{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T14:08:10Z","timestamp":1774447690704,"version":"3.50.1"},"reference-count":25,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T00:00:00Z","timestamp":1642118400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>This nationwide, population-based, retrospective, matched case\u2013control study included 111,960 newly diagnosed patients with scleritis who were identified by the International Classification of Diseases, Ninth Revision, Clinical Modification code 379.0, selected from the Taiwan National Health Insurance Research Database. Demographic characteristics, Sj\u00f6gren syndrome, and comorbid conditions within 1 year before the scleritis diagnosis were examined using univariate logistic regression analyses, and a paired t-test was used for continuous variables. Adjusted logistic regression was used to compare the prognosis odds ratio (OR) of the patients with scleritis with the controls. After adjustment for confounders, patients with Sj\u00f6gren syndrome were remarkably more likely to have scleritis than the controls (OR = 33.53, 95% confidence interval (CI) = 27.43\u201340.97, p &lt; 0.001). Other conditions found to have increased odds of scleritis included post ocular pterygium, glaucoma, and scleral surgery (OR\u2009 = \u20094.01, 95% CI\u2009 = \u20093.64\u20134.43; OR\u2009 = \u20093.16, 95% CI\u2009 = \u20092.24\u20134.47; OR\u2009 = \u20096.83, 95% CI\u2009 = \u20095.34\u20138.74, respectively); systemic infections, such as syphilis, tuberculosis, and a human herpes viral infection (OR\u2009 = \u20094.01, 95% CI\u2009 = \u20092.93\u20135.50; OR\u2009 = \u20092.24, 95% CI\u2009 = \u20091.94\u20132.58; OR\u2009 = \u20098.54, 95% CI\u2009 = \u20098.07\u20139.03, respectively); and systemic diseases, such as rheumatoid arthritis, granulomatous vasculitis, systemic lupus erythematosus, ankylosing spondylitis, and gout (OR\u2009 = \u20092.93, 95% CI\u2009 = \u20092.66\u20133.23; OR\u2009 = \u20097.37, 95% CI\u2009 = \u20093.91\u201313.88; OR\u2009 = \u20093.18, 95% CI\u2009 = \u20092.63\u20133.85; OR\u2009 = \u20095.57, 95% CI\u2009 = \u20094.99\u20136.22; OR\u2009 = \u20092.84, 95% CI\u2009 = \u20092.72\u20132.96, respectively). The results strongly support an association between Sj\u00f6gren syndrome, post ocular surgery, systemic infection disease, systemic autoimmune disease, and scleritis.<\/jats:p>","DOI":"10.3390\/jpm12010105","type":"journal-article","created":{"date-parts":[[2022,1,14]],"date-time":"2022-01-14T03:14:03Z","timestamp":1642130043000},"page":"105","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Associations between Sj\u00f6gren Syndrome, Sociodemographic Factors, Comorbid Conditions, and Scleritis in a Taiwanese Population-Based Study"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3205-7621","authenticated-orcid":false,"given":"Ren-Long","family":"Jan","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Chi Mei Medical Center, Liouying, Tainan 736, Taiwan"},{"name":"Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-8477","authenticated-orcid":false,"given":"Chung-Han","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan"},{"name":"Department of Hospital and Health Care Administration, Chia Nan University of Pharmacy and Science, Tainan 717, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jhi-Joung","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Medical Research, Chi Mei Medical Center, Tainan 710, Taiwan"},{"name":"Department of Anesthesiology, Chi Mei Medical Center, Tainan 710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Huei","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan"},{"name":"Department of Ophthalmology, Chi Mei Medical Center, Tainan 710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6247-5050","authenticated-orcid":false,"given":"Yuh-Shin","family":"Chang","sequence":"additional","affiliation":[{"name":"Graduate Institute of Medical Sciences, College of Health Sciences, Chang Jung Christian University, Tainan 711, Taiwan"},{"name":"Department of Ophthalmology, Chi Mei Medical Center, Tainan 710, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.survophthal.2016.06.002","article-title":"Treatment and management of scleral disorders","volume":"61","author":"Sobol","year":"2016","journal-title":"Surv. 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