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This review will focus on the discoveries made using Omics and the utility of these approaches for Emery\u2013Dreifuss muscular dystrophy.<\/jats:p>","DOI":"10.3390\/jpm10020050","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T12:16:57Z","timestamp":1592223417000},"page":"50","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["An Omics View of Emery\u2013Dreifuss Muscular Dystrophy"],"prefix":"10.3390","volume":"10","author":[{"given":"Nicolas","family":"Vignier","sequence":"first","affiliation":[{"name":"INSERM, Center of Research in Myology, Institute of Myology, Sorbonne University, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4780-9275","authenticated-orcid":false,"given":"Antoine","family":"Muchir","sequence":"additional","affiliation":[{"name":"INSERM, Center of Research in Myology, Institute of Myology, Sorbonne University, 75013 Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,6,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nrg.2018.4","article-title":"Integrative omics for health and disease","volume":"19","author":"Karczewski","year":"2018","journal-title":"Nat. Rev. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Matthews, H., Hanison, J., and Nirmalan, N. (2016). \u201cOmics\u201d-Informed Drug and Biomarker Discovery: Opportunities, Challenges and Future Perspectives. Proteomes, 4.","DOI":"10.3390\/proteomes4030028"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1016\/S0140-6736(19)32910-1","article-title":"Muscular dystrophies","volume":"394","author":"Mercuri","year":"2019","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1016\/j.nmd.2019.10.010","article-title":"The 2020 version of the gene table of neuromuscular disorders (nuclear genome)","volume":"29","author":"Benarroch","year":"2019","journal-title":"Neuromuscul. Disord."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1212\/WNL.11.8.734","article-title":"Survival in x-chromosomal muscular dystrophy","volume":"11","author":"Dreifuss","year":"1961","journal-title":"Neurology"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1136\/jnnp.29.4.338","article-title":"Unusual type of benign x-linked muscular dystrophy","volume":"29","author":"Emery","year":"1966","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1399-0004.1987.tb03302.x","article-title":"X-linked muscular dystrophy with early contractures and cardiomyopathy (Emery-Dreifuss type)","volume":"32","author":"Emery","year":"1987","journal-title":"Clin. Genet."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1056\/NEJM197511132932004","article-title":"Cardiac features of an unusual X-linked humeroperoneal neuromuscular disease","volume":"293","author":"Waters","year":"1975","journal-title":"N. Engl. J. Med."},{"key":"ref_9","first-page":"411","article-title":"Progression of cardiac disease in emery-dreifuss muscular dystrophy","volume":"14","author":"Bialer","year":"1991","journal-title":"Clin. Cardiol. Int. J. Cardiovasc. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1046\/j.1460-9592.2000.01661.x","article-title":"High incidence of sudden death with conduction system and myocardial disease due to lamins A and C gene mutation","volume":"23","author":"Bonne","year":"2000","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00109-004-0589-1","article-title":"Meta-analysis of clinical characteristics of 299 carriers of LMNA gene mutations: Do lamin A\/C mutations portend a high risk of sudden death?","volume":"83","author":"Bonne","year":"2005","journal-title":"J. Mol. Med."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/ng1294-323","article-title":"Identification of a novel X-linked gene responsible for Emery-Dreifuss muscular dystrophy","volume":"8","author":"Bione","year":"1994","journal-title":"Nat. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/6799","article-title":"Mutations in the gene encoding lamin A\/C cause autosomal dominant Emery-Dreifuss muscular dystrophy","volume":"21","author":"Bonne","year":"1999","journal-title":"Nat. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/1531-8249(200008)48:2<170::AID-ANA6>3.0.CO;2-J","article-title":"Clinical and molecular genetic spectrum of autosomal dominant Emery-Dreifuss muscular dystrophy due to mutations of the lamin A\/C gene","volume":"48","author":"Bonne","year":"2000","journal-title":"Ann. Neurol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1086\/520679","article-title":"New perspectives for the elucidation of genetic disorders","volume":"81","author":"Ropers","year":"2007","journal-title":"Am. J. Hum. Genet."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1373\/clinchem.2008.112789","article-title":"Next-generation sequencing: From basic research to diagnostics","volume":"55","author":"Voelkerding","year":"2009","journal-title":"Clin. