{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T19:22:43Z","timestamp":1784056963966,"version":"3.55.0"},"reference-count":46,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T00:00:00Z","timestamp":1652227200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JPM"],"abstract":"<jats:p>The aim of the study is the early detection of OHT (Ocular hypertension) in patients, in the activity of secondary prophylaxis (opportunity screening-medical check-up), to prevent blindness caused by POAG (Primary Open Angle Glaucoma). In Romania, medical examination of personnel with responsibilities in Transport Safety (TS) is legally regulated, being mandatory as a result of the internal transposition of European legislation in the field. The addressability of the patients for examination was determined by personal choice, depending on the accessibility of the medical service on the profile market (availability and price). The design of the study is epidemiological, observational, descriptive and retrospective. The standardized medical protocol included: personal medical history (anamnesis), physical ophthalmological examination, Intraocular pressure (IOP) measurement and Visual Field (VF) performance, with Automated Perimeter \u201cOptopol PTS 910\u201d through \u201cFast Threshold\u201d strategy. The specialized medical research was completed with a dichotomous questionnaire entitled \u201cSymptom Inventory\u201d, made according to the recommendations of patients resulting from \u201cFocus group\u201d research. The study was carried out within the \u201cCheck-up\u201d type medical controls upon request, only for personnel with positions in Transport Safety (TS), during January\u2013December 2021 at S.C. ARTIMED S.R.L. Oradea, Bihor County. Health analysis was performed for 820 people, of whom 71 people (8.65%) tested positive for IOP &gt; 21 mmHg, (suspected OHT) compared to 749 (91.35%) with normal values (Normal intraocular pressure-NIOP); the two lots being statistically significantly different (x2 = 560.590, df = 1, p = 0.000). The study involved 754 men (92.0%) and 66 women (8.0%), the sex ratio is 11.42 (Exp (B) = 0.782, Sig = 0.558, 95% CI = 0.343\u20131783; sex is not a significant predictor at the 5% level). The prevalence of OHT was 8.66% for the whole group, 8.48% for men and 10.60% for women. In the screening action for the whole group of patients the following was determined: IOP reference = 20.85 mmHg, Sensitivity (Se) = 91.5% and 1-Specificity (Sp) = 0.073, (Sp = 92.7%). The predictive value of the screening test was: Positive Predictive Value (PPV) = 90.1% and Negative Predictive Value (NPV) = 91.7%; Area under the ROC Curve (Receiver Operating Characteristic) = 0.986, Sig. = 0.000, CI95% = 0.979\u20130.993. A binary logistical model of a questionnaire was developed to determine the screening parameters which significantly predicted OHT: IOP (OR = 4.154, 95% CI: 3.155\u20135.469), Age &lt; 40 years (OR = 0.408, 95% CI: 0.239\u20130.698) and Pattern Defect (PD) (OR = 1.475% CI: 1.130\u20131.925). The results of this study assess health status through regular medical examinations, and highlight their importance and usefulness in secondary prevention activity. The particularity of this \u201ccheck-up\u201d type for personnel with attributions in transport safety is based on two essential aspects: the legal obligation to perform it and the fact it is financed by the beneficiary (the employer). In patients suspected of OHT after antiglaucoma treatment, IOP statistically significantly decreased.<\/jats:p>","DOI":"10.3390\/jpm12050777","type":"journal-article","created":{"date-parts":[[2022,5,11]],"date-time":"2022-05-11T10:19:46Z","timestamp":1652264386000},"page":"777","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Detection of Intraocular Hypertension during Opportunity Screening (Check-Up Medical Inspections)"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6147-8030","authenticated-orcid":false,"given":"Gabriel Zeno","family":"Munteanu","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeno Virgiliu Ioan","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Roiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian