{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T19:58:45Z","timestamp":1790625525316,"version":"4.1.0"},"reference-count":85,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,3]],"date-time":"2021-12-03T00:00:00Z","timestamp":1638489600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Cirrhotic cardiomyopathy (CCM) is a relatively new medical term. The constant development of novel diagnostic and clinical tools continuously delivers new data and findings about this broad disorder. The purpose of this review is to summarize current facts about CCM, identify gaps of knowledge, and indicate the direction in which to prepare an updated definition of CCM. We performed a review of the literature using scientific data sources with an emphasis on the latest findings. CCM is a clinical manifestation of disorders in the circulatory system in the course of portal hypertension. It is characterized by impaired left ventricular systolic and diastolic dysfunction, and electrophysiological abnormalities, especially QT interval prolongation. However, signs and symptoms reported by patients are non-specific and include reduced exercise tolerance, fatigue, peripheral oedema, and ascites. The disease usually remains asymptomatic with almost normal heart function, unless patients are exposed to stress or exertion. Unfortunately, due to the subclinical course, CCM is rarely recognized. Orthotopic liver transplantation (OLTx) seems to improve circulatory function although there is no consensus about its positive effect, with reported cases of heart failure onset after transplantation. Researchers indicate a careful pre-, peri-, and post-transplant cardiac assessment as a crucial point in detecting CCM and improving patients\u2019 prognosis. There is also an urgent need to update the CCM definition and establish a diagnostic algorithm for early diagnosis of CCM as well as a specific treatment of this condition.<\/jats:p>","DOI":"10.3390\/jpm11121285","type":"journal-article","created":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T21:01:45Z","timestamp":1638738105000},"page":"1285","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["What\u2019s New in Cirrhotic Cardiomyopathy?\u2014Review Article"],"prefix":"10.3390","volume":"11","author":[{"given":"Aleksandra","family":"Bodys-Pe\u0142ka","sequence":"first","affiliation":[{"name":"Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"},{"name":"Doctoral School, Medical University of Warsaw, 02-091 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Kusztal","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Raszeja-Wyszomirska","sequence":"additional","affiliation":[{"name":"Liver and Internal Medicine Unit, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"G\u0142\u00f3wczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3306-0301","authenticated-orcid":false,"given":"Marcin","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Medical University of Warsaw, 02-097 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1172\/JCI102813","article-title":"The cardiac output at rest in Laennec\u2019s cirrhosis","volume":"32","author":"Kowalski","year":"1953","journal-title":"J. Clin. Investig."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1172\/JCI106044","article-title":"Cardiac hemodynamics in alcoholic patients with chronic liver disease and a presystolic gallop","volume":"48","author":"Gould","year":"1969","journal-title":"J. Clin. Investig."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12072-014-9531-y","article-title":"Cirrhotic cardiomyopathy: Review of pathophysiology and treatment","volume":"8","author":"Chayanupatkul","year":"2014","journal-title":"Hepatol. Int."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ultrasmedbio.2017.11.013","article-title":"New Definition Criteria of Myocardial Dysfunction in Patients with Liver Cirrhosis: A Speckle Tracking and Tissue Doppler Imaging Study","volume":"44","author":"Baldea","year":"2018","journal-title":"Ultrasound Med. Biol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"15492","DOI":"10.3748\/wjg.v20.i42.15492","article-title":"Cirrhotic cardiomyopathy: A cardiologist\u2019s perspective","volume":"20","author":"Gassanov","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_6","first-page":"247","article-title":"The heart matters when the liver shatters! Cirrhotic cardiomyopathy: Frequency, comparison, and correlation with severity of disease","volume":"11","author":"Naqvi","year":"2016","journal-title":"Prz. Gastroenterol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/hep.30875","article-title":"Cirrhotic Cardiomyopathy Consortium. Redefining Cirrhotic Cardiomyopathy for the Modern Era","volume":"71","author":"Izzy","year":"2020","journal-title":"Hepatology"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"665","DOI":"10.15403\/jgld-3137","article-title":"Cirrhotic Cardiomyopathy in the Era of Liver Transplantation: Time for Precise Stepwise Evaluation","volume":"29","author":"Rimbas","year":"2020","journal-title":"J. Gastrointest. Liver Dis."