{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:15:39Z","timestamp":1792613739086,"version":"4.5.0"},"reference-count":141,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Considerable interest has arisen concerning the relationship between hereditary connective tissue disorders such as the Ehlers-Danlos syndromes (EDS)\/hypermobility spectrum disorders (HSD) and autism, both in terms of their comorbidity as well as co-occurrence within the same families. This paper reviews our current state of knowledge, as well as highlighting unanswered questions concerning this remarkable patient group, which we hope will attract further scientific interest in coming years. In particular, patients themselves are demanding more research into this growing area of interest, although science has been slow to answer that call. Here, we address the overlap between these two spectrum conditions, including neurobehavioral, psychiatric, and neurological commonalities, shared peripheral neuropathies and neuropathologies, and similar autonomic and immune dysregulation. Together, these data highlight the potential relatedness of these two conditions and suggest that EDS\/HSD may represent a subtype of autism.<\/jats:p>","DOI":"10.3390\/jpm10040260","type":"journal-article","created":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T13:08:51Z","timestamp":1606828131000},"page":"260","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":107,"title":["The Relationship between Autism and Ehlers-Danlos Syndromes\/Hypermobility Spectrum Disorders"],"prefix":"10.3390","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5129-6698","authenticated-orcid":false,"given":"Emily L.","family":"Casanova","sequence":"first","affiliation":[{"name":"School of Medicine Greenville, University of South Carolina, Greenville, SC 29615, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Baeza-Velasco","sequence":"additional","affiliation":[{"name":"Laboratory of Psychopathology and Health Processes, University of Paris, 92100 Boulogne Billancourt, France"},{"name":"Department of Emergency Psychiatry and Acute Care, CHU Montpellier, 34000 Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline B.","family":"Buchanan","sequence":"additional","affiliation":[{"name":"Greenwood Genetic Center, Greenville, SC 29605, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3874-844X","authenticated-orcid":false,"given":"Manuel F.","family":"Casanova","sequence":"additional","affiliation":[{"name":"School of Medicine Greenville, University of South Carolina, Greenville, SC 29615, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, University of Louisville, Louisville, KY 40292, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,12,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/ng.3863","article-title":"Polygenic transmission disequilibrium confirms that common and rare variation act additively to create risk for autism spectrum disorders","volume":"49","author":"Weiner","year":"2017","journal-title":"Nat. Genet."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2040-2392-3-9","article-title":"Common genetic variants, acting additively, are a major source of risk for autism","volume":"3","author":"Klei","year":"2012","journal-title":"Mol. Autism"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1097\/WCO.0b013e328336a01f","article-title":"Contributions of the environment and environmentally vulnerable physiology to autism spectrum disorders","volume":"23","author":"Herbert","year":"2010","journal-title":"Curr. Opin. Neurol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3389\/fpsyt.2014.00053","article-title":"Gene x environment interactions in autism spectrum disorders: Role of epigenetic mechanisms","volume":"5","author":"Tordjman","year":"2014","journal-title":"Front. Psychiatry"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.neuron.2013.01.010","article-title":"Rare inherited variation in autism: Beginning to see the forest and a few trees","volume":"77","author":"Stein","year":"2013","journal-title":"Neuron"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.3389\/fpsyt.2018.00535","article-title":"Widespread genotype-phenotype correlations in intellectual disability","volume":"9","author":"Casanova","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10803-010-1125-5","article-title":"Delineation of behavioral phenotypes in genetic syndromes: Characteristics of autism spectrum disorder, affect and hyperactivity","volume":"41","author":"Oliver","year":"2011","journal-title":"J. Autism Dev. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/ajmg.a.33779","article-title":"Incidence and natural history of mucopolysaccharidosis type III in France and comparison with United Kingdom and Greece","volume":"155","author":"Mikaeloff","year":"2011","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/00041444-200106000-00001","article-title":"Chromosomal abnormalities in a clinic sample of individuals with autistic disorder","volume":"11","author":"Wassink","year":"2001","journal-title":"Psychiatr. Genet."