{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:09:35Z","timestamp":1780481375805,"version":"3.54.1"},"reference-count":51,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T00:00:00Z","timestamp":1639008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>(1) Background: Road traffic accidents (RTAs) are the leading cause of pediatric traumatic brain injury (TBI) and are associated with high mortality. Few studies have focused on RTA-related pediatric TBI. We conducted this study to analyze the clinical characteristics of RTA-related TBI in children and to identify early predictors of in-hospital mortality in children with severe TBI. (2) Methods: In this 15-year observational cohort study, a total of 618 children with RTA-related TBI were enrolled. We collected the patients\u2019 clinical characteristics at the initial presentations in the emergency department (ED), including gender, age, types of road user, the motor components of the Glasgow Coma Scale (mGCS) score, body temperature, blood pressure, blood glucose level, initial prothrombin time, and the intracranial computed tomography (CT) Rotterdam score, as potential mortality predictors. (3) Results: Compared with children exhibiting mild\/moderate RTA-related TBI, those with severe RTA-related TBI were older and had a higher mortality rate (p &lt; 0.001). The in-hospital mortality rate for severe RTA-related TBI children was 15.6%. Compared to children who survived, those who died in hospital had a higher incidence of presenting with hypothermia (p = 0.011), a lower mGCS score (p &lt; 0.001), a longer initial prothrombin time (p &lt; 0.013), hyperglycemia (p = 0.017), and a higher Rotterdam CT score (p &lt; 0.001). Multivariate analyses showed that the mGCS score (adjusted odds ratio (OR): 2.00, 95% CI: 1.28\u20133.14, p = 0.002) and the Rotterdam CT score (adjusted OR: 2.58, 95% CI: 1.31\u20135.06, p = 0.006) were independent predictors of in-hospital mortality. (4) Conclusions: Children with RTA-related severe TBI had a high mortality rate. Patients who initially presented with hypothermia, a lower mGCS score, a prolonged prothrombin time, hyperglycemia, and a higher Rotterdam CT score in brain CT analyses were associated with in-hospital mortality. The mGCS and the Rotterdam CT scores were predictive of in-hospital mortality independently.<\/jats:p>","DOI":"10.3390\/jpm11121339","type":"journal-article","created":{"date-parts":[[2021,12,9]],"date-time":"2021-12-09T21:46:58Z","timestamp":1639086418000},"page":"1339","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of In-Hospital Mortality for Road Traffic Accident-Related Severe Traumatic Brain Injury"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5937-7222","authenticated-orcid":false,"given":"Chien-Hung","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2564-8431","authenticated-orcid":false,"given":"Yu-Wei","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy and Graduate Institute of Behavioral Sciences, School of Medicine, Chang Gung University, Taoyuan 33302, Taiwan"},{"name":"Healthy Aging Research Center, Chang Gung University, Taoyuan 33302, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jen-Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-2800","authenticated-orcid":false,"given":"Chih-Po","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Traumatology and Emergency Surgery, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2146-6040","authenticated-orcid":false,"given":"Chia-Ying","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9132-5289","authenticated-orcid":false,"given":"Chih-Chi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan 33305, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.ejpn.2019.01.009","article-title":"Incidence and Mortality of Moderate and Severe Traumatic Brain Injury in Children: A Ten Year Population-Based Cohort Study in Norway","volume":"23","author":"Olsen","year":"2019","journal-title":"Eur. J. Paediatr. Neurol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1089\/neu.2014.3801","article-title":"Predicting Outcome after Pediatric Traumatic Brain Injury by Early Magnetic Resonance Imaging Lesion Location and Volume","volume":"33","author":"Smitherman","year":"2016","journal-title":"J. Neurotrauma"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1056\/NEJMsr1804754","article-title":"The Major Causes of Death in Children and Adolescents in the United States","volume":"379","author":"Cunningham","year":"2018","journal-title":"N. Engl. J. