{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T21:47:32Z","timestamp":1784843252239,"version":"3.55.0"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T00:00:00Z","timestamp":1636416000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Gastroschisis is a congenital abdominal wall defect that presents an increasing occurrence at great cost for the health system. The aim of the study is to detect the main factors of an unfavorable evolution in the case of gastroschisis and to find the best predictors of death. Methods: we conducted a retrospective cohort study of neonates with gastroschisis treated in a tertiary pediatric center during the last 30 years; 159 patients were eligible for the study. Logistic regression was used to determine the risk of death, estimated based on independent variables previously validated by the chi-square test. Results: if the birth weight is below normal, then we find an increased risk (4.908 times) of evolution to death. Similarly, the risk of death is 7.782 times higher in the case of developing abdominal compartment syndrome, about 3 times in the case of sepsis and 7.883 times in the case of bronchopneumonia. All four independent variables contributed 47.6% to the risk of death. Conclusion: although in the past 30 years in our country we have seen transformational improvements in outcome of gastroschisis, survival rates increasing from 26% to 52%, some factors may still be ameliorated for a better outcome.<\/jats:p>","DOI":"10.3390\/jpm11111168","type":"journal-article","created":{"date-parts":[[2021,11,9]],"date-time":"2021-11-09T12:46:23Z","timestamp":1636461983000},"page":"1168","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Statistical Analysis of the Main Risk Factors of an Unfavorable Evolution in Gastroschisis"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-8011","authenticated-orcid":false,"given":"Elena","family":"\u0162arc\u0103","sequence":"first","affiliation":[{"name":"Department of Surgery II\u2014Pediatric Surgery, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solange Tamara","family":"Ro\u0219u","sequence":"additional","affiliation":[{"name":"Department of Nursing, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7859-840X","authenticated-orcid":false,"given":"Elena","family":"Cojocaru","sequence":"additional","affiliation":[{"name":"Department of Morphofunctional Sciences I\u2014Pathology, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Trandafir","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine\u2014Pediatrics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina Costina","family":"Luca","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine\u2014Pediatrics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2640-8795","authenticated-orcid":false,"given":"Valeriu Vasile","family":"Lupu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine\u2014Pediatrics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4140-0492","authenticated-orcid":false,"given":"\u0218tefana Maria","family":"Mois\u0103","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine\u2014Pediatrics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u0103cr\u0103mioara Ionela","family":"Butnariu","sequence":"additional","affiliation":[{"name":"Department of Mother and Child Medicine\u2014Genetics, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4192-3704","authenticated-orcid":false,"given":"Viorel","family":"\u0162arc\u0103","sequence":"additional","affiliation":[{"name":"County Statistics Department, 700115 Ia\u015fi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1097\/MOP.0000000000000336","article-title":"Management of gastroschisis","volume":"28","author":"Skarsgard","year":"2016","journal-title":"Curr. Opin. Pediatr."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/ppe.12554","article-title":"Mode of delivery and mortality among neonates with gastroschisis: A population-based cohort in Texas","volume":"33","author":"Lopez","year":"2019","journal-title":"Paediatr Perinat. Epidemiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.jss.2019.07.065","article-title":"Predicting Morbidity and Mortality in Neonates Born With Gastroschisis","volume":"245","author":"Raymond","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_4","first-page":"151","article-title":"Birth Weight, Compromised Bowel and Sepsis are the Main Variables Significantly Influencing Outcome in Gastroschisis","volume":"110","author":"Ciongradi","year":"2015","journal-title":"Chirurgia"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"\u0162arc\u0103, E., Ro\u0219u, S., Cojocaru, E., Trandafir, L., Luca, A., Rusu, D., and \u0162arc\u0103, V. (2021). Socio-Epidemiological Factors with Negative Impact on Infant Morbidity, Mortality Rates, and the Occurrence of Birth Defects. Healthcare, 9.","DOI":"10.3390\/healthcare9040384"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/jpsu.2001.20004","article-title":"Gastroschisis: A plea for risk categorization","volume":"36","author":"Molik","year":"2001","journal-title":"J. Pediatr. Surg."},{"key":"ref_7","unstructured":"Mihai, \u021a., and Viorel, \u021a. (2005). Elemente de Statistic\u0103, Editura Junimea."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jpeds.2017.06.013","article-title":"Contemporary Outcomes of Infants with Gastroschisis in North America: A Multicenter Cohort Study","volume":"188","author":"Fullerton","year":"2017","journal-title":"J. Pediatr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1080\/14767058.2018.1529163","article-title":"Prevalence and predictors of mortality in gastroschisis: A population-based study of 4803 cases in the USA","volume":"33","author":"Brebner","year":"2018","journal-title":"J. Matern. Neonatal Med."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"999","DOI":"10.47162\/RJME.61.4.02","article-title":"Endocardial fibroelastosis and dilated cardiomyopathy \u2013 the past and future of the interface between histology and genetics","volume":"61","author":"Luca","year":"2021","journal-title":"Romanian J. Morphol. Embryol. Rev. Roum. Morphol. Embryol."},{"key":"ref_11","first-page":"1875","article-title":"The association of perinatal and clinical factors with outcomes in infants with gastroschisis\u2014a retrospective multicenter study in Finland","volume":"180","author":"Tauriainen","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1016\/j.jpedsurg.2017.08.068","article-title":"Outcomes of gastroschisis early delivery: A systematic review and meta-analysis","volume":"52","author":"Landisch","year":"2017","journal-title":"J. Pediatr. Surg."},{"key":"ref_13","unstructured":"Ferreira, R.G., Mendon\u00e7a, C.R., Ramos, L.L.G., Tacon, F.S.D.A., Amaral, W.N.D., and Ruano, R. (2021). Gastroschisis: A systematic review of diagnosis, prognosis and treatment. J. Matern. Neonatal Med., 1\u201314."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1053\/j.sempedsurg.2018.08.006","article-title":"Advances in prenatal and perinatal diagnosis and management of gastroschisis","volume":"27","author":"Oakes","year":"2018","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.jpedsurg.2016.10.045","article-title":"Mortality-related factors in gastroschisis \u2013 a Jamaican perspective","volume":"52","author":"Niles","year":"2016","journal-title":"J. Pediatr. Surg."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1053\/j.sempedsurg.2018.08.003","article-title":"Surgical strategies in complex gastroschisis","volume":"27","author":"Emil","year":"2018","journal-title":"Semin. Pediatr. Surg."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1097\/01.SLA.0000071568.95915.DC","article-title":"Evolution of Staged Versus Primary Closure of Gastroschisis","volume":"237","author":"Kidd","year":"2003","journal-title":"Ann. Surg."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.jpedsurg.2019.08.002","article-title":"Immediate versus silo closure for gastroschisis: Results of a large multicenter study","volume":"55","author":"Hawkins","year":"2020","journal-title":"J. Pediatr. Surg."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Del Bigio, J.Z., Falc\u00e3o, M.C., Tannuri, A.C.A., de Carvalho, W.B., and Matsushita, F.Y. (2021). Gastroschisis and late-onset neonatal sepsis in a tertiary referral center in Southeastern Brazil. J. Pediatr., in press.","DOI":"10.1016\/j.jped.2021.05.003"}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/11\/1168\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:28:07Z","timestamp":1760167687000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/11\/1168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,9]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["jpm11111168"],"URL":"https:\/\/doi.org\/10.3390\/jpm11111168","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,9]]}}}