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1136\/jmg.2006.043166","article-title":"Array-based comparative genomic hybridization identifies high frequency of cryptic chromosomal rearrangements in patients with syndromic autism spectrum disorders","volume":"43","author":"Jacquemont","year":"2006","journal-title":"J. Med. Genet."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.tig.2020.01.005","article-title":"Genetic variation across phenotypic severity of autism","volume":"36","author":"Toma","year":"2020","journal-title":"Trends Genet."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Nayar, K., Sealock, J.M., Maltman, N., Bush, L., Cook, E.H., Davis, L.K., and Losh, M. (2020). Elevated polygenic burden for ASD is associated with the broad autism phenotype in mothers of individuals with ASD. Biol. Psychiatry, in press.","DOI":"10.1101\/838375"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1002\/ajmg.c.31552","article-title":"The 2017 international classification of the Ehlers-Danlos syndromes","volume":"175","author":"Malfait","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41572-020-0194-9","article-title":"The Ehlers-Danlos syndromes","volume":"6","author":"Malfait","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1002\/ajmg.c.31538","article-title":"Hypermobile Ehlers-Danlos syndrome (aka Ehlers-Danlos syndrome type III and Ehlers-Danlos syndrome hypermobility type): Clinical description and natural history","volume":"175","author":"Tinkle","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_16","first-page":"82","article-title":"Immune, autonomic, and endocrine dysregulation in autism and Ehlers-Danlos syndrome\/hypermobility spectrum disorders versus unaffected controls","volume":"2","author":"Casanova","year":"2020","journal-title":"J. Reatt. Ther. Dev. Divers."},{"key":"ref_17","unstructured":"The Ehlers-Danlos Society (2020, September 25). Hypermobile Ehlers-Danlos Genetic Evaluation (HEDGE) Study. Available online: https:\/\/www.ehlers-danlos.com\/hedge\/."},{"key":"ref_18","first-page":"1722","article-title":"Severity classes in adults with hypermobile Ehlers-Danlos syndrome\/hypermobility spectrum disorders: A pilot study of 105 Italian patients","volume":"58","author":"Copetti","year":"2019","journal-title":"Rheumatology"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2368","DOI":"10.1002\/ajmg.a.33070","article-title":"The lack of clinical distinction between the hypermobility type of Ehlers-Danlos syndrome and the joint hypermobility syndrome (a.k.a. hypermobility syndrome)","volume":"149","author":"Tinkle","year":"2009","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"3010","DOI":"10.1002\/ajmg.a.36805","article-title":"Nosology and inheritance pattern(s) of joint hypermobility syndrome and Ehlers-Danlos syndrome, hypermobility type: A study of intrafamilial and interfamilial variability in 23 Italian pedigrees","volume":"164","author":"Castori","year":"2014","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_21","first-page":"259","article-title":"Early infantile autism and excessive aerophagy with symptomatic megacolon and ileus in a case of Ehlers-Danlos syndrome","volume":"31","author":"Fehlow","year":"1993","journal-title":"Padiatr. Grenzegebiete"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/00004583-199201000-00034","article-title":"Autism and Ehlers-Danlos syndrome","volume":"31","author":"Sieg","year":"1992","journal-title":"J. Am. Med. Acad. Child Adolesc. Psychiatry"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1111\/j.1440-1819.2011.02262.x","article-title":"High-functioning autistic disorder with Ehlers-Danlos syndrome","volume":"65","author":"Takei","year":"2011","journal-title":"Psychiatry Clin. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","unstructured":"Cederl\u00f6f, M., Larsson, H., Lichtenstein, P., Almqvist, C., Serlachius, E., and Ludvigsson, J.F. (2016). Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings. BMC Psychiatry, 16.","DOI":"10.1186\/s12888-016-0922-6"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1136\/jnnp-2014-308883.9","article-title":"Joint hypermobility and autonomic hyperactivity: Relevance to neurodevelopmental disorders","volume":"85","author":"Eccles","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Csecs, J.L., Iodice, V., Rae, C.L., Brooke, A., Simmons, R., Dowell, N.G., Prowse, F., Themelis, K., Critchley, H.D., and Eccles, J.A. (2020). Increased rate of joint hypermobility in autism and related neurodevelopmental conditions is linked to dysautonomia and pain. medRxiv.","DOI":"10.1101\/2020.09.14.20194118"},{"key":"ref_27","first-page":"187","article-title":"Benign joint hypermobility syndrome in patients with attention deficit\/hyperactivity disorders","volume":"26","author":"Taner","year":"2011","journal-title":"Arch. Rheumatol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3389\/fpsyt.2018.00656","article-title":"Autism, joint hypermobility-related disorders and pain","volume":"9","author":"Cohen","year":"2018","journal-title":"Front. Psychiatry"},{"key":"ref_29","first-page":"34","article-title":"Missed diagnosis or misdiagnosis? Girls and women on the autism spectrum","volume":"12","author":"Gould","year":"2011","journal-title":"Good