{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T02:48:21Z","timestamp":1762051701709,"version":"build-2065373602"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T00:00:00Z","timestamp":1651968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Stochastic Models Research group","award":["E46_20R","PID2020-116873GB-I00"],"award-info":[{"award-number":["E46_20R","PID2020-116873GB-I00"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n MCIN\/AEI\/10.13039\/501100011033","award":["E46_20R","PID2020-116873GB-I00"],"award-info":[{"award-number":["E46_20R","PID2020-116873GB-I00"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>Small for gestational age (SGA) is defined as a newborn with a birth weight for gestational age &lt; 10th percentile. Routine third-trimester ultrasound screening for fetal growth assessment has detection rates (DR) from 50 to 80%. For this reason, the addition of other markers is being studied, such as maternal characteristics, biochemical values, and biophysical models, in order to create personalized combinations that can increase the predictive capacity of the ultrasound. With this purpose, this retrospective cohort study of 12,912 cases aims to compare the potential value of third-trimester screening, based on estimated weight percentile (EPW), by universal ultrasound at 35\u201337 weeks of gestation, with a combined model integrating maternal characteristics and biochemical markers (PAPP-A and \u03b2-HCG) for the prediction of SGA newborns. We observed that DR improved from 58.9% with the EW alone to 63.5% with the predictive model. Moreover, the AUC for the multivariate model was 0.882 (0.873\u20130.891 95% C.I.), showing a statistically significant difference with EPW alone (AUC 0.864 (95% C.I.: 0.854\u20130.873)). Although the improvements were modest, contingent detection models appear to be more sensitive than third-trimester ultrasound alone at predicting SGA at delivery.<\/jats:p>","DOI":"10.3390\/jpm12050762","type":"journal-article","created":{"date-parts":[[2022,5,8]],"date-time":"2022-05-08T21:31:20Z","timestamp":1652045480000},"page":"762","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Personalized Model to Predict Small for Gestational Age at Delivery Using Fetal Biometrics, Maternal Characteristics, and Pregnancy Biomarkers: A Retrospective Cohort Study of Births Assisted at a Spanish Hospital"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0488-1832","authenticated-orcid":false,"given":"Pe\u00f1a","family":"Dieste-P\u00e9rez","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miguel Servet University Hospital and Arag\u00f3n Health Research Institute, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-0187","authenticated-orcid":false,"given":"Ricardo","family":"Savir\u00f3n-Cornudella","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, San Carlos Clinical Hospital and San Carlos Health Research Institute (IdISSC), Complutense University, 28040 Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Tajada-Duaso","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miguel Servet University Hospital and Arag\u00f3n Health Research Institute, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faustino R.","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Zaragoza Faculty of Medicine and Arag\u00f3n Health Research Institute, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Cast\u00e1n-Mateo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Miguel Servet University Hospital and Arag\u00f3n Health Research Institute, 50009 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-2252","authenticated-orcid":false,"given":"Gerardo","family":"Sanz","sequence":"additional","affiliation":[{"name":"Department of Statistical Methods and Institute for Biocomputation and Physics of Complex Systems-BIFI, University of Zaragoza,50018 Zaragoza, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3007-302X","authenticated-orcid":false,"given":"Luis Mariano","family":"Esteban","sequence":"additional","affiliation":[{"name":"Engineering School of La Almunia, University of Zaragoza, 50100 La Almunia de Do\u00f1a Godina, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000357592","article-title":"Update on the diagnosis and classification of fetal growth restriction and proposal of a stage-based management protocol","volume":"36","author":"Figueras","year":"2014","journal-title":"Fetal Diagn Ther."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1056\/NEJM199904223401603","article-title":"Weight in relation to morbidity and mortality among newborn infants","volume":"340","author":"McIntire","year":"1999","journal-title":"Eng. 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