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"S44","DOI":"10.1002\/lt.500060510","article-title":"Cirrhotic cardiomyopathy and liver transplantation","volume":"6","author":"Myers","year":"2000","journal-title":"Liver Transplant."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s12072-008-9109-7","article-title":"Cirrhotic cardiomyopathy","volume":"3","author":"Wong","year":"2009","journal-title":"Hepatol. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/S0041-1345(99)00383-8","article-title":"Evaluation of cardiac function before and after liver transplantation","volume":"31","author":"Acosta","year":"1999","journal-title":"Transplant. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0168-8278(03)00271-X","article-title":"Cardiac dysfunction in portal hypertension among patients with cirrhosis and non-cirrhotic portal fibrosis","volume":"39","author":"De","year":"2003","journal-title":"J. Hepatol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1136\/pmj.79.933.408","article-title":"Autonomic neuropathy in patients with hepatic cirrhosis","volume":"79","author":"Bajaj","year":"2003","journal-title":"Postgrad. Med. J."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jacc.2009.12.075","article-title":"Cirrhotic cardiomyopathy","volume":"56","author":"Zardi","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S0168-8278(98)80022-6","article-title":"The sympathetic nervous system in liver disease","volume":"29","author":"Henriksen","year":"1998","journal-title":"J. Hepatol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"H2966","DOI":"10.1152\/ajpheart.01227.2006","article-title":"ReducedReduced baroreflex sensitivity in alcoholic cirrhosis: Relations to hemodynamics and humoral systems","volume":"292","author":"Moller","year":"2007","journal-title":"Am. J. Physiol. Circ. Physiol."},{"key":"ref_17","first-page":"G87","article-title":"Membrane physical properties determine cardiac beta-adrenergic receptor function in cirrhotic rats","volume":"267 Pt 1","author":"Ma","year":"1994","journal-title":"Am. J. Physiol. Content"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0026-0495(93)90166-L","article-title":"Lecithin-cholesterol acyltransferase and lipid transfer protein activities in liver disease","volume":"42","author":"Tahara","year":"1993","journal-title":"Metabolism"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0168-8278(97)80259-0","article-title":"Effects of altered cardiac membrane fluidity on beta-adrenergic receptor signalling in rats with cirrhotic cardiomyopathy","volume":"26","author":"Ma","year":"1997","journal-title":"J. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s00232-004-0668-9","article-title":"Mechanisms of Na+-Ca2+ exchange inhibition by amphiphiles in cardiac myocytes: Importance of transbilayer movement","volume":"198","author":"Keller","year":"2004","journal-title":"J. Membr. Biol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0168-8278(95)80292-4","article-title":"Endogenous factors involved in the control of arterial tone in cirrhosis","volume":"22","author":"Moreau","year":"1995","journal-title":"J. Hepatol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"11502","DOI":"10.3748\/wjg.v21.i41.11502","article-title":"Cirrhotic cardiomyopathy","volume":"21","author":"Serradilla","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jhep.2013.07.044","article-title":"Pathological bacterial translocation in liver cirrhosis","volume":"60","author":"Wiest","year":"2014","journal-title":"J. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2044","DOI":"10.1002\/hep.23918","article-title":"Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis","volume":"52","author":"Bellot","year":"2010","journal-title":"Hepatology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1161\/01.RES.0000150734.79804.92","article-title":"Cytokine-induced modulation of cardiac function","volume":"95","author":"Prabhu","year":"2004","journal-title":"Circ. Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1111\/liv.12263","article-title":"The endocannabinoid system in advanced liver cirrhosis: Pathophysiological implication and future perspectives","volume":"33","author":"Baldassarre","year":"2013","journal-title":"Liver Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1038\/sj.bjp.0706331","article-title":"Role of endocannabinoids in the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats","volume":"146","author":"Gaskari","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0168-8278(96)80272-8","article-title":"Cardiac modifications occurring in the ascitic rat with biliary cirrhosis are nitric oxide related","volume":"24","author":"Vallieres","year":"1996","journal-title":"J. