{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T13:12:24Z","timestamp":1770556344880,"version":"3.49.0"},"reference-count":13,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study examines the IGF serum profile (IGF-1, IGFBP-3 and the IGF Ratio) from 1633 women who undertook an Assessment Cycle prior to any treatment by assisted reproduction. The idea is to progressively study the IGF profile with a view to identify those women who may be classified as having adult growth hormone deficiency (AGHD) and who may benefit from specific dynamic endocrinological testing to identify a potential benefit from growth hormone adjuvant treatment. This first study evaluates the IGF profile on clinical parameters, namely age, body mass index (BMI) and stature. The study shows a significant linear reduction in IGF-1 levels across the four age groups (&lt;35 years, 35\u201339 years, 40\u201344 years and \u226545 years; p &lt; 0.001). However, there was no variation in IGFBP-3 levels but the IGF Ratio showed a progressive linear elevation with advancing age (p &lt; 0.001). With respect to both BMI and stature, none of the IGF profile parameters showed any variation. We conclude that further studies are warranted to examine the notion of underlying AGHD in the causation of the well-known feature of age-related poor prognosis in assisted reproduction.<\/jats:p>","DOI":"10.3390\/jpm10030122","type":"journal-article","created":{"date-parts":[[2020,9,13]],"date-time":"2020-09-13T21:11:32Z","timestamp":1600031492000},"page":"122","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Measuring IGF-1 and IGFBP-3 Profiles in Women Seeking Assisted Reproduction; Relationship to Clinical Parameters (Study 1)"],"prefix":"10.3390","volume":"10","author":[{"given":"John L.","family":"Yovich","sequence":"first","affiliation":[{"name":"PIVET Medical Centre, Perth 6007, WA, Australia"},{"name":"Department of Pharmacy and Biomedical Sciences, Curtin University, Perth 6845, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syeda","family":"Zaidi","sequence":"additional","affiliation":[{"name":"PIVET Medical Centre, Perth 6007, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minh D. K.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"PIVET Medical Centre, Perth 6007, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter M.","family":"Hinchliffe","sequence":"additional","affiliation":[{"name":"PIVET Medical Centre, Perth 6007, WA, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.repbio.2018.11.004","article-title":"Founding Pioneers of IVF: Independent innovative researchers generating livebirths within 4 years of the first birth","volume":"18","author":"Yovich","year":"2018","journal-title":"Reprod. Biol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.repbio.2019.12.008","article-title":"Founding pioneers of IVF update: Innovative researchers generating livebirths by 1982","volume":"20","author":"Yovich","year":"2020","journal-title":"Reprod. Biol."},{"key":"ref_3","unstructured":"Duncan, W.C., Picton, H.M., Nelson, S.M., Tal, R., Seifer, D., Ho, J., Paulson, R.J., Griesinger, G., Kolibianakis, E., and Howles, C.M. (2019). How to Prepare the Egg and Embryo to Maximize IVF Success, Cambridge University Press (CUP)."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"10-4172","DOI":"10.4172\/2375-4508.1000165","article-title":"Cumulative Live Birth Rate: An Outmoded Term","volume":"4","author":"Yovich","year":"2016","journal-title":"JFIV Reprod. Med. 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Steril."},{"key":"ref_11","first-page":"5","article-title":"Low and Normal IGF-1 Levels in Patients with Chronic Medical Disorders(CMD) is Independent of Anterior Pituitary Hormone Deficiencies: Implications for Treating IGF-1 Abnormal Deficiencies with CMD","volume":"4","author":"Braverman","year":"2013","journal-title":"J. Genet. Syndr. Gene Ther."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s10815-011-9543-7","article-title":"The effect of intrafollicular IGF 1 and IGFBP 3 on IVF outcome in patients using different gonadotropins: A prospective study","volume":"28","author":"Genc","year":"2011","journal-title":"J. Assist. Reprod. Genet."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.fertnstert.2020.02.111","article-title":"Cycle day 2 insulin-like growth factor-1 serum levels as a prognostic tool to predict controlled ovarian hyperstimulation outcomes in poor responders","volume":"113","author":"Man","year":"2020","journal-title":"Fertil. 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