{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T03:37:14Z","timestamp":1780371434912,"version":"3.54.1"},"reference-count":93,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T00:00:00Z","timestamp":1605830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19-015-00458"],"award-info":[{"award-number":["19-015-00458"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The budget topic in state assignment","award":["\u0410\u0410\u0410\u0410-\u041019-119100990053-4"],"award-info":[{"award-number":["\u0410\u0410\u0410\u0410-\u041019-119100990053-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The present review deals with the stages of creation, methods of calculation, and the use of a genetic risk score for coronary heart disease in various populations. The concept of risk factors is generally recognized on the basis of the results of epidemiological studies in the 20th century; according to this concept, the high prevalence of diseases of the circulatory system is due to lifestyle characteristics and associated risk factors. An important and relevant task for the healthcare system is to identify the population segments most susceptible to cardiovascular diseases (CVDs). The level of individual risk of an unfavorable cardiovascular prognosis is determined by genetic factors in addition to lifestyle factors.<\/jats:p>","DOI":"10.3390\/jpm10040239","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T02:09:07Z","timestamp":1605838147000},"page":"239","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetic Risk Score for Coronary Heart Disease: Review"],"prefix":"10.3390","volume":"10","author":[{"given":"Sergey","family":"Semaev","sequence":"first","affiliation":[{"name":"Institute of Internal and Preventive Medicine\u2014Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Bogatkova Str. 175\/1, Novosibirsk 630089, Russia"},{"name":"Federal Research Center Institute of Cytology and Genetics, SB RAS, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6108-1025","authenticated-orcid":false,"given":"Elena","family":"Shakhtshneider","sequence":"additional","affiliation":[{"name":"Institute of Internal and Preventive Medicine\u2014Branch of Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (SB RAS), Bogatkova Str. 175\/1, Novosibirsk 630089, Russia"},{"name":"Federal Research Center Institute of Cytology and Genetics, SB RAS, Prospekt Lavrentyeva 10, Novosibirsk 630090, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"ref_1","unstructured":"World Health Organization (2020, October 02). Cardiovascular Diseases (CVDs). Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/cardiovascular-diseases-(cvds)."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1093\/eurheartj\/ehn018","article-title":"Risk factors for myocardial infarction in women and men: In sights from the INTERHEART study","volume":"29","author":"Anand","year":"2008","journal-title":"Eur. Heart J."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1056\/NEJMoa1605086","article-title":"Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease","volume":"375","author":"Khera","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/S0140-6736(10)61267-6","article-title":"A multilocus genetic risk score for coronary heart disease: Case-control and prospective cohort analyses","volume":"376","author":"Ripatti","year":"2010","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1161\/CIRCGENETICS.111.961342","article-title":"A genetic risk score is associated with incident cardiovascular disease and coronary artery calcium: The Framingham Heart Study","volume":"5","author":"Thanassoulis","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.atherosclerosis.2012.05.035","article-title":"A genetic risk score based on direct associations with coronary heart disease improves coronary heart disease risk prediction in the Atherosclerosis Risk in Communities (ARIC), but not in the Rotterdam and Framingham Offspring, Studies","volume":"223","author":"Brautbar","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1016\/S0140-6736(14)61730-X","article-title":"Genetic risk, coronary heart disease events, and the clinical benefit of statin therapy: An analysis of primary and secondary prevention trials","volume":"385","author":"Mega","year":"2015","journal-title":"Lancet"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/eurheartj\/ehv462","article-title":"Risk prediction by genetic risk scores for coronary heart disease is independent of self-reported family history","volume":"37","author":"Tada","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_9","first-page":"12","article-title":"A panel of genetic markers for analyzing the risk of long-term adverse prognosis of cardiovascular diseases","volume":"14","author":"Shakhtshneider","year":"2018","journal-title":"Ateroscleroz"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1097\/HJR.0b013e328322c760","article-title":"Fewer deaths from cardiovascular disease than expected from the Systematic Coronary Risk Evaluation chart in a Swedish population","volume":"16","author":"Stenlund","year":"2009","journal-title":"Eur. J. Cardiovasc. Prev. Rehabil."