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0016-5085(00)70180-6","article-title":"Contribution of nitric oxide to the pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated rats","volume":"118","author":"Liu","year":"2000","journal-title":"Gastroenterology"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"G68","DOI":"10.1152\/ajpgi.2001.280.1.G68","article-title":"Role of heme oxygenase-carbon monoxide pathway in pathogenesis of cirrhotic cardiomyopathy in the rat","volume":"280","author":"Liu","year":"2001","journal-title":"Am. J. Physiol.-Gastrointest. Liver Physiol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1161\/01.RES.0000189270.72915.D1","article-title":"Ca2+ influx-induced sarcoplasmic reticulum Ca2+ overload causes mitochondrial-dependent apoptosis in ventricular myocytes","volume":"97","author":"Chen","year":"2005","journal-title":"Circ. Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jjcc.2015.04.016","article-title":"Cirrhotic cardiomyopathy in the pre- and post-liver transplantation phase","volume":"67","author":"Zardi","year":"2016","journal-title":"J. Cardiol."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Sharma, S., Karamchandani, K., Wilson, R., Baskin, S., and Bezinover, D. (2018). Acute heart failure after Orthotopic liver transplantation: A case series from one center. BMC Anesthesiol., 18.","DOI":"10.1186\/s12871-018-0560-2"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1080\/003655201750313289","article-title":"Cardiovascular dysfunction in cirrhosis. Pathophysiological evidence of a cirrhotic cardiomyopathy","volume":"36","author":"Moller","year":"2001","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1111\/ctr.12778","article-title":"Impact and persistence of cirrhotic cardiomyopathy after liver transplantation","volume":"30","author":"Sonny","year":"2016","journal-title":"Clin. Transplant."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.echo.2016.01.011","article-title":"Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging","volume":"29","author":"Nagueh","year":"2016","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1111\/j.1478-3231.2011.02468.x","article-title":"Resting myocardial dysfunction in cirrhosis quantified by tissue Doppler imaging","volume":"31","author":"Kazankov","year":"2011","journal-title":"Liver Int."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1007\/s10620-014-3432-8","article-title":"Recent advances in cirrhotic cardiomyopathy","volume":"60","author":"Karagiannakis","year":"2015","journal-title":"Dig. Dis. Sci."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1283162","DOI":"10.1080\/19932820.2017.1283162","article-title":"Cirrhotic cardiomyopathy: Is there any correlation between the stage of cardiac impairment and the severity of liver disease?","volume":"12","author":"Hammami","year":"2017","journal-title":"Libyan J. Med."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.transproceed.2016.01.010","article-title":"Diastolic Dysfunction in Liver Cirrhosis: Prognostic Predictor in Liver Transplantation?","volume":"48","author":"Carvalheiro","year":"2016","journal-title":"Transplant. Proc."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.ejim.2012.08.007","article-title":"Cardiac dysfunction in cirrhosis is not associated with the severity of liver disease","volume":"24","author":"Merli","year":"2013","journal-title":"Eur. J. Intern. Med."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"622","DOI":"10.12659\/AOT.908769","article-title":"Pretransplant QT Interval: The Relationship with Severity and Etiology of Liver Disease and Prognostic Value After Liver Transplantation","volume":"23","author":"Glowczynska","year":"2018","journal-title":"Ann. Transplant."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1002\/hep.510270106","article-title":"Q-T interval prolongation in cirrhosis: Prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors","volume":"27","author":"Bernardi","year":"1998","journal-title":"Hepatology"},{"key":"ref_44","first-page":"274","article-title":"Q-T Interval Prolongation in Patients with Liver Cirrhosis","volume":"44","author":"Tieranu","year":"2018","journal-title":"Curr. Health Sci. J."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/j.1540-8167.2006.00622.x","article-title":"QT interval correction in patients with cirrhosis","volume":"18","author":"Zambruni","year":"2007","journal-title":"J. Cardiovasc. Electrophysiol."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0168-8278(02)00010-7","article-title":"Dyssynchronous electrical and mechanical systole in patients with cirrhosis","volume":"36","author":"Henriksen","year":"2002","journal-title":"J. Hepatol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1136\/gut.52.10.1511","article-title":"Increased circulating pro-brain natriuretic peptide (proBNP) and brain natriuretic peptide (BNP) in patients with cirrhosis: Relation to cardiovascular dysfunction and severity of disease","volume":"52","author":"Henriksen","year":"2003","journal-title":"Gut"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/j.ejim.2014.09.004","article-title":"Clinical implications of the hyperdynamic syndrome in cirrhosis","volume":"25","author":"Licata","year":"2014","journal-title":"Eur. J. Intern. Med."