{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T13:32:58Z","timestamp":1777901578723,"version":"3.51.4"},"reference-count":40,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T00:00:00Z","timestamp":1643587200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST110\u20132314\u2013B\u2013038\u2013086\u2013MY3"],"award-info":[{"award-number":["MOST110\u20132314\u2013B\u2013038\u2013086\u2013MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["MOST108\u20132321\u2013B\u2013038\u2013008"],"award-info":[{"award-number":["MOST108\u20132321\u2013B\u2013038\u2013008"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["TMU109-AE1-B18"],"award-info":[{"award-number":["TMU109-AE1-B18"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Concussion, also known as mild traumatic brain injury (mTBI), commonly causes transient neurocognitive symptoms, but in some cases, it causes cognitive impairment, including working memory (WM) deficit, which can be long-lasting and impede a patient\u2019s return to work. The predictors of long-term cognitive outcomes following mTBI remain unclear, because abnormality is often absent in structural imaging findings. Previous studies have demonstrated that WM functional activity estimated from functional magnetic resonance imaging (fMRI) has a high sensitivity to postconcussion WM deficits and may be used to not only evaluate but guide treatment strategies, especially targeting brain areas involved in postconcussion cognitive decline. The purpose of the study was to determine whether machine learning-based models using fMRI biomarkers and demographic or neuropsychological measures at the baseline could effectively predict the 1-year cognitive outcomes of concussion. We conducted a prospective, observational study of patients with mTBI who were compared with demographically matched healthy controls enrolled between September 2015 and August 2020. Baseline assessments were collected within the first week of injury, and follow-ups were conducted at 6 weeks, 3 months, 6 months, and 1 year. Potential demographic, neuropsychological, and fMRI features were selected according to their significance of correlation with the estimated changes in WM ability. The support vector machine classifier was trained using these potential features and estimated changes in WM between the predefined time periods. Patients demonstrated significant cognitive recovery at the third month, followed by worsened performance after 6 months, which persisted until 1 year after a concussion. Approximately half of the patients experienced prolonged cognitive impairment at the 1-year follow up. Satisfactory predictions were achieved for patients whose WM function did not recover at 3 months (accuracy = 87.5%), 6 months (accuracy = 83.3%), and 1 year (accuracy = 83.3%) and performed worse at the 1-year follow-up compared to the baseline assessment (accuracy = 83.3%). This study demonstrated the feasibility of personalized prediction for long-term postconcussive WM outcomes based on baseline fMRI and demographic features, opening a new avenue for early rehabilitation intervention in selected individuals with possible poor long-term cognitive outcomes.<\/jats:p>","DOI":"10.3390\/jpm12020196","type":"journal-article","created":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T09:59:21Z","timestamp":1643709561000},"page":"196","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Personalized Prediction of Postconcussive Working Memory Decline: A Feasibility Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Yung-Chieh","family":"Chen","sequence":"first","affiliation":[{"name":"Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Medical Imaging, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Duen-Pang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Medical Imaging, Taipei Medical University Hospital, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3834-2615","authenticated-orcid":false,"given":"Yi-Tien","family":"Li","sequence":"additional","affiliation":[{"name":"Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Neuroscience Research Center, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yung-Hsiao","family":"Chiang","sequence":"additional","affiliation":[{"name":"Neuroscience Research Center, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Center for Neurotrauma and Neuroregeneration, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Department of Neurosurgery, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1468-6325","authenticated-orcid":false,"given":"Jyh-Jong","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Occupational Therapy, Kaohsiung Medical University, Kaohsiung 807, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hui","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng-Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Translational Imaging Research Center, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Medical Imaging, Taipei Medical University Hospital, Taipei 110, Taiwan"},{"name":"Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan"},{"name":"Research Center for Artificial Intelligence in Medicine, Taipei Medical University, Taipei 110, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,1,31]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1016\/j.apmr.2009.01.023","article-title":"Mild traumatic brain injury and posttraumatic stress disorder and their associations with health symptoms","volume":"90","author":"Vanderploeg","year":"2009","journal-title":"Arch. 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