{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T23:56:03Z","timestamp":1769039763979,"version":"3.49.0"},"reference-count":18,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Surgical ventricular restoration (SVR) has repeatedly been suggested as a viable therapeutic strategy for ischemic heart failure (HF) patients, although the survival benefit is still debated. We investigated a real-world population treated with SVR in a single center with high case volumes. From July 2001 to June 2017, 648 patients (111 females) underwent SVR; coronary surgery was performed in 582 patients. Data were analyzed by dividing the population into two groups: Group I (371 patients operated between July 2001 and December 2007) and Group II (277 patients operated between January 2008 and June 2017). At baseline, Group I patients were more symptomatic for angina (47.4% versus 19.4%, p &lt; 0.0001) and less symptomatic for HF (NYHA class III\/IV, 46.3% versus 57%, p = 0.0071). The end-diastolic volume (106 mL\/m2 versus 118.3 mL\/m2, p &lt; 0.0001) and the end-systolic volume (70.5 mL\/m2 versus 81.5 mL\/m2, p &lt; 0.0001) were lower in Group I. The presence of 3-vessel coronary artery disease (CAD) was higher in Group I (73.3% versus 59.2%, p &lt; 0.0001). Thirty-day mortality (6.64%) was similar in the two groups (p = 0.4475). The Kaplan\u2013Meier estimate for all-cause mortality for the entire population was 13% at 2 years, 19.2% at 4 years and 36.6% at 8 years, and the probability was not different between groups (Log-rank = 0.11). In a real-world ischemic HF population, SVR may be carried out with favorable results; in patients with worse LV remodeling and less extensive CAD, SVR showed a trend toward a better outcome.<\/jats:p>","DOI":"10.3390\/jpm12040567","type":"journal-article","created":{"date-parts":[[2022,4,3]],"date-time":"2022-04-03T02:59:52Z","timestamp":1648954792000},"page":"567","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Surgical Ventricular Restoration for Ischemic Heart Failure: A Glance at a Real-World Population"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5365-7063","authenticated-orcid":false,"given":"Serenella","family":"Castelvecchio","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery, I.R.C.C.S. Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Milani","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics and Data Management, Scientific Directorate, I.R.C.C.S. Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9358-011X","authenticated-orcid":false,"given":"Federico","family":"Ambrogi","sequence":"additional","affiliation":[{"name":"Laboratory of Biostatistics and Data Management, Scientific Directorate, I.R.C.C.S. Policlinico San Donato, 20097 San Donato Milanese, Italy"},{"name":"Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianna","family":"Volpe","sequence":"additional","affiliation":[{"name":"Department of Cardiac Rehabilitation, I.R.C.C.S. Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Ramputi","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, I.R.C.C.S. Policlinico San Donato, 20097 San Donato Milanese, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Giovanni","family":"Soletti","sequence":"additional","affiliation":[{"name":"Cardiothoracic Surgery Department, Weill Cornell Medicine, NewYork-Presbyterian Hospital, New York, NY 10065, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8530-6284","authenticated-orcid":false,"given":"Lorenzo","family":"Menicanti","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, I.R.C.C.S. 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