Marius","family":"Daina","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Georgeta","family":"Daina","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihaela Cristina","family":"Coroi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Domnariu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Lucian Blaga University, 550169 Sibiu, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Carmen","family":"Neculoiu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian Sebastian","family":"Cotovanu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Transilvania University, 500068 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1881-3531","authenticated-orcid":false,"given":"Dana","family":"Badau","sequence":"additional","affiliation":[{"name":"Petru Maior Faculty of Sciences and Letters, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology, 540142 Targu Mures, Romania"},{"name":"Interdisciplinary Doctoral School, Transilvania University, 500068 Brasov, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,11]]},"reference":[{"key":"ref_1","unstructured":"Yanoff, M. (2020). Treatise on Ophthalmology, Publishing House Prior. [5th ed.]. [ro. Tratat de oftalmologie]."},{"key":"ref_2","unstructured":"Dumitrache, M., Filip, M., and Filip, A. (2013). Treatise on Ophthalmology, Universitara Carol Davila. [ro. Tratat de oftalmologie]."},{"key":"ref_3","unstructured":"Boc\u0219an, I.S. (1999). Practical Epidemiology for Family Physicians, Medical\u0103 Universitar\u0103 Iuliu Ha\u021bieganu. [ro. Epidemiologie practic\u0103 pentru medicii de familie]."},{"key":"ref_4","unstructured":"Boc\u0219an, I.S., and R\u0103dulescu, A. (2002). Basic Knowledge for Public Health Managers, Alma-Mater. [ro. Cuno\u0219tin\u021be fundamentale pentru manageri \u00een s\u0103n\u0103tate public\u0103]."},{"key":"ref_5","unstructured":"Enachescu, D., and Marcu, G.M. (1994). Public Health and Health Management, ALL. [ro. S\u0103n\u0103tate public\u0103 \u0219i management sanitar]."},{"key":"ref_6","unstructured":"(2019, February 10). Minister\u2019s Order, no. 1257\/1391\/2013, Official Gazette, Part I no. 745 of 02\/12\/2013, Available online: http:\/\/www.monitoruljuridic.ro\/an\/2021\/."},{"key":"ref_7","unstructured":"(2021, February 17). Annex no. 3. Order of the Minister of Transport no. 1.151\/2021\/Order of the Minister of Health no.1.752\/2021, Chapter II, Methods Used for Medical Examination of Personnel with Responsibilities in Transport Safety and Minimum Equipment for Compulsory Medical Specialties, 3. Ophthalmology, Available online: https:\/\/mt.ro\/web14\/domenii-gestionate\/medical\/medical-reglementari."},{"key":"ref_8","first-page":"LE01","article-title":"Screening in Public Health and Clinical Care: Similarities and Differences in Definitions, Types, and Aims\u2014A Systematic Review","volume":"11","author":"Speechley","year":"2017","journal-title":"J. Clin. Diagn. Res."},{"key":"ref_9","unstructured":"Chiseli\u021b\u0103, D. (2020). Primitive Open-Angle Glaucoma, Critical Thoughts and Syntheses, Cermi. [ro. S\u0103n\u0103tate public\u0103 \u0219i management sanitar]."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1097\/01.ijg.0000212282.88347.c9","article-title":"Glaucoma screening in a high-risk population","volume":"15","author":"Vistamehr","year":"2006","journal-title":"J. Glaucoma"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.2147\/CLEP.S273016","article-title":"Detection of Glaucoma and Other Vision-Threatening Ocular Diseases in the Population Recruited at Specific Health Checkups in Japan","volume":"12","author":"Yamada","year":"2020","journal-title":"Clin. Epidemiol."},{"key":"ref_12","unstructured":"(2021, March 12). Minister\u2019s Order no. 1.151\/2021. Health Minister\u2019s Order no. nr.1.752\/2021, Available online: https:\/\/lege5.ro\/Gratuit\/ha4dcmrwge3a\/ordinul-nr-1151-1752-2021-pentru-aprobarea-cadrului-general-privind-examinarea-medicala-si-psihologica-a-personalului-cu-atributii-in-siguranta-transporturilor."},{"key":"ref_13","unstructured":"(2021, March 12). Annex no. 3. 4.2., Minister\u2019s Order no. 1.151\/2021. Health Minister\u2019s Order no. 1.752\/2021, Available online: https:\/\/legislatie.just.ro\/Public\/DetaliiDocumentAfis\/246042."