{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T04:50:40Z","timestamp":1790484640319,"version":"4.1.0"},"reference-count":29,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Kuwait Ministry of Health, (MOH)","award":["1999-PMS"],"award-info":[{"award-number":["1999-PMS"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study aims to estimate the prevalence rates of \u03b2-thalassemia and Sickle cell disorders in the adult population screened (n = 275,819) as part of the Kuwaiti National Premarital Screening Program. All the individuals who applied for a marriage license during the years 2009 and 2020 were covered by the program. A network of four reception centers in the Ministry of Health facilities and one Premarital Diagnostic Laboratory (PDL) in Maternity Hospital were involved in performing all investigations for hemoglobinopathies. The total number of individuals identified with \u03b2-thal trait was 5861 (2.12%), while 22 individuals (0.008%) were diagnosed with \u03b2-thal disease. A total of 5003 subjects (1.81%) were carrying the Sickle cell trait, while 172 subjects (0.062%) had Sickle cell disease including Sickle cell anemia (SCA). Results showed that the program succeeded indeed in preventing the marriage of 50.4% of risky couples by issuing unsafe marriage certificates. Yet more efforts are needed to improve the program\u2019s main objective of decreasing high-risk marriages. In particular, health care systems should be ameliorated in a way to intensify the counselling mechanism for the high-risk couples, strengthen the awareness of the general population and induce earlier age screening policies.<\/jats:p>","DOI":"10.3390\/jpm11100980","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T00:03:42Z","timestamp":1632960222000},"page":"980","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["The Prevalence of \u03b2-Thalassemia and Other Hemoglobinopathies in Kuwaiti Premarital Screening Program: An 11-Year Experience"],"prefix":"10.3390","volume":"11","author":[{"given":"Najat","family":"Rouh AlDeen","sequence":"first","affiliation":[{"name":"Hematology Department, Maternity Hospital, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asmaa A","family":"Osman","sequence":"additional","affiliation":[{"name":"Hematology Department, Maternity Hospital, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monira J","family":"Alhabashi","sequence":"additional","affiliation":[{"name":"Hematology Department, Maternity Hospital, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2028-8713","authenticated-orcid":false,"given":"Rasha","family":"Al Khaldi","sequence":"additional","affiliation":[{"name":"ATC Learn Center, Advanced Technology Company, P.O. Box 44558, Hawalli 32060, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Alawadi","sequence":"additional","affiliation":[{"name":"Social Health Administration, Kuwait Premarital Center, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maha K","family":"Alromh","sequence":"additional","affiliation":[{"name":"Social Health Administration, Kuwait Premarital Center, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiman G","family":"Alyafai","sequence":"additional","affiliation":[{"name":"Social Health Administration, Kuwait Premarital Center, P.O. Box 4078, Sabah 13001, Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7586-3263","authenticated-orcid":false,"given":"Nagihan","family":"Akbulut-Jeradi","sequence":"additional","affiliation":[{"name":"ATC Learn Center, Advanced Technology Company, P.O. 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Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/03630260802508384","article-title":"Knowledge and attitude toward the hemoglobinopathies premarital screening program in Saudi Arabia: Population-based survey","volume":"32","author":"Suliman","year":"2008","journal-title":"Hemoglobin"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/GIM.0b013e318065a9e8","article-title":"Premarital screening for thalassemia and sickle cell disease in Saudi Arabia","volume":"9","author":"Alhamdan","year":"2007","journal-title":"Genet. Med."},{"key":"ref_4","first-page":"704","article-title":"Inherited haemoglobin disorders: An increasing global health problem","volume":"79","author":"Weatherall","year":"2001","journal-title":"Bull. World Health Organ."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0889-8545(01)00006-7","article-title":"Screening for thalassemia: A model of success","volume":"29","author":"Cao","year":"2002","journal-title":"Obstet. Gynecol. Clin. N. Am."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1136\/bmj.38982.704931.AE","article-title":"Genetic disorders in the Arab world","volume":"333","author":"Hamamy","year":"2006","journal-title":"BMJ"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1159\/000430837","article-title":"Exploring the effectiveness of mandatory premarital screening and genetic counselling programmes for beta-thalassaemia in the Middle East: A scoping review","volume":"18","author":"Saffi","year":"2015","journal-title":"Public Health Genom."},{"key":"ref_8","first-page":"300","article-title":"Incidence of haemoglobinopathies detected through neonatal screening in the United Arab Emirates","volume":"11","author":"Salah","year":"2005","journal-title":"EMHJ"},{"key":"ref_9","first-page":"1","article-title":"Genetic blood disorders survey in the sultanate of Oman","volume":"49","author":"Ebrahim","year":"2003","journal-title":"J. Trop. Pediatr."