Autism Pract. (Gap)"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/s11920-019-1006-3","article-title":"Women and autism spectrum disorder: Diagnosis and implications for treatment of adolescents and adults","volume":"21","author":"Green","year":"2019","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1177\/1362361316671012","article-title":"Quantifying and exploring camouflaging in men and women with autism","volume":"21","author":"Lai","year":"2017","journal-title":"Autism"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1002\/ajmg.a.33585","article-title":"Ehlers-Danlos syndrome hypermobility type and the excess of affected females: Possible mechanisms and perspectives","volume":"152","author":"Castori","year":"2010","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.biopsych.2016.10.020","article-title":"Maternal immune activation and autism spectrum disorder: From rodents to nonhuman and human primates","volume":"81","author":"Careaga","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.3389\/fimmu.2019.02537","article-title":"C1R mutations trigger constitutive complement 1 activation in periodontal Ehlers-Danlos syndrome","volume":"10","author":"Amberger","year":"2019","journal-title":"Front. Immunol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/j.1365-2133.2008.08434.x","article-title":"Periodontal Ehlers-Danlos syndrome associated with type III and I collagen deficiencies","volume":"158","author":"Mataix","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Tassanakijpanich, N., McKenzie, F.J., McLennan, Y.A., Makhoul, E., Tassone, F., Jasoliya, M.J., Romney, C., Cortina Petrasic, I., Napalinga, K., and Buchanan, C. (2020). Hypermobile Ehlers-Danlos syndrome (hEDS) phenotype in fragile X premutation carriers: Case series. under submission.","DOI":"10.1136\/jmedgenet-2020-107609"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ajmg.1320170106","article-title":"Consideration of connective tissue dysfunction in the fragile X syndrome","volume":"17","author":"Hagerman","year":"1984","journal-title":"Am. J. Med. Genet."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1002\/ajmg.a.36023","article-title":"High MMP-9 activity levels in fragile X syndrome are lowered by minocycline","volume":"161","author":"Dziembowska","year":"2013","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"e00224","DOI":"10.1002\/phy2.224","article-title":"MMP-1 and MMP-9 regulate epidermal growth factor-dependent collagen loss in human carotid plaque smooth muscle cells","volume":"2","author":"Rao","year":"2014","journal-title":"Physiol. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ejpn.2015.07.004","article-title":"Is it possible to diagnose Rett syndrome before classical symptoms become obvious? Review of 24 Danish cases born between 2003 and 2012","volume":"19","author":"Bisgaard","year":"2015","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.ajpath.2011.01.002","article-title":"Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis","volume":"178","author":"Hu","year":"2011","journal-title":"Am. J. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"195935","DOI":"10.1155\/2014\/195935","article-title":"Redox imbalance and morphological changes in skin fibroblasts in typical Rett syndrome","volume":"2014","author":"Signorini","year":"2014","journal-title":"Oxidative Med. Cell. Longev."},{"key":"ref_43","unstructured":"Online Mendelian Inheritance in Man, OMIM (2020, May 11). McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University (Baltimore, MD). Available online: https:\/\/omim.org\/."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"W214","DOI":"10.1093\/nar\/gkq537","article-title":"The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function","volume":"38","author":"Donaldson","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"ref_45","first-page":"938","article-title":"Characterizing psychiatric comorbidity in children with autism spectrum disorder receiving publicly funded mental health services","volume":"22","author":"Stadnick","year":"2017","journal-title":"Autism"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1177\/1362361304042718","article-title":"Autism and learning disability","volume":"8","author":"Pearson","year":"2004","journal-title":"Autism"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.ridd.2016.10.011","article-title":"A connective tissue disorder may underlie ESSENCE problems in childhood","volume":"60","author":"Grahame","year":"2017","journal-title":"Res. Dev. Disabil."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s12402-018-0252-2","article-title":"Attention deficit\/hyperactivity disorder, joint hypermobility related disorders and pain: Expanding body-mind connections to the developmental age","volume":"10","author":"Sinibaldi","year":"2018","journal-title":"Atten. Deficit Hyperact. Disord."