{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:36:53Z","timestamp":1782916613720,"version":"3.54.5"},"reference-count":49,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T00:00:00Z","timestamp":1651190400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic","award":["VEGA 1\/0618\/21"],"award-info":[{"award-number":["VEGA 1\/0618\/21"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Parkinson\u2019s disease (PD) is currently considered progressive neurodegeneration of both the central and peripheral nervous systems. Widespread neuropathological changes lead to a complex clinical presentation with typical motor (hypokinesia, tremor, and rigidity) and various nonmotor symptoms. Orthostatic hypotension is one of the most disabling nonmotor features contributing to increased morbidity and mortality and decreased quality of life (QoL). Our study aimed to disclose the effect of a continuous infusion of levodopa-carbidopa intestinal gel (LCIG) on symptoms of orthostatic hypotension. Nine patients indicated for LCIG and eight matched patients on optimized medical treatment (OMT) were examined with scales for orthostatic symptoms (SCOPA-AUT), nonmotor symptoms and motor fluctuations (MDS-UPDRS), and QoL (PDQ39) at both baseline and after six months. The scores of \u201clight-headedness after standing\u201d and \u201cfainting\u201d decreased in the LCIG group compared to the OMT group. Treatment with LCIG was associated with a significantly higher decrease in the score of \u201clight-headedness after standing\u201d. Change in the PDQ39 correlated positively with fluctuation improvement and with change in the scores of both \u201clight-headedness\u201d and \u201cfainting\u201d. LCIG treatment improved symptoms of orthostatic hypotension in patients with PD mainly by a reduction in motor complications. Decreased severity in both motor and nonmotor fluctuations was connected also with improved QoL. Continuous treatment with LCIG should be considered not only in the case of severe motor fluctuation but also in patients with nonmotor fluctuations responsive to dopaminergic treatment.<\/jats:p>","DOI":"10.3390\/jpm12050718","type":"journal-article","created":{"date-parts":[[2022,4,30]],"date-time":"2022-04-30T05:44:07Z","timestamp":1651297447000},"page":"718","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Levodopa-Carbidopa Intestinal Gel Improves Symptoms of Orthostatic Hypotension in Patients with Parkinson\u2019s Disease\u2014Prospective Pilot Interventional Study"],"prefix":"10.3390","volume":"12","author":[{"given":"Simona","family":"Stankov\u00e1","sequence":"first","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, University Hospital in Bratislava, Comenius University in Bratislava, 833 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1134-7029","authenticated-orcid":false,"given":"Igor","family":"Straka","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, University Hospital in Bratislava, Comenius University in Bratislava, 833 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Ko\u0161utzk\u00e1","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, University Hospital in Bratislava, Comenius University in Bratislava, 833 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7837-8781","authenticated-orcid":false,"given":"Peter","family":"Valkovi\u010d","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, University Hospital in Bratislava, Comenius University in Bratislava, 833 05 Bratislava, Slovakia"},{"name":"Institute of Normal and Pathological Physiology, Centre of Experimental Medicine, Slovak Academy of Sciences, 813 71 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0812-2366","authenticated-orcid":false,"given":"Michal","family":"Min\u00e1r","sequence":"additional","affiliation":[{"name":"2nd Department of Neurology, Faculty of Medicine, University Hospital in Bratislava, Comenius University in Bratislava, 833 05 Bratislava, Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"S119","DOI":"10.1016\/j.parkreldis.2015.09.004","article-title":"Non-motor symptoms in Parkinson\u2019s disease","volume":"22","author":"Pfeiffer","year":"2015","journal-title":"Park. 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