{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:48:40Z","timestamp":1760150920479,"version":"build-2065373602"},"reference-count":33,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ANR ImaLang Agence Nationale de la Recherche","award":["ANR-17-EURE-0017, and ANR-11-JSH2-006-1"],"award-info":[{"award-number":["ANR-17-EURE-0017, and ANR-11-JSH2-006-1"]}]},{"name":"French national infrastructure NeurATRIS (Investissement d\u2019Avenir)","award":["ANR-11-INBS-0011"],"award-info":[{"award-number":["ANR-11-INBS-0011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Huntington\u2019s Disease (HD) is an inherited neurodegenerative disease characterized by a combination of motor, cognitive, and behavioral disorders. The social and behavioral symptoms observed in HD patients impact their quality of life and probably explain their relational difficulties, conflicts, and social withdrawal. In this study, we described the development of the Social Relationship Self-Questionnaire (SRSQ), a self-reporting questionnaire that assesses how HD patients perceived their social relationships. The scale was proposed for 66 HD patients at an early stage of the disease, 32 PreHD patients (individuals carrying the mutant gene without motor symptoms), and 66 controls. The HD patients were included in a prospective longitudinal follow-up for an average of 1.07 years with motor, functional, cognitive, and behavioral assessments. Based on the HD patients\u2019 answers at baseline, we identified two domains in the SRSQ. The first domain was related to social motivation and correlated with cognitive performance. The second domain was related to emotional insight and correlated with behavioral symptoms such as apathy, anxiety, and irritability. We discovered that both SRSQ domain scores at baseline predicted future motor, functional, and cognitive decline in HD.<\/jats:p>","DOI":"10.3390\/jpm12020174","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T22:00:56Z","timestamp":1643320856000},"page":"174","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Self-Reported Social Relationship Capacities Predict Motor, Functional and Cognitive Decline in Huntington\u2019s Disease"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1722-8303","authenticated-orcid":false,"given":"Pablo","family":"Lemercier","sequence":"first","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Cleret de Langavant","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0536-9125","authenticated-orcid":false,"given":"Jennifer","family":"Hamet Bagnou","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia","family":"Youssov","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Lemoine","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Etienne","family":"Audureau","sequence":"additional","affiliation":[{"name":"Clinical Epidemiology and Ageing, Service de Sant\u00e9 Publique, Henri Mondor Hospital, AP-HP, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renaud","family":"Massart","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3000-2210","authenticated-orcid":false,"given":"Anne-Catherine","family":"Bachoud-L\u00e9vi","sequence":"additional","affiliation":[{"name":"D\u00e9partement d\u2019Etudes Cognitives, Ecole Normale Sup\u00e9rieure, PSL University, 75005 Paris, France"},{"name":"Equipe NeuroPsychologie Interventionnelle, Institut Mondor de Recherche Biom\u00e9dicale, INSERM U955, University Paris Est Cr\u00e9teil, 94000 Cr\u00e9teil, France"},{"name":"Centre National de R\u00e9f\u00e9rence Maladie de Huntington, Service de Neurologie, H\u00f4pital Henri Mondor-Albert Chenevier, AP-HP, 94000 Cr\u00e9teil, France"},{"name":"NeurATRIS, 94000 Cr\u00e9teil, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Paoli, R.A., Botturi, A., Ciammola, A., Silani, V., Prunas, C., Lucchiari, C., Zugno, E., and Caletti, E. (2017). Neuropsychiatric Burden in Huntington\u2019s Disease. Brain Sci., 7.","DOI":"10.3390\/brainsci7060067"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.parkreldis.2016.02.008","article-title":"Neuropsychiatric Symptoms Are Very Common in Premanifest and Early Stage Huntington\u2019s Disease","volume":"25","author":"Carceller","year":"2016","journal-title":"Park. Relat. Disord."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1176\/appi.neuropsych.17080173","article-title":"Relationships among Apathy, Health-Related Quality of Life, and Function in Huntington\u2019s Disease","volume":"30","author":"Fritz","year":"2018","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbr.2015.10.001","article-title":"Social Cognition in Huntington\u2019s Disease: A Meta-Analysis","volume":"297","author":"Bora","year":"2016","journal-title":"Behav. Brain Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1037\/a0024408","article-title":"Evidence for Deficits on Different Components of Theory of Mind in Huntington\u2019s Disease","volume":"25","author":"Allain","year":"2011","journal-title":"Neuropsychology"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Mason, S.L., Schaepers, M., and Barker, R.A. (2021). Problems with Social Cognition and Decision-Making in Huntington\u2019s Disease: Why Is It Important?. Brain Sci., 11.","DOI":"10.3390\/brainsci11070838"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1002\/mds.22412","article-title":"Health-Related Quality of Life in Huntington\u2019s Disease: Which Factors Matter Most?","volume":"24","author":"Ho","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/j.1399-0004.2011.01748.x","article-title":"Impact of Huntington\u2019s across the Entire Disease Spectrum: The Phases and Stages of Disease from the Patient Perspective","volume":"80","author":"Ho","year":"2011","journal-title":"Clin. Genet."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1177\/1359105312438109","article-title":"Identification of Health-Related Quality of Life (HRQOL) Issues Relevant to Individuals with Huntington Disease","volume":"18","author":"Carlozzi","year":"2013","journal-title":"J. Health Psychol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fneur.2021.678484","article-title":"Ranking the Predictive Power of Clinical and Biological Features Associated With Disease Progression in Huntington\u2019s Disease","volume":"12","author":"Ghazaleh","year":"2021","journal-title":"Front. Neurol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e02151","DOI":"10.1002\/brb3.2151","article-title":"Cognitive and Behavioral Associated Changes in Manifest Huntington Disease: A Retrospective Cross-Sectional Study","volume":"11","author":"Migliore","year":"2021","journal-title":"Brain Behav."