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.wneu.2016.03.045","article-title":"Epidemiology of Global Pediatric Traumatic Brain Injury: Qualitative Review","volume":"91","author":"Dewan","year":"2016","journal-title":"World Neurosurg."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1007\/s00701-015-2512-7","article-title":"Epidemiology of Traumatic Brain Injury in Europe","volume":"157","author":"Peeters","year":"2015","journal-title":"Acta Neurochir."},{"key":"ref_6","unstructured":"(2021, October 24). Road Traffic Injuries. Available online: https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/road-traffic-injuries."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/0974-2700.76831","article-title":"Isolated Traumatic Head Injury in Children: Analysis of 276 Observations","volume":"4","author":"Bahloul","year":"2011","journal-title":"J. Emerg. Trauma Shock"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1542\/peds.2003-1020-L","article-title":"A Population-Based Comparison of Clinical and Outcome Characteristics of Young Children with Serious Inflicted and Noninflicted Traumatic Brain Injury","volume":"114","author":"Keenan","year":"2004","journal-title":"Pediatrics"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/00005373-199907000-00008","article-title":"Severe Head Injury in Children","volume":"47","author":"Feickert","year":"1999","journal-title":"J. Trauma Inj. Infect. Crit. Care"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1136\/jnnp.2007.135178","article-title":"Observational Approach to Subjects with Mild-to-Moderate Head Injury and Initial Non-Neurosurgical Lesions","volume":"79","author":"Fabbri","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Heather, N.L., Derraik, J.G.B., Beca, J., Hofman, P.L., Dansey, R., Hamill, J., and Cutfield, W.S. (2013). Glasgow Coma Scale and Outcomes after Structural Traumatic Head Injury in Early Childhood. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0082245"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1093\/brain\/awn293","article-title":"Childhood Brain Insult: Can Age at Insult Help Us Predict Outcome?","volume":"132","author":"Anderson","year":"2009","journal-title":"Brain"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/00003246-200103000-00011","article-title":"Predictors of Outcome in Severely Head-Injured Children","volume":"29","author":"White","year":"2001","journal-title":"Crit. Care Med."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1227\/NEU.0b013e3181fa7049","article-title":"Mortality in Children With Severe Head Trauma: Predictive Factors and Proposal for a New Predictive Scale","volume":"67","author":"Rocco","year":"2010","journal-title":"Neurosurgery"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1007\/s12028-017-0480-x","article-title":"Age and Mortality in Pediatric Severe Traumatic Brain Injury: Results from an International Study","volume":"28","author":"Sarnaik","year":"2018","journal-title":"Neurocritical Care"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1159\/000121057","article-title":"The Prognostic Value of the Glasgow Coma Scale, Hypoxia and Computerised Tomography in Outcome Prediction of Pediatric Head Injury","volume":"24","author":"Ong","year":"1996","journal-title":"Pediatr. Neurosurg."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Shao, J., Zhu, H., Yao, H., Stallones, L., Yeates, K., Wheeler, K., and Xiang, H. (2012). Characteristics and Trends of Pediatric Traumatic Brain Injuries Treated at a Large Pediatric Medical Center in China, 2002\u20132011. PLoS ONE, 7.","DOI":"10.1371\/journal.pone.0051634"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Chen, C.-C., Hsieh, P.-C., Chen, C.P.C., Hsieh, Y.-W., Chung, C.-Y., and Lin, K.-L. (2019). Prevention, Protection Against Child Abuse, Neglect (PCHAN) Study Group Clinical Characteristics and Predictors of Poor Hospital Discharge Outcome for Young Children with Abusive Head Trauma. J. Clin. Med. Res., 8.","DOI":"10.3390\/jcm8030390"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Chen, C.-C., Chen, C.P.C., Chen, C.-H., Hsieh, Y.-W., Chung, C.-Y., and Liao, C.