{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T08:48:46Z","timestamp":1780390126021,"version":"3.54.1"},"reference-count":82,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T00:00:00Z","timestamp":1614816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Pancreaticobiliary malignancies arise from different areas within the pancreas and biliary tree. Endoscopic ultrasound (EUS) is a well-recognized diagnostic and therapeutic modality in the treatment of pancreaticobiliary diseases, and more specifically, pancreaticobiliary malignancies. Traditionally used for diagnostic purposes, EUS plays a critical role in tissue sampling and cancer staging. The emergence of the new field of interventional EUS has allowed EUS to also play a critical role in therapeutic management. Novel interventional EUS procedures such as EUS-guided gastrojejunostomy (EUS-GE), EUS-guided biliary drainage (EUS-BD), and EUS-guided gallbladder drainage (EUS-GLB) can be utilized to treat complications of pancreaticobiliary malignancies such as gastric outlet obstruction, obstructive jaundice, and cholecystitis. In addition, interventional EUS procedures can be utilized for the palliation of unresectable malignancies both for source control with EUS-radiofrequency ablation (EUS-RFA) and for the treatment of abdominal pain refractory to opioid medications with EUS-guided celiac axis neurolysis. However, patient selection remains a critical component in both diagnostic and therapeutic interventions and must be tailored to individual patient wishes, disease pathology, and overall prognosis.<\/jats:p>","DOI":"10.3390\/jpm11030180","type":"journal-article","created":{"date-parts":[[2021,3,4]],"date-time":"2021-03-04T21:58:07Z","timestamp":1614895087000},"page":"180","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Personalized Approach to the Role of Endoscopic Ultrasound in the Diagnosis and Management of Pancreaticobiliary Malignancies"],"prefix":"10.3390","volume":"11","author":[{"given":"Michael","family":"Makar","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Tyberg","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology &amp; Hepatology, Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,3,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21590","article-title":"Cancer statistics, 2020","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"ref_2","unstructured":"Jn, V., and Lh, B. (1994). Recent advances in the management of cholangiocarcinomas. Seminars in Liver Disease, Thieme Medical Publishers, Inc."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/1097-0142(19950101)75:1+<171::AID-CNCR2820751306>3.0.CO;2-2","article-title":"Liver, gallbladder, extrahepatic bile ducts, and pancreas","volume":"75","author":"Carriaga","year":"1995","journal-title":"Cancer"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00042737-200012010-00014","article-title":"Cancer of the ampulla of Vater: Results of a 20-year population-based study","volume":"12","author":"Benhamiche","year":"2000","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s002619900227","article-title":"Diagnosis of portal venous invasion by pancreatobiliary carcinoma: Value of endoscopic ultrasonography","volume":"22","author":"Sugiyama","year":"1997","journal-title":"Abdom. Imaging"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Skordilis, P., Mouzas, I.A., Dimoulios, P.D., Alexandrakis, G., Moschandrea, J., and Kouroumalis, E. (2002). Is endosonography an effective method for detection and local staging of the ampullary carcinoma? A prospective study. BMC Surg., 2.","DOI":"10.1186\/1471-2482-2-1"},{"key":"ref_7","first-page":"1750","article-title":"The accuracy of endoscopic ultrasound, endoscopic retrograde cholangiopancreatography, computed tomography, and transabdominal ultrasound in the detection and staging of primary ampullary tumors","volume":"48","author":"Chen","year":"2001","journal-title":"Hepatogastroenterology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/jcu.20523","article-title":"Reappraisal of endosonography of ampullary tumors: Correlation with transabdominal sonography, CT, and MRI","volume":"37","author":"Chen","year":"2009","journal-title":"J. Clin. Ultrasound"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0002-9610(00)00526-2","article-title":"Differential diagnosis of polypoid lesions of the gallbladder by endoscopic ultrasonography","volume":"181","author":"Azuma","year":"2001","journal-title":"Am. J. Surg."