{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T11:28:54Z","timestamp":1788866934831,"version":"build-2803163510"},"reference-count":17,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,6]],"date-time":"2022-01-06T00:00:00Z","timestamp":1641427200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Background: To evaluate the effectiveness and safety of radiofrequency ablation (RFA) treatment for benign thyroid nodules (BTNs) in five medical centers in Taiwan. Methods: From April 2016 to July 2020, 762 patients underwent ultrasound guided RFA treatment of 826 benign thyroid nodules at five medical centers in Taiwan. The RFA procedure was performed by radiologists, otolaryngologists, or surgeons. Patients were grouped into three subgroups according to the initial volume of BTNs. The volume reduction ratio (VRR) of each nodule, and complications were analyzed at 1, 3, and 6 months after RFA treatment and the three groups compared. Results: The large nodular group showed greater VRR compared to the other two groups at first 1-month follow-up. At 6-months follow-up, there was no significant difference of VRR among the three groups. Goiters with difference in size can attain a successful VRR (&gt;50%) although different specialists demonstrated variable VRR after 6-months follow-up. A total of 40 (4.8%) complications were reported. All patients recovered spontaneously without surgery intervention. Conclusions: The reliability and safety of RFA for benign thyroid nodules had been established. RFA has gradually become an alternative to surgery in the treatment of benign thyroid nodules in Taiwan.<\/jats:p>","DOI":"10.3390\/jpm12010063","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T01:14:02Z","timestamp":1641518042000},"page":"63","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Multicenter Study of Benign Thyroid Nodules with Radiofrequency Ablation: Results of 762 Cases over 4 Years in Taiwan"],"prefix":"10.3390","volume":"12","author":[{"given":"Wei-Che","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3270-2034","authenticated-orcid":false,"given":"Cheng-Kang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen-Hung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Cathay General Hospital, Taipei 106, Taiwan"},{"name":"Department of Otolaryngology, Sijhih Cathay General Hospital, New Taipei City 221, Taiwan"},{"name":"School of Medicine, Fu-Jen Catholic University, New Taipei City 242, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Yu","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Surgery, MacKay Memorial Hospital, Taipei 104, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-6677","authenticated-orcid":false,"given":"Pi-Ling","family":"Chiang","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An-Ni","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung 833, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0480-4754","authenticated-orcid":false,"given":"Jung Hwan","family":"Baek","sequence":"additional","affiliation":[{"name":"Department of Radiology and Research Institute of Radiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8811-9203","authenticated-orcid":false,"given":"Ming-Hsun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Surgery, National Taiwan University Hospital, Taipei 100, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3883-2104","authenticated-orcid":false,"given":"Kai-Lun","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung 402, Taiwan"},{"name":"School of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung 402, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,6]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1089\/thy.2006.16.361","article-title":"Radiofrequency ablation of benign cold thyroid nodules: Initial clinical experience","volume":"16","author":"Kim","year":"2006","journal-title":"Thyroid"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"836","DOI":"10.3348\/kjr.2014.15.6.836","article-title":"Moving-Shot versus Fixed Electrode Techniques for Radiofrequency Ablation: Comparison in anEx-VivoBovine Liver Tissue Model","volume":"15","author":"Ha","year":"2014","journal-title":"Korean J. 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