-H. (2021). Predictors of In-Hospital Mortality for School-Aged Children with Severe Traumatic Brain Injury. Brain Sci., 11.","DOI":"10.3390\/brainsci11020136"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1097\/SHK.0000000000000151","article-title":"Coagulopathy after Severe Pediatric Trauma: A Review","volume":"41","author":"Christiaans","year":"2014","journal-title":"Shock"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/TA.0000000000001060","article-title":"The Impact of Acute Coagulopathy on Mortality in Pediatric Trauma Patients","volume":"81","author":"Strumwasser","year":"2016","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.resuscitation.2007.07.007","article-title":"PENTA study group Assessing the Level of Consciousness in Children: A Plea for the Glasgow Coma Motor Subscore","volume":"76","author":"Sabbe","year":"2008","journal-title":"Resuscitation"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1097\/TA.0000000000000095","article-title":"Blood Component Transfusion Increases the Risk of Death in Children with Traumatic Brain Injury","volume":"76","author":"Acker","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/PCC.0b013e3182192c30","article-title":"Relationship between Hyperglycemia and Outcome in Children with Severe Traumatic Brain Injury","volume":"13","author":"Smith","year":"2012","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"719476","DOI":"10.1155\/2015\/719476","article-title":"Early Hyperglycemia in Pediatric Traumatic Brain Injury Predicts for Mortality, Prolonged Duration of Mechanical Ventilation, and Intensive Care Stay","volume":"2015","author":"Chong","year":"2015","journal-title":"Int. J. Endocrinol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1007\/s00381-018-3989-1","article-title":"The Role of Coagulopathy on Clinical Outcome Following Traumatic Brain Injury in Children: Analysis of 66 Consecutive Cases in a Single Center Institution","volume":"34","author":"Furlanetti","year":"2018","journal-title":"Childs. Nerv. Syst."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.injury.2010.01.021","article-title":"Epidemiology of Traumatic Epidural Hematoma in Young Age","volume":"41","author":"Irie","year":"2010","journal-title":"Injury"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000056002","article-title":"Prognostic Factors in Children with Severe Diffuse Brain Injuries: A Study of 74 Patients","volume":"34","author":"Pillai","year":"2001","journal-title":"Pediatr. Neurosurg."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s12028-014-9986-7","article-title":"Subarachnoid Hemorrhage Prevalence and Its Association with Short-Term Outcome in Pediatric Severe Traumatic Brain Injury","volume":"21","author":"Hochstadter","year":"2014","journal-title":"Neurocrit. Care"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/TA.0000000000000300","article-title":"Glasgow Motor Scale Alone Is Equivalent to Glasgow Coma Scale at Identifying Children at Risk for Serious Traumatic Brain Injury","volume":"77","author":"Acker","year":"2014","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_31","first-page":"S876","article-title":"Part 14: Pediatric Advanced Life Support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care","volume":"122","author":"Kleinman","year":"2010","journal-title":"Circulation"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1227\/01.NEU.0000186013.63046.6B","article-title":"Prediction of Outcome in Traumatic Brain Injury with Computed Tomographic Characteristics: A Comparison between the Computed Tomographic Classification and Combinations of Computed Tomographic Predictors","volume":"57","author":"Maas","year":"2005","journal-title":"Neurosurgery"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/03610730701239004","article-title":"Population Inference with Mortality and Attrition in Longitudinal Studies on Aging: A Two-Stage Multiple Imputation Method","volume":"33","author":"Harel","year":"2007","journal-title":"Exp. Aging Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Pai, C.-W., Lin, H.-Y., Tsai, S.-H., and Chen, P.-L. (2018). Comparison of Traffic-Injury Related Hospitalisation between Bicyclists and Motorcyclists in Taiwan. PLoS ONE, 13.","DOI":"10.1371\/journal.pone.0191221"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"793","DOI":"10.2105\/AJPH.90.5.793","article-title":"The Effect of the Taiwan Motorcycle Helmet Use Law on Head Injuries","volume":"90","author":"Chiu","year":"2000","journal-title":"Am. J. Public Health"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Lam, C., Wiratama, B.S., Chang, W.-H., Chen, P.-L., Chiu, W.-T., Saleh, W., and Pai, C.