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1474-4422(10)70276-3","article-title":"Biological and Clinical Changes in Premanifest and Early Stage Huntington\u2019s Disease in the TRACK-HD Study: The 12-Month Longitudinal Analysis","volume":"10","author":"Tabrizi","year":"2011","journal-title":"Lancet Neurol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"(1996). Unified Huntington\u2019s Disease Rating Scale: Reliability and Consistency. Huntington Study Group. Mov. Disord., 11, 136\u2013142.","DOI":"10.1002\/mds.870110204"},{"key":"ref_14","unstructured":"Mattis, S. (1976). Mental Status Examination for Organic Mental Syndrome in the Elderly Patient. Geriatric Psychiatry: A Handbook for Psychiatrists and Primary Care Physicians, Grune & Stratton."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1080\/13854049108403297","article-title":"The Hopkins Verbal Learning Test: Development of a New Memory Test with Six Equivalent Forms","volume":"5","author":"Brandt","year":"1991","journal-title":"Clin. Neuropsychol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/ajmg.b.31232","article-title":"Indexing Disease Progression at Study Entry with Individuals At-Risk for Huntington Disease","volume":"156","author":"Zhang","year":"2011","journal-title":"Am. J. Med. Genet. Part B Neuropsychiatr. Genet."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1212\/WNL.0000000000004743","article-title":"Motor, Cognitive, and Functional Declines Contribute to a Single Progressive Factor in Early HD","volume":"89","author":"Schobel","year":"2017","journal-title":"Neurology"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1176\/appi.neuropsych.13070169","article-title":"Reliability and Factor Structure of the Short Problem Behaviors Assessment for Huntington\u2019s Disease (PBA-s) in the TRACK-HD and REGISTRY Studies","volume":"27","author":"Callaghan","year":"2015","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The Hospital Anxiety and Depression Scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Hoelzle, J.B., and Meyer, G.J. (2012). Exploratory Factor Analysis: Basics and Beyond. Handbook of Psychology: Research Methods in Psychology, John Wiley & Sons, Inc.. [2nd ed.].","DOI":"10.1002\/9781118133880.hop202006"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF02289447","article-title":"A Rationale and Test for the Number of Factors in Factor Analysis","volume":"30","author":"Horn","year":"1965","journal-title":"Psychometrika"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF02293557","article-title":"Determining the Number of Components from the Matrix of Partial Correlations","volume":"41","author":"Velicer","year":"1976","journal-title":"Psychometrika"},{"key":"ref_23","first-page":"1","article-title":"Correlation Coefficients for a Study with Repeated Measures","volume":"2020","author":"Shan","year":"2020","journal-title":"Comput. Math. Methods Med."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3389\/fpsyg.2017.00456","article-title":"Repeated Measures Correlation","volume":"8","author":"Bakdash","year":"2017","journal-title":"Front. Psychol."},{"key":"ref_25","unstructured":"Cohen, J. (1988). Statistical Power Analysis for the Behavioral Sciences, Routledge. [2nd ed.]."},{"key":"ref_26","first-page":"6","article-title":"The Many Facets of Unawareness in Huntington Disease","volume":"2014","author":"McCusker","year":"2014","journal-title":"Tremor Other Hyperkinetic Mov."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S1474-4422(12)70191-6","article-title":"Cognitive Reserve in Ageing and Alzheimer\u2019s Disease","volume":"11","author":"Stern","year":"2012","journal-title":"Lancet Neurol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1016\/j.neuropsychologia.2009.03.004","article-title":"Cognitive Reserve","volume":"47","author":"Stern","year":"2009","journal-title":"Neuropsychologia"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuropsychologia.2018.10.017","article-title":"An Active Cognitive Lifestyle as a Potential Neuroprotective Factor in Huntington\u2019s Disease","volume":"122","author":"Escrichs","year":"2019","journal-title":"Neuropsychologia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1080\/17470919.2015.1101014","article-title":"Theory of Mind and Social Reserve: Alternative Hypothesis of Progressive Theory of Mind Decay during Different Stages of Alzheimer\u2019s Disease","volume":"11","author":"Fliss","year":"2016","journal-title":"Soc. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/S2215-0366(16)30144-4","article-title":"Changes in Mental State and Behaviour in Huntington\u2019s Disease","volume":"3","author":"Eddy","year":"2016","journal-title":"Lancet Psychiatry"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1017\/S1355617717000145","article-title":"Feasibility and Efficacy of Brief Computerized Training to Improve Emotion Recognition in Premanifest and Early-Symptomatic Huntington\u2019s Disease","volume":"23","author":"Kempnich","year":"2017","journal-title":"J. Int. Neuropsychol. Soc."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"619","DOI":"10.3233\/JAD-200762","article-title":"Instruments to Assess Social Functioning in Individuals with Dementia: A Systematic Review","volume":"80","author":"Grothe","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/2\/174\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T22:09:27Z","timestamp":1760134167000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/2\/174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,27]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2022,2]]}},"alternative-id":["jpm12020174"],"URL":"https:\/\/doi.org\/10.3390\/jpm12020174","relation":{},"ISSN":["2075-4426"],"issn-type":[{"type":"electronic","value":"2075-4426"}],"subject":[],"published":{"date-parts":[[2022,1,27]]}}}