{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:29:09Z","timestamp":1787588949040,"version":"build-2736575974"},"reference-count":135,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,1,18]],"date-time":"2021-01-18T00:00:00Z","timestamp":1610928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017R1A5A2015391;2019R1I1A2A01062430;2020R1C1C1006757"],"award-info":[{"award-number":["2017R1A5A2015391;2019R1I1A2A01062430;2020R1C1C1006757"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Aging is characterized by a progressive decline or loss of physiological functions, leading to increased susceptibility to disease or death. Several aging hallmarks, including genomic instability, cellular senescence, and mitochondrial dysfunction, have been suggested, which often lead to the numerous aging disorders. The periodontium, a complex structure surrounding and supporting the teeth, is composed of the gingiva, periodontal ligament, cementum, and alveolar bone. Supportive and protective roles of the periodontium are very critical to sustain life, but the periodontium undergoes morphological and physiological changes with age. In this review, we summarize the current knowledge of molecular and cellular physiological changes in the periodontium, by focusing on soft tissues including gingiva and periodontal ligament.<\/jats:p>","DOI":"10.3390\/jpm11010058","type":"journal-article","created":{"date-parts":[[2021,1,19]],"date-time":"2021-01-19T11:39:55Z","timestamp":1611056395000},"page":"58","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effect of Aging on Homeostasis in the Soft Tissue of the Periodontium: A Narrative Review"],"prefix":"10.3390","volume":"11","author":[{"given":"Yu Gyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Min","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungeun","family":"Bae","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taejun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeonjin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujeong","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keonwoo","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwangmin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joonyoung","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Seok","family":"Byun","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2200-7396","authenticated-orcid":false,"given":"Do-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, School of Dentistry, Brain Science and Engineering Institute, Kyungpook National University, Daegu 41940, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"148","DOI":"10.3389\/fgene.2012.00148","article-title":"A new definition of aging?","volume":"3","author":"Flatt","year":"2012","journal-title":"Front. 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