},{"key":"ref_14","unstructured":"(2021, February 09). Health Minister\u2019s Order no. 1390\/2013, Available online: http:\/\/mt.ro\/web14\/domenii-gestionate\/medical\/medical-reglementari."},{"key":"ref_15","unstructured":"(2021, January 24). Optopol Technology, User\u2018s Manual Automated Perimeter PTS 910 Series. Available online: https:\/\/docplayer.net\/42059342-Automated-perimeter-pts-910-910-by.html."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.survophthal.2006.12.008","article-title":"Staging functional damage in glaucoma: Review of Different Classification Methods","volume":"52","author":"Brusini","year":"2007","journal-title":"Surv. Ophthalmol."},{"key":"ref_17","unstructured":"(2021, January 22). Romanian Government Decision no. 355\/2007, Regarding the Surveillance of the Workers\u2019 Health, Published in: Official Gazette, Bucharest, Romania, 2007, Available online: https:\/\/www.ilo.org\/wcmsp5\/groups\/public\/@ed_protect\/@protrav\/@safework\/documents\/normativeinstrument\/wcms_177384.pdf."},{"key":"ref_18","unstructured":"Popa, M. (2010). Multivariate Statistics Applied in Psychology, Polirom. [ro. Statistici multivariate aplicate \u00een psihologie]."},{"key":"ref_19","unstructured":"Jaba, E., and Grama, A. (2004). Statistical Analysis with SPSS under Windows, Polirom."},{"key":"ref_20","unstructured":"Achima\u0219-Cadariu, A. (2000). Methodology of Medical Scientific Research, Iuliu Ha\u021bieganu University Publishing House."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"e885","DOI":"10.1111\/aos.13756","article-title":"Statistics in ophthalmology revisited: The (effect) size matters","volume":"96","author":"Grzybowski","year":"2018","journal-title":"Acta Ophthalmol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1080\/02713683.2021.1927113","article-title":"Analysis of Comparative Clinical Data in Ophthalmology: An Approach","volume":"46","author":"Popovic","year":"2021","journal-title":"Curr. Eye Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.3758\/s13428-020-01471-8","article-title":"Comparing experimental conditions using modern statistics","volume":"53","author":"Martens","year":"2021","journal-title":"Behav. Res. Methods."},{"key":"ref_24","unstructured":"(2022, January 16). European Glaucoma Society. Guidelines\u2014European Glaucoma Society. Paris, France, 2021, 97. Available online: https:\/\/www.eugs.org."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.mcna.2021.01.004","article-title":"Glaucoma","volume":"105","author":"Kang","year":"2021","journal-title":"Med. Clin. North Am."},{"key":"ref_26","unstructured":"Minc\u0103, D.G., and Marcu, M.G. (2005). S\u0103n\u0103tate Public\u0103 \u0219i Management Sanitar, Note de Curs pentru Inv\u0103\u021b\u0103m\u00e2ntul Postuniversitar, Editura Universitar\u0103 Carol Davila. [2nd ed.]."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.jcjo.2014.06.013","article-title":"Ocular hypertension: An approach to assessment and management","volume":"49","author":"Boey","year":"2014","journal-title":"Can. J. Ophthalmol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00347-016-0304-y","article-title":"Abgrenzung der okul\u00e4ren Hypertension. [Differentiation of ocular hypertension]","volume":"113","author":"Hoffmann","year":"2016","journal-title":"Ophthalmologe"},{"key":"ref_29","first-page":"496","article-title":"D\u00e9pistage et pr\u00e9vention des glaucomes. [Glaucoma screening and prevention]","volume":"66","author":"Abitbol","year":"2016","journal-title":"Rev. Prat."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00347-021-01378-5","article-title":"Risk factors for open-angle glaucoma and recommendations for glaucoma screening","volume":"118","author":"Schuster","year":"2021","journal-title":"Ophthalmologe"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1016\/S0140-6736(17)31469-1","article-title":"Glaucoma","volume":"390","author":"Jonas","year":"2017","journal-title":"Lancet"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0212-6567(01)78891-9","article-title":"Glaucoma e hipertensi\u00f3n ocular en atenci\u00f3n primaria [Glaucoma and ocular hypertension in primary care]","volume":"28","year":"2001","journal-title":"Atenci\u00f3n Primaria"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/09286580701427053","article-title":"Issues in screening for glaucoma","volume":"14","author":"Friedman","year":"2007","journal-title":"Ophthalmic Epidemiol."