{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T22:59:41Z","timestamp":1773961181196,"version":"3.50.1"},"reference-count":74,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Obra Social &quot;La Caixa Foundation&quot;","award":["LCF\/PR\/GN16\/50290001 and LCF\/PR\/GN19\/50320002"],"award-info":[{"award-number":["LCF\/PR\/GN16\/50290001 and LCF\/PR\/GN19\/50320002"]}]},{"name":"Instituto Salud Carlos III","award":["FIS PI16\/01203 and FIS, PI17\/01690"],"award-info":[{"award-number":["FIS PI16\/01203 and FIS, PI17\/01690"]}]},{"DOI":"10.13039\/501100010336","name":"Fundacio Privada Daniel Bravo Andreu","doi-asserted-by":"publisher","award":["FPDBA2015"],"award-info":[{"award-number":["FPDBA2015"]}],"id":[{"id":"10.13039\/501100010336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The RBM20 gene encodes the muscle-specific splicing factor RNA-binding motif 20, a regulator of heart-specific alternative splicing. Nearly 40 potentially deleterious variants in RBM20 have been reported in the last ten years, being found to be associated with highly arrhythmogenic events in familial dilated cardiomyopathy. Frequently, malignant arrhythmias can be a primary manifestation of disease. The early recognition of arrhythmic genotypes is crucial in avoiding lethal episodes, as it may have an impact on the adoption of personalized preventive measures. Our study performs a comprehensive update of data concerning rare variants in RBM20 that are associated with malignant arrhythmogenic phenotypes with a focus on personalized medicine.<\/jats:p>","DOI":"10.3390\/jpm11020130","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T03:22:26Z","timestamp":1613359346000},"page":"130","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Malignant Arrhythmogenic Role Associated with RBM20: A Comprehensive Interpretation Focused on a Personalized Approach"],"prefix":"10.3390","volume":"11","author":[{"given":"Paloma","family":"Jord\u00e0","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Clinic, University of Barcelona-IDIBAPS, 08036 Barcelona, 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Arrhythmias, Inherited Cardiac Diseases and Sudden Death Unit, Cardiology Department, Hospital Sant Joan de D\u00e9u, University of Barcelona, 08950 Barcelona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coloma","family":"Tiron","sequence":"additional","affiliation":[{"name":"Cardiology Service, Hospital Josep Trueta, University of Girona, 17001 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Iglesias","sequence":"additional","affiliation":[{"name":"Cardiovascular Genetics Center, University of Girona-IDIBGI, 17001 Girona, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josep","family":"Brugada","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinic, University of Barcelona-IDIBAPS, 08036 Barcelona, Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red Enfermedades Cardiovasculares (CIBERCV), 28029 Madrid, Spain"},{"name":"Pediatric Arrhythmias, 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