{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:48:30Z","timestamp":1791830910291,"version":"4.3.4"},"reference-count":146,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T00:00:00Z","timestamp":1611532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>A tightly regulated protein quality control (PQC) system maintains a healthy balance between correctly folded and misfolded protein species. This PQC system work with the help of a complex network comprised of molecular chaperones and proteostasis. Any intruder, especially environmental pollutants, disrupt the PQC network and lead to PQCs disruption, thus generating damaged and infectious protein. These misfolded\/unfolded proteins are linked to several diseases such as Parkinson\u2019s disease, Alzheimer\u2019s disease, Huntington\u2019s disease, and cataracts. Numerous studies on proteins misfolding and disruption of PQCs by environmental pollutants highlight the necessity of detailed knowledge. This review represents the PQCs network and environmental pollutants\u2019 impact on the PQC network, especially through the protein clearance system.<\/jats:p>","DOI":"10.3390\/jpm11020069","type":"journal-article","created":{"date-parts":[[2021,1,25]],"date-time":"2021-01-25T02:07:00Z","timestamp":1611540420000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Proteotoxicity: A Fatal Consequence of Environmental Pollutants-Induced Impairments in Protein Clearance Machinery"],"prefix":"10.3390","volume":"11","author":[{"given":"Shweta","family":"Devi","sequence":"first","affiliation":[{"name":"Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research, Lucknow 226001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Joo","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9409-1366","authenticated-orcid":false,"given":"Anand Prakash","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, The University of Alabama at Birmingham (UAB), 1720 2nd Ave South, Birmingham, AL 35294-1913, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra","family":"Kumar","sequence":"additional","affiliation":[{"name":"Cytogenetics Lab, Department of Anatomy, All India Institute of Medical Sciences, New Delhi 110029, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish Kant","family":"Dubey","sequence":"additional","affiliation":[{"name":"Department of Neurology, SGPGIMS, Lucknow 226014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, SGPGIMS, Lucknow 226014, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8698-4562","authenticated-orcid":false,"given":"Ravi Shankar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Microbiology &amp; Immunology, University of Saskatchewan, Room 4D40, Health Sciences Building, 107 Wiggins Road, Saskatoon, SK S7N 5E5, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8035-9181","authenticated-orcid":false,"given":"Vijay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk 38541, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,1,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1146\/annurev-biochem-060815-014616","article-title":"Mechanisms and Functions of Spatial Protein Quality Control","volume":"86","author":"Sontag","year":"2017","journal-title":"Annu. 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