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.ajo.2017.05.017","article-title":"SToP Glaucoma Study Group. Optimizing Glaucoma Screening in High-Risk Population: Design and 1-Year Findings of the Screening to Prevent (SToP) Glaucoma Study","volume":"180","author":"Zhao","year":"2017","journal-title":"Am. J. Ophthalmol."},{"key":"ref_35","unstructured":"(2022, January 23). Glaucoma World Week. Available online: https:\/\/societateadeglaucom.ro\/manifestari\/saptamana-mondiala-a-glaucomului\/."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1097\/ICU.0000000000000461","article-title":"Recent developments in visual field testing for glaucoma","volume":"29","author":"Wu","year":"2018","journal-title":"Curr. Opin. Ophthalmol."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Munteanu, G.Z., Munteanu, Z.V.I., Roiu, G., Daina, C.M., Moraru, R., Moraru, L., Trambitas, C., Badau, D., and Daina, L.G. (2021). Aspects of Tertiary Prevention in Patients with Primary Open Angle Glaucoma. J. Pers. Med., 11.","DOI":"10.3390\/jpm11090830"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1001\/archopht.117.5.573","article-title":"The Ocular Hypertension Treatment Study: Design and baseline description of the participants","volume":"117","author":"Gordon","year":"1999","journal-title":"Arch. Ophthalmol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.jfo.2011.10.008","article-title":"Hypertonie oculaire et glaucome primitif \u00e0 angle ouvert [High intraocular pressure and open angle glaucoma]","volume":"35","author":"Agbahoungba","year":"2012","journal-title":"J. Fr. Ophtalmol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1007\/s00417-014-2767-3","article-title":"Results of long-term monitoring of normal-tension glaucoma patients receiving medical therapy: Results of an 18-year follow-up","volume":"252","author":"Komori","year":"2014","journal-title":"Graefe\u2019s Arch. Clin. Exp. Ophthalmol."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.preteyeres.2016.10.001","article-title":"Detection and measurement of clinically meaningful visual field progression in clinical trials for glaucoma","volume":"56","author":"Liebmann","year":"2017","journal-title":"Prog. Retin. Eye Res."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1038\/eye.2010.112","article-title":"Focusing on glaucoma progression and the clinical importance of progression rate measurement: A review","volume":"24","author":"Rossetti","year":"2010","journal-title":"Eye"},{"key":"ref_43","first-page":"263","article-title":"Anatomical variations of the obturator veins and their surgical implications","volume":"38","author":"Capilna","year":"2017","journal-title":"Eur. J. Gynaecol. Oncol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"431","DOI":"10.37358\/MP.18.3.5044","article-title":"Applications of 3D Planning, Plastic Materials and Additive Manufacturing in Functional Rehabilitations in the Head and Neck Surgery","volume":"55","author":"Muhlfay","year":"2018","journal-title":"Mater. Plast."},{"key":"ref_45","first-page":"780","article-title":"Transthoracic versus Transhiatal esophagectomy: A Permanent Dilemma. Our 15-Year Experience","volume":"108","author":"Neagoe","year":"2013","journal-title":"Chirurgia"},{"key":"ref_46","unstructured":"Ministry of Transport and Infrastructure (2022, April 25). Approved Medical\/Psychological Units and Authorized Psychological Units, Available online: http:\/\/mt.ro\/web14\/domenii-gestionate\/medical\/medical-anunturi."}],"container-title":["Journal of Personalized Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/5\/777\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T23:09:28Z","timestamp":1760137768000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/2075-4426\/12\/5\/777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,11]]},"references-count":46,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2022,5]]}},"alternative-id":["jpm12050777"],"URL":"https:\/\/doi.org\/10.3390\/jpm12050777","relation":{},"ISSN":["2075-4426"],"issn-type":[{"value":"2075-4426","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,11]]}}}