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.amjcard.2004.03.023","article-title":"Framingham risk score and prediction of lifetime risk for coronary heart disease","volume":"94","author":"Wilson","year":"2004","journal-title":"Am. J. Cardiol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1001\/jama.286.2.180","article-title":"Validation of the Framingham coronary heart disease prediction scores: Results of a multiple ethnic groups investigation","volume":"286","author":"Grundy","year":"2001","journal-title":"JAMA"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1136\/jech.2005.044842","article-title":"Cardiovascular risk prediction tools for populations in Asia","volume":"61","author":"Barzi","year":"2007","journal-title":"J. Epidemiol. Community Health"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1136\/bmj.327.7426.1267","article-title":"Predictive accuracy of the Framingham coronary risk score in British men: Prospective cohort study","volume":"327","author":"Brindle","year":"2003","journal-title":"BMJ"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0195-668X(03)00081-2","article-title":"Framingham risk function overestimates risk of coronary heart disease in men and women from Germany\u2014Results from the MONICA Augsburg and the PROCAM cohorts","volume":"24","author":"Hense","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: The SCORE project","volume":"24","author":"Conroy","year":"2003","journal-title":"Eur. Heart J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"54","DOI":"10.20996\/1819-6446-2005-1-3-54-56","article-title":"Assessment of cumulative risk of cardio-vascular diseases","volume":"1","author":"Shalnova","year":"2005","journal-title":"Ration. Pharmacother. Cardiol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study","volume":"105","author":"Assmann","year":"2002","journal-title":"Circulation"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1046\/j.1469-1809.2005.00155.x","article-title":"Generating genetic risk scores from intermediate phenotypes for use in association studies of clinically significant endpoints","volume":"69","author":"Horne","year":"2005","journal-title":"Ann. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/aje\/kwm060","article-title":"Prediction of coronary heart disease risk using a genetic risk score: The Atherosclerosis Risk in Communities Study","volume":"166","author":"Morrison","year":"2007","journal-title":"Am. J. Epidemiol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1056\/NEJMoa0706728","article-title":"Polymorphisms associated with cholesterol and risk of cardiovascular events","volume":"358","author":"Kathiresan","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.numecd.2009.03.016","article-title":"A composite scoring of genotypes discriminates coronary heart disease risk beyond conventional risk factors in the Boston Puerto Rican Health Study","volume":"20","author":"Junyent","year":"2010","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"ref_24","first-page":"925","article-title":"Additive effect of multiple genetic variants on the risk of coronary artery disease","volume":"63","author":"Lucas","year":"2010","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.ahj.2010.05.031","article-title":"Joint effects of common genetic variants from multiple genes and pathways on the risk of premature coronary artery disease","volume":"160","author":"Anderson","year":"2010","journal-title":"Am. Heart J."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1161\/CIRCULATIONAHA.110.976613","article-title":"A Genetic Risk Score and Risk of Myocardial Infarction in Hispanics","volume":"123","author":"Qi","year":"2011","journal-title":"Circulation"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.atherosclerosis.2012.02.033","article-title":"Genetic predisposition to coronary heart disease and stroke using an additive genetic risk score: A population-based study in Greece","volume":"222","author":"Yiannakouris","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1253\/circj.CJ-12-0156","article-title":"Joint effects of genetic variants in multiple loci on the risk of coronary artery disease in Chinese Han subjects","volume":"76","author":"Lv","year":"2012","journal-title":"Circ. J."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.atherosclerosis.2012.03.024","article-title":"Assessment of the value of a genetic risk score in improving the estimation of coronary risk","volume":"222","author":"Subirana","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Hughes, M.F., Saarela, O., Stritzke, J., Kee, F., Silander, K., Klopp, N., Kontto, J., Karvanen, J., Willenborg, C., and Salomaa, V. (2012). Genetic markers enhance coronary risk prediction in men: The MORGAM prospective cohorts. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0040922"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1161\/CIRCGENETICS.111.960229","article-title":"Association of a genetic risk score with prevalent and incident myocardial infarction in subjects undergoing coronary angiography","volume":"5","author":"Patel","year":"2012","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1161\/ATVBAHA.113.301236","article-title":"Risk scores of common genetic variants for lipid levels influence atherosclerosis and incident coronary heart disease","volume":"33","author":"Isaacs","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1161\/ATVBAHA.113.301218","article-title":"Multilocus genetic risk scores for coronary heart disease prediction","volume":"33","author":"Ganna","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2261","DOI":"10.1161\/ATVBAHA.112.301120","article-title":"Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease","volume":"33","author":"Tikkanen","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"e004387","DOI":"10.1136\/bmjopen-2013-004387","article-title":"Additive influence of genetic predisposition and conventional risk factors in the incidence of coronary heart disease: A population-based study in Greece","volume":"4","author":"Yiannakouris","year":"2014","journal-title":"BMJ Open"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.atherosclerosis.2014.09.032","article-title":"A multilocus genetic risk score predicts coronary heart disease risk in a Chinese Han population","volume":"237","author":"Gui","year":"2014","journal-title":"Atherosclerosis"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1093\/ije\/dyv070","article-title":"Incremental predictive value of 152 single nucleotide polymorphisms in the 10-year risk prediction of incident coronary heart disease: The Rotterdam Study","volume":"44","author":"Kavousi","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.atherosclerosis.2015.03.022","article-title":"A genetic risk score of 45 coronary artery disease risk variants associates with increased risk of myocardial infarction in 6041 Danish individuals","volume":"240","author":"Krarup","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Beaney, K.E., Cooper, J.A., Shahid, S.U., Ahmed, W., Qamar, R., Drenos, F., Crockard, M.A., and Humphries, S.E. (2015). Clinical Utility of a Coronary Heart Disease Risk Prediction Gene Score in UK Healthy Middle Aged Men and in the Pakistani Population. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0139651"},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Look AHEAD Research Group (2015). Prospective association of a genetic risk score and lifestyle intervention with cardiovascular morbidity and mortality among individuals with type 2 diabetes: The Look AHEAD randomised controlled trial. Diabetologia, 58, 1803\u20131813.","DOI":"10.1007\/s00125-015-3610-z"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1001\/jama.2010.119","article-title":"Association between a literature-based genetic risk score and cardiovascular events in women","volume":"303","author":"Paynter","year":"2010","journal-title":"JAMA"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.atherosclerosis.2015.07.029","article-title":"Utility of a genetic risk score to predict recurrent cardiovascular events 1 year after an acute coronary syndrome: A pooled analysis of the RISCA, PRAXY, and TRIUMPH cohorts","volume":"242","author":"Labos","year":"2015","journal-title":"Atherosclerosis"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00592-015-0720-5","article-title":"Analysis of a cardiovascular disease genetic risk score in the Diabetes Heart Study","volume":"52","author":"Raffield","year":"2015","journal-title":"Acta Diabetol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"513","DOI":"10.2307\/2530355","article-title":"On the use of repeated measurements in regression analysis with dichotomous response","volume":"35","author":"Wu","year":"1979","journal-title":"Biometrics"},{"key":"ref_45","unstructured":"Kalbfleisch, J., and Prentice, R. (1980). The Statistical Analysis of Failure Time Data, John Wiley & Sons, Inc."},{"key":"ref_46","unstructured":"Cox, D.R., and Oakes, D. (1984). Analysis of Survival Data, Chapman and Hall."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1002\/sim.4780091214","article-title":"Relation of pooled logistic regression to time dependent Cox regression analysis: The Framingham Heart Study","volume":"9","author":"Lee","year":"1990","journal-title":"Stat. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0022-2496(75)90001-2","article-title":"The area above the ordinal dominance graph and the area below the receiver operating characteristic graph","volume":"12","author":"Bamber","year":"1975","journal-title":"J. Math. Psychol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1148\/radiology.143.1.7063747","article-title":"The meaning and use of the area under a receiver operating characteristic (ROC) curve","volume":"143","author":"Hanley","year":"1982","journal-title":"Radiology"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1177\/0272989X9701700111","article-title":"A comparison of parametric and nonparametric approaches to ROC analysis of quantitative diagnostic tests","volume":"17","author":"Hanley","year":"1997","journal-title":"Med. Decis. Mak."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/sim.2929","article-title":"Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond","volume":"27","author":"Pencina","year":"2008","journal-title":"Stat. Med."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.atherosclerosis.2015.10.104","article-title":"Association between parental history and genetic risk scores for coronary heart disease prediction: The population-based CoLaus study","volume":"244","author":"Antiochos","year":"2016","journal-title":"Atherosclerosis"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1161\/CIRCGENETICS.115.001271","article-title":"Genetic Risk Scores Predict Recurrence of Acute Coronary Syndrome","volume":"9","author":"Vaara","year":"2016","journal-title":"Circ. Cardiovasc. Genet."