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1111\/liv.12428","article-title":"Cardiac and proinflammatory markers predict prognosis in cirrhosis","volume":"34","author":"Wiese","year":"2014","journal-title":"Liver Int."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1016\/j.transproceed.2018.02.136","article-title":"Troponin I Is Not a Predictor of Early Cardiovascular Morbidity in Liver Transplant Recipients","volume":"50","author":"Glowczynska","year":"2018","journal-title":"Transplant. Proc."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1177\/1753944717727498","article-title":"Left atrial volume index in patients with heart failure and severely impaired left ventricular systolic function: The role of established echocardiographic parameters, circulating cystatin C and galectin-3","volume":"11","author":"Zivlas","year":"2017","journal-title":"Ther. Adv. Cardiovasc. Dis."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.hfc.2017.08.009","article-title":"Galectin-3 in heart failure: An update of the last 3 years","volume":"14","author":"Gehlken","year":"2018","journal-title":"Heart Fail Clin."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11894-020-00783-1","article-title":"Cirrhotic Cardiomyopathy","volume":"22","author":"Yoon","year":"2020","journal-title":"Curr. Gastroenterol. Rep."},{"key":"ref_54","unstructured":"Lyssy, L.A., and Soos, M.P. (2021). Cirrhotic Cardiomyopathy. StatPearls, StatPearls Publishing."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"367","DOI":"10.5152\/tjg.2016.16100","article-title":"Galactin-3 and brain natriuretic peptide versus conventional echocardiography in the early detection of cirrhotic cardiomyopathy","volume":"27","author":"Abbas","year":"2016","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/s10741-016-9552-9","article-title":"Diastolic dysfunction in cirrhosis","volume":"21","author":"Moller","year":"2016","journal-title":"Heart Fail. Rev."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1111\/j.1600-6143.2008.02276.x","article-title":"Predictive value of dobutamine stress echocardiography for coronary artery disease detection in liver transplant candidates","volume":"8","author":"Harinstein","year":"2008","journal-title":"Am. J. Transplant."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1002\/med.21755","article-title":"Analogies and differences between cirrhotic cardiomyopathy and hepatopulmonary syndrome","volume":"41","author":"Zardi","year":"2021","journal-title":"Med. Res. Rev."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrgastro.2013.210","article-title":"Cirrhotic cardiomyopathy: Pathogenesis and clinical relevance","volume":"11","author":"Wiese","year":"2013","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1432-2277.2011.01219.x","article-title":"High brain-natriuretic peptide level predicts cirrhotic cardiomyopathy in liver transplant patients","volume":"24","author":"Saner","year":"2011","journal-title":"Transplant. Int."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Licata, A., Corrao, S., Petta, S., Genco, C., Cardillo, M., Calvaruso, V., Cabibbo, G., Massenti, F., Camm\u00e0, C., and Licata, G. (2013). NT pro BNP plasma level and atrial volume are linked to the severity of liver cirrhosis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0068364"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/lt.20088","article-title":"Aerobic capacity is associated with 100-day outcome after hepatic transplantation","volume":"10","author":"Epstein","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/TP.0b013e318187758b","article-title":"Impact of impaired aerobic capacity on liver transplant candidates","volume":"86","author":"Dharancy","year":"2008","journal-title":"Transplantation"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/lt.22426","article-title":"Submaximal cardiopulmonary exercise testing predicts 90-day survival after liver transplantation","volume":"18","author":"Prentis","year":"2012","journal-title":"Liver Transplant."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"507","DOI":"10.4254\/wjh.v7.i3.507","article-title":"Cirrhotic cardiomyopathy: Implications for the perioperative management of liver transplant patients","volume":"7","author":"Rahman","year":"2015","journal-title":"World J. Hepatol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1750-1172-2-15","article-title":"Cirrhotic cardiomyopathy","volume":"2","author":"Baik","year":"2007","journal-title":"Orphanet J. Rare Dis."