{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:32:05Z","timestamp":1789515125411,"version":"build-2803163510"},"reference-count":39,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,7,25]],"date-time":"2020-07-25T00:00:00Z","timestamp":1595635200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-315-90061"],"award-info":[{"award-number":["19-315-90061"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study aims to establish relationships between inflammatory status, ferrokinetics and lipid metabolism in patients with diabetes mellitus. Subclinical inflammation was assessed by levels of high-sensitive C-reactive protein, tumor necrosis factor-\u03b1 and erythrocyte sedimentation rate. Iron metabolism parameters included complete blood count, serum iron, transferrin and ferritin. Metabolic status assessment included lipid profile, glycated hemoglobin and microalbuminuria measurement. As a result of the study it was possible to establish both general (universal) and diabetes mellitus (DM) type-dependent relationships between the parameters of lipid profile and metabolic control in DM. High-density lipoprotein cholesterol (HDL-C) levels negatively correlated with microalbuminuria (r = \u22120.293; p \u02c2 0.05 for type 1 diabetes and r = \u22120.272; p \u02c2 0.05 for type 2 diabetes). Ferritin concentration positively correlated with triglyceride level (r = 0.346; p \u02c2 0.05 for type 1 diabetes and r = 0.244; p \u02c2 0.05 for type 2 diabetes). In type 1 diabetes, a negative correlation was discovered between estimated glomerular filtration rate (eGFR) and LDL-C (r = \u22120.480; p \u02c2 0.05), very low-density-lipoprotein cholesterol (VLDL-C) (r = \u22120.490; p \u02c2 0.05) and triglycerides (r = \u22120.553; p \u02c2 0.05), and a positive one between C-reactive protein concentration and triglyceride level (r = 0.567; p \u02c2 0.05). Discovered relationships between lipid profile indices, inflammatory status and microalbuminuria confirmed mutual influence of hyperlipidemia, inflammation and nephropathy in diabetes patients. Obtained results justify the strategy of early hypolipidemic therapy in patients with diabetes mellitus to prevent the development and progression of microvascular complications.<\/jats:p>","DOI":"10.3390\/jpm10030070","type":"journal-article","created":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T04:39:50Z","timestamp":1595824790000},"page":"70","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Correlations between Iron Metabolism Parameters, Inflammatory Markers and Lipid Profile Indicators in Patients with Type 1 and Type 2 Diabetes Mellitus"],"prefix":"10.3390","volume":"10","author":[{"given":"Nadezhda","family":"N. Musina","sequence":"first","affiliation":[{"name":"Siberian State Medical University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"V. Saprina","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"S. Prokhorenko","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, 634050 Tomsk, Russia"},{"name":"Tomsk Regional Blood Center, 634034 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9612-8815","authenticated-orcid":false,"given":"Alexander","family":"Kanev","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"P. Zima","sequence":"additional","affiliation":[{"name":"Siberian State Medical University, 634050 Tomsk, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s12013-007-0029-2","article-title":"Roles of cytokines in the pathogenesis and therapy of type 1 diabetes","volume":"48","author":"Rabinovitch","year":"2007","journal-title":"Cell Biophys."},{"key":"ref_2","first-page":"415","article-title":"Compartmentalization of TNF Receptor 1 Signaling","volume":"21","author":"Tchikov","year":"2004","journal-title":"Immunity"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1007\/s00125-006-0569-9","article-title":"Macrophages and dendritic cells infiltrating islets with or without beta cells produce tumour necrosis factor-\u03b1 in patients with recent-onset type 1 diabetes","volume":"50","author":"Uno","year":"2007","journal-title":"Diabetologia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"295","DOI":"10.14341\/DM7928","article-title":"Clinical and metabolic factors associated with chronic low-grade inflammation in type 2 diabetic patients","volume":"19","author":"Klimontov","year":"2016","journal-title":"Diabetes Mellit."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2016\/2543268","article-title":"Analysis of Inflammatory Mediators in Prediabetes and Newly Diagnosed Type 2 Diabetes Patients","volume":"2016","author":"Wang","year":"2016","journal-title":"J. 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