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/107327480401100203","article-title":"Applications of endoscopic ultrasonography in pancreatic cancer","volume":"11","author":"Varadarajulu","year":"2004","journal-title":"Cancer Control"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.gie.2006.08.028","article-title":"Diagnostic accuracy of EUS for vascular invasion in pancreatic and periampullary cancers: A meta-analysis and systematic review","volume":"65","author":"Puli","year":"2007","journal-title":"Gastrointest. Endosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.cgh.2006.02.020","article-title":"Comparison of Endoscopic Ultrasound and Computed Tomography for the Preoperative Evaluation of Pancreatic Cancer: A Systematic Review","volume":"4","author":"DeWitt","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/MPA.0b013e3182153b8c","article-title":"Comparison between Endoscopic Ultrasound and Magnetic Resonance Imaging for the Staging of Pancreatic Cancer","volume":"40","author":"Shami","year":"2011","journal-title":"Pancreas"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/S0016-5107(99)70159-8","article-title":"Role of EUS in the preoperative staging of pancreatic cancer: A large single-center experience","volume":"50","author":"Gress","year":"1999","journal-title":"Gastrointest. Endosc."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.gie.2010.08.050","article-title":"Role of EUS for preoperative evaluation of cholangiocarcinoma: A large single-center experience","volume":"73","author":"Mohamadnejad","year":"2011","journal-title":"Gastrointest. Endosc."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/den.12234","article-title":"Staging accuracy of ampullary tumors by endoscopic ultrasound: Meta-analysis and systematic review","volume":"26","author":"Trikudanathan","year":"2014","journal-title":"Dig. Endosc."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1067\/S0016-5107(03)01961-8","article-title":"Preoperative Diagnosis and Staging of Gallbladder Carcinoma by EUS","volume":"58","author":"Sadamoto","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1067\/mge.2002.124557","article-title":"EUS-guided fine needle aspiration of the liver: Indications, yield, and safety based on an international survey of 167 cases","volume":"55","author":"Tenberge","year":"2002","journal-title":"Gastrointest. Endosc."},{"key":"ref_19","first-page":"148","article-title":"Endoscopic ultrasound-guided fine needle aspiration of pleural and ascitic fluid","volume":"90","author":"Chang","year":"1995","journal-title":"Am. J. Gastroenterol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1097\/MPA.0b013e3182546e79","article-title":"How good is endoscopic ultrasound-guided fine-needle aspiration in diagnosing the correct etiology for a solid pancreatic mass?: A meta-analysis and systematic review","volume":"42","author":"Puli","year":"2013","journal-title":"Pancreas"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/S0016-5107(00)70416-0","article-title":"Factors predicting the number of EUS-guided fine-needle passes for diagnosis of pancreatic malignancies","volume":"51","author":"Erickson","year":"2000","journal-title":"Gastrointest. Endosc."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0032-1325992","article-title":"The diagnostic accuracy of 22-gauge and 25-gauge needles in endoscopic ultrasound-guided fine needle aspiration of solid pancreatic lesions: A meta-analysis","volume":"45","author":"Madhoun","year":"2013","journal-title":"Endoscopy"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e261","DOI":"10.6061\/clinics\/2018\/e261","article-title":"A comparison of the efficiency of 22G versus 25G needles in EUS-FNA for solid pancreatic mass assessment: A systematic review and meta-analysis","volume":"73","author":"Guedes","year":"2018","journal-title":"Clinics"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1055\/s-1999-73","article-title":"Prospective Evaluation of Brush Cytology of Biliary Strictures During Endoscopic Retrograde Cholangiopancreatography","volume":"31","author":"Glasbrenner","year":"1999","journal-title":"Endoscopy"},{"key":"ref_25","first-page":"254","article-title":"Brush cytology of ductal strictures during ERCP","volume":"63","author":"Macken","year":"2000","journal-title":"Acta Gastro-Enterol. Belg."