{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T22:35:21Z","timestamp":1788820521356,"version":"build-2803163510"},"reference-count":29,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T00:00:00Z","timestamp":1641772800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"MSIT","doi-asserted-by":"publisher","award":["2020R1F1A1048130"],"award-info":[{"award-number":["2020R1F1A1048130"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This study investigated the changes in the structural connectivity of the bilateral hemispheres over time following a middle cerebral artery infarction. Eighteen patients in the subacute group and nine patients in the chronic group with mild upper extremity motor impairment (Fugl-Meyer motor assessment score for the upper limb &gt; 43) following middle cerebral artery infarction were retrospectively evaluated in this study. All the patients underwent T1-weighted and diffusion tensor imaging. Tract-based statistical analyses of fractional anisotropy were used to compare the changes in the bilateral structural connectivity with those of age-matched normal controls. The corticospinal tract pathway of the affected hemisphere, corpus callosum, and corona radiata of the unaffected hemisphere had decreased structural connectivity in the subacute group, while the motor association area and anterior corpus callosum in the bilateral frontal lobes had increased structural connectivity in the chronic group. The bilateral hemispheres were influenced even in patients with mild motor impairment following middle cerebral artery infarction, and the structural connectivity of the bilateral hemispheres changed according to the time following the stroke.<\/jats:p>","DOI":"10.3390\/jpm12010081","type":"journal-article","created":{"date-parts":[[2022,1,10]],"date-time":"2022-01-10T17:42:25Z","timestamp":1641836545000},"page":"81","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Bihemispheric Structural Connectivity Following Middle Cerebral Artery Infarction"],"prefix":"10.3390","volume":"12","author":[{"given":"Dae Hyun","family":"Kim","sequence":"first","affiliation":[{"name":"Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-0924","authenticated-orcid":false,"given":"Hyunkoo","family":"Kang","sequence":"additional","affiliation":[{"name":"Veterans Health Service Medical Center, Department of Radiology, Seoul 05368, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1080\/096382899297684","article-title":"Disablement following stroke","volume":"21","author":"Mayo","year":"1999","journal-title":"Disabil. Rehabil."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1093\/brain\/awg145","article-title":"Neural correlates of outcome after stroke: A cross-sectional fmri study","volume":"126","author":"Ward","year":"2003","journal-title":"Brain"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1097\/00004647-200011000-00001","article-title":"Experience-associated structural events, subependymal cellular proliferative activity, and functional recovery after injury to the central nervous system","volume":"20","author":"Schallert","year":"2000","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1126\/science.272.5269.1791","article-title":"Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct","volume":"272","author":"Nudo","year":"1996","journal-title":"Science"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.STR.0000247943.12887.d2","article-title":"Postinfarct cortical plasticity and behavioral recovery","volume":"38","author":"Nudo","year":"2007","journal-title":"Stroke"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/ana.20845","article-title":"Cellular and molecular mechanisms of neural repair after stroke: Making waves","volume":"59","author":"Carmichael","year":"2006","journal-title":"Ann. Neurol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1001\/archneur.55.8.1081","article-title":"Role of the premotor cortex in recovery from middle cerebral artery infarction","volume":"55","author":"Seitz","year":"1998","journal-title":"Arch. Neurol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1161\/01.STR.28.12.2518","article-title":"A functional MRI study of subjects recovered from hemiparetic stroke","volume":"28","author":"Cramer","year":"1997","journal-title":"Stroke"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1002\/ana.410330208","article-title":"Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction","volume":"33","author":"Weiller","year":"1993","journal-title":"Ann. Neurol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1002\/ana.410290112","article-title":"The functional anatomy of motor recovery after stroke in humans: A study with positron emission tomography","volume":"29","author":"Chollet","year":"1991","journal-title":"Ann. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.1093\/brain\/awg245","article-title":"Neural correlates of motor recovery after stroke: A longitudinal fmri study","volume":"126","author":"Ward","year":"2003","journal-title":"Brain"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.apmr.2016.06.023","article-title":"Determining levels of upper extremity movement impairment by applying a cluster analysis to the Fugl-Meyer assessment of the upper extremity in chronic stroke","volume":"98","author":"Woytowicz","year":"2017","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Shafto, M.A., Tyler, L.K., Dixon, M., Taylor, J.R., Rowe, J.B., Cusack, R., Calder, A.J., Marslen-Wilson, W.D., Duncan, J., and Dalgleish, T. (2014). The Cambridge Centre for Ageing and Neuroscience (cam-can) study protocol: A cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing. BMC Neurol., 14.","DOI":"10.1186\/s12883-014-0204-1"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.neuroimage.2011.09.015","article-title":"Fsl","volume":"62","author":"Jenkinson","year":"2012","journal-title":"NeuroImage"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s12031-007-0029-0","article-title":"Diffusion tensor imaging (DTI)-based white matter mapping in brain research: A review","volume":"34","author":"Assaf","year":"2008","journal-title":"J. Mol. Neurosci. MN"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2956","DOI":"10.1161\/STROKEAHA.119.026222","article-title":"Differences in brain areas affecting language function after stroke","volume":"50","author":"Kyeong","year":"2019","journal-title":"Stroke"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/197140091302600502","article-title":"Diffusion tensor imaging of neural tissue organization: Correlations between radiologic and histologic parameters","volume":"26","author":"Wei","year":"2013","journal-title":"Neuroradiol. J."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1804","DOI":"10.1007\/s11682-018-9851-y","article-title":"Early functional mri activation predicts motor outcome after ischemic stroke: A longitudinal, multimodal study","volume":"12","author":"Du","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/S1474-4422(13)70264-3","article-title":"Connectivity-based approaches in stroke and recovery of function","volume":"13","author":"Grefkes","year":"2014","journal-title":"Lancet Neurol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1016\/j.neuroimage.2011.10.023","article-title":"Activation likelihood estimation meta-analysis of motor-related neural activity after stroke","volume":"59","author":"Rehme","year":"2012","journal-title":"NeuroImage"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1002\/ana.24510","article-title":"Corticospinal tract lesion load: An imaging biomarker for stroke motor outcomes","volume":"78","author":"Feng","year":"2015","journal-title":"Ann. Neurol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1161\/STROKEAHA.112.662619","article-title":"Assessing the integrity of corticospinal pathways from primary and secondary cortical motor areas after stroke","volume":"43","author":"Schulz","year":"2012","journal-title":"Stroke"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"469","DOI":"10.3389\/fnhum.2017.00469","article-title":"Role of the contralesional vs. Ipsilesional hemisphere in stroke recovery","volume":"11","author":"Dodd","year":"2017","journal-title":"Front. Hum. Neurosci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1161\/01.STR.30.9.1844","article-title":"The role of diaschisis in stroke recovery","volume":"30","author":"Seitz","year":"1999","journal-title":"Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1161\/01.STR.0000117235.11156.55","article-title":"Evolution of diaschisis in a focal stroke model","volume":"35","author":"Carmichael","year":"2004","journal-title":"Stroke"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1161\/01.STR.0000017100.68294.52","article-title":"Longitudinal study of motor recovery after stroke: Recruitment and focusing of brain activation","volume":"33","author":"Feydy","year":"2002","journal-title":"Stroke"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/S1388-2457(02)00062-7","article-title":"Motor disinhibition in affected and unaffected hemisphere in the early period of recovery after stroke","volume":"113","author":"Manganotti","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1093\/brain\/awf183","article-title":"Motor cortical disinhibition in the unaffected hemisphere after unilateral cortical stroke","volume":"125","author":"Shimizu","year":"2002","journal-title":"Brain"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1001\/archneur.61.12.1844","article-title":"Mechanisms underlying recovery of motor function after stroke","volume":"61","author":"Ward","year":"2004","journal-title":"Arch. Neurol."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/1\/81\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:27:09Z","timestamp":1760362029000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/1\/81"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,10]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["jpm12010081"],"URL":"https:\/\/doi.org\/10.3390\/jpm12010081","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,10]]}}}