-W. (2020). Effect of Motorcycle Helmet Types on Head Injuries: Evidence from Eight Level-I Trauma Centres in Taiwan. BMC Public Health, 20.","DOI":"10.1186\/s12889-020-8191-1"},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Du, R.Y., LoPresti, M.A., Garc\u00eda, R.M., and Lam, S. (2020). Primary Prevention of Road Traffic Accident-Related Traumatic Brain Injuries in Younger Populations: A Systematic Review of Helmet Legislation. J. Neurosurg. Pediatr., 1\u201314.","DOI":"10.3171\/2019.10.PEDS19377"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/j.ajem.2010.06.002","article-title":"Hypothermia Is Associated with Poor Outcome in Pediatric Trauma Patients","volume":"29","author":"Sundberg","year":"2011","journal-title":"Am. J. Emerg. Med."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1097\/01.TA.0000037876.37236.D6","article-title":"Harbingers of Poor Outcome the Day after Severe Brain Injury: Hypothermia, Hypoxia, and Hypoperfusion","volume":"54","author":"Jeremitsky","year":"2003","journal-title":"J. Trauma"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1136\/jramc-151-04-03","article-title":"Accidental Hypothermia","volume":"151","author":"Davis","year":"2005","journal-title":"J. R. Army Med. Corps"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"e20180594","DOI":"10.1542\/peds.2018-0594","article-title":"Blood Pressure Thresholds and Mortality in Pediatric Traumatic Brain Injury","volume":"142","author":"Suttipongkaset","year":"2018","journal-title":"Pediatrics"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1097\/TA.0b013e3182a685b0","article-title":"The Role of Serious Concomitant Injuries in the Treatment and Outcome of Pediatric Severe Traumatic Brain Injury","volume":"75","author":"Stewart","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1097\/01.PCC.0000123545.69133.C3","article-title":"Cerebral Autoregulation in Pediatric Traumatic Brain Injury","volume":"5","author":"Vavilala","year":"2004","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.annemergmed.2016.11.032","article-title":"Predictive Utility of the Total Glasgow Coma Scale Versus the Motor Component of the Glasgow Coma Scale for Identification of Patients With Serious Traumatic Injuries","volume":"70","author":"Chou","year":"2017","journal-title":"Ann. Emerg. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13054-017-1883-y","article-title":"Glycaemic Control Targets after Traumatic Brain Injury: A Systematic Review and Meta-Analysis","volume":"22","author":"Hermanides","year":"2018","journal-title":"Crit. Care"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1080\/02699052.2016.1264629","article-title":"The Impact of Early Hyperglycaemia on Children with Traumatic Brain Injury","volume":"31","author":"Fu","year":"2017","journal-title":"Brain Inj."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1097\/PCC.0000000000000170","article-title":"Hyperglycemia: An Independent Risk Factor for Poor Outcome in Children with Traumatic Brain Injury","volume":"15","author":"Elkon","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/PEC.0b013e31819a8966","article-title":"Traumatic Epidural Hematomas in Children and Adolescents: Outcome Analysis in 39 Consecutive Unselected Cases","volume":"25","author":"Gerlach","year":"2009","journal-title":"Pediatr. Emerg. Care"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1097\/PCC.0000000000000150","article-title":"Use of Rotterdam CT Scores for Mortality Risk Stratification in Children with Traumatic Brain Injury","volume":"15","author":"Liesemer","year":"2014","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/PCC.0000000000001735","article-title":"Guidelines for the Management of Pediatric Severe Traumatic Brain Injury, Third Edition: Update of the Brain Trauma Foundation Guidelines","volume":"20","author":"Kochanek","year":"2019","journal-title":"Pediatr. Crit. Care Med."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jclinepi.2019.02.016","article-title":"The Proportion of Missing Data Should Not Be Used to Guide Decisions on Multiple Imputation","volume":"110","author":"Hughes","year":"2019","journal-title":"J. Clin. Epidemiol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/12\/1339\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:44:01Z","timestamp":1760168641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/11\/12\/1339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,9]]},"references-count":51,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2021,12]]}},"alternative-id":["jpm11121339"],"URL":"https:\/\/doi.org\/10.3390\/jpm11121339","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,9]]}}}