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1080\/03630260701297204","article-title":"Results from the north Cyprus thalassemia prevention program","volume":"31","author":"Bozkurt","year":"2007","journal-title":"Hemoglobin"},{"key":"ref_11","first-page":"572","article-title":"Haemoglobinopathies in Greece: Prevention programme over the past 35 years","volume":"134","author":"Loukopoulos","year":"2011","journal-title":"Indian J. Med. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3109\/03630269.2013.791627","article-title":"Hemoglobinopathy carrier prevalence in the United Arab Emirates: First analysis of the Dubai Health Authority premarital screening program results","volume":"37","author":"Belhoul","year":"2013","journal-title":"Hemoglobin"},{"key":"ref_13","first-page":"1549","article-title":"The natural history and the national pre-marital screening program in Saudi Arabia","volume":"25","year":"2004","journal-title":"Saudi Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"291","DOI":"10.5001\/omj.2012.72","article-title":"Knowledge and attitude of university students towards premarital screening program","volume":"27","year":"2012","journal-title":"Oman Med. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jiph.2010.11.001","article-title":"An educational program about premarital screening for unmarried female students in King Abdul-Aziz University, Jeddah","volume":"4","author":"Ibrahim","year":"2011","journal-title":"J. Infect. Public Health"},{"key":"ref_16","first-page":"793","article-title":"Twenty year outcome analysis of genetic screening programs for Tay-Sachs and B-thalassemia disease carriers in high schools","volume":"59","author":"Mitchell","year":"1996","journal-title":"Am. J. Hum. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1742-4755-6-17","article-title":"Consanguinity and reproductive health among Arabs","volume":"6","author":"Tadmouri","year":"2009","journal-title":"Reprod. Health"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ejmhg.2011.10.002","article-title":"Profile of genetic disorders prevalent in northeast region of Cairo, Egypt","volume":"13","author":"Shawky","year":"2012","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1002\/pd.2507","article-title":"Postmarital follow-up survey on high risk patients subjected to premarital screening program in Saudi Arabia","volume":"30","author":"Saeedi","year":"2010","journal-title":"Prenat. Diagn."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1038\/ejhg.2010.90","article-title":"Carrier screening for beta thalassaemia: A review of international practice","volume":"18","author":"Cousens","year":"2010","journal-title":"Eur. J. Hum. Genet."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1017\/thg.2012.152","article-title":"Current practice and attitudes of Australian obstetricians toward population-based carrier screening for inherited conditions","volume":"16","author":"Stark","year":"2013","journal-title":"Twin Res. Hum. Genet."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.4274\/tjh.2012.0121","article-title":"National thalassemia prevention campaign: The talotir project","volume":"30","author":"Canatan","year":"2013","journal-title":"Turk. J. Haematol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1258\/jms.2008.008029","article-title":"Premarital screening programmes for haemoglobinopathies, HIV and hepatitis viruses: Review and factors affecting their success","volume":"16","author":"Alswaidi","year":"2009","journal-title":"J. Med. Screen."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1111\/j.1399-0004.1984.tb00781.x","article-title":"Control of homozygous \u00df thalassemia by carrier screening and antenatal diagnosis in Sardinia","volume":"26","author":"Cao","year":"1984","journal-title":"Clin. Genet."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000205869","article-title":"Prevention of thalassemia and haemoglobin S syndromes in Greece","volume":"78","author":"Fessas","year":"1987","journal-title":"Acta Haematol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0950-3536(05)80072-1","article-title":"Screening and prenatal diagnosis of the haemoglobinopathies","volume":"6","author":"Cao","year":"1993","journal-title":"Bailli\u00e8res Clin. Haematol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/molehr\/gag038","article-title":"An evaluation of PGD in clinical genetic services through 3 years application for prevention of B-thalassaemia major and sickle cell thalassaemia","volume":"9","author":"Vrettou","year":"2003","journal-title":"Mol. Hum. Reprod."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Satirapod, C., Sukprasert, M., Panthan, B., Charoenyingwattana, A., Chitayanan, P., Chantratita, W., Choktanasiri, W., Trachoo, O., and Hongeng, S. (2019). Clinical utility of combined preimplantation genetic testing methods in couples at risk of passing on beta thalassemia\/hemoglobin E disease: A retrospective review from a single center. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0225457"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1111\/bjh.16930","article-title":"Cumulative outcome of pre-implantation genetic diagnosis for sickle cell disease: A 5-year review","volume":"191","author":"Vali","year":"2020","journal-title":"Br. J. Haematol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/10\/980\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:07:24Z","timestamp":1760166444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/10\/980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,29]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,10]]}},"alternative-id":["jpm11100980"],"URL":"https:\/\/doi.org\/10.3390\/jpm11100980","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,9,29]]}}}