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ejhg.2013.16","article-title":"Doubly heterozygous LMNA and TTN mutations revealed by exome sequencing in a severe form of dilated cardiomyopathy","volume":"21","author":"Roncarati","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"291","DOI":"10.4070\/kcj.2016.0017","article-title":"Hereditary Dilated Cardiomyopathy: Recent Advances in Genetic Diagnostics","volume":"47","author":"Park","year":"2017","journal-title":"Korean Circ. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s11886-018-1061-0","article-title":"Genetics of Dilated Cardiomyopathy","volume":"20","author":"Fu","year":"2018","journal-title":"Curr. Cardiol. Rep."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/s41436-019-0625-8","article-title":"A genome-first approach to aggregating rare genetic variants in LMNA for association with electronic health record phenotypes","volume":"22","author":"Park","year":"2020","journal-title":"Genet. Med."},{"key":"ref_21","doi-asserted-by":"crossref","unstructured":"Meinke, P., Kerr, A.R.W., Czapiewski, R., Heras, J.I.D.L., Dixon, C.R., Harris, E., K\u00f6lbel, H., Muntoni, F., Schara, U., and Straub, V. (2020). A multistage sequencing strategy pinpoints novel candidate alleles for Emery-Dreifuss muscular dystrophy and supports gene misregulation as its pathomechanism. EBioMedicine, 51.","DOI":"10.1016\/j.ebiom.2019.11.048"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1056\/NEJM199912023412302","article-title":"Missense Mutations in the Rod Domain of the Lamin A\/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease","volume":"341","author":"Fatkin","year":"1999","journal-title":"NEJM"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1093\/hmg\/9.9.1453","article-title":"Identification of mutations in the gene encoding lamins A\/C in autosomal dominant limb girdle muscular dystrophy with atrioventricular conduction disturbances (LGMD1B)","volume":"9","author":"Muchir","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ana.21417","article-title":"De novo LMNA mutations cause a new form of congenital muscular dystrophy","volume":"64","author":"Mbieleu","year":"2008","journal-title":"Ann. Neurol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00439-010-0909-1","article-title":"Modifier locus of the skeletal muscle involvement in Emery-Dreifuss muscular dystrophy","volume":"129","author":"Granger","year":"2011","journal-title":"Hum. Genet."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.yexcr.2007.03.028","article-title":"\u201cLaminopathies\u201d: A wide spectrum of human diseases","volume":"313","author":"Worman","year":"2007","journal-title":"Exp. Cell Res."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-60327-369-5_3","article-title":"Microarray technology: Basic methodology and application in clinical research for biomarker discovery in vascular diseases","volume":"1027","author":"Raghavachari","year":"2013","journal-title":"Methods Mol. Biol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1161\/CIRCRESAHA.110.217513","article-title":"Deep mRNA sequencing for in vivo functional analysis of cardiac transcriptional regulators: Application to Galphaq","volume":"106","author":"Matkovich","year":"2010","journal-title":"Circ. Res."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1083\/jcb.147.5.913","article-title":"Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy","volume":"147","author":"Sullivan","year":"1999","journal-title":"J. Cell Biol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"463","DOI":"10.4161\/nucl.21676","article-title":"A truncated lamin A in the Lmna\u2212\/\u2212mouse line","volume":"3","author":"Jahn","year":"2012","journal-title":"Nucleus"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1093\/hmg\/ddi017","article-title":"Mouse model carrying H222P-Lmna mutation develops muscular dystrophy and dilated cardiomyopathy similar to human striated muscle laminopathies","volume":"14","author":"Arimura","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1093\/hmg\/ddr534","article-title":"DelK32-lamin A\/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death","volume":"21","author":"Bertrand","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1093\/hmg\/ddi221","article-title":"Expression of an LMNA-N195K variant of A-type lamins results in cardiac conduction defects and death in mice","volume":"14","author":"Mounkes","year":"2005","journal-title":"Hum. Mol. Genet."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/hmg\/ddi479","article-title":"Loss of emerin at the nuclear envelope disrupts the Rb1\/E2F and MyoD pathways during muscle regeneration","volume":"15","author":"Melcon","year":"2006","journal-title":"Hum. Mol. Genet."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.2353\/ajpath.2006.050564","article-title":"Emerin-lacking mice show minimal motor and cardiac dysfunctions with nuclear-associated vacuoles","volume":"168","author":"Ozawa","year":"2006","journal-title":"Am. J. