{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T06:35:34Z","timestamp":1789108534969,"version":"build-2803163510"},"reference-count":66,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Psychosis can include schizophrenia, mood disorders with psychotic features, delusional disorder, active delirium, and neurodegenerative disorders accompanied by various psychotic symptoms. Late-onset psychosis requires careful intervention due to the greater associated risks of secondary psychosis; higher morbidity and mortality rates than early-onset psychosis; and complicated treatment considerations due to the higher incidence of adverse effects, even with the black box warning against antipsychotics. Pharmacological treatment, including antipsychotics, should be carefully initiated with the lowest dosage for short-term efficacy and monitoring of adverse side effects. Further research involving larger samples, more trials with different countries working in consortia, and unified operational definitions for diagnosis will help elaborate the clinical characteristics of late-onset psychosis and lead to the development of treatment approaches.<\/jats:p>","DOI":"10.3390\/jpm12030381","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T08:37:16Z","timestamp":1646210236000},"page":"381","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Clinical Approaches to Late-Onset Psychosis"],"prefix":"10.3390","volume":"12","author":[{"given":"Kiwon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Depression Center, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Irwon-ro, Gangnam-gu, Seoul 06351, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9985-2032","authenticated-orcid":false,"given":"Woojae","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Neuropsychiatry, Seoul National University Bundang Hospital, Gumi-ro, 173 beon-gil Bundang-gu, Seongnam-si 13619, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Wan","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su Jeong","family":"Seong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-9750","authenticated-orcid":false,"given":"Jae Yeon","family":"Hwang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Kangdong Sacred Heart Hospital, College of Medicine, Hallym University, Seoul 05355, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je il","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, College of Medicine, Hanyang University, Gyungchun-ro 153, Guri-si 11923, Korea"},{"name":"Department of Neurosurgery, Hanyang University Guri Hospital, Gyungchun-ro 153, Guri-si 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3691-4624","authenticated-orcid":false,"given":"Seon-Cheol","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine, Hanyang University, Gyungchun-ro 153, Guri-si 11923, Korea"},{"name":"Department of Psychiatry, Hanyang University Guri Hospital, Gyungchun-ro 153, Guri-si 11923, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"ref_1","unstructured":"Zivetz, L. 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