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1002\/ajmg.b.32646","article-title":"Exploring relationships between joint hypermobility and neurodevelopment in children (4\u201313 years) with hereditary connective tissue disorders and developmental coordination disorder","volume":"177","author":"Piedimonte","year":"2018","journal-title":"Am. J. Med. Genet. B"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.jaac.2017.05.002","article-title":"Autism Spectrum Symptoms in a Tourette\u2019s Disorder Sample","volume":"56","author":"Darrow","year":"2017","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1093\/rheumatology\/keh557","article-title":"Joint hypermobility syndrome in childhood. A not so benign multisystem disorder?","volume":"44","author":"Adib","year":"2005","journal-title":"Rheumatology"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ajmg.c.31424","article-title":"Neurodevelopmental attributes of joint hypermobility syndrome\/Ehlers-Danlos syndrome, hypermobility type: Update and perspectives","volume":"169","author":"Ghibellini","year":"2015","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/j.1540-8159.2000.tb06760.x","article-title":"The Postural Orthostatic Tachycardia Syndrome: A potentially treatable cause of chronic fatigue, exercise intolerance, and cognitive impairment in adolescents","volume":"23","author":"Karas","year":"2000","journal-title":"Pacing Clin. Electrophysiol."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.pneurobio.2011.01.002","article-title":"The effect of pain on cognitive function: A review of clinical and preclinical research","volume":"93","author":"Moriarty","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"ref_55","unstructured":"Baeza-Velasco, C. (2020, January 2\u20133). Neurodiversity: Associations and implications in hypermobility spectrum disorders and Ehlers-Danlos syndrome. Proceedings of the EDS ECHO Summit. Scientific Meeting on EDS, HSD and Co-Morbidities (Virtual Event)."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1007\/s11920-017-0846-y","article-title":"Anxiety Disorders and Obsessive-Compulsive Disorder in Individuals with Autism Spectrum Disorder","volume":"19","author":"Postorino","year":"2017","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ajmg.c.31544","article-title":"Psychiatric and psychological aspects in the Ehlers-Danlos syndrome","volume":"175","author":"Bulbena","year":"2017","journal-title":"Am. J. Med. Genet. Part C"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1177\/1362361319872373","article-title":"Autism and depression are connected: A report of two complementary network studies","volume":"24","author":"Deserno","year":"2020","journal-title":"Autism"},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.jad.2008.02.015","article-title":"High prevalence of bipolar disorder comorbidity in adolescents and young adults with high-functioning autism spectrum disorder: A preliminary study of 44 outpatients","volume":"111","author":"Munesue","year":"2008","journal-title":"J. Affect. Disord."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13229-020-00364-z","article-title":"Alexithymia may explain the relationship between autistic traits and eating disorder psychopathology","volume":"11","author":"Vuiller","year":"2020","journal-title":"Mol. Autism"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Baeza-Velasco, C., Lorente, S., Tasa Vindral, B., Guillaume, S., Mora, M., and Espinoza, P. (2020). Gastrointestinal and eating problems in women with Ehlers-Danlos syndromes. under submission.","DOI":"10.1007\/s40519-021-01146-z"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1007\/s10803-013-1795-x","article-title":"The phenomenology and clinical correlates of suicidal thoughts and behaviors in youth with autism spectrum disorders","volume":"43","author":"Storch","year":"2013","journal-title":"J. Autism Dev. Disord."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/s10803-009-0884-3","article-title":"Emotion recognition in children with autism spectrum disorders: Relations to eye gaze and autonomic state","volume":"40","author":"Bal","year":"2010","journal-title":"J. Autism Dev. Disord."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"230","DOI":"10.3389\/fphys.2014.00230","article-title":"Cognitive function, health-related quality of life, and symptoms of depression and anxiety sensitivity are impaired in patients with postural orthostatic tachycardia syndrome (POTS)","volume":"5","author":"Anderson","year":"2014","journal-title":"Front. Physiol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/dmcn.13598","article-title":"Prevalence and risk factors for autism spectrum disorder in epilepsy: A systematic review and meta-analysis","volume":"60","author":"Strasser","year":"2018","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1203\/PDR.0b013e31819e7168","article-title":"The role of epilepsy and epileptiform EEGs in autism spectrum disorders","volume":"65","author":"Spence","year":"2009","journal-title":"Pediatrics Res."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.biopsych.2008.04.030","article-title":"Epilepsy in autism is associated with intellectual disability and gender: Evidence from a meta-analysis","volume":"64","author":"Amiet","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.seizure.2018.02.013","article-title":"Ehlers-Danlos syndromes and epilepsy: An updated review","volume":"57","author":"Cortini","year":"2018","journal-title":"Seizure"},{"key":"ref_69","first-page":"190","article-title":"Neurological manifestations of Ehlers-Danlos syndrome(s): A review","volume":"13","author":"Castori","year":"2014","journal-title":"Iran. J. Neurol."