","article-title":"A negative correlation between hyperalgesia and analgesia in patients with chronic radicular pain: Is hydromorphone therapy a double-edged sword?","volume":"16","author":"Suzan","year":"2013","journal-title":"Pain Physician"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"383","DOI":"10.5055\/jom.2014.0235","article-title":"Clinical interpretation of opioid tolerance versus opioid-induced hyperalgesia","volume":"10","author":"Chen","year":"2014","journal-title":"J. Opioid Manag."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1155\/2014\/285308","article-title":"Exogenous and endogenous opioid-induced pain hypersensitivity in different rat strains","volume":"19","author":"Laboureyras","year":"2014","journal-title":"Pain Res. Manag."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s40122-018-0094-9","article-title":"A pharmacological rationale to reduce the incidence of opioid induced tolerance and hyperalgesia: A Review","volume":"7","author":"Varrassi","year":"2018","journal-title":"Pain Ther."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.3109\/15360288.2011.589490","article-title":"Pharmacological treatment of opioid-induced hyperalgesia: A review of the evidence","volume":"25","author":"Ramasubbu","year":"2011","journal-title":"J. Pain Palliat. Care Pharmacother."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1111\/j.1526-4637.2012.01467.x","article-title":"Medical and psychological risks and consequences of long-term opioid therapy in women","volume":"13","author":"Darnall","year":"2012","journal-title":"Pain Med."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/2\/27\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:31:40Z","timestamp":1760362300000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/2\/27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4,21]]},"references-count":38,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["jpm10020027"],"URL":"https:\/\/doi.org\/10.3390\/jpm10020027","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,4,21]]}}}