{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T19:58:58Z","timestamp":1784836738710,"version":"3.55.0"},"reference-count":43,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T00:00:00Z","timestamp":1631145600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Halo nevi, known as leukoderma acquisitum centrifugum, Sutton nevus, leukopigmentary nevus, perinevoid vitiligo, or perinevoid leukoderma, together with vitiligo and melanoma-associated hypopigmentation, belong to the group of dermatoses designated as immunological leukodermas. The etiology and pathogenesis of halo nevi has not been fully elucidated. There are several mechanisms through which a lymphocytic infiltrate can induce tumoral regression. In this review, we aimed to update the knowledge about Sutton nevi starting with the clinical appearance and dermoscopic features, continuing with information regarding conventional microscopy, immunohistochemistry, and the immunological mechanisms responsible for the occurrence of halo nevi. We also included in the article original unpublished results when discussing dermoscopic, pathologic and immunohistochemical results in halo nevi. Sutton nevi are valuable models for studying antitumor reactions that the human body can generate. The slow and effective mechanism against a melanocytic skin tumor can teach us important lessons about both autoimmune diseases and anticancer defenses.<\/jats:p>","DOI":"10.3390\/jpm11090904","type":"journal-article","created":{"date-parts":[[2021,9,9]],"date-time":"2021-09-09T12:20:37Z","timestamp":1631190037000},"page":"904","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current Challenges in Deciphering Sutton Nevi\u2014Literature Review and Personal Experience"],"prefix":"10.3390","volume":"11","author":[{"given":"Roxana","family":"Nedelcu","sequence":"first","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma 360 Clinic, 11273 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6052-9027","authenticated-orcid":false,"given":"Alexandra","family":"Dobre","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Brinzea","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma 360 Clinic, 11273 Bucharest, Romania"},{"name":"National Institute for Infectious Diseases, Outpatient Clinic, 021105 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ionela","family":"Hulea","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, 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Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma 360 Clinic, 11273 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorena","family":"Manea","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Pathology and Dermatovenerology, Colentina Clinical Hospital, 020125 Bucharest, Romania"},{"name":"Department of Dermatovenerology, Centre Hospitalier R\u00e9gional D\u2019orl\u00e9ans, 45100 Orl\u00e9ans, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreea","family":"Calinescu","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Derma 360 Clinic, 11273 Bucharest, 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Romania"},{"name":"Department of Pathology and Dermatovenerology, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Popescu","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"},{"name":"Department of Pathology and Dermatovenerology, Colentina Clinical Hospital, 020125 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Balasescu","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Ion","sequence":"additional","affiliation":[{"name":"General Medicine, Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, 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