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00401-010-0655-4","article-title":"The neuropathology of autism: Defects of neurogenesis and neuronal migration, and dysplastic changes","volume":"119","author":"Wegiel","year":"2010","journal-title":"Acta Neuropathol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13023-016-0428-9","article-title":"Brain injury unmasking Ehlers-Danlos syndromes after trauma: The fiber print","volume":"11","author":"Hamonet","year":"2016","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"17m11857","DOI":"10.4088\/JCP.17m11857","article-title":"Traumatic brain injury in early childhood and risk of attention-deficit\/hyperactivity disorder and autism spectrum disorder: A nationwide longitudinal study","volume":"79","author":"Chang","year":"2018","journal-title":"J. Clin. Psychiatry"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1007\/s10803-011-1270-5","article-title":"Parental sleep concerns in autism spectrum disorders: Variations from childhood to adolescence","volume":"42","author":"Goldman","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.smrv.2009.02.003","article-title":"Sleep problems in autism spectrum disorders: Prevalence, nature, & possible biopsychosocial aetiologies","volume":"13","author":"Richdale","year":"2009","journal-title":"Sleep Med. Rev."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"623","DOI":"10.5664\/jcsm.7058","article-title":"Sleep disorders and their management in children with Ehlers-Danlos syndrome referred to sleep clinics","volume":"14","author":"Domany","year":"2018","journal-title":"J. Clin. Sleep Med."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1378\/chest.13-0174","article-title":"Sleep-disordered breathing in Ehlers-Danlos syndrome: A genetic model of OSA","volume":"144","author":"Guilleminault","year":"2013","journal-title":"Chest"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/thoraxjnl-2016-209560","article-title":"Obstructive sleep apnoea and quality of life in Ehlers-Danlos syndrome: A parallel cohort study","volume":"72","author":"Gaisl","year":"2017","journal-title":"Thorax"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/DBP.0000000000000248","article-title":"Prevalence of diagnosed sleep disorders and related diagnostic and surgical procedures in children with autism spectrum disorders","volume":"37","author":"Elrod","year":"2016","journal-title":"J. Dev. Behav. Pediatrics"},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1007\/s10803-010-0981-3","article-title":"Motor coordination in autism spectrum disorders: A synthesis and meta-analysis","volume":"40","author":"Fournier","year":"2010","journal-title":"J. Autism Dev. Disord."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s00431-017-2951-7","article-title":"Early motor delays as diagnostic clues in autism spectrum disorder","volume":"176","author":"Harris","year":"2017","journal-title":"Eur. J. Pediatrics"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1177\/1362361311402230","article-title":"Motor skills of toddlers with autism spectrum disorders","volume":"17","author":"Lloyd","year":"2013","journal-title":"Autism"},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1007\/s10803-016-2794-5","article-title":"Overlapping phenotypes in autism spectrum disorder and developmental coordination disorder: A cross-syndrome comparison of motor and social skills","volume":"46","author":"Sumner","year":"2016","journal-title":"J. Autism Dev. Disord."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.ridd.2009.09.017","article-title":"Developmental coordination disorder and other motor control problems in girls with autism spectrum disorder and\/or attention-deficit\/hyperactivity disorder","volume":"31","author":"Kopp","year":"2010","journal-title":"Res. Dev. Disabil."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1469-8749.1999.tb00592.x","article-title":"Visual-proprioceptive mapping in children with developmental coordination disorder","volume":"41","author":"Wann","year":"1999","journal-title":"Dev. Med. Child Neurol."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.neulet.2018.03.031","article-title":"Wrist position sense acuity and its relation to motor dysfunction in children with developmental coordination disorder","volume":"674","author":"Tseng","year":"2018","journal-title":"Neurosci. Lett."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/00222895.2017.1415200","article-title":"Position sense dysfunction affects proximal and distal arm joints in children with developmental coordination disorder","volume":"51","author":"Tseng","year":"2019","journal-title":"J. Mot. Behav."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"621","DOI":"10.5014\/ajot.2012.004234","article-title":"Proprioceptive processing difficulties among children with autism spectrum disorders and developmental disabilities","volume":"66","author":"Blanche","year":"2012","journal-title":"Am. J. Occup. Ther."