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1136\/gut.40.5.671","article-title":"A prospective evaluation of cytology from biliary strictures","volume":"40","author":"Mansfield","year":"1997","journal-title":"Gut"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1055\/s-2004-828893","article-title":"Endoscopic management of cholangiocarcinoma","volume":"24","author":"Baron","year":"2004","journal-title":"Semin. Liver Dis."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.gie.2013.12.031","article-title":"EUS-FNA is superior to ERCP-based tissue sampling in suspected malignant biliary obstruction: Results of a prospective, single-blind, comparative study","volume":"80","author":"Weilert","year":"2014","journal-title":"Gastrointest. Endosc."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/cncr.21306","article-title":"Cytologic features and diagnostic pitfalls of primary ampullary tumors by endoscopic ultrasound-guided fine-needle aspiration biopsy","volume":"105","author":"Defrain","year":"2005","journal-title":"Cancer"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/MEG.0b013e3283426313","article-title":"Endoscopic ultrasound-guided fine-needle aspiration biopsy in the evaluation of bile duct strictures and gallbladder masses: A systematic review and meta-analysis","volume":"23","author":"Wu","year":"2011","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1148\/radiology.178.1.1984331","article-title":"Pancreatic cancer versus chronic pancreatitis: Diagnosis with CA 19-9 assessment, US, CT, and CT-guided fine-needle biopsy","volume":"178","author":"DelMaschio","year":"1991","journal-title":"Radiology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.gie.2005.09.028","article-title":"A randomized comparison of EUS-guided FNA versus CT or US-guided FNA for the evaluation of pancreatic mass lesions","volume":"63","author":"Horwhat","year":"2006","journal-title":"Gastrointest. Endosc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/S0016-5107(05)00364-0","article-title":"Pancreatic FNA in 1000 cases: A comparison of imaging modalities","volume":"61","author":"Volmar","year":"2005","journal-title":"Gastrointest. Endosc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1111\/j.1572-0241.2004.40042.x","article-title":"A Cost-Minimization Analysis of Alternative Strategies in Diagnosing Pancreatic Cancer","volume":"99","author":"Chen","year":"2004","journal-title":"Am. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1111\/j.1572-0241.2001.04116.x","article-title":"A cost analysis of endoscopic ultrasound in the evaluation of pancreatic head adenocarcinoma","volume":"96","author":"Harewood","year":"2001","journal-title":"Am. J. Gastroenterol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/S0016-5107(03)02009-1","article-title":"Lower frequency of peritoneal carcinomatosis in patients with pancreatic cancer diagnosed by EUS-guided FNA vs. percutaneous FNA","volume":"58","author":"Micames","year":"2003","journal-title":"Gastrointest. Endosc."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"E1403","DOI":"10.1055\/a-0982-2862","article-title":"Role of EUS-FNA for gallbladder mass lesions with biliary obstruction: A large single-center experience","volume":"7","author":"Singla","year":"2019","journal-title":"Endosc. Int. Open"},{"key":"ref_38","first-page":"675","article-title":"Implications of fine-needle aspiration in patients with resectable pancreatic cancer","volume":"63","author":"Johnson","year":"1997","journal-title":"Am. Surg."