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nrm.2016.8","article-title":"A decade of transcription factor-mediated reprogramming to pluripotency","volume":"17","author":"Takahashi","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.stem.2011.04.019","article-title":"Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs","volume":"8","author":"Liu","year":"2011","journal-title":"Cell Stem Cell"},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Lee, Y.-K., Lau, Y.-M., Cai, Z.-J., Lai, W.-H., Wong, L.-Y., Tse, H.-F., Ng, K.-M., and Siu, C.-W. (2017). Modeling Treatment Response for Lamin A\/C Related Dilated Cardiomyopathy in Human Induced Pluripotent Stem Cells. J. Am. Heart Assoc., 6.","DOI":"10.1161\/JAHA.117.005677"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"803","DOI":"10.18632\/aging.100503","article-title":"Modeling of lamin A\/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells","volume":"4","author":"Siu","year":"2012","journal-title":"Aging (Albany NY)"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.3389\/fphys.2018.01332","article-title":"Modeling Skeletal Muscle Laminopathies Using Human Induced Pluripotent Stem Cells Carrying Pathogenic LMNA Mutations","volume":"9","author":"Pinton","year":"2018","journal-title":"Front. Physiol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/s41467-019-09929-w","article-title":"The K219T-Lamin mutation induces conduction defects through epigenetic inhibition of SCN5A in human cardiac laminopathy","volume":"10","author":"Salvarani","year":"2019","journal-title":"Nat. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41586-019-1406-x","article-title":"Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy","volume":"572","author":"Lee","year":"2019","journal-title":"Nature"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1093\/hmg\/ddm137","article-title":"Activation of MAPK in hearts of EMD null mice: Similarities between mouse models of X-linked and autosomal dominant Emery Dreifuss muscular dystrophy","volume":"16","author":"Muchir","year":"2007","journal-title":"Hum. Mol. Genet."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1172\/JCI29042","article-title":"Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy","volume":"117","author":"Muchir","year":"2007","journal-title":"J. Clin. Investig."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"144ra102","DOI":"10.1126\/scitranslmed.3003875","article-title":"Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A\/C gene mutation","volume":"4","author":"Choi","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"4325","DOI":"10.1093\/hmg\/dds265","article-title":"Abnormal p38\u03b1 mitogen-activated protein kinase signaling in dilated cardiomyopathy caused by lamin A\/C gene mutation","volume":"21","author":"Muchir","year":"2012","journal-title":"Hum. Mol. Genet."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"2220","DOI":"10.1093\/hmg\/ddw090","article-title":"ERK1\/2 directly acts on CTGF\/CCN2 expression to mediate myocardial fibrosis in cardiomyopathy caused by mutations in the lamin A\/C gene","volume":"25","author":"Chatzifrangkeskou","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"ref_48","first-page":"333","article-title":"Decreased WNT\/\u03b2-catenin signalling contributes to the pathogenesis of dilated cardiomyopathy caused by mutations in the lamin a\/C gene","volume":"26","author":"Macquart","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/CIRCRESAHA.117.312052","article-title":"Suppression of Activated FOXO Transcription Factors in the Heart Prolongs Survival in a Mouse Model of Laminopathies","volume":"122","author":"Auguste","year":"2018","journal-title":"Circ. Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2732","DOI":"10.1242\/jcs.184150","article-title":"Deleterious assembly of the lamin A\/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy","volume":"129","author":"West","year":"2016","journal-title":"J. Cell. Sci."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1161\/CIRCRESAHA.118.314238","article-title":"DNA Damage Response\/TP53 Pathway Is Activated and Contributes to the Pathogenesis of Dilated Cardiomyopathy Associated With LMNA (Lamin A\/C) Mutations","volume":"124","author":"Chen","year":"2019","journal-title":"Circ. Res."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1172\/JCI37679","article-title":"Laminopathies and the long strange trip from basic cell biology to therapy","volume":"119","author":"Worman","year":"2009","journal-title":"J. Clin. Investig."},{"key":"ref_53","doi-asserted-by":"crossref","unstructured":"Bossone, K.A., Ellis, J.A., and Holaska, J.M. Histone acetyltransferase inhibition rescues differentiation of emerin-deficient myogenic progenitors. Muscle Nerve, 2020.","DOI":"10.1002\/mus.26892"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1016\/j.jacc.2016.08.058","article-title":"Long-Term Arrhythmic and Nonarrhythmic Outcomes of Lamin A\/C Mutation Carriers","volume":"68","author":"Kumar","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"510","DOI":"10.5966\/sctm.2013-0168","article-title":"Induced pluripotent stem cells reveal functional differences between drugs currently investigated in patients with hutchinson-gilford progeria syndrome","volume":"3","author":"Blondel","year":"2014","journal-title":"Stem Cells Transl. Med."