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"1723401","DOI":"10.1155\/2016\/1723401","article-title":"Abnormal pressure pain, touch sensitivity, proprioception, and manual dexterity in children with autism spectrum disorders","volume":"2016","author":"Riquelme","year":"2016","journal-title":"Neural Plast."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s00221-013-3656-4","article-title":"Proprioceptive sensitivity in Ehlers-Danlos syndrome patients","volume":"230","author":"Clayton","year":"2013","journal-title":"Exp. Brain Res."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/s40064-015-1089-1","article-title":"Proprioceptive precision is impaired in Ehlers-Danlos syndrome","volume":"4","author":"Clayton","year":"2015","journal-title":"SpringerPlus"},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Chien, Y.L., Chao, C.C., Wu, S.W., Hsueh, H.W., Chiu, Y.N., Tsai, W.C., Gau, S.S.F., and Hsieh, S.T. (2020). Small fiber pathology in autism and clinical implications. Neurology.","DOI":"10.1212\/WNL.0000000000010932"},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4172\/2329-6895.1000262","article-title":"First skin biopsy reports in children with autism show loss of C-tactile fibers","volume":"4","author":"Silva","year":"2016","journal-title":"J. Neurol. Disord."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/0304-3940(92)90865-5","article-title":"Experimental peripheral neuropathy decreases the dose of substance P required to increase excitatory amino acid release in the CSF of the rat spinal cord","volume":"139","author":"Skilling","year":"1992","journal-title":"Neurosci. Lett."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s10067-014-2499-0","article-title":"Chronic pain in patients with the hypermobility type of Ehlers-Danlos syndrome: Evidence for generalized hyperalgesia","volume":"34","author":"Rombaut","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1212\/WNL.0000000000002847","article-title":"Small fiber neuropathy is a common feature of Ehlers-Danlos syndromes","volume":"87","author":"Cazzato","year":"2016","journal-title":"Neurology"},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1016\/j.jpainsymman.2010.09.012","article-title":"Neuropathic pain is a common feature in Ehlers-Danlos syndrome","volume":"41","author":"Camerota","year":"2011","journal-title":"J. Pain Symptom Manag."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.clinph.2012.12.051","article-title":"Entrapment neuropathies and polyneuropathies in joint hypermobility syndrome\/Ehlers-Danlos syndrome","volume":"124","author":"Granata","year":"2013","journal-title":"Clin. Neurophysiol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1097\/j.pain.0000000000001935","article-title":"Pain-related behaviors and abnormal cutaneous innervation in a murine model of classical Ehlers-Danlos syndrome","volume":"161","author":"Syx","year":"2020","journal-title":"Pain"},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1485","DOI":"10.1007\/s10803-007-0528-4","article-title":"Sensory sensitivities and performance on sensory perceptual tasks in high-functioning individuals with autism","volume":"38","author":"Minshew","year":"2008","journal-title":"J. Autism Dev. Disord."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/joim.12852","article-title":"Postural orthostatic tachycardia syndrome: Clinical presentation, aetiology and management","volume":"285","author":"Fedorowski","year":"2019","journal-title":"J. Intern. Med."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1152\/jn.00764.2011","article-title":"Forebrain organization representing baroreceptor gating of somatosensory afferents within the cortical autonomic network","volume":"108","author":"Goswami","year":"2012","journal-title":"J. Neurophysiol."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1203\/00006450-200008000-00016","article-title":"Autonomic nervous system dysfunction in adolescents with postural orthostatic tachycardia syndrome and chronic fatigue syndrome is characterized by attenuated vagal baroreflex and potentiated sympathetic vasomotion","volume":"48","author":"Stewart","year":"2000","journal-title":"Pediatric Res."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/ajmg.c.31549","article-title":"Neurological and spinal manifestations of the Ehlers-Danlos syndromes","volume":"175","author":"Henderson","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"96","DOI":"10.3171\/2014.10.PEDS13562","article-title":"Chiari malformation I and autism spectrum disorder: An underrecognized coexistence","volume":"15","author":"Jayarao","year":"2015","journal-title":"J. Neurosurg. Pediatrics"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Kushki, A., Drumm, E., Mobarak, M.P., Tanel, N., Dupuis, A., Chau, T., and Anagnostou, E. (2013). Investigating the autonomic nervous system response to anxiety in children with autism spectrum disorders. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0059730"},{"key":"ref_106","doi-asserted-by":"crossref","unstructured":"Vernetti, A., Shic, F., Boccanfuso, L., Macari, S., Kane-Grade, F., Milgramm, A., Hilton, E., Heymann, P., Goodwin, M.S., and Chawarska, K. (2020). Atypical emotional electrodermal activity in toddlers with autism spectrum disorder. Autism Res., in press.","DOI":"10.1002\/aur.2374"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1098\/rspb.2001.1724","article-title":"Autonomic responses of autistic children to people and objects","volume":"268","author":"Hirstein","year":"2001","journal-title":"Proc. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1007\/s10802-017-0339-9","article-title":"Autonomic responses to head-up tilt test in children with autism spectrum disorders","volume":"46","author":"Bricout","year":"2018","journal-title":"J. Abnorm. Child Psychol."},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1002\/dev.20352","article-title":"Larger tonic pupil size in young children with autism spectrum disorder","volume":"51","author":"Anderson","year":"2009","journal-title":"Dev. Psychobiol. J. Int. Soc. Dev. Psychobiol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1037\/0021-843X.96.2.135","article-title":"Autonomic nervous system activity in autistic, schizophrenic, and normal men: Effects of stimulus significance","volume":"96","author":"Zahn","year":"1987","journal-title":"J. Abnorm. Psychol."},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s10286-016-0375-5","article-title":"Heart rate variability during sleep in children with autism spectrum disorder","volume":"26","author":"Harder","year":"2016","journal-title":"Clin. Auton. Res."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/dev.21310","article-title":"Animals may act as social buffers: Skin conductance arousal in children with autism spectrum disorder in a social context","volume":"57","author":"McKenzie","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpsycho.2018.10.004","article-title":"Heart rate variability of typically developing and autistic children and adults before, during and after sleep","volume":"134","author":"Tessier","year":"2018","journal-title":"Int. J. Psychophysiol."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1007\/s10803-014-2124-8","article-title":"Brief report: Emotion regulation and respiratory sinus arrthythmia in autism spectrum disorder","volume":"44","author":"Guy","year":"2014","journal-title":"J. Autism Dev. Disord."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/aur.1646","article-title":"Psychophysiological associations with gastrointestinal symptomatology in autism spectrum disorder","volume":"10","author":"Ferguson","year":"2016","journal-title":"Autism Res."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1177\/0269881118756245","article-title":"Propranolol for treating emotional, behavioural, autonomic dysregulation in children and adolescents with autism spectrum disorders","volume":"32","author":"Lievesley","year":"2018","journal-title":"J. Psychopharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.resp.2012.07.002","article-title":"Autonomic nervous system dysfunction and their relationship with disease severity in children with atopic asthma","volume":"183","author":"Emin","year":"2012","journal-title":"Respir. Physiol. Neurobiol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3389\/fnhum.2014.00851","article-title":"Effects of weekly low-frequency rTMS on autonomic measures in children with autism spectrum disorder","volume":"8","author":"Casanova","year":"2014","journal-title":"Front. Hum. Neurosci."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"65","DOI":"10.15540\/nr.4.2.65","article-title":"Neuromodulation based on rTMS affects behavioral measures and autonomic nervous system activity in children with autism","volume":"4","author":"Sokhadze","year":"2017","journal-title":"NeuroRegulation"},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.semarthrit.2014.05.013","article-title":"Autonomic symptom burden in the hypermobility type of Ehlers-Danlos syndrome: A comparative study with two other EDS types, fibromyalgia, and health controls","volume":"44","author":"Calders","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.semarthrit.2013.12.006","article-title":"Dysautonomia and its underlying mechanisms in the hypermobility type of Ehlers-Danlos syndrome","volume":"44","author":"Rombaut","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/ajmg.c.31543","article-title":"Cardiovascular autonomic dysfunction in Ehlers-Danlos syndrome\u2014Hypermobile type","volume":"175","author":"Hakim","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_123","unstructured":"Health Quality Ontario (2015). Positional magnetic resonance imaging for people with Ehlers-Danlos syndrome or suspected craniovertebral or cervical spine abnormalities: An evidence-based analysis. Ont. Health Technol. Assess. Ser., 15, 1."