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1161\/ATVBAHA.115.306944","article-title":"Association between Family History, a Genetic Risk Score, and Severity of Coronary Artery Disease in Patients with Premature Acute Coronary Syndromes","volume":"36","author":"Hindieh","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/j.cjca.2016.01.004","article-title":"Influence of Genetic Risk Factors on Coronary Heart Disease Occurrence in Afro-Caribbeans","volume":"32","author":"Larifla","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1093\/eurheartj\/ehw450","article-title":"Genomic prediction of coronary heart disease","volume":"37","author":"Abraham","year":"2016","journal-title":"Eur. Heart J."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.cjca.2016.05.014","article-title":"Impact of a Genetic Risk Score on Myocardial Infarction Risk across Different Ethnic Populations","volume":"32","author":"Joseph","year":"2016","journal-title":"Can. J. Cardiol."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"e004067","DOI":"10.1161\/JAHA.116.004067","article-title":"Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic\/Latino Adults Living in Costa Rica","volume":"5","author":"Baylin","year":"2016","journal-title":"J. Am. Heart Assoc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.atherosclerosis.2017.01.010","article-title":"A 45-SNP genetic risk score is increased in early-onset coronary artery disease but independent of familial disease clustering","volume":"257","author":"Christiansen","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.ijcard.2017.04.045","article-title":"A genetic risk score predicts cardiovascular events in patients with stable coronary artery disease","volume":"241","author":"Christiansen","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2017.01.024","article-title":"Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants","volume":"258","author":"Shahid","year":"2017","journal-title":"Atherosclerosis"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"e005254","DOI":"10.1161\/JAHA.116.005254","article-title":"Metabolic Mediators of the Effects of Family History and Genetic Risk Score on Coronary Heart Disease-Findings from the Malm\u00f6 Diet and Cancer Study","volume":"6","author":"Fritz","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Svensson, T., Kitlinski, M., Engstr\u00f6m, G., and Melander, O. (2017). A genetic risk score for CAD, psychological stress, and their interaction as predictors of CAD, fatal MI, non-fatal MI and cardiovascular death. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0176029"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/S0140-6736(03)12948-0","article-title":"Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial\u2013Lipid Lowering Arm (ASCOT-LLA): A multicentre randomised controlled trial","volume":"361","author":"Sever","year":"2003","journal-title":"Lancet"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1056\/NEJMoa0807646","article-title":"Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein","volume":"359","author":"Ridker","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1161\/CIRCULATIONAHA.116.024436","article-title":"Polygenic Risk Score Identifies Subgroup with Higher Burden of Atherosclerosis and Greater Relative Benefit from Statin Therapy in the Primary Prevention Setting","volume":"135","author":"Natarajan","year":"2017","journal-title":"Circulation"},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.jacl.2017.03.019","article-title":"Polygenic risk score predicts prevalence of cardiovascular disease in patients with familial hypercholesterolemia","volume":"11","author":"Paquette","year":"2017","journal-title":"J. Clin. Lipidol."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Pereira, A., Mendonca, M.I., Sousa, A.C., Borges, S., Freitas, S., Henriques, E., Rodrigues, M., Freitas, A.I., Guerra, G., and Ornelas, I. (2017). Genetic risk score and cardiovascular mortality in a southern european population with coronary artery disease. Int. J. Clin. Pract., 71.","DOI":"10.1111\/ijcp.12956"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"e9473","DOI":"10.1097\/MD.0000000000009473","article-title":"Prospective association of a genetic risk score with major adverse cardiovascular events in patients with coronary artery disease","volume":"96","author":"Zhao","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1590\/1678-4685-gmb-2017-0173","article-title":"Additional value of a combined genetic risk score to standard cardiovascular stratification","volume":"41","author":"Pereira","year":"2018","journal-title":"Genet. Mol. Biol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/j.jacc.2016.05.089","article-title":"Left Main Coronary Artery Disease: Secular Trends in Patient Characteristics, Treatments, and Outcomes","volume":"68","author":"Lee","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"2432","DOI":"10.1093\/eurheartj\/ehm377","article-title":"Familial aggregation of left main coronary artery disease and future risk of coronary events in asymptomatic siblings of affected patients","volume":"28","author":"Fischer","year":"2007","journal-title":"Eur. Heart J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/01.CIR.0000155611.41961.BB","article-title":"Distinct heritable patterns of angiographic coronary artery disease in families with myocardial infarction","volume":"111","author":"Fischer","year":"2005","journal-title":"Circulation"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"8610368","DOI":"10.1155\/2018\/8610368","article-title":"Association between a Genetic Risk Score Based on Single Nucleotide Polymorphisms of Coronary Artery Disease-Related Genes and Left Main Coronary Artery Disease","volume":"2018","author":"Xu","year":"2018","journal-title":"BioMed Res. Int."