},{"key":"ref_39","first-page":"339","article-title":"A meta-analysis comparing ProCore and standard fine-needle aspiration needles for endoscopic ultrasound-guided tissue acquisition","volume":"48","author":"Bang","year":"2016","journal-title":"Endoscopy"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"E497","DOI":"10.1055\/s-0042-106958","article-title":"A randomized controlled cross-over trial and cost analysis comparing endoscopic ultrasound fine needle aspiration and fine needle biopsy","volume":"4","author":"Aadam","year":"2016","journal-title":"Endosc. Int. Open"},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Renelus, B.D., Jamorabo, D.S., Boston, I., Briggs, W.M., and Poneros, J.M. (2020). Endoscopic Ultrasound-Guided Fine Needle Biopsy Needles Provide Higher Diagnostic Yield Compared to Endoscopic Ultrasound-Guided Fine Needle Aspiration Needles When Sampling Solid Pancreatic Lesions: A Meta-Analysis. Clin. Endosc., 31.","DOI":"10.5946\/ce.2020.101"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/mc.20855","article-title":"Genetic susceptibility to pancreatic cancer","volume":"51","author":"Klein","year":"2012","journal-title":"Mol. Carcinog."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1200\/JCO.18.01489","article-title":"Evaluating Susceptibility to Pancreatic Cancer: ASCO Provisional Clinical Opinion","volume":"37","author":"Stoffel","year":"2019","journal-title":"J. Clin. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1158\/0008-5472.CAN-03-3823","article-title":"Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds","volume":"64","author":"Klein","year":"2004","journal-title":"Cancer Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.gie.2009.09.042","article-title":"Surgical gastrojejunostomy or endoscopic stent placement for the palliation of malignant gastric outlet obstruction (SUSTENT study): A multicenter randomized trial","volume":"71","author":"Jeurnink","year":"2010","journal-title":"Gastrointest. Endosc."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"E276","DOI":"10.1055\/s-0042-101789","article-title":"Endoscopic ultrasound-guided gastrojejunostomy with a lumen-apposing metal stent: A multicenter, international experience","volume":"4","author":"Tyberg","year":"2016","journal-title":"Endosc. Int. Open"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"E363","DOI":"10.1055\/s-0043-123468","article-title":"EUS-guided gastroenterostomy in management of benign gastric outlet obstruction","volume":"6","author":"Chen","year":"2018","journal-title":"Endosc. Int. Open"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1016\/j.gie.2015.06.017","article-title":"EUS-guided gastroenterostomy: The first U.S. clinical experience (with video)","volume":"82","author":"Khashab","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1136\/gutjnl-2015-310348","article-title":"Prospective evaluation of endoscopic ultrasonography-guided double-balloon-occluded gastrojejunostomy bypass (EPASS) for malignant gastric outlet obstruction","volume":"65","author":"Itoi","year":"2016","journal-title":"Gut"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Fan, W., Tan, S., Wang, J., Wang, C., Xu, H., Zhang, L., Liu, L., Fan, Z., and Tang, X. (2020). Clinical outcomes of endoscopic ultrasound-guided gastroenterostomy for gastric outlet obstruction: A systematic review and meta-analysis. Minim. Invasive Ther. Allied Technol., 1\u20139.","DOI":"10.1080\/13645706.2020.1792500"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"3404","DOI":"10.1007\/s00464-018-06636-3","article-title":"EUS-guided gastroenterostomy versus enteral stent placement for palliation of malignant gastric outlet obstruction","volume":"33","author":"Ge","year":"2019","journal-title":"Surg. Endosc."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"E275","DOI":"10.1055\/s-0043-101695","article-title":"International multicenter comparative trial of endoscopic ultrasonography-guided gastroenterostomy versus surgical gastrojejunostomy for the treatment of malignant gastric outlet obstruction","volume":"5","author":"Khashab","year":"2017","journal-title":"Endosc. Int. Open"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"AB175","DOI":"10.1016\/j.gie.2016.03.154","article-title":"876 EUS guided Gastrojejunostomy versus Laparoscopic Gasrojejunostomy: An International Collaborative Study","volume":"83","author":"Tyberg","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"E1690","DOI":"10.1055\/a-1221-9656","article-title":"Safety and efficacy of endoscopic ultrasound-guided gastroenterostomy using double balloon occlusion methods: A clinical retrospective study in 36 patients with malignant gastric outlet obstruction","volume":"8","author":"Xu","year":"2020","journal-title":"Endosc. Int. Open."