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.cardfail.2019.01.013","article-title":"Physiologic Adaptation or Cirrhotic Cardiomyopathy: It Is Time for New Definitions!","volume":"25","author":"Altayar","year":"2019","journal-title":"J. Card. Fail."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1002\/lt.24768","article-title":"Cirrhotic cardiomyopathy: Implications for liver transplantation","volume":"23","author":"Liu","year":"2017","journal-title":"Liver Transplant."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/lt.22224","article-title":"Predicting cardiovascular complications after liver transplantation: 007 to the rescue?","volume":"17","author":"Liu","year":"2011","journal-title":"Liver Transplant."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1002\/lt.20929","article-title":"The role of trans-oesophageal echocardiography for perioperative cardiovascular monitoring during orthotopic liver transplantation","volume":"12","author":"Burtenshaw","year":"2006","journal-title":"Liver Transplant."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.3748\/wjg.v22.i4.1551","article-title":"Post reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies","volume":"22","author":"Siniscalchi","year":"2016","journal-title":"World J. Gastroenterol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1002\/lt.20298","article-title":"Cardiac morbidity and mortality related to orthotopic liver transplantation","volume":"10","author":"Therapondos","year":"2004","journal-title":"Liver Transplant."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.amjcard.2007.08.056","article-title":"Frequency and significance of acute heart failure following liver transplantation","volume":"101","author":"Eimer","year":"2008","journal-title":"Am. J. Cardiol."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.jhep.2010.11.003","article-title":"The heart in liver transplantation","volume":"54","author":"Ripoll","year":"2011","journal-title":"J. Hepatol."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jhep.2004.09.008","article-title":"Cardiac alterations in cirrhosis: Reversibility after liver transplantation","volume":"42","author":"Torregrosa","year":"2005","journal-title":"J. Hepatol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1002\/hep.20911","article-title":"What happens to cirrhotic cardiomyopathy after liver transplantation?","volume":"42","author":"Liu","year":"2005","journal-title":"Hepatology"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1053\/jlts.2002.34381","article-title":"Cardiac function after orthotopic liver transplantation and the effects of immunosuppression: A prospective randomized trial comparing cyclosporin (Neoral) and tacrolimus","volume":"8","author":"Therapondos","year":"2002","journal-title":"Liver Transplant."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1007\/s12072-014-9544-6","article-title":"Diastolic cardiac dysfunction is a predictor of dismal prognosis in patients with liver cirrhosis","volume":"8","author":"Karagiannakis","year":"2014","journal-title":"Hepatol. Int."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1002\/hep.26509","article-title":"Diastolic dysfunction is a predictor of poor outcomes in patients with cirrhosis, portal hypertension, and a normal creatinine","volume":"58","author":"Serradilla","year":"2013","journal-title":"Hepatology"},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1007\/s10620-013-2955-8","article-title":"Pre-transplant left ventricular diastolic dysfunction is associated with post transplant acute graft rejection and graft failure","volume":"59","author":"Mittal","year":"2014","journal-title":"Dig. Dis. Sci."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1111\/ctr.12304","article-title":"Preoperative left ventricular hypertrophy is associated with reduced patient survival after liver transplantation","volume":"28","author":"Darstein","year":"2013","journal-title":"Clin. Transplant."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1002\/hep.30040","article-title":"Cirrhotic Cardiomyopathy After Transplantation: Neither the Transient Nor Innocent Bystander","volume":"68","author":"Izzy","year":"2018","journal-title":"Hepatology"},{"key":"ref_83","first-page":"31","article-title":"Cardiovascular dysfunction in patients with liver cirrhosis","volume":"28","author":"Fede","year":"2015","journal-title":"Ann. Gastroenterol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/hep.29329","article-title":"A point-based prediction model for cardiovascular risk in orthotopic liver transplantation: The CAR-OLT score","volume":"66","author":"VanWagner","year":"2017","journal-title":"Hepatology"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jhep.2007.11.012","article-title":"Effect of chronic beta-blockade on QT interval in patients with liver cirrhosis","volume":"48","author":"Zambruni","year":"2008","journal-title":"J. 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