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.jacc.2018.07.079","article-title":"Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention","volume":"72","author":"Inouye","year":"2018","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12944-018-0874-6","article-title":"Genetic risk score (GRS) constructed from polymorphisms in the PON1, IL-6, ITGB3, and ALDH2 genes is associated with the risk of coronary artery disease in Pakistani subjects","volume":"17","author":"Shabana","year":"2018","journal-title":"Lipids Health Dis."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/s41598-018-25128-x","article-title":"Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry","volume":"8","author":"Iribarren","year":"2018","journal-title":"Sci. Rep."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1161\/CIRCULATIONAHA.113.004046","article-title":"The global burden of ischemic heart disease in 1990 and 2010: The Global Burden of Disease 2010 study","volume":"129","author":"Moran","year":"2014","journal-title":"Circulation"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1307S","DOI":"10.1093\/ajcn\/72.5.1307s","article-title":"Origin of atherosclerosis in childhood and adolescence","volume":"72","author":"McGill","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"114","DOI":"10.12688\/wellcomeopenres.14788.2","article-title":"Coronary artery disease, genetic risk and the metabolome in young individuals","volume":"3","author":"Battram","year":"2019","journal-title":"Wellcome Open Res."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cjco.2019.01.003","article-title":"Clinical Utility and Practical Considerations of a Coronary Artery Disease Genetic Risk Score","volume":"1","author":"Liu","year":"2019","journal-title":"CJC Open"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2932","DOI":"10.1016\/j.jacc.2019.03.512","article-title":"Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases","volume":"73","author":"Ntalla","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_83","first-page":"100391","article-title":"Polygenetic risk for coronary artery disease increases hospitalization burden and mortality","volume":"24","author":"Almgren","year":"2019","journal-title":"Int. J. Cardiol. Heart Vasc."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/CIRCRESAHA.117.312086","article-title":"Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease","volume":"122","author":"Verweij","year":"2018","journal-title":"Circ. Res."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jcct.2019.05.005","article-title":"Using a genetic risk score to calculate the optimal age for an individual to undergo coronary artery calcium screening","volume":"13","author":"Severance","year":"2019","journal-title":"J. Cardiovasc. Comput. Tomogr."},{"key":"ref_86","first-page":"623","article-title":"A genetic risk score predicts recurrent events after myocardial infarction in young adults","volume":"73","author":"Alonso","year":"2020","journal-title":"Rev. Esp. Cardiol. (Engl. Ed.)"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/cge.13648","article-title":"A genetic risk score predicts coronary artery disease in familial hypercholesterolaemia: Enhancing the precision of risk assessment","volume":"97","author":"Ellis","year":"2020","journal-title":"Clin. Genet."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.resuscitation.2019.11.005","article-title":"Risk prediction of future cardiac arrest by evaluation of a genetic risk score alone and in combination with traditional risk factors","volume":"146","author":"Ohlsson","year":"2020","journal-title":"Resuscitation"},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1001\/jama.2019.21782","article-title":"Predictive Accuracy of a Polygenic Risk Score Compared with a Clinical Risk Score for Incident Coronary Heart Disease","volume":"323","author":"Mosley","year":"2020","journal-title":"JAMA"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/jama.2019.22241","article-title":"Predictive Accuracy of a Polygenic Risk Score-Enhanced Prediction Model vs. a Clinical Risk Score for Coronary Artery Disease","volume":"323","author":"Elliott","year":"2020","journal-title":"JAMA"},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1093\/hmg\/ddaa025","article-title":"Genetic predisposition to coronary artery disease is predictive of recurrent events: A Chinese prospective cohort study","volume":"29","author":"Jiang","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1080\/14737159.2017.1368388","article-title":"How close are we to implementing a genetic risk score for coronary heart disease?","volume":"17","author":"Beaney","year":"2017","journal-title":"Expert Rev. Mol. Diagn."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric Estimation from Incomplete Observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J. Am. Stat. 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