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4253\/wjge.v11.i5.345","article-title":"Endoscopic ultrasound-guided biliary drainage: A change in paradigm?","volume":"11","author":"Ki","year":"2019","journal-title":"World J. Gastrointest. Endosc."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1097\/MCG.0000000000000275","article-title":"Drainage-related Complications in Percutaneous Transhepatic Biliary Drainage: An Analysis over 10 Years","volume":"49","author":"Nennstiel","year":"2015","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.gie.2016.12.023","article-title":"Efficacy and safety of EUS-guided biliary drainage in comparison with percutaneous biliary drainage when ERCP fails: A systematic review and meta-analysis","volume":"85","author":"Sharaiha","year":"2017","journal-title":"Gastrointest. Endosc."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.gie.2014.09.054","article-title":"Multicenter comparative evaluation of endoscopic placement of expandable metal stents for malignant distal common bile duct obstruction by ERCP or EUS-guided approach","volume":"81","author":"Dhir","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1055\/s-2001-17324","article-title":"Endoscopic Ultrasound-Guided Bilioduodenal Anastomosis: A New Technique for Biliary Drainage","volume":"33","author":"Giovannini","year":"2001","journal-title":"Endoscopy"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1007\/s10620-015-3933-0","article-title":"Endoscopic Ultrasound-Guided Biliary Drainage: A Systematic Review and Meta-Analysis","volume":"61","author":"Khan","year":"2016","journal-title":"Dig. Dis. Sci."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"16551","DOI":"10.1038\/s41598-019-52993-x","article-title":"EUS-guided biliary drainage versus ERCP for first-line palliation of malignant distal biliary obstruction: A systematic review and meta-analysis","volume":"9","author":"Han","year":"2019","journal-title":"Sci. Rep."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/s41395-018-0122-8","article-title":"EUS-Guided Biliary Drainage versus ERCP for the Primary Palliation of Malignant Biliary Obstruction: A Multicenter Randomized Clinical Trial","volume":"113","author":"Paik","year":"2018","journal-title":"Am. J. Gastroenterol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.gie.2015.03.1912","article-title":"Endoscopic gallbladder drainage compared with percutaneous drainage","volume":"82","author":"Kedia","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"48","DOI":"10.4103\/eus.eus_100_17","article-title":"Patient perception and preference of EUS-guided drainage over percutaneous drainage when endoscopic transpapillary biliary drainage fails: An international multicenter survey","volume":"7","author":"Nam","year":"2018","journal-title":"Endosc. Ultrasound"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1055\/s-0034-1365720","article-title":"Long-term outcomes after endoscopic ultrasonography-guided gallbladder drainage for acute cholecystitis","volume":"46","author":"Choi","year":"2014","journal-title":"Endoscopy"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1007\/s00464-018-6406-7","article-title":"Three-way comparative study of endoscopic ultrasound-guided transmural gallbladder drainage using lumen-apposing metal stents versus endoscopic transpapillary drainage versus percutaneous cholecystostomy for gallbladder drainage in high-risk surgical patients with acute cholecystitis: Clinical outcomes and success in an International, Multicenter Study","volume":"33","author":"Siddiqui","year":"2019","journal-title":"Surg. Endosc."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1055\/a-1020-3932","article-title":"Endoscopic ultrasound-guided gallbladder drainage, transpapillary drainage, or percutaneous drainage in high risk acute cholecystitis patients: A systematic review and comparative meta-analysis","volume":"52","author":"Mohan","year":"2020","journal-title":"Endoscopy"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1055\/a-0929-6603","article-title":"Endoscopic ultrasound-guided gallbladder drainage versus percutaneous cholecystostomy for high risk surgical patients with acute cholecystitis: A systematic review and