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1101\/gad.1735208","article-title":"The A- and B-type nuclear lamin networks: Microdomains involved in chromatin organization and transcription","volume":"22","author":"Shimi","year":"2008","journal-title":"Genes Dev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"948","DOI":"10.1038\/nature06947","article-title":"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions","volume":"453","author":"Guelen","year":"2008","journal-title":"Nature"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1016\/j.cell.2012.04.035","article-title":"DNA sequence-dependent compartmentalization and silencing of chromatin at the nuclear lamina","volume":"149","author":"Zullo","year":"2012","journal-title":"Cell"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.cell.2013.01.009","article-title":"LBR and lamin A\/C sequentially tether peripheral heterochromatin and inversely regulate differentiation","volume":"152","author":"Solovei","year":"2013","journal-title":"Cell"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"335ra58","DOI":"10.1126\/scitranslmed.aad4991","article-title":"Laminopathies disrupt epigenomic developmental programs and cell fate","volume":"8","author":"Perovanovic","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1172\/JCI128161","article-title":"Dysfunctional polycomb transcriptional repression contributes to lamin A\/C-dependent muscular dystrophy","volume":"130","author":"Bianchi","year":"2020","journal-title":"J. Clin. Investig."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Mewborn, S.K., Puckelwartz, M.J., Abuisneineh, F., Fahrenbach, J.P., Zhang, Y., MacLeod, H., Dellefave, L., Pytel, P., Selig, S., and Labno, C.M. (2010). Altered Chromosomal Positioning, Compaction, and Gene Expression with a Lamin A\/C Gene Mutation. PLoS ONE, 5.","DOI":"10.1371\/journal.pone.0014342"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1161\/CIRCRESAHA.118.314177","article-title":"Genomic Reorganization of Lamin-Associated Domains in Cardiac Myocytes Is Associated With Differential Gene Expression and DNA Methylation in Human Dilated Cardiomyopathy","volume":"124","author":"Cheedipudi","year":"2019","journal-title":"Circ. Res."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1083\/jcb.201902117","article-title":"Chromatin compartment dynamics in a haploinsufficient model of cardiac laminopathy","volume":"218","author":"Bertero","year":"2019","journal-title":"J. Cell Biol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11306-016-0956-2","article-title":"A targeted metabolomics assay for cardiac metabolism and demonstration using a mouse model of dilated cardiomyopathy","volume":"12","author":"West","year":"2016","journal-title":"Metabolomics"},{"key":"ref_66","first-page":"202","article-title":"Improvement in cardiac energetics by perhexiline in heart failure due to dilated cardiomyopathy","volume":"3","author":"Beadle","year":"2015","journal-title":"J. Am. Coll. Cardiol. Heart Fail."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1161\/CIRCULATIONAHA.108.778019","article-title":"Trimetazidine, a metabolic modulator, has cardiac and extracardiac benefits in idiopathic dilated cardiomyopathy","volume":"118","author":"Tuunanen","year":"2008","journal-title":"Circulation"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1093\/hmg\/ddy243","article-title":"N-acetyl cysteine alleviates oxidative stress and protects mice from dilated cardiomyopathy caused by mutations in nucelar A-type lamins gene","volume":"27","author":"Khouzami","year":"2018","journal-title":"Hum. Mol. Genet."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Olivier, M., Asmis, R., Hawkins, G.A., Howard, T.D., and Cox, L.A. (2019). The Need for Multi-Omics Biomarker Signatures in Precision Medicine. Int. J. Mol. Sci., 20.","DOI":"10.3390\/ijms20194781"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1080\/14789450.2018.1429923","article-title":"Proteomic serum biomarkers for neuromuscular diseases","volume":"15","author":"Murphy","year":"2018","journal-title":"Expert Rev. Proteom."},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Vignier, N., Amor, F., Fogel, P., Duvallet, A., Poupiot, J., Charrier, S., Arock, M., Montus, M., Nelson, I., and Richard, I. (2013). Distinctive Serum miRNA Profile in Mouse Models of Striated Muscular Pathologies. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0055281"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/2\/50\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T09:39:07Z","timestamp":1760175547000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/2\/50"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,15]]},"references-count":71,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,6]]}},"alternative-id":["jpm10020050"],"URL":"https:\/\/doi.org\/10.3390\/jpm10020050","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,15]]}}}