{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T15:25:32Z","timestamp":1772551532913,"version":"3.50.1"},"reference-count":24,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T00:00:00Z","timestamp":1626652800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Apathy is a neuropsychiatric condition characterized by reduced motivation, initiative, and interest in daily life activities, and it is commonly reported in several neurodegenerative disorders. The study aims to investigate large-scale brain networks involved in apathy syndrome in patients with frontotemporal dementia (FTD) and Parkinson\u2019s disease (PD) compared to a group of healthy controls (HC). The study sample includes a total of 60 subjects: 20 apathetic FTD and PD patients, 20 non apathetic FTD and PD patients, and 20 HC matched for age. Two disease-specific apathy-evaluation scales were used to measure the presence of apathy in FTD and PD patients; in the same day, a 3T brain magnetic resonance imaging (MRI) with structural and resting-state functional (fMRI) sequences was acquired. Differences in functional connectivity (FC) were assessed between apathetic and non-apathetic patients with and without primary clinical diagnosis revealed, using a whole-brain, seed-to-seed approach. A significant hypoconnectivity between apathetic patients (both FTD and PD) and HC was detected between left planum polare and both right pre- or post-central gyrus. Finally, to investigate whether such neural alterations were due to the underlying neurodegenerative pathology, we replicated the analysis by considering two independent patients\u2019 samples (i.e., non-apathetic PD and FTD). In these groups, functional differences were no longer detected. These alterations may subtend the involvement of neural pathways implicated in a specific reduction of information\/elaboration processing and motor outcome in apathetic patients.<\/jats:p>","DOI":"10.3390\/jpm11070679","type":"journal-article","created":{"date-parts":[[2021,7,19]],"date-time":"2021-07-19T21:39:15Z","timestamp":1626730755000},"page":"679","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identifying a Common Functional Framework for Apathy Large-Scale Brain Network"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5869-754X","authenticated-orcid":false,"given":"Vincenzo","family":"Alfano","sequence":"first","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariachiara","family":"Longarzo","sequence":"additional","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Mele","sequence":"additional","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcello","family":"Esposito","sequence":"additional","affiliation":[{"name":"AOU Cardarelli, 80131 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Aiello","sequence":"additional","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9734-7702","authenticated-orcid":false,"given":"Marco","family":"Salvatore","sequence":"additional","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario","family":"Grossi","sequence":"additional","affiliation":[{"name":"Department of Psychology, Universit\u00e0 degli Studi della Campania Luigi Vanvitelli, 81100 Caserta, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Cavaliere","sequence":"additional","affiliation":[{"name":"IRCCS SDN, Via Emanuele Gianturco, 113, 80142 Naples, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,7,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1093\/cercor\/bhj043","article-title":"Apathy and the functional anatomy of the prefrontal cortex-basal ganglia circuits","volume":"16","author":"Levy","year":"2006","journal-title":"CEREB Cortex"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1176\/jnp.17.1.7","article-title":"Apathy: Why care?","volume":"17","author":"Stuss","year":"2005","journal-title":"J. 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