meta-analysis","volume":"51","author":"Luk","year":"2019","journal-title":"Endoscopy"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1136\/gutjnl-2019-319996","article-title":"Endosonography-guided gallbladder drainage versus percutaneous cholecystostomy in very high-risk surgical patients with acute cholecystitis: An international randomised multicentre controlled superiority trial (DRAC 1)","volume":"69","author":"Teoh","year":"2020","journal-title":"Gut"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.gie.2019.04.238","article-title":"EUS-guided gallbladder drainage with a lumen-apposing metal stent versus endoscopic transpapillary gallbladder drainage for the treatment of acute cholecystitis (with videos)","volume":"90","author":"Higa","year":"2019","journal-title":"Gastrointest. Endosc."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1007\/s00464-020-07409-7","article-title":"EUS-guided versus endoscopic transpapillary gallbladder drainage in high-risk surgical patients with acute cholecystitis: A systematic review and meta-analysis","volume":"34","author":"Krishnamoorthi","year":"2020","journal-title":"Surg. Endosc."},{"key":"ref_72","doi-asserted-by":"crossref","unstructured":"Gillen, S., Schuster, T., B\u00fcschenfelde, C.M.Z., Friess, H., and Kleeff, J. (2010). Preoperative\/Neoadjuvant Therapy in Pancreatic Cancer: A Systematic Review and Meta-analysis of Response and Resection Percentages. PLoS Med., 7.","DOI":"10.1371\/journal.pmed.1000267"},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1053\/ge.1999.v50.98847","article-title":"EUS-guided radiofrequency ablation in the pancreas: Results in a porcine model","volume":"50","author":"Goldberg","year":"1999","journal-title":"Gastrointest. Endosc."},{"key":"ref_74","first-page":"431451","article-title":"Endoscopic Ultrasound-Guided Radiofrequency Ablation (EUS-RFA) of the Pancreas in a Porcine Model","volume":"2012","author":"Gaidhane","year":"2012","journal-title":"Gastroenterol. Res. Pr."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"E1243","DOI":"10.1055\/a-1221-5012","article-title":"Efficacy of EUS-RFA in pancreatic tumors: Is it ready for prime time? A systematic review and meta-analysis","volume":"8","author":"Dhaliwal","year":"2020","journal-title":"Endosc. Int. Open"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1055\/a-0583-8387","article-title":"Endoscopic ultrasound-guided radiofrequency ablation for management of benign solid pancreatic tumors","volume":"50","author":"Choi","year":"2018","journal-title":"Endoscopy"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"AB84","DOI":"10.1016\/j.gie.2018.04.092","article-title":"Safety and efficacy of endoscopic ultrasound guided radiofrequency ablation (EUS-RFA) in the treatment of pancreatic lesions: A multi-center experience","volume":"87","author":"Thosani","year":"2018","journal-title":"Gastrointest. Endosc."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"8257","DOI":"10.3748\/wjg.v22.i37.8257","article-title":"Review of endoscopic radiofrequency in biliopancreatic tumours with emphasis on clinical benefits, controversies and safety","volume":"22","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"3541","DOI":"10.1200\/JCO.2010.32.2750","article-title":"Randomized, Double-Blind, Controlled Trial of Early Endoscopic Ultrasound\u2013Guided Celiac Plexus Neurolysis to Prevent Pain Progression in Patients with Newly Diagnosed, Painful, Inoperable Pancreatic Cancer","volume":"29","author":"Wyse","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1007\/s10620-008-0651-x","article-title":"EUS-guided celiac plexus neurolysis for pain due to chronic pancreatitis or pancreatic cancer pain: A meta-analysis and systematic review","volume":"54","author":"Puli","year":"2009","journal-title":"Dig. Dis. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.gie.2014.12.036","article-title":"Impact of celiac neurolysis on survival in patients with pancreatic cancer","volume":"82","author":"Bamlet","year":"2015","journal-title":"Gastrointest. Endosc."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/den.12824","article-title":"Endoscopic ultrasound-guided celiac plexus block and neurolysis","volume":"29","author":"Yasuda","year":"2017","journal-title":"Dig. 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