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","article-title":"The role of immune dysfunction in the pathophysiology of autism","volume":"26","author":"Onore","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1007\/s12035-016-9977-0","article-title":"Dysregulation of Th1, Th2, Th17, and T regulatory cell-related transcription factor signaling in children with autism","volume":"54","author":"Ahmad","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/mp.2016.77","article-title":"Autism with intellectual disability is associated with increased levels of maternal cytokines and chemokines during gestation","volume":"22","author":"Jones","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s11481-012-9372-1","article-title":"Maternal immune activation increases neonatal mouse cortex thickness and cell density","volume":"7","author":"Smith","year":"2012","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.stem.2013.10.002","article-title":"Transient maternal IL-6 mediates long-lasting changes in neural stem cell pools by deregulating an endogenous self-renewal pathway","volume":"13","author":"Gallagher","year":"2013","journal-title":"Cell Stem Cell"},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1001\/jamapsychiatry.2013.265","article-title":"Brain surface anatomy in adults with autism: The relationship between surface area, cortical thickness, and autistic symptoms","volume":"70","author":"Ecker","year":"2013","journal-title":"JAMA Psychiatry"},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1093\/brain\/awu083","article-title":"Longitudinal changes in cortical thickness in autism and typical development","volume":"137","author":"Zielinski","year":"2014","journal-title":"Brain"},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1002\/ajmg.c.31555","article-title":"Mast cell disorders in Ehlers-Danlos syndrome","volume":"175","author":"Seneviratne","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"AB182","DOI":"10.1016\/j.jaci.2018.12.558","article-title":"Prevalence of symptoms of mast cell activation in patients with postural orthostatic tachycardia syndrome and hypermobile Ehlers-Danlos syndrome","volume":"143","author":"Chang","year":"2019","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_133","doi-asserted-by":"crossref","unstructured":"Chiarelli, N., Ritelli, M., Zoppi, N., and Colombi, M. (2019). Cellular and molecular mechanisms in the pathogenesis of classical, vascular, and hypermobile Ehlers-Danlos syndromes. Genes, 10.","DOI":"10.3390\/genes10080609"},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.4049\/jimmunol.156.11.4354","article-title":"TNF-alpha inactivation of collagen receptors: Implications for fibroblast function and fibrosis","volume":"156","author":"Chou","year":"1996","journal-title":"J. Immunol."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/0022-202X(89)90185-1","article-title":"Differential regulation of collagen, glycosaminoglycan, fibronectin, and collagenase activity production in cultured human adult dermal fibroblasts by interleukin 1-alpha and beta and tumor necrosis factor-alpha and beta","volume":"92","author":"Duncan","year":"1989","journal-title":"J. Investig. Dermatol."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1002\/ajmg.a.35569","article-title":"Immune-mediated disorders among women carriers of fragile X premutation alleles","volume":"158","author":"Winarni","year":"2012","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_137","doi-asserted-by":"crossref","unstructured":"Careaga, M., Rose, D., Tassone, F., Berman, R.F., Hagerman, R., and Ashwood, P. (2014). Immune dysregulation as a cause of autoinflammation in fragile X premutation carriers: Link between FMR1 CGG repeat number and decreased cytokine responses. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0094475"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/ajmg.a.36748","article-title":"Immune mediated disorders in women with a fragile X expansion and FXTAS","volume":"167","author":"Jalnapurkar","year":"2015","journal-title":"Am. J. Med. Genet. Part A"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"453","DOI":"10.3109\/09593985.2014.899414","article-title":"Measurement properties of existing clinical assessment methods evaluating scapular positioning and function. A systematic review","volume":"30","author":"Larsen","year":"2014","journal-title":"Physiother. Theory Pract."},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/ajmg.c.31545","article-title":"The evidence-based rationale for physical therapy treatment of children, adolescents, and adults diagnosed with joint hypermobility syndrome\/hypermobile Ehlers Danlos syndrome","volume":"175","author":"Engelbert","year":"2017","journal-title":"Am. J. Med. Genet. Part C Semin. Med. Genet."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1002\/art.20582","article-title":"Amelioration of symptoms by enhancement of proprioception in patients with joint hypermobility syndrome","volume":"50","author":"Ferrell","year":"2004","journal-title":"Arthritis Rheum."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/4\/260\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:40:10Z","timestamp":1760179210000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/10\/4\/260"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,1]]},"references-count":141,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,12]]}},"alternative-id":["jpm10040260"],"URL":"https:\/\/doi.org\/10.3390\/jpm10040260","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,1]]}}}